<SEC-DOCUMENT>0001178913-20-002178.txt : 20200730
<SEC-HEADER>0001178913-20-002178.hdr.sgml : 20200730
<ACCEPTANCE-DATETIME>20200730071858
ACCESSION NUMBER:		0001178913-20-002178
CONFORMED SUBMISSION TYPE:	F-3
PUBLIC DOCUMENT COUNT:		8
FILED AS OF DATE:		20200730
DATE AS OF CHANGE:		20200730

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		F-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-240183
		FILM NUMBER:		201059183

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>F-3
<SEQUENCE>1
<FILENAME>zk2024695.htm
<DESCRIPTION>F-3
<TEXT>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">As filed with the Securities and Exchange Commission on July 30, 2020</div>
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    <div style="text-align: right; line-height: 1.25; font-weight: bold;">Registration No. 333-</div>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">WASHINGTON, D.C. 20549</div>
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">FORM F-3</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</div>
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    <div style="text-align: center; margin-right: 4.95pt; line-height: 1.25;">(Exact name of registrant as specified in its charter)</div>
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    <div style="text-align: center; margin-right: 4.95pt; line-height: 1.25;">(Translation of Registrant&#8217;s Name into English)</div>
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            <div style="text-align: center; line-height: 1.25;">(State or other jurisdiction of<br>
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            <div style="text-align: center; line-height: 1.25;">(I.R.S. Employer Identification Number)</div>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">26 Harokmim Street<br>
      Holon 5885849, Israel<br>
      +972-3-765-8585</div>
    <div style="text-align: center; line-height: 1.25;">(Address and telephone number of Registrant&#8217;s principal executive offices)</div>
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      <font style="font-weight: bold;">Compugen USA, Inc.</font>.<br>
      <font style="font-weight: bold;">395 Oyster Point Boulevard, Suite 307</font><br>
      <font style="font-weight: bold;">South San Francisco, CA 94080</font><br>
      <font style="font-weight: bold;">Phone: 415-373-0556</font><br>
      <font style="font-weight: bold;">Fax: 415-373-0776</font><br>
      (Name, address, and telephone number of agent for service)</div>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Copies to:</div>
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          <td style="width: 33%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Ari Krashin<br>
              Chief Financial and Operating Officer<br>
              Compugen Ltd.<br>
              26 Harokmim Street<br>
              Holon 5885849, Israel<br>
              Phone: +972-3-765-8585<br>
              Fax: +972-3-765-8555</div>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Daniel I. Goldberg, Esq.<br>
              Cooley LLP<br>
              55 Hudson Yards<br>
              New York, New York 10001-2157<br>
              Tel: 212-479-6000<br>
              Fax: 212-479-6275</div>
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          <td style="width: 33%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Lior Aviram, Adv.<br>
              <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Shibolet &amp; Co., Law Firm</div>
              Museum Tower<br>
              4 Berkowitz St., Tel Aviv 6423806<br>
              Tel: +972-3-7778333<br>
              Fax: +972-3-7778444</div>
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    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">Approximate date of commencement of proposed sale to the public: From time to time after the effective date of this Registration Statement.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. <font style="font-family: 'Segoe UI Symbol', 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. <font style="font-family: 'Segoe UI Symbol', 'Segoe UI Symbol', sans-serif;">&#9746;</font></div>
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    <div style="line-height: 1.25;">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the
      earlier effective registration statement for the same offering. <font style="font-family: 'Segoe UI Symbol', 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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    <div style="line-height: 1.25;">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration
      statement for the same offering. <font style="font-family: 'Segoe UI Symbol', 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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    <div style="line-height: 1.25;">If this Form is a registration statement pursuant to General Instruction I.C. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities
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    <div style="line-height: 1.25;">If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.C. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under
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    </div>
    <div style="line-height: 1.25;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933.</div>
    <div style="text-align: right; line-height: 1.25;">Emerging growth company <font style="font-family: 'Segoe UI Symbol', 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
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    </div>
    <div style="line-height: 1.25;">If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">CALCULATION OF REGISTRATION FEE</div>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Title of each class of securities to be </div>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Amount to be </div>
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          <td style="width: 1.79%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Proposed </div>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Proposed maximum</div>
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            <div style="text-align: center; line-height: 1.25; font-weight: bold;">offering price(2)(3)</div>
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          <td style="width: 0.7%; vertical-align: bottom; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
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          <td style="width: 10.94%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;" colspan="2">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Amount of </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">registration</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">fee(4)</div>
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            <div style="line-height: 1.25;">Ordinary Shares, par value NIS 0.01 per share</div>
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          <td style="width: 11.61%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 10.71%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 2.28%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.05%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 12.08%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 1.26%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.17%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 8.77%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 2.82%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">)</div>
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          <td style="width: 40.18%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">Debt Securities</div>
          </td>
          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 11.61%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 10.71%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 2.28%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.05%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 12.08%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 1.26%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.17%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 8.77%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 2.82%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">)</div>
          </td>
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          <td style="width: 40.18%; vertical-align: top; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">Rights</div>
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          <td style="width: 1.79%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 11.61%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 10.71%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 2.28%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.05%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 12.08%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 1.26%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.17%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 8.77%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 2.82%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">)</div>
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        <tr>
          <td style="width: 40.18%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">Warrants</div>
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          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 11.61%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 10.71%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 2.28%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.05%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 12.08%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 1.26%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.17%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 8.77%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 2.82%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 40.18%; vertical-align: top; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">Units</div>
          </td>
          <td style="width: 1.79%; vertical-align: top; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 11.61%; vertical-align: bottom; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 1.79%; vertical-align: bottom; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 1.79%; vertical-align: bottom; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 10.71%; vertical-align: bottom; background-color: #CCEEFF;">&#160;</td>
          <td style="width: 2.28%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.05%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 12.08%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 1.26%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">)</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.17%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 8.77%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="text-align: right; line-height: 1.25;">(5</div>
          </td>
          <td style="width: 2.82%; vertical-align: bottom; background-color: #CCEEFF;">
            <div style="line-height: 1.25;">)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 40.18%; vertical-align: top; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">Total</div>
          </td>
          <td style="width: 1.79%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 11.61%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1.79%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 1.79%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 10.71%; vertical-align: bottom; background-color: rgb(255, 255, 255);">&#160;</td>
          <td style="width: 2.28%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.05%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">$</div>
          </td>
          <td style="width: 12.08%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">350,000,000</div>
          </td>
          <td style="width: 1.26%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 0.7%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 2.17%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">$</div>
          </td>
          <td style="width: 8.77%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="text-align: right; line-height: 1.25;">45,430(6</div>
          </td>
          <td style="width: 2.82%; vertical-align: bottom; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">)&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-weight: bold;">__________</div>
    <table cellspacing="0" cellpadding="0" id="z6376b9f7a8be41a28a910ed437b6d77a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 6%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;">(1)</div>
          </td>
          <td style="width: 94%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;">There are being registered hereunder such indeterminate number of ordinary shares, such indeterminate number of debt securities, such indeterminate number of rights to purchase ordinary shares or debt securities
              or warrants, such indeterminate number of warrants to purchase ordinary shares, and such indeterminate number of units comprising any combination of these securities as shall have an aggregate initial offering price not to exceed
              $350,000,000. If any debt securities are issued at an original issue discount, then the issue price, and not the principal amount, of such debt securities shall be used for purposes of calculating the aggregate initial offering price of all
              securities issued. Any securities registered hereunder may be sold separately or as units with other securities registered hereunder. The securities registered also include such indeterminate amounts and numbers of ordinary shares and
              principal amounts of debt securities, as may be issued upon conversion of or exchange for debt securities that provide for conversion or exchange, upon exercise of warrants or pursuant to the anti-dilution provisions of any such securities.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">(2)</div>
          </td>
          <td style="width: 94%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">In United States dollars or the equivalent thereof in any other currency, currency unit or units, or composite currency or currencies.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">(3)</div>
          </td>
          <td style="width: 94%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">The proposed maximum aggregate offering prices per class of security will be determined from time to time by the Registrant in connection with the issuance by the Registrant of the securities registered
              hereunder.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">(4)</div>
          </td>
          <td style="width: 94%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">Calculated pursuant to Rule 457(o) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;). Pursuant to Rule 415(a)(6) under the Securities Act, the total amount of the filing fee payable in
              connection with this Registration Statement is $45,430. The filing fee of $12,610 paid with respect to the unsold securities described in Note (6) below will continue to be applied to such unsold securities registered by this Registration
              Statement.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">(5)</div>
          </td>
          <td style="width: 94%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">Not required to be included in accordance with General Instruction II.C of Form F-3.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">(6)</div>
          </td>
          <td style="width: 94%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">Pursuant to&#160;Rule 415(a)(6) under the Securities Act, the securities being registered hereunder include $104,043,700 of unsold securities previously registered by the registrant&#8217;s Registration Statement on
              Form&#160;F-3&#160;(File&#160;No. 333-233001)&#160;(the &#8220;Prior Registration Statement&#8221;), which was declared effective on August 12, 2019. The filing fee paid in connection with such unsold securities was $12,610 and will continue to apply to such unsold
              securities registered hereby. To the extent that, after the filing date hereof and prior to the effectiveness of this Registration Statement, the Registrant sells any such unsold securities pursuant to the Prior Registration Statement, the
              Registrant will identify in a&#160;pre-effective&#160;amendment to this Registration Statement the updated amount of unsold securities from the Prior Registration Statement to be included in this Registration Statement pursuant to&#160;Rule 415(a)(6).
              Pursuant to&#160;Rule 415(a)(6), the offering of the unsold securities under the Prior Registration Statement will be deemed terminated as of the date of effectiveness of this Registration Statement.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically
      states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until this Registration Statement shall become effective on such date as the Securities and Exchange
      Commission, acting pursuant to said Section 8(a), may determine.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">EXPLANATORY NOTE</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This registration statement contains two prospectuses:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zd65b2d479c354bbca888d6f0ca66b004" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 1.25;">a base prospectus which covers the offering, issuance and sale by us of up to $350,000,000 of our ordinary shares, debt securities, rights, warrants and units comprising any combination of these securities;&#160;and</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zd83f004c0b2e48ef89174ea297821c09" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 1.25;">a warrant share prospectus covering the offering, issuance and sale by us of up to 749,104 of our ordinary shares that may be issued and sold upon the exercise of certain outstanding warrants for an aggregate
                exercise price of up to $3,550,753.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">The base prospectus immediately follows this explanatory note. The specific terms of any securities to be offered pursuant to the base prospectus will be specified in a prospectus supplement to the
      base prospectus.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">The warrant share prospectus immediately follows the base prospectus. The ordinary shares that may be offered, issued and sold by us under the warrant share prospectus are included in the $350,000,000
      of securities that may be offered, issued and sold by us under the base prospectus. In the event of the termination of the offering of warrant shares under the warrant share prospectus, any portion of the $3,550,753 aggregate exercise price for the
      warrant shares covered by the warrant share prospectus that is not sold pursuant to the warrant share prospectus will be available for sale in other offerings pursuant to the base prospectus.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold; color: rgb(255, 0, 0);">The information in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange
      Commission is effective. This prospectus is not an offer to sell securities and it is not soliciting an offer to buy securities in any state where the offer or sale is not permitted.</div>
    <font style="color: rgb(255, 0, 0);"> </font>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; color: rgb(255, 0, 0);">&#160;</div>
    <font style="color: rgb(255, 0, 0);"> </font>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; color: rgb(255, 0, 0);">Subject to Completion, Dated July 30, 2020</div>
    <font style="color: rgb(255, 0, 0);"> </font>
    <div style="line-height: 1.25; color: rgb(255, 0, 0);">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">PROSPECTUS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><img width="238" height="75" src="image0.jpg"></div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; margin-right: 0.2pt; line-height: 1.25; font-weight: bold;">$350,000,000<br>
      Ordinary Shares<br>
      Debt Securities<br>
      Rights<br>
      Warrants<br>
      Units</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may offer and sell from time to time in one or more offerings our ordinary shares, debt securities, rights, warrants and units comprising any combination of these securities having an aggregate
      offering price up to $350,000,000.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Each time we sell securities pursuant to this prospectus, we will provide in a supplement to this prospectus the price and any other material terms of any such offering and the securities offered. Any
      prospectus supplement may also add, update or change information contained in the prospectus. You should read this prospectus and any applicable prospectus supplement, as well as the documents incorporated by reference or deemed incorporated by
      reference into this prospectus, carefully before you invest in any securities.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our ordinary shares are traded on The Nasdaq Global Market and on the Tel Aviv Stock Exchange under the symbol &#8220;CGEN.&#8221; The closing sale price of our ordinary shares on The Nasdaq Global Market and on
      the Tel Aviv Stock Exchange on July 27, 2020, was $14.82 and $14.43 per share, respectively. The currency in which our stock is traded on the Tel Aviv Stock Exchange is the New Israeli Shekel, or NIS. The above closing price on the Tel Aviv Stock
      Exchange represents a conversion from NIS to dollar amounts in accordance with the dollar - NIS conversion rate as of July 27, 2020, as reported by the Bank of Israel.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">An investment in our securities involves a high degree of risk. See the section entitled &#8220;Risk Factors&#8221; on page 2 of this prospectus and under similar headings in any amendment or
      supplement to this prospectus or in any filing with the Securities and Exchange Commission that is incorporated by reference herein.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">Neither the Securities and Exchange Commission nor any state or other securities commission has approved or disapproved of these securities or determined if this prospectus is
      truthful or complete. Any representation to the contrary is a criminal offense.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This prospectus may not be used to consummate sales of securities unless it is accompanied by a prospectus supplement.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; margin-right: 36pt; line-height: 1.25;">The date of this prospectus is&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; , 2020</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">TABLE OF CONTENTS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z98769d749a99422384371f20ce97719d" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#ABOUTTHISPROSPECTUS">ABOUT THIS PROSPECTUS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">i</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#PROSPECTUSSUMMARY">PROSPECTUS SUMMARY</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">1</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#RISKFACTORS">RISK FACTORS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">2</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#NOTEREGARDINGFORWARD-LOOK">NOTE REGARDING FORWARD-LOOKING STATEMENTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">3</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#OFFERSTATISTICSANDEXPECTE">OFFER STATISTICS AND EXPECTED TIMETABLE</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">4</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#CAPITALIZATION">CAPITALIZATION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">5</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#REASONSFORTHEOFFERANDUSEO">REASONS FOR THE OFFER AND USE OF PROCEEDS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">6</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFSECURITIES">DESCRIPTION OF SECURITIES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">7</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFORDINARYSHAR">DESCRIPTION OF ORDINARY SHARES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">8</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFDEBTSECURITI">DESCRIPTION OF DEBT SECURITIES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFRIGHTS">DESCRIPTION OF RIGHTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">19</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFWARRANTS">DESCRIPTION OF WARRANTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">20</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFUNITS">DESCRIPTION OF UNITS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">23</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#PLANOFDISTRIBUTION">PLAN OF DISTRIBUTION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">24</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#LEGALMATTERS">LEGAL MATTERS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">26</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#EXPERTS">EXPERTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">26</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#EXPENSES">EXPENSES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">26</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#INCORPORATIONOFCERTAININF">INCORPORATION OF CERTAIN INFORMATION BY REFERENCE</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">26</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#WHEREYOUCANFINDADDITIONAL">WHERE YOU CAN FIND ADDITIONAL INFORMATION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">28</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#ENFORCEABILITYOFCIVILLIAB">ENFORCEABILITY OF CIVIL LIABILITIES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">28</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#INDEMNIFICATIONFORSECURIT">INDEMNIFICATION FOR SECURITIES ACT LIABILITIES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">29</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
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    <div style="text-align: center; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="ABOUTTHISPROSPECTUS"><!--Anchor--></a>ABOUT THIS PROSPECTUS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or the SEC, using a &#8220;shelf&#8221; registration process. Under this shelf registration process,
      we may from time to time sell ordinary shares, debt securities, rights, warrants or units comprising any combination of these securities, in one or more offerings up to a total dollar amount of $350,000,000. We have provided to you in this prospectus
      a general description of the securities we may offer. Each time we sell securities, we will, to the extent required by law, provide a prospectus supplement that will contain specific information about the terms of the offering. We may also add,
      update or change in any accompanying prospectus supplement or any free writing prospectus we may authorize to be delivered to you any of the information contained in this prospectus. To the extent there is a conflict between the information contained
      in this prospectus and the prospectus supplement, you should rely on the information in the prospectus supplement, provided that if any statement in one of these documents is inconsistent with a statement in another document having a later date-for
      example, a document incorporated by reference in this prospectus or any prospectus supplement-the statement in the document having the later date modifies or supersedes the earlier statement. This prospectus, together with any accompanying prospectus
      supplement and any free writing prospectus we may authorize to be delivered to you, includes all material information relating to the offering of our securities.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">As permitted by the rules and regulations of the SEC, the registration statement, of which this prospectus forms a part, includes additional information not contained in this prospectus. You may read
      the registration statement and the other reports we file with the SEC at the SEC&#8217;s web site or at the SEC&#8217;s offices described below under the heading &#8220;Where You Can Find Additional Information.&#8221;</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">In this prospectus, unless otherwise stated or the context otherwise requires, references to &#8220;Compugen,&#8221;&#160;&#8220;the Company,&#8221;&#160;&#8220;we,&#8221;&#160;&#8220;us,&#8221;&#160;&#8220;our&#8221; and similar references refer to Compugen Ltd. and our wholly
      owned subsidiary, Compugen USA, Inc. except where the context otherwise requires or as otherwise indicated.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">You should rely only on the information contained or incorporated by reference in this prospectus, any accompanying prospectus supplement or any &#8220;free writing prospectus&#8221; we may
      authorize to be delivered to you. We have not authorized anyone to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. You should assume that the information appearing
      in this prospectus, any prospectus supplement and the documents incorporated by reference herein and therein are accurate only as of their respective dates. Our business, financial condition, results of operations and prospects may have changed since
      those dates.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">Neither this prospectus nor any accompanying prospectus supplement shall constitute an offer or solicitation by anyone in any jurisdiction in which such offer or solicitation is not
      authorized or in which the person making such offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make such offer or solicitation.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">i</font></div>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">
      <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
        <div>
          <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;"><a name="PROSPECTUSSUMMARY"><!--Anchor--></a>PROSPECTUS SUMMARY</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
          <div style="text-align: left; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-style: italic; font-weight: normal;">This summary highlights only some of the information included or incorporated by reference
            in this prospectus. You should carefully read this prospectus together with the additional information about us described in the sections entitled &#8220;Where You Can Find Additional Information&#8221; and &#8220;Incorporation of Certain Information by
            Reference&#8221; before purchasing our securities.</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
          <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Compugen Ltd.</div>
          <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Overview</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
          <div style="text-align: left; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">We are a clinical-stage therapeutic discovery and development company utilizing our broadly applicable,
            predictive computational discovery platforms to identify novel drug targets and develop therapeutics in the field of cancer immunotherapy. Our innovative immuno-oncology pipeline consists of three clinical stage programs, COM701, COM902 and BAY
            1905254, targeting immune checkpoints we discovered computationally. Our lead product candidate, COM701, a first-in-class anti-PVRIG antibody, for the treatment of solid tumors, is undergoing a Phase 1 clinical study and is under clinical
            collaboration with Bristol-Myers Squibb. COM902, our therapeutic antibody targeting TIGIT, is in a Phase 1 clinical study and BAY 1905254 a first-in-class therapeutic antibody targeting ILDR2, is licensed to Bayer under a research and discovery
            collaboration and license agreement and is also in Phase 1 studies in patients with advanced solid tumors. Our therapeutic pipeline further includes early-stage immuno-oncology programs focused largely on myeloid targets. Our innovative
            immuno-oncology pipeline, strategic collaborations and computational discovery engine serve as the Company&#8217;s three key building blocks. Our business model is to selectively enter into collaborations for our novel targets and related drug
            product candidates at various stages of research and development.</div>
          <div style="line-height: 1.25; font-weight: normal;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: left; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">In 2018, we entered into two agreements with leading pharmaceutical companies-a clinical collaboration agreement
            with Bristol-Myers Squibb in connection with our lead immuno-oncology program, COM701, and an exclusive license agreement with AstraZeneca for the development of bi-specific and multi-specific antibody products derived from one of our
            immuno-oncology programs. The first pipeline agreement we entered into was with Bayer in 2013 for the research, development, and commercialization of immuno-oncology therapeutics against novel targets identified by us. Under this agreement, we
            collaborate with Bayer on BAY 1905254 targeting ILDR2. We are also engaged in collaboration with Johns Hopkins School of Medicine, a leading academic research center in the United States to advance research and development efforts relating to
            our pipeline programs.</div>
          <div style="line-height: 1.25; font-weight: normal;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: left; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">We are headquartered in Holon, Israel. Our clinical development activities operate from our U.S. site in South
            San Francisco, California.&#160;</div>
          <div style="line-height: 1.25; font-weight: normal;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Corporate Information</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
          <div style="text-align: left; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">Our legal and commercial name is Compugen Ltd. We were incorporated on February 10, 1993 as an Israeli
            corporation and operate under the Israel Companies Law, 5759-1999, as amended, or the Companies Law. Our principal offices are located at 26 Harokmim Street, Holon 5885849, Israel, and our telephone number is +972-3-765-8585. Our web address is
            <font style="font-family: 'Times New Roman', Times, serif; font-style: italic;">www.cgen.com</font>. The information on our website is not incorporated by reference into this prospectus, is not considered a part of this prospectus and should
            not be relied upon with respect to any offering.</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
          <div style="text-align: left; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">Compugen USA, Inc., our wholly owned subsidiary, was incorporated in Delaware in March 1997 and is qualified to
            do business in California.&#160;This subsidiary did not have any significant operations from 2008 to March 2012.</div>
          <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;&#160; </div>
        </div>
      </div>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
    </div>
  </div>
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  <div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;"><a name="RISKFACTORS"><!--Anchor--></a>RISK FACTORS</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: normal;">Investing in our securities may involve a high degree of risk. Before making an investment decision, you should carefully consider the
      risks described under <font style="font-family: 'Times New Roman', Times, serif;">&#8220;</font>Risk Factors<font style="font-family: 'Times New Roman', Times, serif;">&#8221;</font> in the applicable prospectus supplement and in our most recent Annual Report
      on Form 20-F, or any updates in our Reports on Form 6-K, together with all of the other information appearing in this prospectus or incorporated by reference into this prospectus and any applicable prospectus supplement, in light of your particular
      investment objectives and financial circumstances. The risks so described are not the only risks facing our company. Additional risks not presently known to us or that we currently deem immaterial may also impair our business operations. Our
      business, financial condition and results of operations could be materially adversely affected by any of these risks. The trading price of our securities could decline due to any of these risks, and you may lose all or part of your investment.</div>
    <div style="line-height: 1.25; font-weight: normal;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">The COVID-19 pandemic may adversely affect our business and operations</font><font style="font-family: 'Times New Roman',Times,serif; font-weight: normal;"><br>
      </font><br>
      <div style="line-height: 1.25;">The recent outbreak of COVID-19 has been declared by the World Health Organization to be a &#8220;pandemic,&#8221; and has spread across the globe to many countries, including the United States and Israel and is impacting
        worldwide economic activity. The current COVID-19 pandemic may disrupt or prevent us, our suppliers and other business partners from conducting business activities as usual (including, without limitation, the availability and pricing of materials,
        manufacturing and delivery efforts, clinical trials and other aspects of our business) for a period of time, the duration of which is uncertain. In addition, we, our suppliers and other business partners may also experience significant impairments
        of business activities due to operational shutdowns or suspensions that may be requested or mandated by national or local governmental authorities or self-imposed by us, our suppliers or other business partners.<br style="line-height: 1.25;">
      </div>
      <font style="font-weight: normal;"> <br>
        While it is not possible at this time to estimate the future impact that COVID-19 could have on our business, suppliers or other business partners, the continued spread of COVID-19, the measures taken in Israel and the United States by federal and
        local governments, actions taken to protect employees, and the impact of the pandemic on various business activities could adversely affect our business, results of operations and financial condition.<br>
        <br>
        The capital markets have experienced significant volatility due to the ongoing spread of COVID-19. As a result, the price of our shares may be negatively impacted and affect our ability to raise additional capital.</font></div>
    <br>
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      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
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    </div>
    <br>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="NOTEREGARDINGFORWARD-LOOK"><!--Anchor--></a>NOTE REGARDING FORWARD-LOOKING STATEMENTS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This prospectus contains, and any accompanying prospectus supplement will contain, forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, or the
      Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act, and the Private Securities Litigation Reform Act of 1995. Also, documents that we incorporate by reference into this prospectus, including
      documents that we subsequently file with the SEC, will contain forward-looking statements. Forward-looking statements are those that predict or describe future events or trends and that do not relate solely to historical matters. You can generally
      identify forward-looking statements as statements containing the words &#8220;may,&#8221;&#160;&#8220;will,&#8221;&#160;&#8220;could,&#8221;&#160;&#8220;should,&#8221;&#160;&#8220;expect,&#8221;&#160;&#8220;anticipate&#8220;&#160;&#8220;objective,&#8221;&#160;&#8220;goal,&#8221;&#160;&#8220;intend,&#8221;&#160;&#8220;estimate,&#8221;&#160;&#8220;believe,&#8221;&#160;&#8220;project,&#8221;&#160;&#8220;plan,&#8221;&#160;&#8220;assume,&#8221; &#8220;potential,&#8221; &#8220;likely,&#8221; &#8220;confident&#8221; or
      other similar expressions, or negatives of those expressions, although not all forward-looking statements contain these identifying words. All statements contained or incorporated by reference in this prospectus and any prospectus supplement
      regarding our future strategy, future operations, projected financial position, the timing, progress, and results of preclinical studies and clinical trials,&#160;the timing, scope, or likelihood of regulatory filings and approvals, proposed products,
      anticipated collaborations, our ability to identify, develop and advance any future product candidates into, and successfully complete, clinical studies, estimated future revenues, projected costs, future prospects, the future of our industry and
      results that might be obtained by pursuing management&#8217;s current plans and objectives are forward-looking statements.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">You should not place undue reliance on our forward-looking statements because the matters they describe are subject to certain risks, uncertainties and assumptions, including in many cases decisions or
      actions by third parties that are difficult to predict. Our forward-looking statements are based on the information currently available to us and speak only as of the date on the cover of this prospectus, the date of any prospectus supplement, or, in
      the case of forward-looking statements incorporated by reference, the date of the filing that includes the statement. Over time, our actual results, performance or achievements may differ from those expressed or implied by our forward-looking
      statements, and such difference might be significant and materially adverse to our security holders. We undertake no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We have identified some of the important factors that could cause future events to differ from our current expectations and they are described in this prospectus and supplements to this prospectus
      under the caption &#8220;Risk Factors,&#8221; as well as in our most recent Annual Report on Form 20-F, including without limitation under the captions &#8220;Risk Factors&#8221; and &#8220;Operating and Financial Review and Prospects,&#8221; and in other documents that we may file
      with the SEC, all of which you should review carefully. Please consider our forward-looking statements in light of those risks as you read this prospectus and any prospectus supplement.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <br>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="OFFERSTATISTICSANDEXPECTE"><!--Anchor--></a>OFFER STATISTICS AND EXPECTED TIMETABLE</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may sell from time to time pursuant to this prospectus (as may be detailed in prospectus supplements) an indeterminate number of securities as shall have a maximum aggregate offering price of
      $350,000,000. The actual number of securities and price of the securities that we will offer pursuant hereto will depend on a number of factors that may be relevant as of the time of offer (see &#8220;Plan of Distribution&#8221; below).</div>
    <div style="line-height: 1.25;">&#160;</div>
  </div>
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    <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
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  </div>
  <div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="CAPITALIZATION"><!--Anchor--></a>CAPITALIZATION</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The table below sets forth our cash and cash equivalents, restricted cash, short-term bank deposits, and capitalization as of June 30, 2020. The information set forth in the following table should be
      read in conjunction with, and is qualified in its entirety by, reference to our audited and unaudited financial statements and the notes thereto incorporated by reference into this prospectus.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z9b67f5241af44930aa2073b6f19cf0dd" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF; padding-bottom: 2px;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
          <td valign="bottom" colspan="2" style="vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 solid 2px;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">As of June 30, 2020</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #FFFFFF; vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
          <td valign="bottom" colspan="2" style="vertical-align: bottom; background-color: #FFFFFF;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">(in thousands, except share and per share data)</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #FFFFFF; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 88%; padding-bottom: 2px;">
            <div style="line-height: 1.25;">Cash and cash equivalents, restricted cash and short-term bank deposits</div>
          </td>
          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
            <div style="line-height: 1.25;">136,066</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 88%;">
            <div style="line-height: 1.25;">Shareholder&#8217;s equity:</div>
          </td>
          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 88%;">
            <div style="line-height: 1.25;">Ordinary shares, NIS 0.01 nominal value: 200,000,000 shares authorized and 82,694,209 shares issued and outstanding</div>
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          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">227</div>
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          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 88%;">
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          </td>
          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">500,792</div>
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          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 88%; padding-bottom: 2px;">
            <div style="line-height: 1.25;">Accumulated deficit</div>
          </td>
          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
            <div style="line-height: 1.25;">(371,552</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;">
            <div style="line-height: 1.25;">)</div>
          </td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 88%; padding-bottom: 2px;">
            <div style="line-height: 1.25;">Total shareholders&#8217; equity</div>
          </td>
          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">129,467</div>
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          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 88%; padding-bottom: 4px;">
            <div style="line-height: 1.25;">Total capitalization</div>
          </td>
          <td valign="bottom" colspan="1" style="text-align: right; vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;">
            <div style="line-height: 1.25;">129,467</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;">&#160;</td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The number of outstanding ordinary shares set forth above excludes, as of June 30, 2020:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="zdb16584b32a444a1b50bbd832e250684" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 90pt; vertical-align: top; align: right;">
              <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 1.25;">5,481,735 ordinary shares issuable upon the exercise of outstanding options to purchase ordinary shares granted under our 2010 Share Incentive Plan, having a weighted average exercise price of $4.33 per share;</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" id="z4e6b22c69441408091c63c174de5e20c" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 90pt; vertical-align: top; align: right;">
              <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 1.25;">an aggregate 3,464,441 ordinary shares issuable and reserved for future grants under our 2010 Share Incentive Plan; and</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
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          <tr>
            <td style="width: 90pt; vertical-align: top; align: right;">
              <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div style="line-height: 1.25;">749,104 ordinary shares issuable upon the exercise of warrants issued to certain institutional investors in a registered direct offering completed in June 2018, with an exercise price of $4.74 per share.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="REASONSFORTHEOFFERANDUSEO"><!--Anchor--></a>REASONS FOR THE OFFER AND USE OF PROCEEDS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We cannot assure you that we will receive any proceeds in connection with securities offered pursuant to this prospectus. Unless otherwise indicated in the applicable prospectus supplement, we intend
      to use any net proceeds from the sale of securities under this prospectus for our operations and for other general corporate purposes, which may include working capital, intellectual property protection and enforcement, capital expenditures,
      investments, acquisitions or collaborations, pre-clinical and clinical development of our product candidates, research and development and product development and repayment or refinancing of indebtedness or other corporate borrowings. We may set
      forth additional information on the use of proceeds from the sale of securities we offer under this prospectus in a prospectus supplement relating to the specific offering. We have not determined the amount of net proceeds to be used specifically for
      the foregoing purposes. As a result, our management will have broad discretion in the allocation of the net proceeds. Pending use of the net proceeds, we would expect to invest any proceeds in a variety of capital preservation instruments, including
      short-term and long-term, investment&#8209;grade, interest&#8209;bearing instruments.</div>
    <div style="line-height: 1.25;">&#160;&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFSECURITIES"><!--Anchor--></a>DESCRIPTION OF SECURITIES</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The descriptions of the securities contained in this prospectus, together with the applicable prospectus supplements, summarize the material terms and provisions of the various types of securities that
      we may offer. We will describe in the applicable prospectus supplement relating to any securities the particular terms of the securities offered by that prospectus supplement. If we so indicate in the applicable prospectus supplement, the terms of
      the securities may differ from the terms we have summarized below.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may sell from time to time, in one or more offerings, ordinary shares, debt securities, rights, warrants to purchase ordinary shares and units comprising any combination of these securities.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">In this prospectus, we refer to the ordinary shares, debt securities, rights, warrants and units that may be offered by us collectively as &#8220;securities.&#8221; The total dollar amount of all securities that
      we may issue under this prospectus will not exceed $350,000,000.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This prospectus may not be used to consummate a sale of securities unless it is accompanied by a prospectus supplement.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">7</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFORDINARYSHAR"><!--Anchor--></a>DESCRIPTION OF ORDINARY SHARES</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">Our authorized share capital consists of 200,000,000 ordinary shares, nominal (par) value NIS 0.01 per share. As of June 30, 2020, 82,694,209 ordinary shares were issued and outstanding. Subject to our
      amended and restated articles of association, or our Articles, fully paid ordinary shares of the Company confer on the holders thereof rights to attend and to vote at general meetings of the shareholders. Subject to the rights of holders of shares
      with limited or preferred rights which may be issued in the future, the ordinary shares of the Company confer upon the holders thereof equal rights to vote, to receive dividends and to participate in the distribution of the assets of the Company upon
      its winding-up, in proportion to the amount paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in respect of which such dividends are being paid or such distribution is being made, without
      regard to any premium paid in excess of the nominal value, if any. All outstanding ordinary shares are validly issued and fully paid.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Registration Number and Purpose of the Company</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our registration number with the Israeli Registrar of Companies is 51-177-963-9. Our purpose as set forth in our Articles is to engage in any lawful act or activity for which companies may be organized
      under the Companies Law.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Rights Attached to Our Shares</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">Subject to our Articles, fully paid ordinary shares confer on the holders thereof rights to attend and to vote at general meetings of the shareholders. Subject to the rights of holders of shares with
      limited or preferred rights which may be issued in the future, our ordinary shares confer upon the holders thereof equal rights to receive dividends and to participate in the distribution of our assets upon our winding-up, in proportion to the amount
      paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in respect of which such dividends are being paid or such distribution is being made, without regard to any premium paid in excess of the
      nominal value, if any. No preferred shares are currently authorized. All outstanding ordinary shares are validly issued and fully paid.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Voting Rights</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">Subject to the provisions of our Articles, holders of ordinary shares have one vote for each ordinary share held by such shareholder of record, on all matters submitted to a vote of shareholders.
      Shareholders may vote in person, by proxy or by proxy card. Alternatively, shareholders who hold shares through members of the Tel Aviv Stock Exchange may vote electronically via the electronic voting system of the Israel Securities Authority, or
      Electronic Vote. These voting rights may be affected by the grant of any special voting rights to the holders of a class of shares with preferential rights that may be authorized in the future. As our ordinary shares do not have cumulative voting
      rights in the election of directors, the holders of the majority of the shares present and voting at a shareholders meeting have the power to elect all of our directors.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Transfer of Shares</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our ordinary shares which have been fully paid-up are transferable by submission of a proper instrument of transfer together with the certificate of the shares to be transferred and such other evidence
      of title, as our Board of Directors may require, unless such transfer is prohibited by another instrument or by applicable securities laws.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Dividends</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Under the Companies Law, dividends may be distributed only out of profits available for dividends as determined by the Companies Law, provided that there is no reasonable concern that the distribution
      will prevent the Company from being able to meet its existing and anticipated obligations when they become due. If the company does not meet the profit requirement, a court may nevertheless allow the company to distribute a dividend, as long as the
      court is convinced that there is no reasonable concern that such distribution will prevent the company from being able to meet its existing and anticipated obligations when they become due. Pursuant to our Articles, no dividend shall be paid other
      than out of the profits of the Company. Generally, under the Companies Law, the decision to distribute dividends and the amount to be distributed is made by a company&#8217;s board of directors.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our Articles provide that our Board of Directors, may, subject to the Companies Law, from time to time, declare and cause the Company to pay such dividends as may appear to the Board of Directors to be
      justified by the profits of our Company. Subject to the rights of the holders of shares with preferential, special or deferred rights that may be authorized in the future, our profits which shall be declared as dividends shall be distributed
      according to the proportion of the nominal (par) value paid up or credited as paid up on account of the shares held at the date so appointed by the Company and in respect of which such dividend is being paid, without regard to the premium paid in
      excess of the nominal (par) value, if any. The declaration of dividends does not require shareholders&#8217; approval.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">8</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">To date, we have not declared or distributed any dividend and we do not intend to pay cash dividends on our ordinary shares in the foreseeable future.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Liquidation Rights</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">In the event of our winding up on liquidation or dissolution, subject to applicable law and after satisfaction of liabilities to creditors, our assets available for distribution among the shareholders
      shall be distributed to the holders of ordinary shares in proportion to the amount paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in respect of which such distribution is being made, without
      regard to any premium paid in excess of the nominal value, if any. This liquidation right may be affected by the grant of limited or preferential rights as to liquidation to the holders of a class of shares that may be authorized in the future.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Redemption Provisions</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may, subject to applicable law and to our Articles, issue redeemable shares and redeem the same upon such terms and conditions as determined by our Board of Directors.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Limitation of Liability</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Under our Articles, the liability of each shareholder for the Company&#8217;s obligations is limited to the unpaid sum, if any, owing to the Company in consideration for the issuance of the shares held by
      such shareholder.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Modification of Class Rights</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our amended and restated Memorandum of Association, or Memorandum, provides that we may amend the Memorandum in order to increase, consolidate or divide or otherwise amend our share capital by a simple
      majority of the voting power present at a shareholders meeting as currently provided in our Articles or by such other majority as shall be set forth in our Articles from time to time.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to our Articles, if at any time our share capital is divided into different classes of shares, the rights attached to any class, unless otherwise provided by our Articles, may be modified or
      abrogated by the Company, subject to the consent in writing of, or sanction of a resolution passed by, the holders of a majority of the issued shares of such class at a separate general meeting of the holders of the shares of such class.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Limitations on the Rights to Own Securities</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our Articles and Israeli law do not restrict the ownership or voting of ordinary shares by non-residents or persons who are not citizens of Israel, though such ownership is prohibited under applicable
      law with respect to subjects of nations which are in a state of war with Israel.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Changes in Authorized Share Capital</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our Articles enable us, among others, to increase or reduce our authorized share capital. Any such changes are subject to the provisions of the Companies Law and our Articles and must be approved by a
      resolution duly passed by a simple majority of our shareholders at a general meeting by voting on such change in capital.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Shareholders&#8217; Meetings and Resolutions</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our Articles provide that our annual general meeting shall be held once in every calendar year at such time (within a period of not more than fifteen months after the last preceding annual general
      meeting), and place determined by our Board of Directors. Our Board of Directors may, in its discretion, convene additional special shareholders meetings and, pursuant to the Companies Law, must convene a meeting upon the demand of: (a) two directors
      or one quarter of the directors in office; or (b) the holder or holders of (i) 5% or more of our issued share capital and one percent or more of our voting rights; or (ii) 5% or more of our voting rights. All demands for shareholders meetings must
      set forth the items to be considered at that meeting.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">9</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The chairman of the Board of Directors, or any other director or office holder of the Company which may be designated for this purpose by the Board of Directors, shall preside as chairman at each of
      our general meetings. If there is no such chairman, or if the appointed chairman is unwilling to take the chair, or if he shall have indicated in advance that he will not be attending, or if at any meeting such chairman is not present within thirty
      (30) minutes after the time fixed for holding the meeting, then those present at the meeting shall choose someone present to be chairman of the meeting. The office of chairman shall not, by itself, entitle the holder thereof to vote at any general
      meeting nor shall it entitle a second or casting vote.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">According to regulations promulgated pursuant to the Companies Law and governing the terms of notice and publication of shareholder meetings of public companies, or the General Meeting Regulations,
      holder(s) of one percent or more of the Company&#8217;s voting rights may propose any matter appropriate for deliberation at a shareholder meeting to be included on the agenda of a shareholder meeting, generally by submitting a proposal within seven days
      of publicizing the convening of a shareholder meeting, or within fourteen days, if the Company publishes at least 21 days prior to publicizing the proxy materials for a shareholder meeting, a preliminary notice stating its intention to convene such
      meeting, the agenda thereof, shareholder&#8217;s right to propose a matter to be included on the agenda of such meeting and company&#8217;s right not to examine such proposals received upon termination of 14 day period from the publication of such notice. Any
      such proposal must further comply with the information requirements under applicable law and our Articles. The agenda for a shareholder meeting is determined by the Board of Directors and must include matters in respect of which the convening of a
      shareholder meeting was demanded and any matter requested to be included by holder(s) of one percent of the Company&#8217;s voting rights, as detailed above.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to the Companies Law and the General Meeting Regulations shareholder meetings generally require prior notice of not less than 21 days, and not less than 35 days in certain cases. Pursuant to
      our Articles, we are not required to deliver or serve notice of a general meeting or of any adjournments thereof to any shareholder. However, subject to applicable law and stock exchange rules and regulations, we will publicize the convening of a
      general meeting in any manner reasonably determined by us, and any such publication shall be deemed duly made, given and delivered to all shareholders on the date on which it is first made, posted, filed or published in the manner so determined by us
      in our sole discretion.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The function of the annual general meeting is to elect directors, receive and consider the profit and loss account, the balance sheet and the ordinary reports and accounts of the directors and
      auditors, appoint auditors and transact any other business which under our Articles or applicable law may be transacted by the shareholders of the Company in a general meeting.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to our Articles, the quorum required for a meeting of shareholders consists of at least two shareholders, present in person, by proxy, by proxy card or by Electronic Vote and holding shares
      conferring in the aggregate twenty-five percent (25%) or more of the voting power of the Company. If within half an hour from the time appointed for the meeting a quorum is not present, the meeting shall stand adjourned to the same day in the
      following week at the same time and place or to such other later day, time and place as the Board of Directors may determine and specify in the publication with respect to the Meeting. At the adjourned meeting, any number of participants will
      constitute a quorum present, in person, by proxy, by proxy card or by Electronic Vote; provided, however, that special general meeting which was convened by the Board upon the demand of shareholders or directors then in office, as detailed above, or
      directly by such shareholders or directors, in accordance the terms of the Companies Law, shall be cancelled.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Generally, under the Companies Law and our Articles, shareholder resolutions are deemed adopted if approved by the holders of a simple majority of the voting rights represented at the meeting, in
      person, by proxy, by proxy card or by Electronic Vote, and voting on the matter, unless a different majority is required by law or pursuant to our Articles such as a resolution for the voluntary winding up of our Company which requires the approval
      of holders of 75% of the voting power presented and voting at the meeting, or resolutions concerting certain related party transactions as set forth in Sections 267 and 270-275 of the Companies Law.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Change of Control</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Merger</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Under the Companies Law, a merger is generally required to be approved by the shareholders and board of directors of each of the merging companies. If the share capital of the company that will not be
      the surviving company is divided into different classes of shares, the approval of each class is also required, unless determined otherwise by the court. Similarly, unless an Israeli court determines otherwise, a merger will not be approved if it is
      objected to by shareholders holding a majority of the voting rights participating and voting at the meeting (abstentions are disregarded), after excluding the shares held by the other party to the merger, by any person who holds 25% or more of the
      other party to the merger or by anyone on their behalf, including by the relatives of, or corporations controlled by, these persons. In approving a merger, the board of directors of both merging companies must determine that there is no reasonable
      concern that, as a result of the merger, the surviving company will not be able to satisfy its obligations to its creditors. Similarly, upon the request of a creditor of either party to the proposed merger, an Israeli court may prevent or delay the
      merger if it concludes that there exists a reasonable concern that, as a result of the merger, the surviving company will not be able to satisfy the obligations of the merging parties. A court may also issue other instructions for the protection of
      the creditors&#8217; rights in connection with a merger. Further, a merger may not be completed unless at least (i) 50 days have passed from the time that the requisite proposals for the approval of the merger were filed with the Israeli registrar of
      companies; and (ii) 30 days have passed since the merger was approved by the shareholders of each party.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">10</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Special Tender Offer</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The Companies Law provides that an acquisition of shares of an Israeli public company must be made by means of a special tender offer if as a result of the acquisition the purchaser would become a
      holder of 25% or more of the voting rights in the company. This rule does not apply if there is already another holder of 25% or more of the voting rights in the company. Similarly, the Companies Law provides that an acquisition of shares in a public
      company must be made by means of a special tender offer if as a result of the acquisition the purchaser would become a holder of more than 45% of the voting rights in the company, if there is no other shareholder of the company who holds more than
      45% of the voting rights in the company. These requirements do not apply if the acquisition (i) occurs in the context of a private placement by the company that received shareholder approval for the purpose of allowing the purchaser to hold more than
      25% of 45% of the voting rights in the company, as the case may be, (ii) was from a shareholder holding 25% or more of the voting rights in the company and resulted in the acquirer becoming a holder of 25% or more of the voting rights in the company,
      or (iii) was from a holder of more than 45% of the voting rights in the company and resulted in the acquirer becoming a holder of more than 45% of the voting rights in the company. A special tender offer may be consummated only if (i) at least 5% of
      the voting power attached to the company&#8217;s outstanding shares will be acquired by the offeror and (ii) the number of shares tendered in the offer exceeds the number of shares whose holders objected to the offer (excluding controlling shareholders,
      holders of 25% or more of the voting rights in the company and any person having a personal interest in the acceptance of the tender offer).</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">In the event that a special tender offer is made, a company&#8217;s board of directors is required to express its opinion on the advisability of the offer, or shall abstain from expressing any opinion if it
      is unable to do so, provided that it gives the reasons for its abstention. An office holder in a target company who, in his or her capacity as an office holder, performs an action the purpose of which is to cause the failure of an existing or
      foreseeable special tender offer or is to impair the chances of its acceptance, is liable to the potential purchaser and shareholders for damages, unless such office holder acted in good faith and had reasonable grounds to believe he or she was
      acting for the benefit of the company. However, office holders of the target company may negotiate with the potential purchaser in order to improve the terms of the special tender offer and may further negotiate with third parties in order to obtain
      a competing offer. Shares purchased in contradiction to the tender offer rules under the Companies Law will have no rights and will become dormant shares.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">If a special tender offer is accepted, then shareholders who did not respond to or that had objected the offer may accept the offer within four days of the last day set for the acceptance of the offer.
      In the event that a special tender offer is accepted, then the purchaser or any person or entity controlling it or under common control with the purchaser or such controlling person or entity may not make a subsequent tender offer for the purchase of
      shares of the target company and may not enter into a merger with the target company for a period of one year from the date of the offer, unless the purchaser or such person or entity undertook to effect such an offer or merger in the initial special
      tender offer.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Full Tender Offer</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Under the Companies Law, a person may not acquire shares in a public company if, after the acquisition, the acquirer will hold more than 90% of the shares or more than 90% of any class of shares of
      that company, unless a tender offer is made to purchase all of the shares or all of the shares of the particular class. The Companies Law also generally provides that as long as a shareholder in a public company holds more than 90% of the company&#8217;s
      shares or of a class of shares, that shareholder shall be precluded from purchasing any additional shares. In order for all of the shares that the purchaser offered to purchase be transferred to him by operation of law, one of the following needs to
      have occurred: (i) the shareholders who declined or do not respond to the tender offer hold less than 5% of the company&#8217;s outstanding share capital or of the relevant class of shares and the majority of offerees who do not have a personal interest in
      accepting the tender offer accepted the offer, or (ii) the shareholders who declined or do not respond to the tender offer hold less than 2% of the company&#8217;s outstanding share capital or of the relevant class of shares.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">11</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">A shareholder that had his or her shares so transferred, whether he or she accepted the tender offer or not, has the right, within six months from the date of acceptance of the tender offer, to
      petition the court to determine that the tender offer was for less than fair value and that the fair value should be paid as determined by the court. However, the purchaser may provide in its offer that shareholders who accept the tender offer will
      not be entitled to such rights.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">If the conditions set forth above are not met, the purchaser may not acquire additional shares of the company from shareholders who accepted the tender offer to the extent that following such
      acquisition, the purchaser would own more than 90% of the company&#8217;s issued and outstanding share capital. The above restrictions apply, in addition to the acquisition of shares, to the acquisition of voting power.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Transfer Agent and Registrar</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">The transfer agent and registrar for our ordinary shares is American Stock Transfer &amp; Trust Company, LLC.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">The Nasdaq Global Market and the Tel Aviv Stock Exchange</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">Our ordinary shares are listed on The Nasdaq Global Market and the Tel Aviv Stock Exchange under the symbol &#8220;CGEN.&#8221;</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Warrants</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">As of June 30, 2020, we had warrants outstanding to purchase an aggregate 749,104 ordinary shares. See &#8220;Description of Warrants&#8212;Outstanding Warrants.&#8221;</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Share History</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The following is a summary of the history of our share capital for the last three years.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Ordinary Share Issuances</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z067024fec2bf4274a255891883ce7597" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
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            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><font style="font-style: italic;">Share Options.</font> Since January 1, 2017 and through June 30, 2020, we have issued a total of 4,256,307 ordinary shares upon the exercise of share options.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z733c9152ed6b4000bea5220c5df63c33" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 9.85%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 4.43%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><font style="font-style: italic;">ATM Sales Agreement</font>. In May 2018, we entered into a Controlled Equity Offering<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">SM</sup> Sales Agreement, or the ATM Sales Agreement, with Cantor Fitzgerald &amp; Co.,
              or Cantor, as sales agent, pursuant to which we may offer and sell, from time to time through Cantor, our ordinary shares having an aggregate offering price of up to $25 million. Under the ATM Sales Agreement, Cantor may sell Shares by any
              method permitted by law and deemed to be an &#8220;at the market offering&#8221; as defined in Rule 415(a)(4) promulgated under the Securities Act, including sales made directly on the Nasdaq Global Market, or on any other existing trading market for the
              ordinary shares. As of December 31, 2019, we sold 7,245,268 shares through the ATM Sales Agreement for an aggregate purchase price of approximately $23.7 million. The program was terminated in 2019.</div>
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.85%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 4.43%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><font style="font-style: italic;">Registered Direct Offering</font>. In June 2018, we entered into a definitive securities purchase agreement with certain institutional investors and a placement agency agreement
              with JMP Securities LLC, in connection with a registered direct offering which resulted in the issuance of 5,316,457 of our ordinary shares at a purchase price of $3.95 per share. In connection with the issuance of the ordinary shares, we
              also issued warrants to purchase up to 4,253,165 additional ordinary shares. The warrants have an exercise price of $4.74 per share and have a term of five years from the date of issuance. Gross proceeds from this offering were approximately
              $21 million, before deducting the underwriting discounts and commissions and estimated offering expenses payable by us. As of June 30, 2020, warrants to purchase up to 749,104 ordinary shares remained outstanding (warrants to purchase
              3,504,061 ordinary shares were exercised as of such date).</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.85%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 4.43%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="background-color: #FFFFFF; line-height: 1.25;">
              <div style="line-height: 1.25;"><font style="background-color: #FFFFFF; font-style: italic;">Bristol-Myers Squibb Securities Purchase Agreement. </font><font style="background-color: #FFFFFF;">In October 2018, we and Bristol-Myers Squibb
                  entered into a Securities Purchase Agreement pursuant to which Bristol-Myers&#160;Squibb purchased 2,424,243 ordinary shares at a purchase price of $4.95 per share, which represented a 33% premium over the average closing price on the last 20
                  Nasdaq trading days. Gross proceeds from this private placement were approximately $12 million.</font></div>
            </div>
            <div style="background-color: #FFFFFF; line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">12</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;"> </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 9.82%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
              <td style="width: 4.46%; vertical-align: top; background-color: #FFFFFF;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;"><font style="background-color: #FFFFFF; font-style: italic;">Public Offering.</font><font style="background-color: #FFFFFF;"> In March 2020, we entered into an underwriting agreement with SVB Leerink LLC
                      and Stifel,&#160;Nicolaus &amp; Company, Incorporated, as representatives of several underwriters relating to the issuance and sale in a public offering of 8,333,334 of our ordinary shares at a price to the public of $9.00 per share (and a
                      price of $8.46 per share to the underwriters). In addition, we granted the underwriters a 30-day option to purchase additional ordinary shares at the price set forth above. On April 14, 2020, we issued and sold, pursuant to that
                      underwriting agreement an additional 483,005 ordinary shares pursuant to the underwriters&#8217; option specified above.&#160;We sold a total of 8,816,339 ordinary shares in the offering with gross proceeds of approximately $79.3 million.</font></div>
                </div>
              </td>
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        </table>
        <div style="line-height: 1.25;">&#160;</div>
      </div>
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Authorized Share Capital</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our authorized share capital is equal to NIS2,000,000 divided into 200,000,000 ordinary shares nominal (par) value NIS 0.01 per share.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">13</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFDEBTSECURITI"><!--Anchor--></a>DESCRIPTION OF DEBT SECURITIES</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The following description, together with the additional information we include in any applicable prospectus supplements, summarizes the material terms and provisions of the debt securities that we may
      offer under this prospectus. While the terms we have summarized below will apply generally to any future debt securities we may offer pursuant to this prospectus, we will describe the particular terms of any debt securities that we may offer in more
      detail in the applicable prospectus supplement. If we so indicate in a prospectus supplement, the terms of any debt securities offered under such prospectus supplement may differ from the terms we describe below, and to the extent the terms set forth
      in a prospectus supplement differ from the terms described below, the terms set forth in the prospectus supplement shall control.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may sell from time to time, in one or more offerings under this prospectus, debt securities, which may be senior or subordinated. We will issue any such senior debt securities or subordinated debt
      securities under an indenture that we will enter into with a trustee to be named in the indenture. We have filed a form of this document as an exhibit to the registration statement, of which this prospectus is a part. The indenture will be qualified
      under the Trust Indenture Act of 1939, as in effect on the date of the indenture. We use the term &#8220;debenture trustee&#8221; to refer to the trustee under the indenture.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The following summaries of material provisions of the senior debt securities, the subordinated debt securities and the indenture are subject to, and qualified in their entirety by reference to, all the
      provisions of the indenture applicable to a particular series of debt securities.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">General</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The indenture provides that debt securities may be issued from time to time in one or more series and may be denominated and payable in foreign currencies or units based on or relating to foreign
      currencies. The indenture does not limit the amount of debt securities that may be issued thereunder, and it provides that the specific terms of any series of debt securities shall be set forth in, or determined pursuant to, an authorizing resolution
      and/or a supplemental indenture, if any, relating to such series.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We will describe in each prospectus supplement the following terms relating to a series of debt securities:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" id="z5ebf10669d08485f82e079ea5c1d3286" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">title or designation;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the aggregate principal amount and any limit on the amount that may be issued;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the currency or units based on or relating to currencies in which debt securities of such series are denominated and the currency or units in which principal or interest or both will or may be payable;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the maturity date and the date or dates on which principal will be payable;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the interest rate, which may be fixed or variable, or the method for determining the rate and the date interest will begin to accrue, the date or dates interest will be payable and the record dates for interest
              payment dates or the method for determining such dates;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">whether or not the debt securities will be secured or unsecured, and the terms of any secured debt;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the terms of the subordination of any series of subordinated debt;<br>
              <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the place or places where payments will be payable;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">our right, if any, to defer payment of interest and the maximum length of any such deferral period;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the date, if any, after which, and the price at which, we may, at our option, redeem the series of debt securities pursuant to any optional redemption provisions;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the date, if any, on which, and the price at which we are obligated, pursuant to any mandatory sinking fund provisions or otherwise, to redeem, or at the holder&#8217;s option to purchase, any series of debt
              securities;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">whether the indenture will restrict our ability to pay dividends, or will require us to maintain any asset ratios or reserves;</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">14</font></div>
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    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">whether we will be restricted from incurring any additional indebtedness;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">a discussion of any material or special U.S. federal income tax considerations applicable to a series of debt securities;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the denominations in which we will issue the series of notes, if other than denominations of $1,000 and any integral multiple thereof; and</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">any other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities.</div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div style="line-height: 1.25;">We may issue debt securities that provide for an amount less than their stated principal amount to be due and payable upon declaration of acceleration of their maturity pursuant to the terms of the indenture. We will
      provide you with information on the federal income tax considerations and other special considerations applicable to any of these debt securities in the applicable prospectus supplement.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Conversion or Exchange Rights</div>
    <div style="line-height: 1.25; font-weight: bold;">&#160;</div>
    <div style="line-height: 1.25;">We will set forth in the prospectus supplement the terms, if any, on which a series of debt securities may be convertible into or exchangeable for our ordinary shares or our other securities. We will include provisions
      as to whether conversion or exchange is mandatory, at the option of the holder or at our option. We may include provisions pursuant to which the number of ordinary shares or our other securities that the holders of the series of debt securities
      receive would be subject to adjustment.</div>
    <div style="line-height: 1.25; font-weight: bold;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Consolidation, Merger or Sale; No Protection in Event of a Change of Control or Highly Leveraged Transaction</div>
    <div style="line-height: 1.25; font-weight: bold;">&#160;</div>
    <div style="line-height: 1.25;">The indenture does not contain any covenant that restricts our ability to merge or consolidate, or sell, convey, transfer or otherwise dispose of all or substantially all of our assets. However, any successor to or
      acquirer of such assets must assume all of our obligations under the indenture or the debt securities, as appropriate.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">Unless we state otherwise in the applicable prospectus supplement, the debt securities will not contain any provisions that may afford holders of the debt securities protection in the event we have a change of control or
      in the event of a highly leveraged transaction (whether or not such transaction results in a change of control), which could adversely affect holders of debt securities.</div>
    <div style="line-height: 1.25; font-weight: bold;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Events of Default Under the Indenture</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">The following are events of default under the indenture with respect to any series of debt securities that we may issue:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z7190ccd6651a48da97a6b540913f8530" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">if we fail to pay interest when due and our failure continues for 90 days and the time for payment has not been extended or deferred;<br>
              <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">if we fail to pay the principal, or premium, if any, when due and the time for payment has not been extended or delayed;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">if we fail to observe or perform any other covenant set forth in the debt securities of such series or the indenture, other than a covenant specifically relating to and for the benefit of holders of another
              series of debt securities, and our failure continues for 90 days after we receive written notice from the debenture trustee or holders of not less than a majority in aggregate principal amount of the outstanding debt securities of the
              applicable series; and<br>
              <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">if we experience specified events of bankruptcy, insolvency or reorganization.</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;No event of default with respect to a particular series of debt securities (except as to certain events of bankruptcy, insolvency or reorganization) necessarily constitutes an event of default with respect to any other
      series of debt securities. The occurrence of an event of default may constitute an event of default under any bank credit agreements we may have in existence from time to time. In addition, the occurrence of certain events of default or an
      acceleration under the indenture may constitute an event of default under certain of our other indebtedness outstanding from time to time.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">If an event of default with respect to debt securities of any series at the time outstanding occurs and is continuing, then the trustee or the holders of not less than a majority in principal amount of the outstanding
      debt securities of that series may, by a notice in writing to us (and to the debenture trustee if given by the holders), declare to be due and payable immediately the principal (or, if the debt securities of that series are discount securities, that
      portion of the principal amount as may be specified in the terms of that series) of and premium and accrued and unpaid interest, if any, on all debt securities of that series. Before a judgment or decree for payment of the money due has been obtained
      with respect to debt securities of any series, the holders of a majority in principal amount of the outstanding debt securities of that series (or, at a meeting of holders of such series at which a quorum is present, the holders of a majority in
      principal amount of the debt securities of such series represented at such meeting) may rescind and annul the acceleration if all events of default, other than the non-payment of accelerated principal, premium, if any, and interest, if any, with
      respect to debt securities of that series, have been cured or waived as provided in the indenture (including payments or deposits in respect of principal, premium or interest that had become due other than as a result of such acceleration). We refer
      you to the applicable prospectus supplement(s) relating to any series of debt securities that are discount securities for the particular provisions relating to acceleration of a portion of the principal amount of such discount securities upon the
      occurrence of an event of default.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">15</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Subject to the terms of the indenture, if an event of default under an indenture shall occur and be continuing, the debenture trustee will be under no obligation to exercise any of its rights or powers under such
      indenture at the request or direction of any of the holders of the applicable series of debt securities, unless such holders have offered the debenture trustee reasonable indemnity. The holders of a majority in principal amount of the outstanding
      debt securities of any series will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the debenture trustee, or exercising any trust or power conferred on the debenture trustee, with respect
      to the debt securities of that series, provided that:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z7705c50e747e4533854e4b328e4e9e75" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the direction so given by the holder is not in conflict with any law or the indenture; and</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">subject to its duties under the Trust Indenture Act, the debenture trustee need not take any action that might involve it in personal liability or might be unduly prejudicial to the holders not involved in the
              proceeding.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">A holder of the debt securities of any series will only have the right to institute a proceeding under the indenture or to appoint a receiver or trustee, or to seek other remedies if:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" id="z2ccdc8afe7e04808af1a81eb9fa092a1" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the holder previously has given written notice to the debenture trustee of a continuing event of default with respect to that series;</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the holders of at least a majority in aggregate principal amount of the outstanding debt securities of that series have made written request, and such holders have offered reasonable indemnity to the debenture
              trustee to institute the proceeding as trustee; and</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the debenture trustee does not institute the proceeding, and does not receive from the holders of a majority in aggregate principal amount of the outstanding debt securities of that series (or at a meeting of
              holders of such series at which a quorum is present, the holders of a majority in principal amount of the debt securities of such series represented at such meeting) other conflicting directions within 60 days after the notice, request and
              offer.</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">These limitations do not apply to a suit instituted by a holder of debt securities if we default in the payment of the principal, premium, if any, or interest on, the debt securities.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">We will periodically file statements with the applicable debenture trustee regarding our compliance with specified covenants in the indenture.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Modification of Indenture; Waiver</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">The debenture trustee and we may change the indenture without the consent of any holders with respect to specific matters, including:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zfab4deaa63b2440888414d9aaad967b4" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 10.71%; vertical-align: top;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top;">
            <div style="line-height: 1.25;">to fix any ambiguity, defect or inconsistency in the indenture; and</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 10.71%; vertical-align: top;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top;">
            <div style="line-height: 1.25;">to change anything that does not materially adversely affect the interests of any holder of debt securities of any series issued pursuant to such indenture.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">16</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">In addition, under the indenture, the rights of holders of a series of debt securities may be changed by us and the debenture trustee with the written consent of the holders of at least a majority in aggregate principal
      amount of the outstanding debt securities of each series (or, at a meeting of holders of such series at which a quorum is present, the holders of a majority in principal amount of the debt securities of such series represented at such meeting) that
      is affected. However, the debenture trustee and we may make the following changes only with the consent of each holder of any outstanding debt securities affected:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 10.71%; vertical-align: top;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top;">
              <div style="line-height: 1.25;">
                <div style="line-height: 1.25;">extending the fixed maturity of the series of debt securities;</div>
                <div style="line-height: 1.25;"> <br>
                </div>
              </div>
            </td>
          </tr>
          <tr>
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              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top;">
              <div style="line-height: 1.25;">
                <div style="line-height: 1.25;">reducing the principal amount, reducing the rate of or extending the time of payment of interest, or any premium payable upon the redemption of any debt securities;</div>
              </div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 10.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.57%; vertical-align: top;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 85.71%; vertical-align: top;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">reducing the principal amount of discount securities payable upon acceleration of maturity;</div>
                  <div style="line-height: 1.25;"> <br>
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                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.57%; vertical-align: top;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 85.71%; vertical-align: top;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">making the principal of or premium or interest on any debt security payable in currency other than that stated in the debt security; or</div>
                </div>
              </td>
            </tr>

        </table>
        <div style="line-height: 1.25;">&#160;
          <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 10.71%; vertical-align: top;">&#160;</td>
                <td style="width: 3.57%; vertical-align: top;">
                  <div style="line-height: 1.25;">&#8226;</div>
                </td>
                <td style="width: 85.71%; vertical-align: top;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">reducing the percentage of debt securities, the holders of which are required to consent to any amendment or waiver.</div>
                  </div>
                </td>
              </tr>

          </table>
          <div style="line-height: 1.25;">&#160;</div>
        </div>
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    </div>
    <div style="line-height: 1.25;">Except for certain specified provisions, the holders of at least a majority in principal amount of the outstanding debt securities of any series (or, at a meeting of holders of such series at which a quorum is present,
      the holders of a majority in principal amount of the debt securities of such series represented at such meeting) may on behalf of the holders of all debt securities of that series waive our compliance with provisions of the indenture. The holders of
      a majority in principal amount of the outstanding debt securities of any series may on behalf of the holders of all the debt securities of such series waive any past default under the indenture with respect to that series and its consequences, except
      a default in the payment of the principal of, premium or any interest on any debt security of that series or in respect of a covenant or provision, which cannot be modified or amended without the consent of the holder of each outstanding debt
      security of the series affected; <font style="font-style: italic;">provided</font>, <font style="font-style: italic;">however</font>, that the holders of a majority in principal amount of the outstanding debt securities of any series may rescind an
      acceleration and its consequences, including any related payment default that resulted from the acceleration.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Discharge</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">Each indenture provides that we can elect to be discharged from our obligations with respect to one or more series of debt securities, except for obligations to:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
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              <td style="width: 3.57%; vertical-align: top;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 85.71%; vertical-align: top;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">the transfer or exchange of debt securities of the series;</div>
                    <div style="line-height: 1.25;"> <br>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="width: 10.71%; vertical-align: top;">&#160;</td>
              <td style="width: 3.57%; vertical-align: top;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 85.71%; vertical-align: top;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">replace stolen, lost or mutilated debt securities of the series;</div>
                  </div>
                </div>
              </td>
            </tr>

        </table>
        <div style="line-height: 1.25;">&#160;
          <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 10.71%; vertical-align: top;">&#160;</td>
                <td style="width: 3.57%; vertical-align: top;">
                  <div style="line-height: 1.25;">&#8226;</div>
                </td>
                <td style="width: 85.71%; vertical-align: top;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">maintain paying agencies;</div>
                    </div>
                    <div style="line-height: 1.25;"> <br>
                    </div>
                  </div>
                </td>
              </tr>
              <tr>
                <td style="width: 10.71%; vertical-align: top;">&#160;</td>
                <td style="width: 3.57%; vertical-align: top;">
                  <div style="line-height: 1.25;">&#8226;</div>
                </td>
                <td style="width: 85.71%; vertical-align: top;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">hold monies for payment in trust;</div>
                    </div>
                  </div>
                </td>
              </tr>

          </table>
          <div style="line-height: 1.25;">&#160;
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 10.71%; vertical-align: top;">&#160;</td>
                  <td style="width: 3.57%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 85.71%; vertical-align: top;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">compensate and indemnify the trustee; and</div>
                      </div>
                    </div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;">&#160;
              <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                  <tr>
                    <td style="width: 10.71%; vertical-align: top;">&#160;</td>
                    <td style="width: 3.57%; vertical-align: top;">
                      <div style="line-height: 1.25;">&#8226;</div>
                    </td>
                    <td style="width: 85.71%; vertical-align: top;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">appoint any successor trustee.</div>
                          </div>
                        </div>
                      </div>
                    </td>
                  </tr>

              </table>
              <div style="line-height: 1.25;">&#160;</div>
            </div>
          </div>
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;"> </div>
    <div style="line-height: 1.25;">In order to exercise our rights to be discharged with respect to a series, we must deposit with the trustee money or government obligations sufficient to pay all the principal of, the premium, if any, and interest on,
      the debt securities of the series on the dates payments are due.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Form, Exchange, and Transfer</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">We will issue the debt securities of each series only in fully registered form without coupons and, unless we otherwise specify in the applicable prospectus supplement, in denominations of $1,000 and any integral
      multiple thereof. The indenture provides that we may issue debt securities of a series in temporary or permanent global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust Company or another depositary
      named by us and identified in a prospectus supplement with respect to that series.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">At the option of the holder, subject to the terms of the indenture and the limitations applicable to global securities described in the applicable prospectus supplement, the holder of the debt securities of any series
      can exchange the debt securities for other debt securities of the same series, in any authorized denomination and of like tenor and aggregate principal amount.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">Subject to the terms of the indenture and the limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt securities may present the debt securities for exchange or
      for registration of transfer, duly endorsed or with the form of transfer endorsed thereon duly executed if so required by us or the security registrar, at the office of the security registrar or at the office of any transfer agent designated by us
      for this purpose. Unless otherwise provided in the debt securities that the holder presents for transfer or exchange or in the indenture, we will make no service charge for any registration of transfer or exchange, but we may require payment of any
      taxes or other governmental charges.</div>
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      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">17</font></div>
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    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">We will name in the applicable prospectus supplement the security registrar, and any transfer agent in addition to the security registrar, that we initially designate for any debt securities. We may at any time designate
      additional transfer agents or rescind the designation of any transfer agent or approve a change in the office through which any transfer agent acts, except that we will be required to maintain a transfer agent in each place of payment for the debt
      securities of each series.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">If we elect to redeem the debt securities of any series, we will not be required to:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z5352fc61af2b4406871cf5200486a4a7" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top;">
            <div style="line-height: 1.25;">issue, register the transfer of, or exchange any debt securities of that series during a period beginning at the opening of business 15 days before the day of mailing of a notice of redemption of any debt
              securities that may be selected for redemption and ending at the close of business on the day of the mailing; or</div>
            <div style="line-height: 1.25;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 7.14%; vertical-align: top;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top;">
            <div style="line-height: 1.25;">register the transfer of or exchange any debt securities so selected for redemption, in whole or in part, except the unredeemed portion of any debt securities we are redeeming in part.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-weight: bold;">Information Concerning the Debenture Trustee</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">The debenture trustee, other than during the occurrence and continuance of an event of default under the indenture, undertakes to perform only those duties as are specifically set forth in the indenture. Upon an event of
      default under an indenture, the debenture trustee under such indenture must use the same degree of care as a prudent person would exercise or use in the conduct of his or her own affairs. Subject to this provision, the debenture trustee is under no
      obligation to exercise any of the powers given it by the indenture at the request of any holder of debt securities unless it is offered reasonable security and indemnity against the costs, expenses and liabilities that it might incur.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Payment and Paying Agents</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">Unless we otherwise indicate in the applicable prospectus supplement, we will make payment of the interest on any debt securities on any interest payment date to the person in whose name the debt securities, or one or
      more predecessor securities, are registered at the close of business on the regular record date for the interest.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">We will pay the principal of and any premium and interest due on the debt securities of a particular series at the office of the paying agents designated by us, except that unless we otherwise indicate in the applicable
      prospectus supplement, will we make interest payments by check which we will mail to the holder. Unless we otherwise indicate in a prospectus supplement, we will designate the corporate trust office of the debenture trustee in the City of New York as
      our sole paying agent for payments with respect to debt securities of each series. We will name in the applicable prospectus supplement any other paying agents that we initially designate for the debt securities of a particular series. We will
      maintain a paying agent in each place of payment for the debt securities of a particular series.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">All money we pay to a paying agent or the debenture trustee for the payment of the principal of or any premium or interest on any debt securities which remains unclaimed at the end of two years after such principal,
      premium or interest has become due and payable will be repaid to us, and the holder of the security thereafter may look only to us for payment thereof.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Governing Law</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">The indenture and the debt securities will be governed by and construed in accordance with the laws of the State of New York, except to the extent that the Trust Indenture Act is applicable.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Subordination of Subordinated Debt Securities</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">Our obligations pursuant to any subordinated debt securities will be unsecured and will be subordinate and junior in priority of payment to certain of our other indebtedness to the extent described in a prospectus
      supplement. The subordinated indenture does not limit the amount of senior indebtedness we may incur. It also does not limit us from issuing any other secured or unsecured debt.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">18</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFRIGHTS"><!--Anchor--></a>DESCRIPTION OF RIGHTS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">General</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may issue rights to purchase any of our securities or any combination thereof. Rights may be issued independently or together with any other offered security and may or may not be transferable by
      the person purchasing or receiving the rights. In connection with any rights offering to our shareholders, we may enter into a standby underwriting arrangement with one or more underwriters pursuant to which such underwriters will purchase any
      offered securities remaining unsubscribed for after such rights offering. We may also appoint a rights agent that may act solely as our agent in connection with the rights that are sold. Any such agent will not assume any obligation or relationship
      of agency or trust with any of the holders of the rights. In connection with a rights offering to our shareholders, we will distribute certificates evidencing the rights and a prospectus supplement to our shareholders on the record date that we set
      for receiving rights in such rights offering.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The applicable prospectus supplement will describe the following terms of rights in respect of which this prospectus is being delivered:</div>
    <div style="line-height: 1.25;">&#160;</div>
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        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the title of such rights;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z608ef4d4d6304f75b591d5a38ee09d27" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the securities for which such rights are exercisable;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z3879a2b4a9674b8283515d685a24e004" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the exercise price for such rights;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zad9b2a98b7ac45c4a1c2bdeb3d417c26" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the number of such rights issued with respect to each ordinary share;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z8bc05fab90ee4d94b74433b362822144" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the extent to which such rights are transferable;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z1049751e1e7c48bda2a292a497b08178" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">if applicable, a discussion of the material Israeli and U.S. income tax considerations applicable to the issuance or exercise of such rights;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z29559f80f9f14582a73c7b271b399c98" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the date on which the right to exercise such rights shall commence, and the date on which such rights shall expire (subject to any extension);</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z07fc8f7c00844bd8a0530aac116894d8" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the extent to which such rights include an over-subscription privilege with respect to unsubscribed securities;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zc75860a12fa4481196626a5e51572775" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">if applicable, the material terms of any standby underwriting or other purchase arrangement, or any agency agreement, that we may enter into in connection with the rights offering; and</div>
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    <div style="line-height: 1.25;">&#160;</div>
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            <div style="line-height: 1.25;">any other terms of such rights, including terms, procedures and limitations relating to the exchange and exercise of such rights.</div>
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        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Exercise of Rights</div>
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    <div style="text-indent: 36pt; line-height: 1.25;">Each right will entitle the holder of the right to purchase for cash such securities or any combination thereof at such exercise price as shall in each case be set forth in, or be determinable as set
      forth in, the prospectus supplement relating to the rights offered thereby. Rights may be exercised at any time up to the close of business on the expiration date for such rights set forth in the prospectus supplement. After the close of business on
      the expiration date, all unexercised rights will become void.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Rights may be exercised as set forth in the prospectus supplement relating to the rights offered thereby. Upon receipt of payment and the rights certificate properly completed and duly executed at the
      corporate trust office of the rights agent or any other office indicated in the prospectus supplement, we will forward, as soon as practicable, the securities purchasable upon such exercise. We may determine to offer any unsubscribed offered
      securities directly to persons other than shareholders, to or through agents, underwriters or dealers or through a combination of such methods, including pursuant to standby underwriting arrangements, as set forth in the applicable prospectus
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFWARRANTS"><!--Anchor--></a>DESCRIPTION OF WARRANTS</div>
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    <div style="text-indent: 36pt; line-height: 1.25;">We may issue warrants to purchase ordinary shares. We may issue warrants independently or together with any other securities offered by any prospectus supplement and the warrants may be attached to or
      separate from those securities. Any series of warrants may be issued under a separate warrant agreement, which may be entered into between us and a warrant agent specified in a prospectus supplement. Any such warrant agent will act solely as our
      agent in connection with the warrants of such series and will not assume any obligation or relationship of agency or trust with any of the holders of the warrants. We will set forth further terms of the warrants and any applicable warrant agreements
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            <div style="line-height: 1.25;">the title of the warrants;</div>
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    <div style="line-height: 1.25;">&#160;</div>
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            <div style="line-height: 1.25;">the aggregate number of the warrants;</div>
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    </table>
    <div style="line-height: 1.25;">&#160;</div>
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            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">the number of ordinary shares purchasable upon exercise of the warrants;</div>
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        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zbf2059e71c9b4731b97f47039f7bbecc" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the designation and terms of the securities, if any, with which the warrants are issued and the number of the warrants issued with each such offered security;</div>
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        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
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          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
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            <div style="line-height: 1.25;">&#8226;</div>
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          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the date, if any, on and after which the warrants and the related securities will be separately transferable;</div>
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        </tr>

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    <div style="line-height: 1.25;">&#160;</div>
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            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">the price at which, and form of consideration for which, each security purchasable upon exercise of the warrants may be purchased;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
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            <div style="line-height: 1.25;">&#160;</div>
          </td>
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            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">the date on which the right to exercise the warrants will commence and the date on which the right will expire;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zcf1a624f5dca428989c77b1954aaa9b2" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">the minimum or maximum amount of the warrants which may be exercised at any one time;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="zbe9892d377cb499da6fd92b857004bb3" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
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            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">any circumstances that will cause the warrants to be deemed to be automatically exercised; and</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="za013d8cb7f63458791c0562605c63ceb" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">any other material terms of the warrants.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">Outstanding Warrants</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">In connection with the issuance of the ordinary shares in our June 2018 registered direct offering, we also issued to certain institutional investors warrants to purchase up to 4,253,165 additional
      ordinary shares, out of which 749,104 were outstanding as of June 30, 2020. The following is a brief summary of certain terms and conditions of the warrants and is subject in all respects to the provisions contained in the warrants.</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Term</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">The warrants are exercisable during the period beginning six months from the date of issuance and ending at 5:00 P.M. on June 19, 2023.</div>
    <div style="text-indent: 35pt; line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exercise Price</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">The exercise price of the warrants is $4.74 per whole ordinary share. The exercise price is subject to appropriate adjustment in the event of certain stock splits, dividends, recapitalizations or
      similar events affecting our ordinary shares.</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exercisability</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">Holders may exercise the warrants beginning six months from June 19, 2018, the date of issuance, and at any time during the applicable term of the warrant. The warrants will be exercisable, at the
      option of each holder, in whole or in part, by delivering to us a written notice and, within&#160;one&#160;trading&#160;day&#160;of delivering such notice, payment&#160;shall be made&#160;in full for the number of ordinary shares purchased upon such exercise. If there is no
      effective registration statement registering the issuance and sale of the ordinary shares underlying the warrants, the holder may exercise the warrant through a cashless exercise, in which case the holder would receive upon such exercise the net
      number of ordinary shares determined according to the formula set forth in the warrant.</div>
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    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exercise Limitation</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">Holders shall not have the right to exercise the warrant, to the extent that after giving effect to such exercise, such holder, together with such holder&#8217;s affiliates and any other persons acting as a
      group together with the holder or any of the holder&#8217;s affiliates, would beneficially own in excess of 4.99% of the ordinary shares outstanding immediately after giving effect to such exercise which limitation may be increased to 9.99% by the holder.</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">No Fractional Shares</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">No fractional ordinary shares will be issued upon exercise of the warrants. If there is a fractional share issuable upon exercise, we will, at our election, either pay a cash adjustment or it will be
      rounded up to the nearest whole share.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Transferability</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">Subject to applicable laws and the restriction on transfer set forth in the warrant, the warrant may be transferred at the option of the holder upon surrender of the warrant to us together with the
      appropriate instruments of transfer.</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Authorized Shares</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 35pt; line-height: 1.25;">During the period the warrants are outstanding, we will reserve from our authorized and unissued ordinary shares a sufficient number of shares to provide for the issuance of ordinary shares underlying
      the warrants upon the exercise of the warrants.</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exchange Listing</div>
    <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We have not and do not plan on applying to list the warrants on Nasdaq, the TASE, any other national securities exchange or any other nationally recognized trading system.</div>
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    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Purchase Rights</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">Subject to certain limitations, if at any time during the period the warrants are outstanding we grant, issue or sell certain of our securities pro rata to the record holders of our ordinary shares,
      the warrant holders shall be entitled to participate upon the same terms in an amount up to the number of ordinary shares acquirable upon complete exercise of the warrant.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Pro Rata Distributions</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">Subject to certain limitations, if at any time during the period the warrants are outstanding we declare or make any dividend or other distribution of assets to our ordinary shareholders, the warrant
      holders shall be entitled to distributions upon the same terms in an amount up to the number of ordinary shares acquirable upon complete exercise of the warrant.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Fundamental Transactions</div>
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    <div style="text-indent: 36pt; line-height: 1.25;">In the event of any fundamental transaction, as defined in the warrants and generally including any consolidation or merger with or into another entity, the sale of all or substantially all of our
      assets, tender offer or exchange offer, reorganization or recapitalization through which another entity acquires us, or reclassification of our ordinary shares, then the successor entity in such transaction will assume in writing all of our
      obligations under the warrant pursuant to written agreements, including an adjusted exercise price equal to the value for the ordinary shares reflected by the terms of such fundamental transaction, and exercisable for a corresponding number of shares
      equivalent to the ordinary shares acquirable and receivable upon exercise of the warrant prior to such fundamental transaction.</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Failure to Timely Deliver Securities</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If we fail for any reason to deliver to a holder the number of shares of ordinary shares due to the holder pursuant to the holder&#8217;s written notice on or before the second trading
      day following receipt of such notice, we will pay to the holder, in cash, as liquidated damages and not as a penalty, for each $1,000 of ordinary shares subject to such exercise, $10 per trading day (increasing to $20 per trading day on the fifth
      trading day after such liquidated damages begin to accrue) for each trading day until such ordinary shares are delivered or the holder rescinds such exercise.</div>
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    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Right as a Shareholder</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Except as otherwise provided in the warrants or by virtue of such holder&#8217;s ownership of our ordinary shares, the holders of the warrants do not have the rights or privileges of holders of our ordinary
      shares, including any voting rights, until they exercise their warrants.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Waivers and Amendments</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Any term of the warrants issued in the offering may be amended or waived with our written consent and the written consent of the holder.</div>
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      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">22</font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25;"></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFUNITS"><!--Anchor--></a>DESCRIPTION OF UNITS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">As specified in the applicable prospectus supplement, we may issue units consisting of our ordinary shares, debt securities, rights, warrants or any combination of such securities. The applicable
      prospectus supplement will describe:</div>
    <div style="line-height: 1.25;">&#160;</div>
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        <tr>
          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
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            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the terms of the units and of the ordinary shares, debt securities, rights and/or warrants comprising the units, including whether and under what circumstances the securities comprising the units may be traded
              separately;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
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          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the terms of any unit agreement governing the units or any arrangement with an agent that may act on our behalf in connection with the unit offering; and</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z70462581e10a43e38a43732076463195" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <div style="line-height: 1.25;">the provisions for the payment, settlement, transfer or exchange of the units.</div>
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    <div style="line-height: 1.25;">&#160;</div>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="PLANOFDISTRIBUTION"><!--Anchor--></a>PLAN OF DISTRIBUTION</div>
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    <div style="text-indent: 36pt; line-height: 1.25;">We may sell the offered securities on a negotiated or competitive bid basis to or through underwriters or dealers. We may also sell the securities directly to corporate partners in various programs of
      the Company, institutional investors or other purchasers or through agents. We will identify any underwriter, dealer, or agent involved in the offer and sale of the securities, and any applicable commissions, discounts and other terms constituting
      compensation to such underwriters, dealers or agents, in a prospectus supplement.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We may distribute our securities from time to time in one or more transactions:</div>
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            <div style="line-height: 1.25;">at a fixed price or prices, which may be changed;</div>
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    <div style="line-height: 1.25;">&#160;</div>
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            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">at market prices prevailing at the time of sale;</div>
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    <div style="line-height: 1.25;">&#160;</div>
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          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
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            <div style="line-height: 1.25;">at prices related to such prevailing market prices; or</div>
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    <div style="line-height: 1.25;">&#160;</div>
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        <tr>
          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
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          <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">at negotiated prices.</div>
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        </tr>

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    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Only underwriters named in the prospectus supplement are underwriters of our securities offered by the prospectus supplement.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">If underwriters are used in the sale of our securities, such securities will be acquired by the underwriters for their own account and may be resold from time to time in one or more transactions,
      including negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale. Unless stated otherwise in a prospectus supplement, the obligation of any underwriters to purchase our securities will be subject
      to certain conditions and the underwriters will be obligated to purchase all of the applicable securities if any are purchased. If a dealer is used in a sale, we may sell our securities to the dealer as principal. The dealer may then resell the
      securities to the public at varying prices to be determined by the dealer at the time of resale. In effecting sales, dealers engaged by us may arrange for other dealers to participate in the resales.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We or our agents may solicit offers to purchase securities from time to time. Unless stated otherwise in a prospectus supplement, any agent will be acting on a best efforts basis for the period of its
      appointment. In addition, we may enter into derivative, sale or forward sale transactions with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions. If the applicable prospectus
      supplement indicates, in connection with such transaction, the third parties may, pursuant to this prospectus and the applicable prospectus supplement, sell securities covered by this prospectus and the applicable prospectus supplement. If so, the
      third party may use securities borrowed from us or others to settle such sales and may use securities received from us or others to close out any related short positions. We may also loan or pledge securities covered by this prospectus and the
      applicable prospectus supplement to third parties, who may sell the loaned securities or, in the event of default in the case of a pledge, sell the pledged securities pursuant to this prospectus and the applicable prospectus supplement. The third
      party in such transactions will be an underwriter and will be identified in the applicable prospectus supplement or in a post-effective amendment.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">In connection with the sale of our securities, underwriters or agents may receive compensation (in the form of discounts, concessions or commissions) from us or from purchasers of securities for whom
      they may act as agents. Underwriters may sell securities to or through dealers, and such dealers may receive compensation in the form of discounts, concessions or commissions from the underwriters and/or commissions from the purchasers for whom they
      may act as agents. Underwriters, dealers and agents that participate in the distribution of our securities may be deemed to be &#8220;underwriters&#8221; as that term is defined in the Securities Act, and any discounts or commissions received by them from us and
      any profits on the resale of the shares by them may be deemed to be underwriting discounts and commissions under the Securities Act. Compensation as to a particular underwriter, dealer or agent might be in excess of customary commissions and will be
      in amounts to be negotiated in connection with transactions involving our securities. We will identify any such underwriter or agent, and we will describe any such compensation paid, in the related prospectus supplement. Maximum compensation to any
      underwriters, dealers or agents will not exceed any applicable limitations of the Financial Industry Regulatory Authority, Inc.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Underwriters, dealers and agents may be entitled, under agreements with us, to indemnification against and contribution toward certain civil liabilities, including liabilities under the Securities Act.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">If stated in a prospectus supplement, we will authorize agents and underwriters to solicit offers by certain specified institutions or other persons to purchase our securities at the public offering
      price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specific date in the future. Institutions with whom such contracts may be made include commercial savings banks, insurance
      companies, pension funds, investment companies, educational and charitable institutions, and other institutions, but shall in all cases be subject to our approval. Such contracts will be subject only to those conditions set forth in the prospectus
      supplement, and the prospectus supplement will set forth the commission payable for solicitation of such contracts. The obligations of any purchase under any such contract will be subject to the condition that the purchase of the securities shall not
      be prohibited at the time of delivery under the laws of Israel and of the jurisdiction to which the purchaser is subject. The underwriters and other agents will not have any responsibility in respect of the validity or performance of such contracts.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">24</font></div>
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    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">If underwriters or dealers are used in the sale, until the distribution of our securities is completed, SEC rules may limit the ability of any such underwriters and selling group members to bid for and
      purchase the securities. As an exception to these rules, representatives of any underwriters are permitted to engage in certain transactions that stabilize the price of the securities. Such transactions may consist of bids or purchases for the
      purpose of pegging, fixing or maintaining the price of the securities. If the underwriters create a short position in the securities in connection with the offering (in other words, if they sell more shares than are set forth on the cover page of the
      prospectus supplement), the representatives of the underwriters may reduce that short position by purchasing securities in the open market. The representatives of the underwriters also may elect to reduce any short position by exercising all or part
      of any over-allotment option we may grant to the underwriters, as described in the prospectus supplement. In addition, the representatives of the underwriters may impose a penalty bid on certain underwriters and selling group members. This means that
      if the representatives purchase securities in the open market to reduce the underwriters&#8217; short position or to stabilize the price of our securities, they may reclaim the amount of the selling concession from the underwriters and selling group
      members who sold those securities as part of the offering. In general, purchases of a security for the purpose of stabilizing or to reduce a short position could cause the price of the security to be higher than it might be in the absence of such
      purchases. The imposition of a penalty bid might also have the effect of causing the price of the securities to be higher than it would otherwise be. If commenced, the representatives of the underwriters may discontinue any of the transactions at any
      time. These transactions may be affected on any exchange on which our securities are traded, in the over-the-counter market, or otherwise.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Certain of the underwriters or agents and their associates may engage in transactions with and perform services for us or our affiliates in the ordinary course of their respective businesses.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">25</font></div>
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="LEGALMATTERS"><!--Anchor--></a>LEGAL MATTERS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">Certain matters of Israeli law with respect to the legality of the issuance of the ordinary shares offered by this prospectus will be passed upon for us by Shibolet &amp; Co., Law
      Firm, Tel Aviv, Israel. Certain matters of U.S. law will be passed upon for us by&#160;Cooley&#160;LLP, New York, New York.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="EXPERTS"><!--Anchor--></a>EXPERTS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">The consolidated financial statements of Compugen Ltd. appearing in the Annual Report on Form 20-F for the year ended December 31, 2019 and the effectiveness of Compugen Ltd.
      internal control over financial reporting as of December 31, 2019, as filed with the SEC on&#160; February 24, 2020, have been audited by Kost Forer Gabbay &amp; Kasierer (a Member of Ernst &amp; Young Global), independent registered public accounting
      firm, as set forth in their report thereon, included therein, and incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such reports pertaining to such consolidated financial
      statements and the effectiveness of Compugen Ltd. internal control over financial reporting as of the respective dates, given on the authority of such firm as experts in accounting and auditing. The address of Kost Forer Gabbay &amp; Kasierer is 144
      Menachem Begin Road, Building A, Tel-Aviv, Israel 6492102.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="EXPENSES"><!--Anchor--></a>EXPENSES</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The following are the estimated expenses related to the filing of the registration statement of which this prospectus forms a part, all of which will be paid by us. In addition, we anticipate incurring
      additional expenses in the future in connection with the offering of our securities pursuant to this prospectus. Any such additional expenses will be disclosed in a prospectus supplement.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table align="right" cellspacing="0" cellpadding="0" border="0" id="z51caecd546c04145bb110949be0960dd" style="width: 95%; color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">

        <tr>
          <td valign="bottom" colspan="1" style="vertical-align: top; background-color: rgb(204, 238, 255); width: 88%;">
            <div style="text-align: justify; line-height: 1.25;">SEC registration fee&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">45,430</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" colspan="1" style="vertical-align: top; width: 88%; background-color: rgb(255, 255, 255);">
            <div style="text-align: justify; line-height: 1.25;">Printing expenses*</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">1,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" colspan="1" style="vertical-align: top; background-color: rgb(204, 238, 255); width: 88%;">
            <div style="text-align: justify; line-height: 1.25;">Legal fees and expenses*&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
            <div style="line-height: 1.25;">25,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" colspan="1" style="vertical-align: top; width: 88%; background-color: rgb(255, 255, 255);">
            <div style="text-align: justify; line-height: 1.25;">Accounting fees and expenses*&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);">
            <div style="line-height: 1.25;">5,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" colspan="1" style="vertical-align: top; background-color: rgb(204, 238, 255); width: 88%; padding-bottom: 2px;">
            <div style="text-align: justify; line-height: 1.25;">Miscellaneous*&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
          <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
            <div style="line-height: 1.25;">570</div>
          </td>
          <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" colspan="1" style="vertical-align: top; width: 88%; padding-bottom: 4px; background-color: rgb(255, 255, 255);">
            <div style="text-align: justify; line-height: 1.25;">Total*&#160;</div>
          </td>
          <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(255, 255, 255);">&#160;</td>
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            <div style="line-height: 1.25;">$</div>
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            <div style="line-height: 1.25;">77,000</div>
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          <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(255, 255, 255);">&#160;</td>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; clear: both;">__________</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">*Estimated</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="INCORPORATIONOFCERTAININF"><!--Anchor--></a>INCORPORATION OF CERTAIN INFORMATION BY REFERENCE</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">The SEC allows us to &#8220;incorporate by reference&#8221; the information we file with it, which means that we can disclose important information to you by referring you to those documents. The information
      incorporated by reference is considered to be part of this prospectus and information we file later with the SEC will automatically update and supersede this information. The documents we are incorporating by reference as of their respective dates of
      filing are:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z760714538e7f42dca202e545e3f4e3cd" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">Annual Report on Form 20-F for the year ended December 31, 2019, filed on February 24, 2020 and as amended on February 27, 2020 (File Nos. 000-30902);</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
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        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
          <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">Reports on Form 6-K filed on January 9, 2020, February 20, 2020, February 20, 2020, March 9, 2020, March 11, 2020, March 12, 2020, March 13, 2020, March 17, 2020, April 6, 2020, April 15, 2020, April 27, 2020,
              May 6, 2020, May 27, 2020, June 1, 2020 and July 30, 2020&#160;(File Nos. 000-30902); and</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="z1f66e8d220294be7a6d8c22e9469e808" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
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            <div style="line-height: 1.25;">&#8226;</div>
          </td>
          <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">the description of our ordinary shares contained in our Form 8-A filed on August 2, 2000 (File No. 000-30902), as updated and amended by the disclosure contained under &#8220;Description of Ordinary Shares&#8221; in this
              registration statement on Form F-3.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">All subsequent annual reports on Form 20-F, Form 40-F or Form 10-K filed by us, all subsequent reports on Forms 10-Q and 8-K filed by us, and all subsequent reports on Form 6-K filed by us that are
      identified by us as being incorporated by reference shall be deemed to be incorporated by reference into this prospectus and deemed to be a part hereof after the date of this prospectus but before the termination of the offering by this prospectus.</div>
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    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Any statement contained in a document incorporated by reference herein shall be deemed to be modified or superseded for all purposes to the extent that a statement contained in this prospectus, or in
      any other subsequently filed document which is also incorporated or deemed to be incorporated by reference, modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to
      constitute a part of this prospectus.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">You may request, orally or in writing, a copy of these documents, which will be provided to you at no cost, by contacting:</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">Ari Krashin</font><br>
      <font style="font-weight: bold;">Chief Financial Officer</font><br>
      <font style="font-weight: bold;">Compugen Ltd.</font><br>
      <font style="font-weight: bold;">26 Harokmim Street</font><br>
      <font style="font-weight: bold;">Holon 5885849, Israel</font><br>
      <font style="font-weight: bold;">Phone: +972-3-765-8585</font><br>
      <font style="font-weight: bold;">Fax: +972-3-765-8555</font><br>
      &#160;</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="WHEREYOUCANFINDADDITIONAL"><!--Anchor--></a>WHERE YOU CAN FIND ADDITIONAL INFORMATION</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This prospectus is part of a registration statement on Form F-3 that we filed with the SEC relating to the securities offered by this prospectus, which includes additional information. You should refer
      to the registration statement and its exhibits for additional information. Whenever we make reference in this prospectus to any of our contracts, agreements or other documents, the references are not necessarily complete, and you should refer to the
      exhibits attached to the registration statement for copies of the actual contract, agreements or other document.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We are subject to the informational requirements of the Exchange Act applicable to foreign private issuers. We, as a &#8220;foreign private issuer,&#8221; are exempt from the rules under the Exchange Act
      prescribing certain disclosure and procedural requirements for proxy solicitations, and our office holders, directors and principal shareholders are exempt from the reporting and &#8220;short-swing&#8221; profit recovery provisions contained in Section 16 of the
      Exchange Act, with respect to their purchases and sales of shares. In addition, we are not required to file annual, quarterly and current reports and financial statements with the SEC as frequently or as promptly as U.S. companies whose securities
      are registered under the Exchange Act. So long as we are a foreign private issuer, we anticipate filing with the SEC, within three months after the end of each fiscal year, an Annual Report on Form 20-F containing financial statements audited by an
      independent accounting firm. We also furnish or file with the SEC Reports of Foreign Private Issuer on Form 6-K and other information with the SEC as required by the Exchange Act. You can review our SEC filings and the registration statement by
      accessing the SEC&#8217;s internet site at <font style="font-style: italic;">http://www.sec.gov</font>.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">We also maintain a website at <font style="font-style: italic;">www.cgen.com</font>, through which you can access certain SEC filings. The information set forth on our website is not part of this
      prospectus.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="ENFORCEABILITYOFCIVILLIAB"><!--Anchor--></a>ENFORCEABILITY OF CIVIL LIABILITIES</div>
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    <div style="text-indent: 36pt; line-height: 1.25;">We are incorporated under the laws of the State of Israel. Service of process upon us and upon our directors and office holders, almost all of whom reside outside the United States, may be difficult to
      obtain within the United States. Furthermore, because the majority of our assets and investments, and almost all of our directors and officer holders are located outside the United States, any judgment obtained in the United States against us or any
      of them may not be collectible within the United States.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Additionally, it may be difficult to assert U.S. securities law claims in original actions instituted in Israel. Israeli courts may refuse to hear a claim based on an alleged violation of U.S.
      securities laws because Israel is not the most appropriate forum to bring such a claim. In addition, even if an Israeli court agrees to hear such a claim, it may determine that Israeli law and not U.S. law is applicable to the claim. If U.S. law is
      found to be applicable, the content of applicable U.S. law must be proved as a fact which can be a time-consuming and costly process. Certain matters of procedure will also be governed by Israeli law. There is little binding case law in Israel that
      addresses the matters described above.</div>
    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Subject to specified time limitations and legal procedures, Israeli courts may enforce a United States judgment in a civil matter which, subject to certain exceptions, is non-appealable, including
      judgments based upon the civil liability provisions of the Securities Act and the Exchange Act and including a monetary or compensatory judgment in a non-civil matter, provided that among other things:</div>
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            <div style="line-height: 1.25;">the judgments are obtained after due process before a court of competent jurisdiction, according to the laws of the state in which the judgment is given and the rules of private international law currently
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            <div style="line-height: 1.25;">the prevailing law of the foreign state in which the judgments were rendered allows for the enforcement of judgments of Israeli courts;</div>
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            <div style="line-height: 1.25;">adequate service of process has been effected and the defendant has had a reasonable opportunity to be heard and to present his or her evidence;</div>
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            <div style="line-height: 1.25;">the judgments are not contrary to public policy of Israel, and the enforcement of the civil liabilities set forth in the judgment is not likely to impair the security or sovereignty of Israel;</div>
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            <div style="line-height: 1.25;">the judgments were not obtained by fraud and do not conflict with any other valid judgments in the same matter between the same parties;</div>
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            <div style="line-height: 1.25;">an action between the same parties in the same matter is not pending in any Israeli court at the time the lawsuit is instituted in the foreign court;</div>
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            <div style="line-height: 1.25;">the judgment is not subject to any further appeal procedures; and</div>
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            <div style="line-height: 1.25;">&#160;&#8226;</div>
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            <div style="line-height: 1.25;">the judgment is enforceable according to the laws of Israel and according to the law of the foreign state in which the relief was granted.</div>
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    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Generally, an Israeli court will not enforce a foreign judgment if the motion for enforcement was filed more than five years after the date of its award in the United States, unless Israel and the
      United States have agreed otherwise on a different period, or if an Israeli court finds exceptional reasons justifying the delay.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">If a foreign judgment is enforced by an Israeli court, it generally will be payable in Israeli currency, which can then be converted into non-Israeli currency and transferred out of Israel. The usual
      practice in an action before an Israeli court to recover an amount in a non-Israeli currency is for the Israeli court to issue a judgment for the equivalent amount in Israeli currency at the rate of exchange in force on the date of the judgment, but
      the judgment debtor may make payment in foreign currency. Pending collection, the amount of the judgment of an Israeli court stated in Israeli currency ordinarily will be linked to the Israeli consumer price index plus interest at the annual
      statutory rate set by Israeli regulations prevailing at the time. Judgment creditors must bear the risk of unfavorable exchange rates.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="INDEMNIFICATIONFORSECURIT"><!--Anchor--></a>INDEMNIFICATION FOR SECURITIES ACT LIABILITIES</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to our directors, officer holders and controlling persons, we have been informed that in the opinion of the
      SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.</div>
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      </div>
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    <div style="line-height: 1.25; font-weight: bold; color: rgb(255, 0, 0);">The information in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange
      Commission is effective. This prospectus is not an offer to sell securities and it is not soliciting an offer to buy securities in any state where the offer or sale is not permitted.</div>
    <font style="color: rgb(255, 0, 0);"> </font>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; color: rgb(255, 0, 0);">&#160;</div>
    <font style="color: rgb(255, 0, 0);"> </font>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; color: rgb(255, 0, 0);">Subject to Completion, Dated July 30, 2020</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25; font-weight: bold;">PROSPECTUS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><img width="238" height="75" src="image0.jpg"></div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; margin-right: 0.2pt; line-height: 1.25; font-weight: bold;">749,104 Ordinary Shares Issuable Upon</div>
    <div style="text-align: center; margin-right: 0.2pt; line-height: 1.25; font-weight: bold;">Exercise of Outstanding Warrants</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This prospectus relates to the offer and sale by us of an aggregate 749,104 of our ordinary shares that are issuable at an exercise price of $4.74 per share upon the exercise of our currently
      outstanding warrants that we issued to certain institutional investors in a registered direct offering in June 2018.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;">We will receive the proceeds from any cash exercises of the outstanding warrants. Additionally, in the event there is no effective registration statement at the time of exercise, the warrants may be
      exercised on a cashless basis. If the warrants are exercised on a cashless basis, we would not receive any cash payment upon any exercise of the warrants. Each warrant is exercisable at any time until its expiration date, which is June 19, 2023. If
      all of these outstanding warrants are exercised for cash, we will receive aggregate proceeds of approximately $3.6 million for the warrants.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">Our ordinary shares are traded on The Nasdaq Global Market and on the Tel Aviv Stock Exchange under the symbol &#8220;CGEN.&#8221; The closing sale price of our ordinary shares on The Nasdaq Global Market and on
      the Tel Aviv Stock Exchange on July 27, 2020, was $14.82 and $14.43 per share, respectively. The currency in which our stock is traded on the Tel Aviv Stock Exchange is the New Israeli Shekel, or NIS. The above closing price on the Tel Aviv Stock
      Exchange represents a conversion from NIS to dollar amounts in accordance with the dollar - NIS conversion rate as of July 27, 2020, as reported by the Bank of Israel.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">An investment in our securities involves a high degree of risk. See the section entitled &#8220;Risk Factors&#8221; on page SA-3 of this prospectus and under similar headings in any amendment or
      supplement to this prospectus or in any filing with the Securities and Exchange Commission that is incorporated by reference herein.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">Neither the Securities and Exchange Commission nor any state or other securities commission has approved or disapproved of these securities or determined if this prospectus is
      truthful or complete. Any representation to the contrary is a criminal offense.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This prospectus may not be used to consummate sales of securities unless it is accompanied by a prospectus supplement.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; margin-right: 36pt; line-height: 1.25;">The date of this prospectus is&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160; ,2020</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    <div style="line-height: 1.25;"></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">TABLE OF CONTENTS</div>
    <div style="line-height: 1.25;">&#160;</div>
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        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#ABOUTTHISPROSPECTUS1">ABOUT THIS PROSPECTUS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-i</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#OSPECTUSSUMMARY">PROSPECTUS SUMMARY</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-1</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#ISKFACTORS">RISK FACTORS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-3</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#NOTEREGARDINGFORARD-LOOK">NOTE REGARDING FORWARD-LOOKING STATEMENTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-5</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#SANDEXPECTEDT">OFFER STATISTICS AND EXPECTED TIMETABLE</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-6</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#PITALIZATION">CAPITALIZATION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-7</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#USEOFPROCEEDS">REASONS FOR THE OFFER AND USE OF PROCEEDS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-8</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#OFORDINARYSHARES">DESCRIPTION OF ORDINARY SHARES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-9</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#TIONOFWARRANTS">DESCRIPTION OF WARRANTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-15</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#DILUTION">DILUTION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-17</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#OFDISTRIBUTION">PLAN OF DISTRIBUTION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-18</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#LMATTERS">LEGAL MATTERS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-19</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#PERTS">EXPERTS</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-19</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#NSES">EXPENSES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-19</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#IONOFCERTAININFORMATIONBY">INCORPORATION OF CERTAIN INFORMATION BY REFERENCE</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-19</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#EYOUCANFINDADDITIONALINFO">WHERE YOU CAN FIND ADDITIONAL INFORMATION</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#RCEABILITYOFCIVI">ENFORCEABILITY OF CIVIL LIABILITIES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-21</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.99%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;"><a href="#TIONFORSECURITIESACTLIABI">INDEMNIFICATION FOR SECURITIES ACT LIABILITIES</a></div>
          </td>
          <td style="width: 6.01%; vertical-align: top; background-color: #FFFFFF;">
            <div style="line-height: 1.25;">SA-22</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="ABOUTTHISPROSPECTUS1"><!--Anchor--></a>ABOUT THIS PROSPECTUS</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or the SEC, using a &#8220;shelf&#8221; registration process. Under this shelf registration process,
      we may from time to time sell ordinary shares, debt securities, rights, warrants or units comprising any combination of these securities, in one or more offerings up to a total dollar amount of $350,000,000. Under this prospectus, we may from time to
      time offer and sell an aggregate 749,104 of our ordinary shares that are issuable at an exercise price of $4.74 upon the exercise of our previously issued warrants. The $3,550,753 of securities that may be sold under this prospectus are included in
      the $350,000,000 of securities that may be sold under the registration statement.</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">As permitted by the rules and regulations of the SEC, the registration statement, of which this prospectus forms a part, includes additional information not contained in this prospectus. You may read
      the registration statement and the other reports we file with the SEC at the SEC&#8217;s web site or at the SEC&#8217;s offices described below under the heading &#8220;Where You Can Find Additional Information.&#8221;</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">In this prospectus, unless otherwise stated or the context otherwise requires, references to &#8220;Compugen,&#8221;&#160;&#8220;the Company,&#8221;&#160;&#8220;we,&#8221;&#160;&#8220;us,&#8221;&#160;&#8220;our&#8221; and similar references refer to Compugen Ltd. and our wholly
      owned subsidiary, Compugen USA, Inc. except where the context otherwise requires or as otherwise indicated.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">You should rely only on the information contained or incorporated by reference in this prospectus or any &#8220;free writing prospectus&#8221; we may authorize to be delivered to you. We have
      not authorized anyone to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. You should assume that the information appearing in this prospectus and the documents
      incorporated by reference herein and therein are accurate only as of their respective dates. Our business, financial condition, results of operations and prospects may have changed since those dates.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-weight: bold;">This prospectus shall not constitute an offer or solicitation by anyone in any jurisdiction in which such offer or solicitation is not authorized or in which the person making such
      offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make such offer or solicitation.</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    <div style="line-height: 1.25;">&#160;
      <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
        <div>&#160;
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">PROSPECTUS SUMMARY<a name="OSPECTUSSUMMARY"><!--Anchor--></a></div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-indent: 36pt; line-height: 1.25; font-style: italic;">This summary highlights only some of the information included or incorporated by reference in this prospectus. You should carefully read this prospectus together with the
            additional information about us described in the sections entitled &#8220;Where You Can Find Additional Information&#8221; and &#8220;Incorporation of Certain Information by Reference&#8221; before purchasing our securities.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="line-height: 1.25; font-weight: bold;">Overview</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-indent: 36pt; line-height: 1.25;">We are a clinical-stage therapeutic discovery and development company utilizing our broadly applicable, predictive computational discovery platforms to identify novel drug targets and develop
            therapeutics in the field of cancer immunotherapy. Our innovative immuno-oncology pipeline consists of three clinical stage programs, COM701, COM902 and BAY 1905254, targeting immune checkpoints we discovered computationally. Our lead product
            candidate, COM701, a first-in-class anti-PVRIG antibody, for the treatment of solid tumors, is undergoing a Phase 1 clinical study and is under clinical collaboration with Bristol-Myers Squibb. COM902, our therapeutic antibody targeting TIGIT,
            is in a Phase 1 clinical study and BAY 1905254, a first-in-class therapeutic antibody targeting ILDR2, is licensed to Bayer under a research and discovery collaboration and license agreement and is also in Phase 1 studies in patients with
            advanced solid tumors. Our therapeutic pipeline further includes early-stage immuno-oncology programs focused largely on myeloid targets. Our innovative immuno-oncology pipeline, strategic collaborations and computational discovery engine serve
            as the Company&#8217;s three key building blocks. Our business model is to selectively enter into collaborations for our novel targets and related drug product candidates at various stages of research and development.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-indent: 36pt; line-height: 1.25;">In 2018, we entered into two agreements with leading pharmaceutical companies&#8212;a clinical collaboration agreement with Bristol-Myers Squibb in connection with our lead immuno-oncology program,
            COM701, and an exclusive license agreement with AstraZeneca for the development of bi-specific and multi-specific antibody products derived from one of our immuno-oncology programs. The first pipeline agreement we entered into was with Bayer in
            2013 for the research, development, and commercialization of immuno-oncology therapeutics against novel targets identified by us. Under this agreement, we collaborate with Bayer on BAY 1905254 targeting ILDR2. We are also engaged in
            collaboration with Johns Hopkins School of Medicine, a leading academic research center in the United States to advance research and development efforts relating to our pipeline programs.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-indent: 36pt; line-height: 1.25;">We are headquartered in Holon, Israel. Our clinical development activities operate from our U.S. site in South San Francisco, California.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="line-height: 1.25; font-weight: bold;">Corporate Information</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-indent: 36pt; line-height: 1.25;">Our legal and commercial name is Compugen Ltd. We were incorporated on February 10, 1993 as an Israeli corporation and operate under the Israel Companies Law, 5759-1999, as amended, or the
            Companies Law. Our principal offices are located at 26 Harokmim Street, Holon 5885849, Israel, and our telephone number is +972-3-765-8585. Our web address is <font style="font-style: italic;">www.cgen.com</font>. The information on our
            website is not incorporated by reference into this prospectus, is not considered a part of this prospectus and should not be relied upon with respect to any offering.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-indent: 36pt; line-height: 1.25;">Compugen USA, Inc., our wholly owned subsidiary, was incorporated in Delaware in March 1997 and is qualified to do business in California.<font style="font-weight: bold;">&#160;</font>This subsidiary
            did not have any significant operations from 2008 to March 2012.</div>
        </div>
        <div>&#160;</div>
      </div>
    </div>
    <div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 1</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: center; font-weight: bold;">
        <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
          <div>
            <div style="font-weight: bold;"> <br>
            </div>
            <div style="font-weight: bold;">THE OFFERING<a name="HEOFFERING"><!--Anchor--></a> </div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 33.04%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="text-indent: -10pt; margin-left: 10pt; line-height: 1.25;">Securities offered</div>
                  </td>
                  <td style="width: 0.88%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 66.08%; vertical-align: bottom; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">749,104 ordinary shares issuable upon the exercise of outstanding warrants.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 33.04%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="text-indent: -10pt; margin-left: 10pt; line-height: 1.25;">Description of warrants</div>
                  </td>
                  <td style="width: 0.88%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 66.08%; vertical-align: bottom; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">The warrants entitle holders to purchase ordinary shares at an exercise price of $4.74 per share for a period of five years from June 19, 2018, the date of issuance.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 33.04%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="text-indent: -10pt; margin-left: 10pt; line-height: 1.25;">Ordinary shares to be outstanding immediately following this offering</div>
                  </td>
                  <td style="width: 0.88%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 66.08%; vertical-align: bottom; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">83,443,313 shares assuming exercise of the warrants in full based on our issued and outstanding share capital as of June 30, 2020.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 33.04%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="text-indent: -10pt; margin-left: 10pt; line-height: 1.25;">Use of Proceeds</div>
                  </td>
                  <td style="width: 0.88%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 66.08%; vertical-align: bottom; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">We intend to use the net proceeds from this offering for pre-clinical and clinical development of our product candidates and for other general corporate purposes. See &#8220;Reasons for the Offer and Use of
                      Proceeds&#8221; on page SA-8 of this prospectus.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 33.04%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="text-indent: -10pt; margin-left: 10pt; line-height: 1.25;">Risk Factors</div>
                  </td>
                  <td style="width: 0.88%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 66.08%; vertical-align: bottom; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">Investing in our securities involves significant risks. See the information under the heading &#8220;Risk Factors&#8221; beginning on page SA-3 of this prospectus and in the documents incorporated by reference into
                      this prospectus for a discussion of factors you should carefully consider before deciding to invest in our securities.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 33.04%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="text-indent: -10pt; margin-left: 10pt; line-height: 1.25;">Trading Markets</div>
                  </td>
                  <td style="width: 0.88%; vertical-align: top; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 66.08%; vertical-align: bottom; background-color: #FFFFFF;">
                    <div style="line-height: 1.25;">Our ordinary shares are traded on the Nasdaq Global Market and on the TASE under the symbol &#8220;CGEN.&#8221;</div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="text-indent: 36pt; line-height: 1.25;">The number of outstanding ordinary shares set forth above excludes, as of June 30, 2020:</div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div>
              <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                  <tr>
                    <td style="width: 90pt; vertical-align: top; align: right;">
                      <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
                    </td>
                    <td style="width: auto; vertical-align: top;">
                      <div style="line-height: 1.25;">5,481,735 ordinary shares issuable upon the exercise of outstanding options to purchase ordinary shares granted under our 2010 Share Incentive Plan, having a weighted average exercise price of $4.33 per
                        share;</div>
                    </td>
                  </tr>

              </table>
            </div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div>
              <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                  <tr>
                    <td style="width: 90pt; vertical-align: top; align: right;">
                      <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
                    </td>
                    <td style="width: auto; vertical-align: top;">
                      <div style="line-height: 1.25;">an aggregate 3,464,441 ordinary shares issuable and reserved for future grants under our 2010 Share Incentive Plan; and</div>
                    </td>
                  </tr>

              </table>
            </div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div>
              <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                  <tr>
                    <td style="width: 90pt; vertical-align: top; align: right;">
                      <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
                    </td>
                    <td style="width: auto; vertical-align: top;">
                      <div style="line-height: 1.25;">749,104 ordinary shares issuable upon the exercise of warrants issued to certain institutional investors in a registered direct offering completed in June 2018, with an exercise price of $4.74 per
                        share.</div>
                    </td>
                  </tr>

              </table>
            </div>
            <div style="line-height: 1.25;">&#160;</div>
          </div>
        </div>
      </div>
      <div style="text-align: center; font-weight: bold;"> <br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 2</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">RISK FACTORS<a name="ISKFACTORS"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Investing in our securities may involve a high degree of risk. Before making an investment decision, you should carefully consider the risks described below as well as those discussed under &#8220;Risk
        Factors&#8221; in our most recent Annual Report on Form 20-F, or any updates in our Reports on Form 6-K, together with all of the other information appearing in this prospectus or incorporated by reference into this prospectus, in light of your
        particular investment objectives and financial circumstances. The risks so described are not the only risks facing our company. Additional risks not presently known to us or that we currently deem immaterial may also impair our business operations.
        Our business, financial condition and results of operations could be materially adversely affected by any of these risks. The trading price of our securities could decline due to any of these risks, and you may lose all or part of your investment.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Risks Related to our Securities and this Offering</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;"><font style="font-weight: bold; font-style: italic;">The COVID-19 pandemic may adversely affect our business and operations</font><br>
        <br>
        <div style="line-height: 1.25;">The recent outbreak of COVID-19 has been declared by the World Health Organization to be a &#8220;pandemic,&#8221; and has spread across the globe to many countries, including the United States and Israel and is impacting
          worldwide economic activity. The current COVID-19 pandemic may disrupt or prevent us, our suppliers and other business partners from conducting business activities as usual (including, without limitation, the availability and pricing of
          materials, manufacturing and delivery efforts, clinical trials and other aspects of our business) for a period of time, the duration of which is uncertain. In addition, we, our suppliers and other business partners may also experience significant
          impairments of business activities due to operational shutdowns or suspensions that may be requested or mandated by national or local governmental authorities or self-imposed by us, our suppliers or other business partners.</div>
        <br>
        While it is not possible at this time to estimate the future impact that COVID-19 could have on our business, suppliers or other business partners, the continued spread of COVID-19, the measures taken in Israel and the United States by federal and
        local governments, actions taken to protect employees, and the impact of the pandemic on various business activities could adversely affect our business, results of operations and financial condition.<br>
        <br>
        The capital markets have experienced significant volatility due to the ongoing spread of COVID-19. As a result, the price of our shares may be negatively impacted and affect our ability to raise additional capital.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Our management will have broad discretion in the use of the net proceeds we receive in this offering and might not apply the proceeds in ways that increase the value of your
        investment.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our management and board of directors will have broad discretion over the use of our net proceeds from this offering, and you will be relying on their judgment regarding the application of these
        proceeds, which can be different from that contemplated at the time of this offering. Our management and board of directors might not apply our net proceeds in ways that ultimately increase the value of your investment and we might not be able to
        yield a significant return, if any, on any investment of these net proceeds. Our failure to apply these funds effectively could have a material adverse effect on our business, delay the development of our products and cause the price of our
        ordinary shares to decline.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Investors in this offering will experience immediate and substantial dilution.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The exercise price of the warrants is higher than the net tangible book value per share of our ordinary shares. Therefore, if you purchase securities in this offering by exercising your warrants, you
        will incur immediate and substantial dilution in the net tangible book value per share from the exercise price. If the holders of outstanding options to acquire ordinary shares exercise those options at prices below the exercise price of the
        warrants, you will incur further dilution. See the section entitled&#160;&#8220;Dilution&#8221;&#160;herein for a more detailed discussion of the dilution associated with this offering.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Because we do not intend to declare cash dividends on our ordinary shares in the foreseeable future, shareholders must rely on appreciation of the value of our ordinary shares for
        any return on their investment and may not receive any funds without selling their ordinary shares.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We have never declared or paid cash dividends on our ordinary shares and do not anticipate declaring or paying any cash dividends in the foreseeable future. As a result, we expect that only
        appreciation of the price of our ordinary shares, if any, will provide a return to investors in this offering for the foreseeable future. In addition, because we do not pay cash dividends, if our shareholders want to receive funds in respect of our
        ordinary shares, they must sell their ordinary shares to do so.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 3</font></div>
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      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">There is no public market for the warrants.</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">There is no established public trading market for the warrants, and we do not expect a market to develop. In addition, we have not and do not intend to apply to list the warrants on any national
        securities exchange or other nationally recognized trading system, including Nasdaq. Without an active market, the liquidity of the warrants will be limited.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">The warrants are speculative in nature. You may not be able to recover your investment in the warrants, and the warrants may expire worthless.</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">If our ordinary share price does not increase to an amount sufficiently above the applicable exercise price of the warrants during the period the warrants are exercisable, you will be unable to
        recover any of your investment in the warrants. There can be no assurance that the market price of the ordinary shares will continue to be above the exercise price of the warrants, and consequently, whether it will be profitable for holders of the
        warrants to exercise the warrants when they decide to do so.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Holders of the warrants will have no rights as ordinary shareholders until they acquire our ordinary shares.</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Until you acquire our ordinary shares upon exercise of the warrants, you will have no rights with respect to our ordinary shares issuable upon exercise of the warrants, including the right to vote or
        respond to tender offers. Upon exercise of your warrants, you will be entitled to exercise the rights of an ordinary shareholder only as to matters for which the record date occurs after the exercise date.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 4</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">NOTE REGARDING FORWARD-LOOKING STATEMENTS<a name="NOTEREGARDINGFORARD-LOOK"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">This prospectus contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, or the Securities Act, and Section 21E of the Securities Exchange Act
        of 1934, as amended, or the Exchange Act, and the Private Securities Litigation Reform Act of 1995. Also, documents that we incorporate by reference into this prospectus, including documents that we subsequently file with the SEC, will contain
        forward-looking statements. Forward-looking statements are those that predict or describe future events or trends and that do not relate solely to historical matters. You can generally identify forward-looking statements as statements containing
        the words &#8220;may,&#8221;&#160;&#8220;will,&#8221;&#160;&#8220;could,&#8221;&#160;&#8220;should,&#8221;&#160;&#8220;expect,&#8221;&#160;&#8220;anticipate&#8220;&#160;&#8220;objective,&#8221;&#160;&#8220;goal,&#8221;&#160;&#8220;intend,&#8221;&#160;&#8220;estimate,&#8221;&#160;&#8220;believe,&#8221;&#160;&#8220;project,&#8221;&#160;&#8220;plan,&#8221;&#160;&#8220;assume,&#8221; &#8220;potential,&#8221; &#8220;likely,&#8221; &#8220;confident&#8221; or other similar expressions, or negatives of those
        expressions, although not all forward-looking statements contain these identifying words. All statements contained or incorporated by reference in this prospectus regarding our future strategy, future operations, projected financial position,
        proposed products, anticipated collaborations, estimated future revenues, projected costs, future prospects, the future of our industry and results that might be obtained by pursuing management&#8217;s current plans and objectives are forward-looking
        statements.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">You should not place undue reliance on our forward-looking statements because the matters they describe are subject to certain risks, uncertainties and assumptions, including in many cases decisions
        or actions by third parties that are difficult to predict. Our forward-looking statements are based on the information currently available to us and speak only as of the date on the cover of this prospectus or, in the case of forward-looking
        statements incorporated by reference, the date of the filing that includes the statement. Over time, our actual results, performance or achievements may differ from those expressed or implied by our forward-looking statements, and such difference
        might be significant and materially adverse to our security holders. We undertake no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We have identified some of the important factors that could cause future events to differ from our current expectations and they are described in this prospectus under the caption &#8220;Risk Factors,&#8221; as
        well as in our most recent Annual Report on Form 20-F, including without limitation under the captions &#8220;Risk Factors&#8221; and &#8220;Operating and Financial Review and Prospects,&#8221; and in other documents that we may file with the SEC, all of which you should
        review carefully. Please consider our forward-looking statements in light of those risks as you read this prospectus.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 5</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">OFFER STATISTICS AND EXPECTED T<a name="SANDEXPECTEDT"><!--Anchor--></a>IMETABLE</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We may offer and sell from time to time pursuant to this prospectus an aggregate 749,104 ordinary shares that are issuable at an exercise price of $4.74 per share for a maximum aggregate offering
        price of $3,550,753.&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 6</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">CAPITALIZATION<a name="PITALIZATION"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The table below sets forth our cash and cash equivalents, restricted cash, short-term bank deposits, and capitalization as of June 30, 2020:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z46adf6259d204f3aa2d6b3dc2b7d02d9" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 90pt; vertical-align: top; align: right;">
                <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="line-height: 1.25;">on an actual basis; and</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="zf51b20b374e0438b8b79c045ae520c87" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 90pt; vertical-align: top; align: right;">
                <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="line-height: 1.25;">on an as adjusted basis to reflect the sale and issuance of 749,104 ordinary shares issuable upon the exercise of warrants, with an exercise price of $4.74 per share.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">The information set forth in the following table should be read in conjunction with, and is qualified in its entirety by, reference to our audited and unaudited financial statements and the notes
        thereto incorporated by reference into this prospectus.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="zfefab03c64264d3990478951834f2c1a">

          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF; padding-bottom: 2px;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 solid 2px;" colspan="6">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">As of June 30, 2020</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #FFFFFF; vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF; padding-bottom: 2px;">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 solid 2px;" colspan="2">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Actual</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #FFFFFF; vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 solid 2px;" colspan="2">
              <div style="line-height: 1.25; font-weight: bold; text-align: center;">As Adjusted</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #FFFFFF; vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; background-color: #FFFFFF;" colspan="6">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">(in thousands, except share and per share data)</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #FFFFFF; vertical-align: bottom;" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%; padding-bottom: 2px;">
              <div style="line-height: 1.25;">Cash and cash equivalents, restricted cash and short-term bank deposits</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1">
              <div style="line-height: 1.25;">136,066</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1">
              <div style="line-height: 1.25;">139,601</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; width: 76%; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">Shareholder&#8217;s equity:</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
              <div style="line-height: 1.25;">Ordinary shares, NIS 0.01 nominal value:200,000,000 shares authorized; 82,694,209 shares issued and outstanding, actual; 83,443,313 shares issued and outstanding, as adjusted</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1">
              <div style="line-height: 1.25;">227</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1">
              <div style="line-height: 1.25;">229</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; width: 76%; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">Additional paid-in capital</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
              <div style="line-height: 1.25;">500,792</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
              <div style="line-height: 1.25;">504,325</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%; padding-bottom: 2px;">
              <div style="line-height: 1.25;">Accumulated deficit</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1">
              <div style="line-height: 1.25;">(371,552</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1">
              <div style="line-height: 1.25;">)</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1">
              <div style="line-height: 1.25;">(371,552</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1">
              <div style="line-height: 1.25;">)</div>
            </td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; width: 76%; padding-bottom: 2px; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">Total shareholders&#8217; equity</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" colspan="1">
              <div style="line-height: 1.25;">129,467</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0); background-color: rgb(255, 255, 255);" colspan="1">
              <div style="line-height: 1.25;">133,002</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%; padding-bottom: 4px;">
              <div style="line-height: 1.25;">Total capitalization</div>
            </td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1">
              <div style="line-height: 1.25;">129,467</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1">&#160;</td>
            <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1">
              <div style="line-height: 1.25;">133,002</div>
            </td>
            <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1">&#160;</td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The number of outstanding ordinary shares set forth above excludes, as of June 30, 2020:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="z9a1725e517c747bfbc7e29a9e7b0f987" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 90pt; vertical-align: top; align: right;">
                <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="line-height: 1.25;">5,481,735 ordinary shares issuable upon the exercise of outstanding options to purchase ordinary shares granted under our 2010 Share Incentive Plan, having a weighted average exercise price of $4.33 per
                  share; and</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div>
          <table cellspacing="0" cellpadding="0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 90pt; vertical-align: top; align: right;">
                  <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
                </td>
                <td style="width: auto; vertical-align: top;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">an aggregate 3,464,441 ordinary shares issuable and reserved for future grants under our 2010 Share Incentive Plan.</div>
                  </div>
                </td>
              </tr>

          </table>
        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
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        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 7</font></div>
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      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">REASONS FOR THE OFFER AND USE OF PROCEEDS<a name="USEOFPROCEEDS"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;If the warrants to purchase our ordinary shares to which this prospectus relates are exercised in full, we will receive gross proceeds of approximately $3.6 million, however we do not know when, if
        or the extent to which such warrants may be exercised, and it is possible that no warrants may be exercised, in which case we would not receive any proceeds from this offering.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We currently expect to use the net proceeds from this offering&#160;for pre-clinical and clinical development of our product candidates and for other general corporate purposes. We have not determined the
        amount of net proceeds to be used specifically for the foregoing purposes.&#160;This expected use of the net proceeds from this offering represents our intentions based upon our current plans and business conditions. The amounts and timing of our actual
        expenditures may vary significantly depending on numerous factors, including the progress of our development efforts, the status of and results from clinical trials, as well as any collaborations that we may enter into with third parties for our
        product candidates, and any unforeseen cash needs. As a result, our management will retain broad discretion over the allocation of the net proceeds from this offering.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Pending use of the net proceeds, we intend to invest any proceeds in a variety of capital preservation instruments, including short-term and long-term, investment-grade and interest-bearing
        instruments.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 8</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">DESCRIPTION OF ORDINARY SHARES<a name="OFORDINARYSHARES"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">Our authorized share capital consists of 200,000,000 ordinary shares, nominal (par) value NIS 0.01 per share. As of June 30, 2020, 82,694,209 ordinary shares were issued and outstanding. Subject to
        our amended and restated articles of association, or our Articles, fully paid ordinary shares of the Company confer on the holders thereof rights to attend and to vote at general meetings of the shareholders. Subject to the rights of holders of
        shares with limited or preferred rights which may be issued in the future, the ordinary shares of the Company confer upon the holders thereof equal rights to vote, to receive dividends and to participate in the distribution of the assets of the
        Company upon its winding-up, in proportion to the amount paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in respect of which such dividends are being paid or such distribution is being
        made, without regard to any premium paid in excess of the nominal value, if any. All outstanding ordinary shares are validly issued and fully paid.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Registration Number and Purpose of the Company</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our registration number with the Israeli Registrar of Companies is 51-177-963-9. Our purpose as set forth in our Articles is to engage in any lawful act or activity for which companies may be
        organized under the Companies Law.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Rights Attached to Our Shares</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">Subject to our Articles, fully paid ordinary shares confer on the holders thereof rights to attend and to vote at general meetings of the shareholders. Subject to the rights of holders of shares with
        limited or preferred rights which may be issued in the future, our ordinary shares confer upon the holders thereof equal rights to receive dividends and to participate in the distribution of our assets upon our winding-up, in proportion to the
        amount paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in respect of which such dividends are being paid or such distribution is being made, without regard to any premium paid in excess of
        the nominal value, if any. No preferred shares are currently authorized. All outstanding ordinary shares are validly issued and fully paid.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Voting Rights</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">Subject to the provisions of our Articles, holders of ordinary shares have one vote for each ordinary share held by such shareholder of record, on all matters submitted to a vote of shareholders.
        Shareholders may vote in person, by proxy or by proxy card. Alternatively, shareholders who hold shares through members of the Tel Aviv Stock Exchange may vote electronically via the electronic voting system of the Israel Securities Authority, or
        Electronic Vote. These voting rights may be affected by the grant of any special voting rights to the holders of a class of shares with preferential rights that may be authorized in the future. As our ordinary shares do not have cumulative voting
        rights in the election of directors, the holders of the majority of the shares present and voting at a shareholders meeting have the power to elect all of our directors.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Transfer of Shares</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our ordinary shares which have been fully paid-up are transferable by submission of a proper instrument of transfer together with the certificate of the shares to be transferred and such other
        evidence of title, as our Board of Directors may require, unless such transfer is prohibited by another instrument or by applicable securities laws.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Dividends</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Under the Companies Law, dividends may be distributed only out of profits available for dividends as determined by the Companies Law, provided that there is no reasonable concern that the
        distribution will prevent the Company from being able to meet its existing and anticipated obligations when they become due. If the company does not meet the profit requirement, a court may nevertheless allow the company to distribute a dividend,
        as long as the court is convinced that there is no reasonable concern that such distribution will prevent the company from being able to meet its existing and anticipated obligations when they become due. Pursuant to our Articles, no dividend shall
        be paid other than out of the profits of the Company. Generally, under the Companies Law, the decision to distribute dividends and the amount to be distributed is made by a company&#8217;s board of directors.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our Articles provide that our Board of Directors, may, subject to the Companies Law, from time to time, declare and cause the Company to pay such dividends as may appear to the Board of Directors to
        be justified by the profits of our Company. Subject to the rights of the holders of shares with preferential, special or deferred rights that may be authorized in the future, our profits which shall be declared as dividends shall be distributed
        according to the proportion of the nominal (par) value paid up or credited as paid up on account of the shares held at the date so appointed by the Company and in respect of which such dividend is being paid, without regard to the premium paid in
        excess of the nominal (par) value, if any. The declaration of dividends does not require shareholders&#8217; approval.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 9</font></div>
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      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">To date, we have not declared or distributed any dividend and we do not intend to pay cash dividends on our ordinary shares in the foreseeable future.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Liquidation Rights</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">In the event of our winding up on liquidation or dissolution, subject to applicable law and after satisfaction of liabilities to creditors, our assets available for distribution among the
        shareholders shall be distributed to the holders of ordinary shares in proportion to the amount paid up or credited as paid up on account of the nominal value of the shares held by them respectively and in respect of which such distribution is
        being made, without regard to any premium paid in excess of the nominal value, if any. This liquidation right may be affected by the grant of limited or preferential rights as to liquidation to the holders of a class of shares that may be
        authorized in the future.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Redemption Provisions</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We may, subject to applicable law and to our Articles, issue redeemable shares and redeem the same upon such terms and conditions as determined by our Board of Directors.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Limitation of Liability</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Under our Articles, the liability of each shareholder for the Company&#8217;s obligations is limited to the unpaid sum, if any, owing to the Company in consideration for the issuance of the shares held by
        such shareholder.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Modification of Class Rights</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our amended and restated Memorandum of Association, or Memorandum, provides that we may amend the Memorandum in order to increase, consolidate or divide or otherwise amend our share capital by a
        simple majority of the voting power present at a shareholders meeting as currently provided in our Articles or by such other majority as shall be set forth in our Articles from time to time.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to our Articles, if at any time our share capital is divided into different classes of shares, the rights attached to any class, unless otherwise provided by our Articles, may be modified or
        abrogated by the Company, subject to the consent in writing of, or sanction of a resolution passed by, the holders of a majority of the issued shares of such class at a separate general meeting of the holders of the shares of such class.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Limitations on the Rights to Own Securities</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our Articles and Israeli law do not restrict the ownership or voting of ordinary shares by non-residents or persons who are not citizens of Israel, though such ownership is prohibited under
        applicable law with respect to subjects of nations which are in a state of war with Israel.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Changes in Authorized Share Capital</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our Articles enable us, among others, to increase or reduce our authorized share capital. Any such changes are subject to the provisions of the Companies Law and our Articles and must be approved by
        a resolution duly passed by a simple majority of our shareholders at a general meeting by voting on such change in capital.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Shareholders&#8217; Meetings and Resolutions</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our Articles provide that our annual general meeting shall be held once in every calendar year at such time (within a period of not more than fifteen months after the last preceding annual general
        meeting), and place determined by our Board of Directors. Our Board of Directors may, in its discretion, convene additional special shareholders meetings and, pursuant to the Companies Law, must convene a meeting upon the demand of: (a) two
        directors or one quarter of the directors in office; or (b) the holder or holders of (i) 5% or more of our issued share capital and one percent or more of our voting rights; or (ii) 5% or more of our voting rights. All demands for shareholders
        meetings must set forth the items to be considered at that meeting.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 10</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
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      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The chairman of the Board of Directors, or any other director or office holder of the Company which may be designated for this purpose by the Board of Directors, shall preside as chairman at each of
        our general meetings. If there is no such chairman, or if the appointed chairman is unwilling to take the chair, or if he shall have indicated in advance that he will not be attending, or if at any meeting such chairman is not present within thirty
        (30) minutes after the time fixed for holding the meeting, then those present at the meeting shall choose someone present to be chairman of the meeting. The office of chairman shall not, by itself, entitle the holder thereof to vote at any general
        meeting nor shall it entitle a second or casting vote.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">According to regulations promulgated pursuant to the Companies Law and governing the terms of notice and publication of shareholder meetings of public companies, or the General Meeting Regulations,
        holder(s) of one percent or more of the Company&#8217;s voting rights may propose any matter appropriate for deliberation at a shareholder meeting to be included on the agenda of a shareholder meeting, generally by submitting a proposal within seven days
        of publicizing the convening of a shareholder meeting, or within fourteen days, if the Company publishes at least 21 days prior to publicizing the proxy materials for a shareholder meeting, a preliminary notice stating its intention to convene such
        meeting, the agenda thereof, shareholder&#8217;s right to propose a matter to be included on the agenda of such meeting and company&#8217;s right not to examine such proposals received upon termination of 14 day period from the publication of such notice. Any
        such proposal must further comply with the information requirements under applicable law and our Articles. The agenda for a shareholder meeting is determined by the Board of Directors and must include matters in respect of which the convening of a
        shareholder meeting was demanded and any matter requested to be included by holder(s) of one percent of the Company&#8217;s voting rights, as detailed above.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to the Companies Law and the General Meeting Regulations shareholder meetings generally require prior notice of not less than 21 days, and not less than 35 days in certain cases. Pursuant to
        our Articles, we are not required to deliver or serve notice of a general meeting or of any adjournments thereof to any shareholder. However, subject to applicable law and stock exchange rules and regulations, we will publicize the convening of a
        general meeting in any manner reasonably determined by us, and any such publication shall be deemed duly made, given and delivered to all shareholders on the date on which it is first made, posted, filed or published in the manner so determined by
        us in our sole discretion.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The function of the annual general meeting is to elect directors, receive and consider the profit and loss account, the balance sheet and the ordinary reports and accounts of the directors and
        auditors, appoint auditors and transact any other business which under our Articles or applicable law may be transacted by the shareholders of the Company in a general meeting.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to our Articles, the quorum required for a meeting of shareholders consists of at least two shareholders, present in person, by proxy, by proxy card or by Electronic Vote and holding shares
        conferring in the aggregate twenty-five percent (25%) or more of the voting power of the Company. If within half an hour from the time appointed for the meeting a quorum is not present, the meeting shall stand adjourned to the same day in the
        following week at the same time and place or to such other later day, time and place as the Board of Directors may determine and specify in the publication with respect to the Meeting. At the adjourned meeting, any number of participants will
        constitute a quorum present, in person, by proxy, by proxy card or by Electronic Vote; provided, however, that special general meeting which was convened by the Board upon the demand of shareholders or directors then in office, as detailed above,
        or directly by such shareholders or directors, in accordance the terms of the Companies Law, shall be cancelled.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Generally, under the Companies Law and our Articles, shareholder resolutions are deemed adopted if approved by the holders of a simple majority of the voting rights represented at the meeting, in
        person, by proxy, by proxy card or by Electronic Vote, and voting on the matter, unless a different majority is required by law or pursuant to our Articles such as a resolution for the voluntary winding up of our Company which requires the approval
        of holders of 75% of the voting power presented and voting at the meeting, or resolutions concerting certain related party transactions as set forth in Sections 267 and 270-275 of the Companies Law.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Change of Control</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Merger</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Under the Companies Law, a merger is generally required to be approved by the shareholders and board of directors of each of the merging companies. If the share capital of the company that will not
        be the surviving company is divided into different classes of shares, the approval of each class is also required, unless determined otherwise by the court. Similarly, unless an Israeli court determines otherwise, a merger will not be approved if
        it is objected to by shareholders holding a majority of the voting rights participating and voting at the meeting (abstentions are disregarded), after excluding the shares held by the other party to the merger, by any person who holds 25% or more
        of the other party to the merger or by anyone on their behalf, including by the relatives of, or corporations controlled by, these persons. In approving a merger, the board of directors of both merging companies must determine that there is no
        reasonable concern that, as a result of the merger, the surviving company will not be able to satisfy its obligations to its creditors. Similarly, upon the request of a creditor of either party to the proposed merger, an Israeli court may prevent
        or delay the merger if it concludes that there exists a reasonable concern that, as a result of the merger, the surviving company will not be able to satisfy the obligations of the merging parties. A court may also issue other instructions for the
        protection of the creditors&#8217; rights in connection with a merger. Further, a merger may not be completed unless at least (i) 50 days have passed from the time that the requisite proposals for the approval of the merger were filed with the Israeli
        registrar of companies; and (ii) 30 days have passed since the merger was approved by the shareholders of each party.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 11</font></div>
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      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Special Tender Offer</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The Companies Law provides that an acquisition of shares of an Israeli public company must be made by means of a special tender offer if as a result of the acquisition the purchaser would become a
        holder of 25% or more of the voting rights in the company. This rule does not apply if there is already another holder of 25% or more of the voting rights in the company. Similarly, the Companies Law provides that an acquisition of shares in a
        public company must be made by means of a special tender offer if as a result of the acquisition the purchaser would become a holder of more than 45% of the voting rights in the company, if there is no other shareholder of the company who holds
        more than 45% of the voting rights in the company. These requirements do not apply if the acquisition (i) occurs in the context of a private placement by the company that received shareholder approval for the purpose of allowing the purchaser to
        hold more than 25% of 45% of the voting rights in the company, as the case may be, (ii) was from a shareholder holding 25% or more of the voting rights in the company and resulted in the acquirer becoming a holder of 25% or more of the voting
        rights in the company, or (iii) was from a holder of more than 45% of the voting rights in the company and resulted in the acquirer becoming a holder of more than 45% of the voting rights in the company. A special tender offer may be consummated
        only if (i) at least 5% of the voting power attached to the company&#8217;s outstanding shares will be acquired by the offeror and (ii) the number of shares tendered in the offer exceeds the number of shares whose holders objected to the offer (excluding
        controlling shareholders, holders of 25% or more of the voting rights in the company and any person having a personal interest in the acceptance of the tender offer).</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">In the event that a special tender offer is made, a company&#8217;s board of directors is required to express its opinion on the advisability of the offer, or shall abstain from expressing any opinion if
        it is unable to do so, provided that it gives the reasons for its abstention. An office holder in a target company who, in his or her capacity as an office holder, performs an action the purpose of which is to cause the failure of an existing or
        foreseeable special tender offer or is to impair the chances of its acceptance, is liable to the potential purchaser and shareholders for damages, unless such office holder acted in good faith and had reasonable grounds to believe he or she was
        acting for the benefit of the company. However, office holders of the target company may negotiate with the potential purchaser in order to improve the terms of the special tender offer, and may further negotiate with third parties in order to
        obtain a competing offer. Shares purchased in contradiction to the tender offer rules under the Companies Law will have no rights and will become dormant shares.</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">If a special tender offer is accepted, then shareholders who did not respond to or that had objected the offer may accept the offer within four days of the last day set for the acceptance of the
        offer. In the event that a special tender offer is accepted, then the purchaser or any person or entity controlling it or under common control with the purchaser or such controlling person or entity may not make a subsequent tender offer for the
        purchase of shares of the target company and may not enter into a merger with the target company for a period of one year from the date of the offer, unless the purchaser or such person or entity undertook to effect such an offer or merger in the
        initial special tender offer.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Full Tender Offer</div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Under the Companies Law, a person may not acquire shares in a public company if, after the acquisition, the acquirer will hold more than 90% of the shares or more than 90% of any class of shares of
        that company, unless a tender offer is made to purchase all of the shares or all of the shares of the particular class. The Companies Law also generally provides that as long as a shareholder in a public company holds more than 90% of the company&#8217;s
        shares or of a class of shares, that shareholder shall be precluded from purchasing any additional shares. In order for all of the shares that the purchaser offered to purchase be transferred to him by operation of law, one of the following needs
        to have occurred: (i) the shareholders who declined or do not respond to the tender offer hold less than 5% of the company&#8217;s outstanding share capital or of the relevant class of shares and the majority of offerees who do not have a personal
        interest in accepting the tender offer accepted the offer, or (ii) the shareholders who declined or do not respond to the tender offer hold less than 2% of the company&#8217;s outstanding share capital or of the relevant class of shares.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 12</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">A shareholder that had his or her shares so transferred, whether he or she accepted the tender offer or not, has the right, within six months from the date of acceptance of the tender offer, to
        petition the court to determine that the tender offer was for less than fair value and that the fair value should be paid as determined by the court. However, the purchaser may provide in its offer that shareholders who accept the tender offer will
        not be entitled to such rights.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">If the conditions set forth above are not met, the purchaser may not acquire additional shares of the company from shareholders who accepted the tender offer to the extent that following such
        acquisition, the purchaser would own more than 90% of the company&#8217;s issued and outstanding share capital. The above restrictions apply, in addition to the acquisition of shares, to the acquisition of voting power.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Transfer Agent and Registrar</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">The transfer agent and registrar for our ordinary shares is American Stock Transfer &amp; Trust Company, LLC.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">The Nasdaq Global Market and the Tel Aviv Stock Exchange</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">Our ordinary shares are listed on The Nasdaq Global Market and the Tel Aviv Stock Exchange under the symbol &#8220;CGEN.&#8221;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Warrants</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">As of June 30, 2020, we had warrants outstanding to purchase an aggregate 749,104 ordinary shares. See &#8220;Description of Warrants&#8212;Outstanding Warrants.&#8221;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-weight: bold;">Share History</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The following is a summary of the history of our share capital for the last three years.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Ordinary Share Issuances</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z2f9897023be54a6a883d722527acc2d9" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 9.82%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 4.46%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><font style="font-style: italic;">Share Options.</font> Since January 1, 2017 and through June 30, 2020, we have issued a total of 4,256,307 ordinary shares upon the exercise of share options.</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zd3dac3f771bd4d939f98e5e3021988a4" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 9.85%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 4.43%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><font style="font-style: italic;">ATM Sales Agreement</font>. In May 2018, we entered into a Controlled Equity Offering<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">SM</sup> Sales Agreement, or the ATM Sales Agreement, with Cantor Fitzgerald &amp;
                Co., or Cantor, as sales agent, pursuant to which we may offer and sell, from time to time through Cantor, our ordinary shares having an aggregate offering price of up to $25 million. Under the ATM Sales Agreement, Cantor may sell Shares by
                any method permitted by law and deemed to be an &#8220;at the market offering&#8221; as defined in Rule 415(a)(4) promulgated under the Securities Act, including sales made directly on the Nasdaq Global Market, or on any other existing trading market
                for the ordinary shares. As of December 31, 2019, we sold 7,245,268 shares through the ATM Sales Agreement for an aggregate purchase price of approximately $23.7 million. The program was terminated in 2019.</div>
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.85%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 4.43%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><font style="font-style: italic;">Registered Direct Offering</font>. In June 2018, we entered into a definitive securities purchase agreement with certain institutional investors and a placement agency
                agreement with JMP Securities LLC, in connection with a registered direct offering which resulted in the issuance of 5,316,457 of our ordinary shares at a purchase price of $3.95 per share. In connection with the issuance of the ordinary
                shares, we also issued warrants to purchase up to 4,253,165 additional ordinary shares. The warrants have an exercise price of $4.74 per share and have a term of five years from the date of issuance. Gross proceeds from this offering were
                approximately $21 million, before deducting the underwriting discounts and commissions and estimated offering expenses payable by us. As of June 30, 2020, warrants to purchase up to 749,104 ordinary shares remained outstanding (warrants to
                purchased 3,504,061 ordinary shares were exercised as of such date).</div>
              <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.85%; vertical-align: middle; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 4.43%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="background-color: #FFFFFF; line-height: 1.25;">
                <div style="text-align: justify; line-height: 1.25;"><font style="background-color: #FFFFFF; font-style: italic;">Bristol-Myers Squibb Securities Purchase Agreement. </font><font style="background-color: #FFFFFF;">In October 2018, we and
                    Bristol-Myers Squibb entered into a Securities Purchase Agreement pursuant to which Bristol-Myers&#160;Squibb purchased 2,424,243 ordinary shares at a purchase price of $4.95 per share, which represented a 33% premium over the average
                    closing price on the last 20 Nasdaq trading days. Gross proceeds from this private placement were approximately $12 million.</font></div>
                <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
              </div>
            </td>
          </tr>

      </table>
      <div>
        <div>
          <div style="line-height: 1.25;">&#160;</div>
          <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
            <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 13</font></div>
            <div id="DSPFPageBreak" style="page-break-after: always;">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 9.82%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
                <td style="width: 4.46%; vertical-align: top; background-color: #FFFFFF;">
                  <div style="line-height: 1.25;">&#8226;</div>
                </td>
                <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;"><font style="background-color: #FFFFFF; font-style: italic;">Public Offering.</font><font style="background-color: #FFFFFF;"> In March 2020, we entered into an underwriting agreement with SVB Leerink LLC
                        and Stifel,&#160;Nicolaus &amp; Company, Incorporated, as representatives of several underwriters relating to the issuance and sale in a public offering of 8,333,334 of our ordinary shares at a price to the public of $9.00 per share (and
                        a price of $8.46 per share to the underwriters). In addition, we granted the underwriters a 30-day option to purchase additional ordinary shares at the price set forth above. On April 14, 2020, we issued and sold, pursuant to that
                        underwriting agreement an additional 483,005 ordinary shares pursuant to the underwriters&#8217; option specified above.&#160;We sold a total of 8,816,339 ordinary shares in the offering with gross proceeds of approximately $79.3 million.</font><font style="font-style: italic;"> <br>
                      </font></div>
                  </div>
                </td>
              </tr>

          </table>
          <div style="line-height: 1.25;">&#160;</div>
        </div>
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Authorized Share Capital</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Our authorized share capital is equal to NIS2,000,000 divided into 200,000,000 ordinary shares nominal (par) value NIS 0.01 per share.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 14</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">DESCRIPTION OF WARRANTS<a name="TIONOFWARRANTS"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">The following is a brief summary of certain terms and conditions of the warrants and is subject in all respects to the provisions contained in the warrants. You should review a copy of the form of
        ordinary share purchase warrant for a complete description of the terms and conditions applicable to the warrants.</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Term</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">The warrants are exercisable during the period beginning six months from the date of issuance and ending at 5:00 P.M. on June 19, 2023.</div>
      <div style="text-indent: 35pt; line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exercise Price</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">The exercise price of the warrants is $4.74 per whole ordinary share. The exercise price is subject to appropriate adjustment in the event of certain share splits, dividends, recapitalizations or
        similar events affecting our ordinary shares.</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exercisability</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">Holders may exercise the warrants beginning six months from June 19, 2018, the date of issuance, and at any time during the applicable term of the warrant. The warrants will be exercisable, at the
        option of each holder, in whole or in part, by delivering to us a written notice and, within&#160;one&#160;trading&#160;day&#160;of delivering such notice, payment&#160;shall be made&#160;in full for the number of ordinary shares purchased upon such exercise. If there is no
        effective registration statement registering the issuance and sale of the ordinary shares underlying the warrants, the holder may exercise the warrant through a cashless exercise, in which case the holder would receive upon such exercise the net
        number of ordinary shares determined according to the formula set forth in the warrant.</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exercise Limitation</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">Holders shall not have the right to exercise the warrant, to the extent that after giving effect to such exercise, such holder, together with such holder&#8217;s affiliates and any other persons acting as
        a group together with the holder or any of the holder&#8217;s affiliates, would beneficially own in excess of 4.99% of the ordinary shares outstanding immediately after giving effect to such exercise which limitation may be increased to 9.99% by the
        holder.</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">No Fractional Shares</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">No fractional ordinary shares will be issued upon exercise of the warrants. If there is a fractional share issuable upon exercise, we will, at our election, either pay a cash adjustment or it will be
        rounded up to the nearest whole share.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Transferability</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">Subject to applicable laws and the restriction on transfer set forth in the warrant, the warrant may be transferred at the option of the holder upon surrender of the warrant to us together with the
        appropriate instruments of transfer.</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Authorized Shares</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 35pt; line-height: 1.25;">During the period the warrants are outstanding, we will reserve from our authorized and unissued ordinary shares a sufficient number of shares to provide for the issuance of ordinary shares
        underlying the warrants upon the exercise of the warrants.</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Exchange Listing</div>
      <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We have not and do not plan on applying to list the warrants on Nasdaq, the TASE, any other national securities exchange or any other nationally recognized trading system.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Purchase Rights</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">Subject to certain limitations, if at any time during the period the warrants are outstanding we grant, issue or sell certain of our securities pro rata to the record holders of our ordinary shares,
        the warrant holders shall be entitled to participate upon the same terms in an amount up to the number of ordinary shares acquirable upon complete exercise of the warrant.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 15</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Pro Rata Distributions</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">Subject to certain limitations, if at any time during the period the warrants are outstanding we declare or make any dividend or other distribution of assets to our ordinary shareholders, the warrant
        holders shall be entitled to distributions upon the same terms in an amount up to the number of ordinary shares acquirable upon complete exercise of the warrant.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Fundamental Transactions</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">In the event of any fundamental transaction, as defined in the warrants and generally including any consolidation or merger with or into another entity, the sale of all or substantially all of our
        assets, tender offer or exchange offer, reorganization or recapitalization through which another entity acquires us, or reclassification of our ordinary shares, then the successor entity in such transaction will assume in writing all of our
        obligations under the warrant pursuant to written agreements, including an adjusted exercise price equal to the value for the ordinary shares reflected by the terms of such fundamental transaction, and exercisable for a corresponding number of
        shares equivalent to the ordinary shares acquirable and receivable upon exercise of the warrant prior to such fundamental transaction.</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Failure to Timely Deliver Securities</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If we fail for any reason to deliver to a holder the number of shares of ordinary shares due to the holder pursuant to the holder&#8217;s written notice on or before the second trading
        day following receipt of such notice, we will pay to the holder, in cash, as liquidated damages and not as a penalty, for each $1,000 of ordinary shares subject to such exercise, $10 per trading day (increasing to $20 per trading day on the fifth
        trading day after such liquidated damages begin to accrue) for each trading day until such ordinary shares are delivered or the holder rescinds such exercise.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Right as a Shareholder</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Except as otherwise provided in the warrants or by virtue of such holder&#8217;s ownership of our ordinary shares, the holders of the warrants do not have the rights or privileges of holders of our
        ordinary shares, including any voting rights, until they exercise their warrants.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Waivers and Amendments</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Any term of the warrants issued in the offering may be amended or waived with our written consent and the written consent of the holder.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 16</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DILUTION"><!--Anchor--></a>DILUTION</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">If you purchase ordinary shares in this offering by exercising your warrants, your ownership interest will be immediately diluted to the extent of the difference between the exercise price and the as
        adjusted net tangible book value per ordinary share after this offering. Net tangible book value per ordinary share is calculated by subtracting our total liabilities from our total tangible assets, which is total assets, and dividing this amount
        by the number of ordinary shares outstanding. Our net tangible book value as of June 30, 2020 was $129.5 million, or $1.57 per ordinary share.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">After giving effect to the sale of 749,104 ordinary shares in this offering issuable upon the exercise of warrants at an exercise price of $4.74 per share, our as adjusted net tangible book value as
        of June 30, 2020 would have been approximately $133.0 million, or $1.59 per ordinary share. This amount represents an immediate increase in the net tangible book value of $0.02 per ordinary share to our existing shareholders and an immediate and
        substantial dilution in net tangible book value of $3.15 per ordinary share to holders purchasing ordinary shares by exercising warrants in this offering. The following table illustrates this per share dilution:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z1fa8f40222de4ffd99a4394b73310bf6" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF;">
              <div style="line-height: 1.25;">Exercise price per share</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="2" style="vertical-align: bottom; background-color: #CCEEFF;">&#160;</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom;">&#160;</td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom;">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right;">
              <div style="line-height: 1.25;">4.74</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 76%;">
              <div style="text-indent: -8.65pt; margin-left: 17.3pt; line-height: 1.25;">Net tangible book value per share as of June 30, 2020</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%;">
              <div style="line-height: 1.25;">1.57</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
              <div style="text-indent: -8.65pt; margin-left: 17.3pt; line-height: 1.25;">Increase in net tangible book value per share attributable to the offering</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
              <div style="line-height: 1.25;">0.02</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: rgb(255, 255, 255); width: 76%;">
              <div style="line-height: 1.25;">As adjusted net tangible book value per share after this offering</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; text-align: right; width: 9%;">
              <div style="line-height: 1.25;">1.59</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(255, 255, 255); vertical-align: bottom; width: 1%;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
              <div style="line-height: 1.25;">Net dilution per share to new investors in this offering</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
              <div style="line-height: 1.25;">3.15</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The information above is based on 82,694,209 ordinary shares outstanding as of June 30, 2020, and does not include the following as of June 30, 2020:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="zf63d2cf7a3b949a0b1c3bea94701ffd0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 90pt; vertical-align: top; align: right;">
                <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="line-height: 1.25;">5,481,735 ordinary shares issuable upon the exercise of outstanding options to purchase ordinary shares granted under our 2010 Share Incentive Plan, having a weighted average exercise price of $4.33 per
                  share;</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="zb01ae8cef9cc480ca9e73afe3762c26f" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 90pt; vertical-align: top; align: right;">
                <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="line-height: 1.25;">an aggregate 3,464,441 ordinary shares issuable and reserved for future grants under our 2010 Share Incentive Plan; and</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" id="za550cc3ee7384540b4a84f2764bcf4de" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 90pt; vertical-align: top; align: right;">
                <div style="margin-left: 72pt; line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="line-height: 1.25;">749,104 ordinary shares issuable upon the exercise of warrants issued to certain institutional investors in a registered direct offering completed in June 2018, with an exercise price of $4.74 per share.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">To the extent that outstanding options outstanding as of June 30, 2020 have been or may be exercised, investors purchasing our securities in this offering may experience further dilution.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 17</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">PLAN OF DISTRIBUTION<a name="OFDISTRIBUTION"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">In accordance with the terms of the warrants to which this prospectus relates, we will issue ordinary shares underlying the warrants to the holders thereof upon due exercise of such warrants. No
        underwriter or other person has been engaged by us to facilitate the sale of our ordinary shares we are offering in this offering. We will receive all of the proceeds from any cash exercise of the warrants. All costs associated with this
        registration were borne by us.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">&#160;Each warrant has an exercise price of $4.74 per share, is exercisable in full and will expire on the fifth anniversary the original issuance date of June 19, 2018. The exercise price is subject to
        appropriate adjustment in the event of certain share splits, dividends, recapitalizations or similar events affecting our ordinary shares.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">The warrants are exercisable, at the option of each holder, in whole or in part, by delivering to us a written notice and, within&#160;one&#160;trading&#160;day&#160;of delivering such notice, payment&#160;shall be made&#160;in
        full for the number of ordinary shares purchased upon such exercise. If there is no effective registration statement registering the issuance and sale of the ordinary shares underlying the warrants, the holder may exercise the warrant through a
        cashless exercise, in which case the holder would receive upon such exercise the net number of ordinary shares determined according to the formula set forth in the warrant.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">Holders shall not have the right to exercise the warrant, to the extent that after giving effect to such exercise, such holder, together with such holder&#8217;s affiliates and any other persons acting as
        a group together with the holder or any of the holder&#8217;s affiliates, would beneficially own in excess of 4.99% of the ordinary shares outstanding immediately after giving effect to such exercise which limitation may be increased to 9.99% by the
        holder.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-indent: 36pt; line-height: 1.25;">No fractional ordinary shares will be issued upon exercise of the warrants. If there is a fractional share issuable upon exercise, we will, at our election, either pay a cash adjustment or it will be
        rounded up to the nearest whole share.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 18</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">LEGAL MATTERS<a name="LMATTERS"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">Certain matters of Israeli law with respect to the legality of the issuance of the ordinary shares offered by this prospectus will be passed upon for us by Shibolet &amp; Co.,
        Law Firm, Tel Aviv, Israel. Certain matters of U.S. law will be passed upon for us by&#160;Cooley&#160;LLP, New York, New York.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">EXPERTS<a name="PERTS"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">The consolidated financial statements of Compugen Ltd. appearing in the Annual Report on Form 20-F for the year ended December 31, 2019 and the effectiveness of Compugen Ltd.
        internal control over financial reporting as of December 31, 2019, as filed with the SEC on February 24, 2020, have been audited by Kost Forer Gabbay &amp; Kasierer (a Member of Ernst &amp; Young Global), independent registered public accounting
        firm, as set forth in their report thereon, included therein, and incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such reports pertaining to such consolidated financial
        statements and the effectiveness of Compugen Ltd. internal control over financial reporting as of the respective dates, given on the authority of such firm as experts in accounting and auditing. The address of Kost Forer Gabbay &amp; Kasierer is
        144 Menachem Begin Road, Building A, Tel-Aviv, Israel 6492102.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">EXPENSES<a name="NSES"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The following are the estimated expenses related to the filing of the registration statement of which this prospectus forms a part, all of which will be paid by us. In addition, we anticipate
        incurring additional expenses in the future in connection with the offering of our securities pursuant to this prospectus. Any such additional expenses will be disclosed in a prospectus supplement.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table align="right" cellspacing="0" cellpadding="0" border="0" id="z30eae8410fe6449ca001df8cbb505b13" style="width: 95%; color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">

          <tr>
            <td valign="bottom" colspan="1" style="vertical-align: top; background-color: rgb(204, 238, 255); width: 88%;">
              <div style="text-align: justify; line-height: 1.25;">Printing and engraving expenses*</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;">
              <div style="line-height: 1.25;">1,000</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" colspan="1" style="vertical-align: top; background-color: rgb(255, 255, 255); width: 88%;">
              <div style="text-align: justify; line-height: 1.25;">Legal fees and expenses*&#160;</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #FFFFFF; vertical-align: bottom; width: 1%;">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #FFFFFF; vertical-align: bottom; text-align: right; width: 9%;">
              <div style="line-height: 1.25;">10,000</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #FFFFFF; vertical-align: bottom; width: 1%;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" colspan="1" style="vertical-align: top; background-color: rgb(204, 238, 255); width: 88%; padding-bottom: 2px;">
              <div style="text-align: justify; line-height: 1.25;">Accounting fees and expenses*&#160;</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;">&#160;</td>
            <td valign="bottom" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;">
              <div style="line-height: 1.25;">5,000</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
          </tr>
          <tr>
            <td valign="bottom" colspan="1" style="vertical-align: top; width: 88%; padding-bottom: 4px; background-color: rgb(255, 255, 255);">
              <div style="text-align: justify; line-height: 1.25;">Total*&#160;</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(255, 255, 255);">&#160;</td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">$</div>
            </td>
            <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 4px double rgb(0, 0, 0); background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">16,000</div>
            </td>
            <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(255, 255, 255);">&#160;</td>
          </tr>

      </table>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; clear: both;">__________</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">*Estimated</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">INCORPORATION OF CERTAIN INFORMATION BY REFERENCE<a name="IONOFCERTAININFORMATIONBY"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">The SEC allows us to &#8220;incorporate by reference&#8221; the information we file with it, which means that we can disclose important information to you by referring you to those documents. The information
        incorporated by reference is considered to be part of this prospectus and information we file later with the SEC will automatically update and supersede this information. The documents we are incorporating by reference as of their respective dates
        of filing are:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z3ef15c52c3a54095a467effd9ebdccfd" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Annual Report on Form 20-F for the year ended December 31, 2019, filed on February 24, 2020 and as amended on February 27, 2020 (File No. 000-30902);</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zec3f663d299a4d118c1f7f54eaba0cbc" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Reports on Form 6-K filed on January 9, 2020, February 20, 2020, February 20, 2020, March 9, 2020, March 11, 2020, March 12, 2020, March 13, 2020, March 17, 2020, April 6, 2020, April 15, 2020, April 27, 2020,
                May 6, 2020, May 27, 2020, June 1, 2020 and July 30, 2020 (File Nos. 000-30902); and</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z81e5463f213f4731ab87cf10bc068a21" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 7.14%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#8226;</div>
            </td>
            <td style="width: 85.71%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the description of our ordinary shares contained in our Form 8-A filed on August 2, 2000 (File No. 000-30902), as updated and amended by the disclosure contained under &#8220;Description of Ordinary Shares&#8221; in this
                registration statement on Form F-3.</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">All subsequent annual reports on Form 20-F, Form 40-F or Form 10-K filed by us, all subsequent reports on Forms 10-Q and 8-K filed by us, and all subsequent reports on Form 6-K filed by us that are
        identified by us as being incorporated by reference shall be deemed to be incorporated by reference into this prospectus and deemed to be a part hereof after the date of this prospectus but before the termination of the offering by this prospectus.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Any statement contained in a document incorporated by reference herein shall be deemed to be modified or superseded for all purposes to the extent that a statement contained in this prospectus, or in
        any other subsequently filed document which is also incorporated or deemed to be incorporated by reference, modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to
        constitute a part of this prospectus.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 19</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">You may request, orally or in writing, a copy of these documents, which will be provided to you at no cost, by contacting:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">Ari Krashin</font><br>
        <font style="font-weight: bold;">Chief Financial Officer</font><br>
        <font style="font-weight: bold;">Compugen Ltd.</font><br>
        <font style="font-weight: bold;">26 Harokmim Street</font><br>
        <font style="font-weight: bold;">Holon 5885849, Israel</font><br>
        <font style="font-weight: bold;">Phone: +972-3-765-8585</font><br>
        <font style="font-weight: bold;">Fax: +972-3-765-8555</font><br>
        &#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">SA - 20</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">WHERE YOU CAN FIND ADDITIONAL INFORMATION<a name="EYOUCANFINDADDITIONALINFO"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">This prospectus is part of a registration statement on Form F-3 that we filed with the SEC relating to the securities offered by this prospectus, which includes additional information. You should
        refer to the registration statement and its exhibits for additional information. Whenever we make reference in this prospectus to any of our contracts, agreements or other documents, the references are not necessarily complete, and you should refer
        to the exhibits attached to the registration statement for copies of the actual contract, agreements or other document.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We are subject to the informational requirements of the Exchange Act applicable to foreign private issuers. We, as a &#8220;foreign private issuer,&#8221; are exempt from the rules under the Exchange Act
        prescribing certain disclosure and procedural requirements for proxy solicitations, and our office holders, directors and principal shareholders are exempt from the reporting and &#8220;short-swing&#8221; profit recovery provisions contained in Section 16 of
        the Exchange Act, with respect to their purchases and sales of shares. In addition, we are not required to file annual, quarterly and current reports and financial statements with the SEC as frequently or as promptly as U.S. companies whose
        securities are registered under the Exchange Act. So long as we are a foreign private issuer, we anticipate filing with the SEC, within three months after the end of each fiscal year, an Annual Report on Form 20-F containing financial statements
        audited by an independent accounting firm. We also furnish or file with the SEC Reports of Foreign Private Issuer on Form 6-K and other information with the SEC as required by the Exchange Act. You can review our SEC filings and the registration
        statement by accessing the SEC&#8217;s internet site at <font style="font-style: italic;">http://www.sec.gov</font>.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We also maintain a website at <font style="font-style: italic;">www.cgen.com</font>, through which you can access certain SEC filings. The information set forth on our website is not part of this
        prospectus.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">ENFO<a name="RCEABILITYOFCIVI"><!--Anchor--></a>RCEABILITY OF CIVIL LIABILITIES</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">We are incorporated under the laws of the State of Israel. Service of process upon us and upon our directors and office holders, almost all of whom reside outside the United States, may be difficult
        to obtain within the United States. Furthermore, because the majority of our assets and investments, and almost all of our directors and office holders are located outside the United States, any judgment obtained in the United States against us or
        any of them may not be collectible within the United States.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Additionally, it may be difficult to assert U.S. securities law claims in original actions instituted in Israel. Israeli courts may refuse to hear a claim based on an alleged violation of U.S.
        securities laws because Israel is not the most appropriate forum to bring such a claim. In addition, even if an Israeli court agrees to hear such a claim, it may determine that Israeli law and not U.S. law is applicable to the claim. If U.S. law is
        found to be applicable, the content of applicable U.S. law must be proved as a fact which can be a time-consuming and costly process. Certain matters of procedure will also be governed by Israeli law. There is little binding case law in Israel that
        addresses the matters described above.</div>
      <div style="text-align: justify; line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Subject to specified time limitations and legal procedures, Israeli courts may enforce a United States judgment in a civil matter which, subject to certain exceptions, is non-appealable, including
        judgments based upon the civil liability provisions of the Securities Act and the Exchange Act and including a monetary or compensatory judgment in a non-civil matter, provided that among other things:</div>
      <div style="text-align: justify; line-height: 1.25;">&#160;</div>
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          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the judgments are obtained after due process before a court of competent jurisdiction, according to the laws of the state in which the judgment is given and the rules of private international law currently
                prevailing in Israel;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
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          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the prevailing law of the foreign state in which the judgments were rendered allows for the enforcement of judgments of Israeli courts;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z82dd2fec35fa4caeac92b0f428c17f50" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">adequate service of process has been effected and the defendant has had a reasonable opportunity to be heard and to present his or her evidence;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zdb8bf05b4a6b4d6f9fcafed16dd7324f" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the judgments are not contrary to public policy of Israel, and the enforcement of the civil liabilities set forth in the judgment is not likely to impair the security or sovereignty of Israel;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
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          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the judgments were not obtained by fraud and do not conflict with any other valid judgments in the same matter between the same parties;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
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            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">an action between the same parties in the same matter is not pending in any Israeli court at the time the lawsuit is instituted in the foreign court;</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z40bf628012f647a980f4a702b7a2416d" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the judgment is not subject to any further appeal procedures; and</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="zf87e809b748542aab12dba66fa088551" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 7.14%; vertical-align: middle; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 3.57%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;&#8226;</div>
            </td>
            <td style="width: 89.29%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">the judgment is enforceable according to the laws of Israel and according to the law of the foreign state in which the relief was granted.</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Generally, an Israeli court will not enforce a foreign judgment if the motion for enforcement was filed more than five years after the date of its award in the United States, unless Israel and the
        United States have agreed otherwise on a different period, or if an Israeli court finds exceptional reasons justifying the delay.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">If a foreign judgment is enforced by an Israeli court, it generally will be payable in Israeli currency, which can then be converted into non-Israeli currency and transferred out of Israel. The usual
        practice in an action before an Israeli court to recover an amount in a non-Israeli currency is for the Israeli court to issue a judgment for the equivalent amount in Israeli currency at the rate of exchange in force on the date of the judgment,
        but the judgment debtor may make payment in foreign currency. Pending collection, the amount of the judgment of an Israeli court stated in Israeli currency ordinarily will be linked to the Israeli consumer price index plus interest at the annual
        statutory rate set by Israeli regulations prevailing at the time. Judgment creditors must bear the risk of unfavorable exchange rates.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">INDEMNIFICATION FOR SECURITIES ACT LIABILITIES<a name="TIONFORSECURITIESACTLIABI"><!--Anchor--></a></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to our directors, office holders and controlling persons, we have been informed that in the opinion of the
        SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.</div>
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        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
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        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<img width="238" height="75" src="image0.jpg"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; margin-right: 0.2pt; line-height: 1.25; font-weight: bold;">749,104 Ordinary Shares Issuable Upon</div>
      <div style="text-align: center; margin-right: 0.2pt; line-height: 1.25; font-weight: bold;">Exercise of Outstanding Warrants</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25;">
        <hr align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;">&#160;&#160;&#160;&#160; </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">PROSPECTUS</div>
      <div style="line-height: 1.25;">&#160;&#160;&#160;&#160; <br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <hr align="center" style="height: 2px; width: 25%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"> </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"></div>
      <div style="text-align: center; text-indent: 72pt; line-height: 1.25; font-weight: bold;">, 2020</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <!--PROfilePageNumberReset%Num%1%II - %%-->
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        </div>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">PART II<br style="line-height: 1.25;">
        <br>
        INFORMATION NOT REQUIRED IN PROSPECTUS</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25;"><font style="font-weight: bold;">Item 8.</font>&#160;<font style="font-weight: bold;">Indemnification of Directors and Office Holders</font></div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="text-align: justify; line-height: 1.25;"><font style="font-style: italic;">Our Office Holders&#8217; Insurance</font>. Our Articles provide that, subject to the provisions of the Companies Law, we may enter into contracts to insure the
          liabilities of our Office Holders for any liabilities or expenses incurred by or imposed upon them as a result of any act (or omission) carried out by them as our Office Holders, including with respect to any of the following:</div>
        <div style="text-align: justify; line-height: 1.25;"> <br>
        </div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
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                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">a breach of duty of care to us or to another person;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
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                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">a breach of duty of loyalty to us, provided that the Office Holder acted in good faith and had reasonable grounds to assume that such act would not prejudice our interests;</div>
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                </div>
              </td>
            </tr>

        </table>
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                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">monetary liabilities or obligations imposed upon him or her in favor of another person;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
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                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">A payment which the Office Holder is obligated to make to an injured party as set forth in Section 52(54)(a)(1)(a) of the Israel Securities Law, 5728-1968, or the Securities Law, and
                  expenses that the Office Holder incurred in connection with a proceeding under Chapters H&#8217;3, H&#8217;4 or I&#8217;1 of the Securities Law, including reasonable litigation expenses, including attorney&#8217;s fees, or in connection with Article D of Chapter
                  Four of Part Nine of the Companies Law;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
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            <tr>
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                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">Expenses incurred by the Office Holder in connection with a proceeding under Chapter G&#8217;1, of the Israel Restrictive Trade Practices Law, 5748-1988, or the Restrictive Trade Law, including
                  reasonable litigation expenses, including attorney&#8217;s fees.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="line-height: 1.25;">&#160;</div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="text-align: justify; line-height: 1.25;">Under the Companies Law, exemption and indemnification of, and procurement of insurance coverage for, our Office Holders, must be approved by our Compensation Committee and our Board of Directors
          and, with respect to an Office Holder who is the CEO or a director, also by our shareholders. However, according to regulations promulgated under the Companies Law, shareholders and Board approvals for the procurement of such insurance are not
          required if the insurance policy is approved by our Compensation Committee and: (i) the terms of such policy are within the framework for insurance coverage as approved by our shareholders and set forth in our Compensation Policy; (ii) the
          premium paid under the insurance policy is at fair market value; and (iii) the insurance policy does not and may not have a substantial effect on the Company&#8217;s profitability, assets or obligations.</div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="text-align: justify; line-height: 1.25;">In&#160;accordance with our Compensation Policy, we are currently entitled to hold directors&#8217; and officers&#8217; liability insurance policy for the benefit of our Office Holders with insurance coverage of
          up to $50 million and with an annual premium of up to $900,000.</div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;"><font style="font-style: italic;">Our Office Holders&#8217; Indemnification.&#160;</font>Our Articles provide that, subject to the provisions of the Companies Law, we may indemnify any of our Office Holders
          for all liabilities and expenses incurred by them arising from or as a result of any act (or omission) carried out by them as Office Holders of the Company, including as follows:</div>
        <div style="line-height: 1.25">&#160;</div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
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                <div style="line-height: 1.25;">&#8226;</div>
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                <div style="text-align: justify; line-height: 1.25;">For any monetary liabilities or obligations imposed on our Office Holder in favor of another person pursuant to a court judgment, including a compromise judgment or an arbitrator&#8217;s
                  decision approved by a court;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z0cd09c5a19e24680a6cfdc0a62cb2efd" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">For any payments which our Office Holder is obligated to make to an injured party as set forth in Section 52(54)(a)(1)(a) of the Securities Law and expenses the Office Holder incurred in
                  connection with a proceeding under Chapters H&#8217;3, H&#8217;4 or I&#8217;1 of the Securities Law, including reasonable litigation expenses, including attorney&#8217;s fees, or in connection with Article D of Chapter Four of Part Nine of the Companies Law;<br>
                  <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z07aa173d4bd8497c9c7665416148d79c" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">For reasonable litigation expenses, including attorney&#8217;s fees, incurred by the Office Holder in consequence of an investigation or proceeding instituted against the Office Holder by an
                  authority that is authorized to conduct such investigation or proceeding, and which was concluded without filing of an indictment against the Office Holder and without imposing on the Office Holder a financial obligation in lieu of
                  criminal proceedings, or which was concluded without filing of an indictment against the Office Holder but with imposing on such Office Holder a financial obligation in lieu of criminal proceedings in respect of an offense that does not
                  require proof of criminal intent or in connection with a financial sanction;&#160; For the purposes hereof: (i) &#8220;a proceeding that concluded without filing an indictment in a matter in respect of which an investigation was conducted&#8221;; and (ii)
                  &#8220;financial obligation in lieu of a criminal proceeding&#8221;, shall have the meanings specified in Section 260(a)(1A) of the Companies Law;</div>
              </td>
            </tr>

        </table>
        <div> <br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II - 1</font></div>
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <table cellspacing="0" cellpadding="0" id="z77dd9d36ca0c4634b6493ad2984c02ea" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">For reasonable litigation expenses, including attorney&#8217;s fees, incurred by the Office Holder or which the Office Holder is ordered to pay by a court, in a proceeding filed against the
                  Office Holder by the Company or on its behalf or by another person, or in a criminal action of which the Office Holder is acquitted, or in a criminal action in which the Office Holder is convicted of an offense that does not require proof
                  of criminal intent;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z5ef86c5a3f6f43d6b4bbd8a0e38f215d" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">For expenses incurred by our Office Holder in connection with a proceeding under Chapter G&#8217;1, of the Restrictive Trade Law, including reasonable litigation expenses, including attorney&#8217;s
                  fees;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z62120e8924b84427a5a9cb96ece41498" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">For any other liability, obligation or expense indemnifiable or which our Officer Holders may from time to time be indemnifiable by law.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;">The Company may undertake to indemnify an office holder as mentioned above: (a) prospectively, provided that with respect of the first act (financial liability) the undertaking is limited to events which in the
          opinion of the board of directors are foreseeable in light of the Company&#8217;s actual operations when the undertaking to indemnify is given, and to an amount or criteria set by the board of directors as reasonable under the circumstances, and
          further provided that such events and amount or criteria are set forth in the undertaking to indemnify, and (b) retroactively.</div>
        <div style="line-height: 1.25">&#160;</div>
        <div style="line-height: 1.25;">Indemnification letters, covering indemnification of those liabilities discussed above, were granted to each of our present Office Holders. Hence, we undertook to indemnify our Office Holders to the fullest extent
          permitted under the Companies Law.</div>
        <div style="line-height: 1.25">&#160;</div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="text-align: justify; line-height: 1.25;"><font style="font-style: italic;">Our Office Holder&#8217;s Exemption.&#160;</font>Our Articles provide that, subject to the provisions of the Companies Law, we may exempt and release our Office Holders,
          including in advance, from all or part of such Office Holder&#8217;s liability for monetary or other damages due to a breach of their duty of care to the Company. Our directors are released and exempt from all liability as aforesaid to the fullest
          extent permitted by law with respect to any such breach, which has been or may be committed.</div>
        <div style="line-height: 1.25">&#160;</div>
        <div style="line-height: 1.25;"></div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <div style="background-color: #FFFFFF; line-height: 1.25;">
          <div style="text-align: justify; line-height: 1.25;"><font style="font-style: italic;">Limitations on Insurance, Indemnification and Exemption.</font>&#160;The Companies Law provides that a company may not insure, exempt or indemnify an office holder
            for any breach of his or her liability arising from any of the following:</div>
          <div style="line-height: 1.25">&#160;</div>
        </div>
      </div>
      <div style="background-color: #FFFFFF; line-height: 1.25;">
        <table cellspacing="0" cellpadding="0" id="zc2ddb08aa1ea4e21bf3ff7c277323475" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">a breach by the office holder of his or her duty of loyalty, except that the company may enter into an insurance contract or indemnify an office holder if the office holder acted in good
                  faith and had a reasonable basis to believe that the act would not prejudice the company;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z08fcb48db0cd409096106c5a9d9cc873" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">a breach by the office holder of his or her duty of care if such breach was intentional or reckless, but unless such breach was solely negligent;</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z4484026f470e44c88c03f10636cceeb0" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">any act or omission done with the intent to derive an illegal personal benefit; or</div>
                <div style="text-align: justify; line-height: 1.25;"> <br>
                </div>
              </td>
            </tr>

        </table>
        <table cellspacing="0" cellpadding="0" id="z630a8ee852844b6f9856dd340bc4af93" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 21.3pt; vertical-align: top; align: right;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: auto; vertical-align: top;">
                <div style="text-align: justify; line-height: 1.25;">any fine, civil fine, financial sanction or monetary settlement in lieu of criminal proceedings imposed on such office holder.</div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="margin-right: 4.95pt; line-height: 1.25; font-weight: bold;">Item 9. Exhibits</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="ze34147b9856840f9a689a90c0eef2435" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 9.59%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
              <div style="text-align: center; margin-right: 4.95pt; line-height: 1.25; font-weight: bold;">Exhibit<br>
                Number</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: bottom; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
              <div style="margin-right: 4.95pt; line-height: 1.25; font-weight: bold;">Description of Document</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">1.1**</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Form of Underwriting Agreement.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">4.1</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Specimen Certificate for Ordinary Shares (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form F-1/A filed with the SEC on August 2, 2000 (File. No 333-12316).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_4-2.htm">4.2*</a></div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;"> <br>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><a href="exhibit_4-2.htm">Form of Indenture between the Registrant and one or more trustees to be named.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">4.3**</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Form of Debt Securities.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="http://www.sec.gov/Archives/edgar/data/1119774/000117891318001935/exhibit_4-1.htm">4.4</a></div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><a href="http://www.sec.gov/Archives/edgar/data/1119774/000117891318001935/exhibit_4-1.htm">Form of Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Report on Form 6-K
                  filed with the SEC on June 19, 2018 (File No. 000-30902)).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">4.5**</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Form of Warrant.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">4.6**</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Form of Unit Agreement.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_5-1.htm">5.1*</a></div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;"> <br>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><a href="exhibit_5-1.htm">Opinion of Shibolet &amp; Co,, Law Firm</a></div>
            </td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
            <td rowspan="1" style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">&#160;</td>
            <td rowspan="1" style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_5-2.htm">5.2*</a></div>
            </td>
            <td rowspan="1" style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">&#160;</td>
            <td rowspan="1" style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;"><a href="exhibit_5-2.htm">Opinion of Cooley LLP</a></div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II - 2</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_23-1.htm">23.1*</a></div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="margin-right: 4.95pt; line-height: 1.25;"><a href="exhibit_23-1.htm">Consent of Kost Forer Gabbay &amp; Kasierer, a member of Ernst &amp;
                  Young Global.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: middle; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 90.41%; vertical-align: middle; background-color: #FFFFFF;" colspan="2">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_5-1.htm">23.2</a></div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;"> <br>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="margin-right: 4.95pt; line-height: 1.25;"><a href="exhibit_5-1.htm">Consent of Shibolet &amp; Co., Law Firm (included in Exhibit 5.1 to
                  this registration statement on Form F-3).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">&#160;</td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_5-2.htm">23.3</a></div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;"> <br>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="margin-right: 4.95pt; line-height: 1.25;"><a href="exhibit_5-2.htm">Consent of Cooley LLP (included in Exhibit 5.2)</a></div>
            </td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
            <td rowspan="1" style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">&#160;</td>
            <td rowspan="1" style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">&#160;</td>
          </tr>
          <tr>
            <td rowspan="1" style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;"><a href="#POWEROFATTORNEY">24.1</a></div>
            </td>
            <td rowspan="1" style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;"><br>
            </td>
            <td rowspan="1" style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="margin-right: 4.95pt; line-height: 1.25;"><a href="#POWEROFATTORNEY">Power of Attorney (included on signature page).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.59%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">25.1+</div>
            </td>
            <td style="width: 1.83%; vertical-align: bottom; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 88.58%; vertical-align: top; background-color: #FFFFFF;">
              <div style="margin-right: 4.95pt; line-height: 1.25;">The Statement of Eligibility on Form T-1 under the Trust Indenture Act of 1939 of the Trustee under the Indenture.</div>
            </td>
          </tr>

      </table>
      <div style="margin-right: 4.95pt; line-height: 1.25;">_____________</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">* Filed herewith.&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">** To be filed, if applicable, as an exhibit to a post-effective amendment to this registration statement or as an exhibit to a report filed under the Securities Exchange Act of 1934, as amended,
        and incorporated herein by reference.</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">+ To be filed, if applicable, as an exhibit to a post-effective amendment to this registration statement or as an exhibit to a report filed under the Securities Exchange Act of 1934, as amended,
        and incorporated herein by reference, in accordance with Section 305(b)(2) of the Trust Indenture Act of 1939.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25; font-weight: bold;">Item 10. Undertakings</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">(a) The undersigned Registrant hereby undertakes:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; margin-right: 4.95pt; line-height: 1.25;">(i) To include any prospectus required by section 10(a)(3) of the Securities Act of 1933;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; margin-right: 4.95pt; line-height: 1.25;">(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which,
        individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of
        securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in
        the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; margin-right: 4.95pt; line-height: 1.25;">(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such
        information in the registration statement;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;"><font style="font-style: italic;">Provided however</font>, That: Paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do not apply if the information required to be included in a
        post-effective amendment by those paragraphs is contained in reports filed with or furnished to the SEC by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the
        registration statement, or is contained in a form of prospectus filed pursuant to Rule 424(b) that is part of the registration statement.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">(2) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement
        relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">(4) To file a post-effective amendment to the registration statement to include any financial statements required by Item 8.A. of Form 20-F at the start of any delayed offering
        or throughout a continuous offering. Financial statements and information otherwise required by Section 10(a)(3) of the Act need not be furnished, <font style="font-style: italic;">provided</font>, that the registrant includes in the prospectus,
        by means of a post-effective amendment, financial statements required pursuant to this paragraph (a)(4) and other information necessary to ensure that all other information in the prospectus is at least as current as the date of those financial
        statements. Notwithstanding the foregoing, with respect to registration statements on Form F-3, a post-effective amendment need not be filed to include financial statements and information required by Section 10(a)(3) of the Act or Rule 3-19 of
        this chapter if such financial statements and information are contained in periodic reports filed with or furnished to the Commission by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are
        incorporated by reference in the Form F-3.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II - 3</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-indent: 36pt; margin-right: 4.95pt; line-height: 1.25;">(5) That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; margin-right: 4.95pt; line-height: 1.25;">(i) If the registrant is relying on Rule 430B:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 108pt; margin-right: 4.95pt; line-height: 1.25;">(A) Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed
        part of and included in the registration statement; and</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 108pt; margin-right: 4.95pt; line-height: 1.25;">(B) Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made
        pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by section 10(a) of the Securities Act of 1933 shall be deemed to be part of and included in the registration statement as of the earlier of the date
        such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at
        that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time
        shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated
        by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the
        registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date; or</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; margin-right: 4.95pt; line-height: 1.25;">(ii) If the registrant is subject to Rule 430C, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than
        registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness. Provided, however,
        that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the
        registration statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made
        in any such document immediately prior to such date of first use.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">(6) That, for the purpose of determining liability of a registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities, the undersigned Registrant
        undertakes that in a primary offering of securities of the undersigned Registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to
        such purchaser by means of any of the following communications, the undersigned Registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; line-height: 1.25;">(i) Any preliminary prospectus or prospectus of the undersigned Registrant relating to the offering required to be filed pursuant to Rule 424;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; line-height: 1.25;">(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned Registrant or used or referred to by the undersigned Registrant;</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; line-height: 1.25;">(iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned Registrant or its securities provided by or on behalf of the
        undersigned Registrant; and</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 72pt; line-height: 1.25;">(iv) Any other communication that is an offer in the offering made by the undersigned Registrant to the purchaser.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II - 4</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">(b) That, for purposes of determining any liability under the Securities Act of 1933, each filing of the Registrant&#8217;s Annual Report pursuant to Section 13(a) or Section 15(d) of the Securities
        Exchange Act of 1934 that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to
        be the initial bona fide offering thereof.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">(c) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, office holders and controlling persons of the Registrant, the Registrant has
        been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such
        liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, office holder or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director,
        office holder or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction
        the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="margin-right: 4.95pt; line-height: 1.25;">(d) To file an application for the purpose of determining the eligibility of the trustee to act under subsection (a) of Section 310 of the Trust Indenture Act of 1939, or the Act, in accordance
        with the rules and regulations prescribed by the Commission under Section 305(b)(2) of the Act.</div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">II - 5</font></div>
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">SIGNATURES</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form F-3 and has
        duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunder duly authorized, in the City of Holon, State of Israel, on July 30, 2020.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" border="0" id="z4d315300fe3241f3995ed84e12ba7af5" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 50%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="vertical-align: top; background-color: rgb(255, 255, 255);" colspan="3">
              <div style="line-height: 1.25;">COMPUGEN LTD.</div>
            </td>
            <td style="width: 2%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 3%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">By:</div>
            </td>
            <td style="vertical-align: top; background-color: rgb(255, 255, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
              <div style="line-height: 1.25;">/s/ Anat Cohen-Dayag, Ph.D.</div>
            </td>
            <td style="width: 2%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 3%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 4%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">Name:</div>
            </td>
            <td style="width: 41%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">Anat Cohen-Dayag, Ph.D.</div>
            </td>
            <td style="width: 2%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 3%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 4%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">Title:</div>
            </td>
            <td style="width: 41%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">President and Chief Executive Officer</div>
            </td>
            <td style="width: 2%; vertical-align: top; background-color: rgb(255, 255, 255);">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>

      </table>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="POWEROFATTORNEY"><!--Anchor--></a>POWER OF ATTORNEY</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">That the undersigned officers and directors of Compugen Ltd., an Israeli corporation, do hereby constitute and appoint Anat Cohen-Dayag, Ph.D., President and Chief Executive Officer, and Ari Krashin,
        Chief Financial Officer, and each of them individually, with full powers of substitution and resubstitution, the lawful attorneys-in-fact and agents with full power and authority to do any and all acts and things and to execute any and all
        instruments which said attorneys and agents, determine may be necessary or advisable or required to enable said corporation to comply with the Securities Act of 1933, as amended, and any rules or regulations or requirements of the Securities and
        Exchange Commission in connection with this Registration Statement. Without limiting the generality of the foregoing power and authority, the powers granted include the power and authority to sign the names of the undersigned officers and directors
        in the capacities indicated below to this Registration Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and to any and all instruments or documents filed as part of or in
        conjunction with this Registration Statement or amendments or supplements thereof, and each of the undersigned hereby ratifies and confirms that said attorneys and agents, shall do or cause to be done by virtue hereof. This Power of Attorney may be
        signed in several counterparts.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-indent: 36pt; line-height: 1.25;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by each of the following persons in the capacities and on the dates indicated:</div>
      <div style="line-height: 1.25;">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="ze3d0c141e3764289b1d0e9fcb4cffb34" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 30.06%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signature</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 30.13%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
              <div style="text-align: center; margin-right: 9pt; margin-left: 9pt; line-height: 1.25; font-weight: bold;">Title(s)</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 19.97%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Date</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30.06%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 30.13%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 19.97%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30.06%; vertical-align: top; background-color: #FFFFFF; border-bottom: #000000 2px solid;">
              <div style="line-height: 1.25;">/s/ Anat Cohen-Dayag, Ph.D.</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 30.13%; vertical-align: top; background-color: #FFFFFF;" rowspan="2">
              <div style="line-height: 1.25;">President, Chief Executive Officer and Director</div>
              <div style="line-height: 1.25;">(principal executive officer)</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 19.97%; vertical-align: top; background-color: #FFFFFF;">
              <div style="text-align: center; line-height: 1.25;">July 30, 2020</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30.06%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">Anat Cohen-Dayag, Ph.D.</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 19.97%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 30.06%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 30.13%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 9.92%; vertical-align: top; background-color: #FFFFFF;">
              <div style="line-height: 1.25;">&#160;</div>
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<DOCUMENT>
<TYPE>EX-4.2
<SEQUENCE>2
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<DESCRIPTION>EXHIBIT 4.2
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      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;">Table Of Contents</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;"> <br>
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;">
        <div style="text-align: right; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Page</div>
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      </div>
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        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" id="z474c61fc308243d1a2b700c59921b1c0">

            <tr>
              <td rowspan="1" colspan="3">
                <div>
                  <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;">
                    <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25; font-weight: normal;">ARTICLE 1 DEFINITIONS</div>
                  </div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;1</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 1.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Definitions of Terms</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;1</div>
              </td>
            </tr>
            <tr>
              <td rowspan="1" colspan="3">
                <div>
                  <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE&#160;OF SECURITIES</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right; vertical-align: bottom;">
                <div>&#160;5</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Designation and Terms of Securities</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;5</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.02</td>
              <td style="width: 63%;">
                <div>
                  <div>Form of Securities and Trustee&#8217;s Certificate</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;8</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Denominations: Provisions for Payment</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;8</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.04</td>
              <td style="width: 63%;">
                <div>
                  <div>Execution and Authentications</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;10</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.05</td>
              <td style="width: 63%;">
                <div>
                  <div>Registration of Transfer and Exchange</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;10</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.06</td>
              <td style="width: 63%;">
                <div>Temporary Securities</div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;12</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.07</td>
              <td style="width: 63%;">
                <div>
                  <div>Mutilated, Destroyed, Lost or Stolen Securities</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;12</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.08</td>
              <td style="width: 63%;">
                <div>
                  <div>Cancellation</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;13</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.09</td>
              <td style="width: 63%;">
                <div>Benefits of Indenture</div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;13</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.10</td>
              <td style="width: 63%;">
                <div>
                  <div>Authenticating Agent</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">13<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.11</td>
              <td style="width: 63%;">
                <div>Global Securities</div>
              </td>
              <td style="width: 25%; text-align: right;">14<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 2.12</td>
              <td style="width: 63%;">
                <div>CUSIP Numbers</div>
              </td>
              <td style="width: 25%; text-align: right;">15<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div>
                  <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 3 REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">15<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 3.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Redemption</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">15<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 3.02</td>
              <td style="width: 63%;">
                <div>
                  <div>Notice of Redemption</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">15<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 3.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Payment Upon Redemption</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">16<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 3.04</td>
              <td style="width: 63%;">
                <div>
                  <div>Sinking Fund</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">17<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 3.05</td>
              <td style="width: 63%;">
                <div>
                  <div>Satisfaction of Sinking Fund Payments with Securities</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">17<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 3.06</td>
              <td style="width: 63%;">
                <div>
                  <div>Redemption of Securities for Sinking Fund</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">17<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 4 COVENANTS</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">18<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 4.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Payment of Principal, Premium and Interest</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">18<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 4.02</td>
              <td style="width: 63%;">
                <div>Maintenance of Office or Agency</div>
              </td>
              <td style="width: 25%; text-align: right;">18<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 4.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Paying Agents</div>
                </div>
              </td>
              <td style="width: 25%; text-align: right;">19<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 4.04</td>
              <td style="width: 63%;">
                <div>Appointment to Fill Vacancy in Office of Trustee</div>
              </td>
              <td style="width: 25%; text-align: right;">20<br>
              </td>
            </tr>

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          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Table Of Contents</div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">(continued)</div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;"> <br>
          </div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">
            <div style="text-align: right; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Page</div>
          </div>
          <div style="line-height: 1.25; font-variant: small-caps; font-weight: bold;">&#160;</div>
        </div>
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 5 SECURITYHOLDERS&#8217; LISTS AND REPORTS BY THE COMPANY AND THE&#160;TRUSTEE</div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;20</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 5.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Company to Furnish Trustee Names and Addresses of Securityholders</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;20</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 5.02</td>
              <td style="width: 63%;">
                <div>
                  <div>Preservation Of Information; Communications With Securityholders</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;20</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 5.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Reports by the Company</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;20</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 5.04</td>
              <td style="width: 63%;">
                <div>
                  <div>Reports by the Trustee</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;21</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div>
                  <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 6 REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF DEFAULT</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;21</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.01</td>
              <td style="width: 63%;">
                <div>Events of Default</div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;21</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.02</td>
              <td style="width: 63%;">
                <div>
                  <div>Collection of Indebtedness and Suits for Enforcement by Trustee</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;23</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Application of Moneys Collected</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;25</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.04</td>
              <td style="width: 63%;">
                <div>
                  <div>Limitation on Suits</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;25</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.05</td>
              <td style="width: 63%;">
                <div>
                  <div>Rights and Remedies Cumulative; Delay or Omission Not Waiver</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;26</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.06</td>
              <td style="width: 63%;">
                <div>
                  <div>Control by Securityholders</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;26</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 6.07</td>
              <td style="width: 63%;">
                <div>
                  <div>Undertaking to Pay Costs</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;27</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div>
                  <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 7 CONCERNING THE TRUSTEE</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;27</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Certain Duties and Responsibilities of Trustee</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;27</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.02</td>
              <td style="width: 63%;">
                <div>
                  <div>Certain Rights of Trustee</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;28</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Trustee Not Responsible for Recitals or Issuance or Securities</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;30</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.04</td>
              <td style="width: 63%;">
                <div>
                  <div>May Hold Securities</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;31</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.05</td>
              <td style="width: 63%;">
                <div>
                  <div>Moneys Held in Trust</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;31</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.06</td>
              <td style="width: 63%;">
                <div>
                  <div>Compensation and Reimbursement</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;31</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.07</td>
              <td style="width: 63%;">
                <div>
                  <div>Reliance on Officer&#8217;s Certificate</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;32</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.08</td>
              <td style="width: 63%;">
                <div>
                  <div>Disqualification; Conflicting Interests</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;32</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.09</td>
              <td style="width: 63%;">
                <div>
                  <div>Corporate Trustee Required; Eligibility</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;32</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.10</td>
              <td style="width: 63%;">
                <div>
                  <div>Resignation and Removal; Appointment of Successor</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;32</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.11</td>
              <td style="width: 63%;">
                <div>
                  <div>
                    <div>Acceptance of Appointment By Successor</div>
                  </div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;34</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.12</td>
              <td style="width: 63%;">
                <div>
                  <div>Merger, Conversion, Consolidation or Succession to Business</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;35</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 7.13</td>
              <td style="width: 63%;">
                <div>Preferential Collection of Claims Against the Company</div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;35</div>
              </td>
            </tr>
            <tr>
              <td rowspan="1" style="width: 3%;">&#160;</td>
              <td rowspan="1" style="width: 9%;" colspan="1">Section 7.14</td>
              <td rowspan="1" style="width: 63%;">
                <div>
                  <div>Notice of Default.</div>
                </div>
              </td>
              <td rowspan="1" style="width: 25%;">
                <div style="text-align: right;">&#160;35</div>
              </td>
            </tr>

        </table>
        <br>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">ii</font></div>
          <div style="page-break-after: always;" id="DSPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Table Of Contents</div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">(continued)</div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;"> <br>
          </div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">
            <div style="text-align: right; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Page</div>
          </div>
          <div style="line-height: 1.25; font-variant: small-caps; font-weight: bold;">
            <div><br>
            </div>
          </div>
        </div>
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div>
                  <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 8 CONCERNING THE SECURITYHOLDERS</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;36</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 8.01</td>
              <td style="width: 63%;">
                <div>
                  <div>Evidence of Action by Securityholders</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;36</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 8.02</td>
              <td style="width: 63%;">
                <div>
                  <div>Proof of Execution by Securityholders</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;36</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;">
                <div>&#160;</div>
              </td>
              <td style="width: 9%;" colspan="1">Section 8.03</td>
              <td style="width: 63%;">
                <div>
                  <div>Who May be Deemed Owners</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;37</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 8.04</td>
              <td style="width: 63%;" rowspan="1">
                <div>Certain Securities Owned by Company Disregarded</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;37</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 8.05</td>
              <td style="width: 63%;" rowspan="1">
                <div>Actions Binding on Future Securityholders</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;37</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 9 SUPPLEMENTAL INDENTURES</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;38</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 9.01</td>
              <td style="width: 63%;" rowspan="1">
                <div>Supplemental Indentures Without the Consent of Securityholders</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;38</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 9.02</td>
              <td style="width: 63%;" rowspan="1">
                <div>Supplemental Indentures With Consent of Securityholders</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;39</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 9.03</td>
              <td style="width: 63%;" rowspan="1">
                <div>Effect of Supplemental Indentures</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;39</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 9.04</td>
              <td style="width: 63%;" rowspan="1">
                <div>Securities Affected by Supplemental Indentures</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;39</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 9.05</td>
              <td style="width: 63%;" rowspan="1">
                <div>Execution of Supplemental Indentures</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;40</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">ARTICLE 10 SUCCESSOR ENTITY</td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;40</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 10.01</td>
              <td style="width: 63%;" rowspan="1">
                <div>Company May Consolidate, Etc.</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;40</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 10.02</td>
              <td style="width: 63%;" rowspan="1">
                <div>Successor Entity Substituted</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;41</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 11 SATISFACTION AND DISCHARGE</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;41</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 11.01</td>
              <td style="width: 63%;" rowspan="1">
                <div>Satisfaction and Discharge of Indenture</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;41</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 11.02</td>
              <td style="width: 63%;" rowspan="1">
                <div>Discharge of Obligations</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;42</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 11.03</td>
              <td style="width: 63%;" rowspan="1">
                <div>Deposited Moneys to be Held in Trust</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;42</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 11.04</td>
              <td style="width: 63%;" rowspan="1">
                <div>Payment of Moneys Held by Paying Agents</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;42</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 11.05</td>
              <td style="width: 63%;" rowspan="1">
                <div>Repayment to Company</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;42</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div>
                  <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 12 IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS AND DIRECTORS</div>
                </div>
              </td>
              <td style="width: 25%;">
                <div style="text-align: right;">&#160;43</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 12.01</td>
              <td style="width: 63%;" rowspan="1">
                <div>No Recourse</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;43</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1" colspan="3">
                <div style="text-align: left; text-indent: -36pt; margin-right: 36pt; margin-left: 36pt; line-height: 1.25;">ARTICLE 13 MISCELLANEOUS PROVISIONS</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;43</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.01</td>
              <td style="width: 63%;" rowspan="1">
                <div>Effect on Successors and Assigns</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;43</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.02</td>
              <td style="width: 63%;" rowspan="1">
                <div>Actions by Successor</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;43</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.03</td>
              <td style="width: 63%;" rowspan="1">
                <div>Surrender of Company Powers</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;44</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.04</td>
              <td style="width: 63%;" rowspan="1">
                <div>Notices</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">&#160;44</td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">iii</font></div>
          <div style="page-break-after: always;" id="DSPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Table Of Contents</div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">(continued)</div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;"> <br>
          </div>
          <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">
            <div style="text-align: right; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Page</div>
          </div>
          <div style="line-height: 1.25; font-variant: small-caps; font-weight: bold;">&#160;</div>
        </div>
        <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.05</td>
              <td style="width: 63%;" rowspan="1">
                <div>Governing Law; Jury Trial Waiver</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">44</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.06</td>
              <td style="width: 63%;" rowspan="1">
                <div>Treatment of Securities as Debt</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">44</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.07</td>
              <td style="width: 63%;" rowspan="1">
                <div>Certificates and Opinions as to Conditions Precedent</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">44</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.08</td>
              <td style="width: 63%;" rowspan="1">
                <div>Payments on Business Days</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">45</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.09</td>
              <td style="width: 63%;" rowspan="1">
                <div>Conflict with Trust Indenture Act</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">45</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.10</td>
              <td style="width: 63%;" rowspan="1">
                <div>Counterparts</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">45 <br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.11</td>
              <td style="width: 63%;" rowspan="1">
                <div>Separability</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">45</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.12</td>
              <td style="width: 63%;" rowspan="1">
                <div>Compliance Certificates</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">45</td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.13</td>
              <td style="width: 63%;" rowspan="1">
                <div>U.S.A Patriot Act</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">46<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.14</td>
              <td style="width: 63%;" rowspan="1">
                <div>Force Majeure</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">46<br>
              </td>
            </tr>
            <tr>
              <td style="width: 3%;" rowspan="1">&#160;</td>
              <td style="width: 9%;" colspan="1" rowspan="1">Section 13.15</td>
              <td style="width: 63%;" rowspan="1">
                <div>Table of Contents; Headings</div>
              </td>
              <td style="width: 25%; text-align: right;" rowspan="1">46<br>
              </td>
            </tr>

        </table>
      </div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;"> <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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        <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">INDENTURE</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-variant: small-caps;">Indenture</font>, dated as of [&#8226;], 20__, among <font style="font-weight: bold; font-variant: small-caps;">Compugen Ltd.</font>,<font style="font-weight: bold; font-variant: small-caps;">&#160;</font>a company organized under the laws of the State of Israel under company number 51-177-963-9 and having its registered office at 26 Harokmim Street, Holon 5885849 Israel (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221;), and [<font style="font-weight: bold; font-variant: small-caps;">Trustee</font>], as trustee (the &#8220;<font style="font-weight: bold; font-style: italic;">Trustee</font>&#8221;):</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-variant: small-caps;">Whereas</font>, for its lawful corporate purposes, the Company has duly authorized the execution and delivery of this
      Indenture to provide for the issuance of debt securities (hereinafter referred to as the &#8220;<font style="font-weight: bold; font-style: italic;">Securities</font>&#8221;), in an unlimited aggregate principal amount to be issued from time to time in one or
      more series as in this Indenture provided, as registered Securities without coupons, to be authenticated by the certificate of the Trustee;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-variant: small-caps;">Whereas</font>, to provide the terms and conditions upon which the Securities are to be authenticated, issued and
      delivered, the Company has duly authorized the execution of this Indenture; and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-variant: small-caps;">Whereas</font>, all things necessary to make this Indenture a valid agreement of the Company, in accordance with its
      terms, have been done.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-variant: small-caps;">Now, Therefore</font>, in consideration of the premises and the purchase of the Securities by the holders thereof, it is
      mutually covenanted and agreed as follows for the equal and ratable benefit of the holders of Securities:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 1<br>
      <br>
      DEFINITIONS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 1.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Definitions of Terms</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The terms defined in this Section (except as in this Indenture or any indenture supplemental hereto otherwise expressly provided or unless the context otherwise requires) for all
      purposes of this Indenture and of any indenture supplemental hereto shall have the respective meanings specified in this Section and shall include the plural as well as the singular.&#160; All other terms used in this Indenture that are defined in the
      Trust Indenture Act of 1939, as amended, or that are by reference in such Act defined in the Securities Act of 1933, as amended (except as herein or any indenture supplemental hereto otherwise expressly provided or unless the context otherwise
      requires), shall have the meanings assigned to such terms in said Trust Indenture Act and in said Securities Act as in force at the date of the execution of this instrument.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Authenticating Agent</font>&#8221; means the Trustee or an authenticating agent with respect to all or any of the series of
      Securities appointed by the Trustee pursuant to Section 2.10.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Bankruptcy Law</font>&#8221; means Title 11, U.S. Code, or any similar federal or state law for the relief of debtors.</div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Board of Directors</font>&#8221; means the Board of Directors (or the functional equivalent thereof) of the Company or any duly
      authorized committee of such Board.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Board Resolution</font>&#8221; means a copy of a resolution certified by the Secretary of the Company to have been duly adopted by
      the Board of Directors (or duly authorized committee thereof, as applicable) and to be in full force and effect on the date of such certification.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Business Day</font>&#8221; means, with respect to any series of Securities, any day other than a day on which federal or state
      banking institutions in Israel, in the Borough of Manhattan, the City of New York, or in the city of the Corporate Trust Office of the Trustee are authorized or obligated by law, executive order or regulation to close.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;&#8220;<font style="font-weight: bold; font-style: italic;">Commission</font>&#8221; means the Securities and Exchange Commission, as from time to time constituted, created under the Exchange
      Act, or, if at any time after the execution of this instrument such Commission is not existing and performing the duties now assigned to it under the Trust Indenture Act, then the body performing such duties at such time.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221; means Compugen Ltd., a company organized under the laws of the State of Israel with a registration number
      51-177-963-9 and having its registered office at 26 Harokmim Street, Holon 5885849 Israel, and, subject to the provisions of Article Ten, shall also include its successors and assigns.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Corporate Trust Office</font>&#8221; means the office of the Trustee at which, at any particular time, its corporate trust business
      shall be principally administered, which office at the date hereof is located at <u>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</u>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Custodian</font>&#8221; means any receiver, trustee, assignee, liquidator or similar official under any Bankruptcy Law.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Defaulted Interest</font>&#8221; has the meaning set forth in Section 2.03.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Depositary</font>&#8221; means, with respect to Securities of any series for which the Company shall determine that such Securities
      will be issued as a Global Security, The Depository Trust Company, another clearing agency, or any successor registered as a clearing agency under the Exchange Act, or other applicable statute or regulation, which, in each case, shall be designated
      by the Company pursuant to either Section 2.01 or 2.11.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Event of Default</font>&#8221; means, with respect to Securities of a particular series, any event specified in Section 6.01,
      continued for the period of time, if any, therein designated.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Exchange Act</font>&#8221; means the United States Securities and Exchange Act of 1934, as amended, and the rules and regulations
      promulgated by the Commission thereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The term &#8220;<font style="font-weight: bold; font-style: italic;">given</font>&#8221;, &#8220;<font style="font-weight: bold; font-style: italic;">mailed</font>&#8221;, &#8220;<font style="font-weight: bold; font-style: italic;">notify</font>&#8221; or &#8220;<font style="font-weight: bold; font-style: italic;">sent</font>&#8221; with respect to any notice to be given to a Securityholder pursuant to this Indenture, shall mean notice (x) given to the Depositary (or its
      designee) pursuant to the standing instructions from the Depositary or its designee, including by electronic mail in accordance with accepted practices or procedures at the Depositary (in the case of a Global Security) or (y) mailed to such Holder by
      first class mail, postage prepaid, at its address as it appears on the Security Register (in the case of a definitive Security).&#160; Notice so &#8220;given&#8221; shall be deemed to include any notice to be &#8220;mailed&#8221; or &#8220;delivered,&#8221; as applicable, under this
      Indenture.</div>
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      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Global Security</font>&#8221; means a Security issued to evidence all or a part of any series of Securities which is executed by the
      Company and authenticated and delivered by the Trustee to the Depositary or pursuant to the Depositary&#8217;s instruction, all in accordance with the Indenture, which shall be registered in the name of the Depositary or its nominee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Governmental Obligations</font>&#8221; means securities that are (a)&#160;direct obligations of the United States of America for the
      payment of which its full faith and credit is pledged or (b)&#160;obligations of a Person controlled or supervised by and acting as an agency or instrumentality of the United States of America, the payment of which is unconditionally guaranteed as a full
      faith and credit obligation by the United States of America that, in either case, are not callable or redeemable at the option of the issuer thereof at any time prior to the stated maturity of the Securities, and shall also include a depositary
      receipt issued by a bank or trust company as custodian with respect to any such Governmental Obligation or a specific payment of principal of or interest on any such Governmental Obligation held by such custodian for the account of the holder of such
      depositary receipt; provided, however, that (except as required by law) such custodian is not authorized to make any deduction from the amount payable to the holder of such depositary receipt from any amount received by the custodian in respect of
      the Governmental Obligation or the specific payment of principal of or interest on the Governmental Obligation evidenced by such depositary receipt.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">herein</font>&#8221;, &#8220;<font style="font-weight: bold; font-style: italic;">hereof</font><font style="font-weight: bold;">&#8221;</font>
      and &#8220;<font style="font-weight: bold; font-style: italic;">hereunder</font>&#8221;, and other words of similar import, refer to this Indenture as a whole and not to any particular Article, Section or other subdivision.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Indenture</font>&#8221; means this instrument as originally executed or as it may from time to time be supplemented or amended by
      one or more indentures supplemental hereto entered into in accordance with the terms hereof and shall include the terms of particular series of Securities established as contemplated by Section 2.01.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Interest Payment Date</font>&#8221;, when used with respect to any installment of interest on a Security of a particular series,
      means the date specified in such Security or in a Board Resolution or in an indenture supplemental hereto with respect to such series as the fixed date on which an installment of interest with respect to Securities of that series is due and payable.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Officer</font>&#8221; means, with respect to the Company, the chairman of the Board of Directors, a chief executive officer, a
      president, a chief financial officer, a chief operating officer, any executive vice president, any senior vice president, any vice president, the treasurer or any assistant treasurer, the controller or any assistant controller or the secretary or any
      assistant secretary.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;&#8220;<font style="font-weight: bold; font-style: italic;">Officer&#8217;s Certificate</font>&#8221; means a certificate signed by any Officer.&#160; Each such certificate shall include the statements
      provided for in Section 13.07, if and to the extent required by the provisions thereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Opinion of Counsel</font>&#8221; means an opinion in writing subject to customary exceptions of legal counsel, who may be an
      employee of or counsel for the Company, that is delivered to the Trustee in accordance with the terms hereof.&#160; Each such opinion shall include the statements provided for in Section 13.07, if and to the extent required by the provisions thereof.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Outstanding</font>&#8221;, when used with reference to Securities of any series, means, subject to the provisions of Section 8.04,
      as of any particular time, all Securities of that series theretofore authenticated and delivered by the Trustee under this Indenture, except (a) Securities theretofore canceled by the Trustee or any paying agent, or delivered to the Trustee or any
      paying agent for cancellation or that have previously been canceled; (b) Securities or portions thereof for the payment or redemption of which moneys or Governmental Obligations in the necessary amount shall have been deposited in trust with the
      Trustee or with any paying agent (other than the Company) or shall have been set aside and segregated in trust by the Company (if the Company shall act as its own paying agent); provided, however, that if such Securities or portions of such
      Securities are to be redeemed prior to the maturity thereof, notice of such redemption shall have been given as provided in Article Three, or provision satisfactory to the Trustee shall have been made for giving such notice; and (c) Securities in
      lieu of or in substitution for which other Securities shall have been authenticated and delivered pursuant to the terms of Section 2.07.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Person</font>&#8221; means any individual, corporation, partnership, joint venture, joint-stock company, limited liability company,
      association, trust, unincorporated organization, any other entity or organization, including a government or political subdivision or an agency or instrumentality thereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Predecessor Security</font>&#8221; of any particular Security means every previous Security evidencing all or a portion of the same
      debt as that evidenced by such particular Security; and, for the purposes of this definition, any Security authenticated and delivered under Section 2.07 in lieu of a lost, destroyed or stolen Security shall be deemed to evidence the same debt as the
      lost, destroyed or stolen Security.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Responsible Officer</font>&#8221; when used with respect to the Trustee means any officer within the Corporate Trust Office of the
      Trustee (or any successor group of the Trustee) or any other officer of the Trustee customarily performing functions similar to those performed by any of the above designated officers and also means, with respect to a particular corporate trust
      matter, any other officer to whom such matter is referred because of his or her knowledge of and familiarity with the particular subject and in each case who shall have direct responsibility for the administration of this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;&#8220;<font style="font-weight: bold; font-style: italic;">Securities</font>&#8221; has the meaning stated in the first recital of this Indenture and more particularly means any Securities
      authenticated and delivered under this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221; means the Securities Act of 1933, as amended.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Securityholder</font>&#8221;, &#8220;<font style="font-weight: bold; font-style: italic;">holder of Securities</font>&#8221;, &#8220;<font style="font-weight: bold; font-style: italic;">registered holder</font>&#8221;, or other similar term, means the Person or Persons in whose name or names a particular Security is registered on the Security Register kept for that purpose in accordance with the terms of this
      Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;&#8220;<font style="font-weight: bold; font-style: italic;">Security Register</font>&#8221; and &#8220;<font style="font-weight: bold; font-style: italic;">Security Registrar</font>&#8221; shall have the
      meanings as set forth in Section&#160;2.05.</div>
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      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Subsidiary</font>&#8221; means, with respect to any Person, any corporation, association, partnership or other business entity of which more than 50% of
      the total voting power of shares of capital stock or other interests (including partnership interests) entitled (without regard to the occurrence of any contingency) to vote in the election of directors, managers, general partners or trustees thereof
      is at the time owned or controlled, directly or indirectly, by (i) such Person; (ii) such Person and one or more Subsidiaries of such Person; or (iii) one or more Subsidiaries of such Person.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Trustee</font>&#8221; means _________________________, and, subject to the provisions of Article Seven, shall also include its
      successors and assigns, and, if at any time there is more than one Person acting in such capacity hereunder, &#8220;Trustee&#8221; shall mean each such Person.&#160; The term &#8220;Trustee&#8221; as used with respect to a particular series of the Securities shall mean the
      trustee with respect to that series.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#8220;<font style="font-weight: bold; font-style: italic;">Trust Indenture Act</font>&#8221; means the Trust Indenture Act of 1939, as amended.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-style: italic;">&#8220;U.S.A. Patriot Act&#8221;</font> means the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept
      and Obstruct Terrorism Act of 2001, Pub. L. 107-56, as amended and signed into law October 26, 2001.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 2<br>
      <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">EXCHANGE&#160;OF SECURITIES</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Designation and Terms of Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The aggregate principal amount of Securities that may be authenticated and delivered under this Indenture is unlimited.&#160; The
      Securities may be issued in one or more series up to the aggregate principal amount of Securities of that series from time to time authorized by or pursuant to a Board Resolution or pursuant to one or more indentures supplemental hereto.&#160; Prior to
      the initial issuance of Securities of any series, there shall be established in or pursuant to a Board Resolution, and set forth in an Officer&#8217;s Certificate, or established in one or more indentures supplemental hereto:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 108pt;"><font style="font-weight: bold;">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the title of the
        Securities of the series (which shall distinguish the Securities of that series from all other Securities);</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 108pt;"><font style="font-weight: bold;">(2)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;any limit upon the
        aggregate principal amount of the Securities of that series that may be authenticated and delivered under this Indenture (except for Securities authenticated and delivered upon registration of transfer of, or in exchange for, or in lieu of, other
        Securities of that series);</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 108pt;"><font style="font-weight: bold;">(3)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the maturity date or dates
        on which the principal of the Securities of the series is payable;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 108pt;"><font style="font-weight: bold;">(4)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the form of the Securities
        of the series including the form of the certificate of authentication for such series;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
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    <div style="line-height: 1.25">&#160;
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(5)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the applicability of any
          guarantees;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(6)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;whether or not the
          Securities will be secured or unsecured, and the terms of any secured debt;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(7)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the place or places
          where payments will be payable;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(8)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;whether the Securities
          rank as senior debt, senior subordinated debt, subordinated debt or any combination thereof, and the terms of any subordination;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(9)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;if the price (expressed
          as a percentage of the aggregate principal amount thereof) at which such Securities will be issued is a price other than the principal amount thereof, the portion of the principal amount thereof payable upon declaration of acceleration of the
          maturity thereof, or if applicable, the portion of the principal amount of such Securities that is convertible into another security or the method by which any such portion shall be determined;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(10)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the interest rate or
          rates, which may be fixed or variable, or the method for determining the rate and the date interest will begin to accrue, the dates interest will be payable and the regular record dates for interest payment dates or the method for determining
          such dates;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(11)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company&#8217;s right, if
          any, to defer the payment of interest and the maximum length of any such deferral period;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(12)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;if applicable, the date
          or dates after which, and the price or prices at which, the Company may at its option, redeem the series of Securities pursuant to any optional redemption provisions and the terms of those redemption provisions;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(13)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the date or dates, if
          any, on which, and the price or prices at which the Company is obligated, pursuant to any mandatory sinking fund or analogous fund provisions or otherwise, to redeem, or at the Securityholder&#8217;s option to purchase, any series of Securities;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(14)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;whether the Company&#8217;s
          ability to pay dividends will be restricted pursuant to the Indenture, or whether the Company will be required pursuant to the Indenture to maintain any asset ratios or reserves;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(15)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;whether the Company
          will be restricted from incurring any additional indebtedness;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(16)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the denominations in
          which the Securities of the series shall be issuable, if other than denominations of one thousand U.S. dollars ($1,000) or any integral multiple thereof;</div>
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      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(17)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;any and all terms, if
          applicable, relating to any auction or remarketing of the Securities of that series and any security for the obligations of the Company with respect to such Securities and any other terms which may be advisable in connection with the marketing of
          Securities of that series;</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
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    <div style="line-height: 1.25">&#160;
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(18)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;whether the Securities
          of the series shall be issued in whole or in part in the form of a Global Security or Securities; the terms and conditions, if any, upon which such Global Security or Securities may be exchanged in whole or in part for other individual
          Securities; and the Depositary for such Global Security or Securities;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(19)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;if applicable, the
          provisions relating to conversion or exchange of any Securities of the series and the terms and conditions upon which such Securities will be so convertible or exchangeable, including the conversion or exchange price, as applicable, or how it
          will be calculated and may be adjusted, any mandatory or optional (at the Company&#8217;s option or the holders&#8217; option) conversion or exchange features, the applicable conversion or exchange period and the manner of settlement for any conversion or
          exchange, which may, without limitation, include the payment of cash as well as the delivery of securities;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(20)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;if other than the full
          principal amount thereof, the portion of the principal amount of Securities of the series which shall be payable upon declaration of acceleration of the maturity thereof pursuant to Section 6.01;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(21)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;additions to or changes
          in the covenants applicable to the series of Securities being issued, including, among others, the consolidation, merger or sale covenant;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(22)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;additions to or changes
          in the Events of Default with respect to the Securities and any change in the right of the Trustee or the Securityholders to declare the principal, premium, if any, and interest, if any, with respect to such Securities to be due and payable;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(23)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;additions to or changes
          in or deletions of the provisions relating to covenant defeasance and legal defeasance;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(24)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;additions to or changes
          in the provisions relating to satisfaction and discharge of this Indenture;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(25)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;additions to or changes
          in the provisions relating to the modification of this Indenture both with and without the consent of Securityholders of Securities issued under this Indenture;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(26)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the currency or units based on or relating to currencies in which Securities are denominated and the currency or units in which principal or interest may be payable; and if the currency is other than U.S. dollars &#8211; the manner of determining the
          equivalent amount in U.S. dollars;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(27)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;any material or special
          U.S. federal income tax considerations applicable to a series of Securities;</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25">
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(28)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;whether interest will
          be payable in cash or additional Securities at the Company&#8217;s or the Securityholders&#8217; option and the terms and conditions upon which the election may be made;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(29)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the terms and
          conditions, if any, upon which the Company shall pay amounts in addition to the stated interest, premium, if any and principal amounts of the Securities of the series to any Securityholder that is not a &#8220;United States person&#8221; for federal tax
          purposes;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(30)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;any restrictions on
          transfer, sale or assignment of the Securities of the series;<font style="font-weight: bold;">&#160;</font>and</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(31)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;any other specific
          terms, preferences, rights or limitations of, or restrictions on, the Securities, any other additions or changes in the provisions of this Indenture, and any terms that may be required by us or advisable under applicable laws or regulations.</div>
    </div>
    <div style="line-height: 1.25"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All Securities of any one series shall be substantially identical except as may otherwise be provided in or pursuant to any such Board Resolution or in any indentures supplemental
      hereto.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If any of the terms of the series are established by action taken pursuant to a Board Resolution of the Company, a copy of an appropriate record of such action shall be certified
      by the secretary or an assistant secretary of the Company and delivered to the Trustee at or prior to the delivery of the Officer&#8217;s Certificate of the Company setting forth the terms of the series.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Securities of any particular series may be issued at various times, with different dates on which the principal or any installment of principal is payable, with different rates of
      interest, if any, or different methods by which rates of interest may be determined, with different dates on which such interest may be payable and with different redemption dates.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Form of Securities and Trustee&#8217;s Certificate</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Securities of any series and the Trustee&#8217;s certificate of authentication to be borne by such Securities shall be substantially of the tenor and purport as set forth in one or
      more indentures supplemental hereto or as provided in a Board Resolution, and set forth in an Officer&#8217;s Certificate, and they may have such letters, numbers or other marks of identification or designation and such legends or endorsements printed,
      lithographed or engraved thereon as the Company may deem appropriate and as are not inconsistent with the provisions of this Indenture, or as may be required to comply with any law or with any rule or regulation made pursuant thereto or with any rule
      or regulation of any securities exchange on which Securities of that series may be listed, or to conform to usage.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Denominations: Provisions for Payment</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Securities shall be issuable as registered Securities and in the denominations of one thousand U.S. dollars ($1,000) or any integral multiple thereof, subject to Section
      2.01(a)(13).&#160; The Securities of a particular series shall bear interest payable on the dates and at the rate specified with respect to that series.&#160; Subject to Section 2.01(a)(23), the principal of and the interest on the Securities of any series, as
      well as any premium thereon in case of redemption or repurchase thereof prior to maturity, and any cash amount due upon conversion or exchange thereof, shall be payable in the coin or currency of the United States of America that at the time is legal
      tender for public and private debt, at the office or agency of the Company maintained for that purpose.&#160; Each Security shall be dated the date of its authentication.&#160; Interest on the Securities shall be computed on the basis of a 360-day year
      composed of twelve 30-day months.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The interest installment on any Security that is payable, and is punctually paid or duly provided for, on any Interest Payment Date for Securities of that series shall be paid to
      the Person in whose name said Security (or one or more Predecessor Securities) is registered at the close of business on the regular record date for such interest installment.&#160; In the event that any Security of a particular series or portion thereof
      is called for redemption and the redemption date is subsequent to a regular record date with respect to any Interest Payment Date and prior to such Interest Payment Date, interest on such Security will be paid upon presentation and surrender of such
      Security as provided in Section 3.03.</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any interest on any Security that is payable, but is not punctually paid or duly provided for, on any Interest Payment Date for Securities of the same series (herein called
      &#8220;Defaulted Interest&#8221;) shall forthwith cease to be payable to the registered holder on the relevant regular record date by virtue of having been such holder; and such Defaulted Interest shall be paid by the Company, at its election, as provided in
      clause (1) or clause (2) below:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company may make payment of any Defaulted Interest on Securities to the Persons in whose names such Securities (or their
      respective Predecessor Securities) are registered in the Security Register at the close of business on a special record date for the payment of such Defaulted Interest, which shall be fixed in the following manner: the Company shall notify the
      Trustee in writing of the amount of Defaulted Interest proposed to be paid on each such Security and the date of the proposed payment, and at the same time the Company shall deposit with the Trustee an amount of money equal to the aggregate amount
      proposed to be paid in respect of such Defaulted Interest or shall make arrangements satisfactory to the Trustee for such deposit prior to the date of the proposed payment, such money when deposited to be held in trust for the benefit of the Persons
      entitled to such Defaulted Interest as in this clause provided.&#160; Thereupon the Trustee shall fix a special record date for the payment of such Defaulted Interest which shall not be more than 15 nor less than 10 days prior to the date of the proposed
      payment and not less than 10 days after the receipt by the Trustee of the notice of the proposed payment.&#160; The Trustee shall promptly notify the Company of such special record date and, in the name and at the expense of the Company, shall cause
      notice of the proposed payment of such Defaulted Interest and the special record date therefor to be sent, to each Securityholder not less than 10 days prior to such special record date.&#160; Notice of the proposed payment of such Defaulted Interest and
      the special record date therefor having been sent as aforesaid, such Defaulted Interest shall be paid to the Persons in whose names such Securities (or their respective Predecessor Securities) are registered in the Security Register on such special
      record date.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(2)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company may make payment of any Defaulted Interest on any Securities in any other lawful manner not inconsistent with the
      requirements of any securities exchange on which such Securities may be listed, and upon such notice as may be required by such exchange, if, after notice given by the Company to the Trustee of the proposed payment pursuant to this clause, such
      manner of payment shall be deemed practicable by the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Unless otherwise set forth in a Board Resolution or one or more indentures supplemental hereto establishing the terms of any series of Securities pursuant to Section 2.01 hereof,
      the term &#8220;regular record date&#8221; as used in this Section with respect to a series of Securities and any Interest Payment Date for such series shall mean either the fifteenth day of the month immediately preceding the month in which an Interest Payment
      Date established for such series pursuant to Section 2.01 hereof shall occur, if such Interest Payment Date is the first day of a month, or the first day of the month in which an Interest Payment Date established for such series pursuant to Section
      2.01 hereof shall occur, if such Interest Payment Date is the fifteenth day of a month, whether or not such date is a Business Day.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Subject to the foregoing provisions of this Section, each Security of a series delivered under this Indenture upon transfer of or in exchange for or in lieu of any other Security
      of such series shall carry the rights to interest accrued and unpaid, and to accrue, that were carried by such other Security.</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Execution and Authentications</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Securities shall be signed on behalf of the Company by one of its Officers.&#160; Signatures may be in the form of a manual or facsimile signature.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company may use the facsimile signature of any Person who shall have been an Officer (at the time of execution), notwithstanding the fact that at the time the Securities shall
      be authenticated and delivered or disposed of such Person shall have ceased to be such an officer of the Company.&#160; The Securities may contain such notations, legends or endorsements required by law, stock exchange rule or usage.&#160; Each Security shall
      be dated the date of its authentication by the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">A Security shall not be valid until authenticated manually by an authorized signatory of the Trustee, or by an Authenticating Agent.&#160; Such signature shall be conclusive evidence
      that the Security so authenticated has been duly authenticated and delivered hereunder and that the holder is entitled to the benefits of this Indenture.&#160; At any time and from time to time after the execution and delivery of this Indenture, the
      Company may deliver Securities of any series executed by the Company to the Trustee for authentication, together with a written order of the Company for the authentication and delivery of such Securities, signed by an Officer, and the Trustee in
      accordance with such written order shall authenticate and deliver such Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Upon the Company&#8217;s delivery of any such authentication order to the Trustee at any time after the initial issuance of Securities under this Indenture, the Trustee shall be provided
      with, and (subject to Sections 315(a) through 315(d) of the Trust Indenture Act) shall be fully protected in relying upon, (1) an Opinion of Counsel or reliance letter and (2) an Officer&#8217;s Certificate stating that all conditions precedent to the
      execution, authentication and delivery of such Securities are in conformity with the provisions of this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Trustee shall not be required to authenticate such Securities if the issue of such Securities pursuant to this Indenture will affect the Trustee&#8217;s own rights, duties or
      immunities under the Securities and this Indenture or otherwise in a manner that is not reasonably acceptable to the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Registration of Transfer and Exchange</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Securities of any series may be exchanged upon presentation thereof at the office or agency of the Company designated for such
      purpose, for other Securities of such series of authorized denominations, and for a like aggregate principal amount, upon payment of a sum sufficient to cover any tax or other governmental charge in relation thereto, all as provided in this Section.&#160;
      In respect of any Securities so surrendered for exchange, the Company shall execute, the Trustee shall authenticate and such office or agency shall deliver in exchange therefor the Security or Securities of the same series that the Securityholder
      making the exchange shall be entitled to receive, bearing numbers not contemporaneously outstanding.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company shall keep, or cause to be kept, at its office or agency designated for such purpose a register or registers
      (herein referred to as the &#8220;Security Register&#8221;) in which, subject to such reasonable regulations as it may prescribe, the Company shall register the Securities and the transfers of Securities as in this Article provided and which at all reasonable
      times shall be open for inspection by the Trustee.&#160; The registrar for the purpose of registering Securities and transfer of Securities as herein provided shall be appointed as authorized by Board Resolution or Supplemental Indenture (the &#8220;Security
      Registrar&#8221;).</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Upon surrender for transfer of any Security at the office or agency of the Company designated for such purpose, the Company shall execute, the Trustee shall authenticate and such
      office or agency shall deliver in the name of the transferee or transferees a new Security or Securities of the same series as the Security presented for a like aggregate principal amount.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company initially appoints the Trustee as initial Security Registrar for each series of Securities</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All Securities presented or surrendered for exchange or registration of transfer, as provided in this Section, shall be accompanied (if so required by the Company or the Security
      Registrar) by a written instrument or instruments of transfer, in form satisfactory to the Company or the Security Registrar, duly executed by the registered holder or by such holder&#8217;s duly authorized attorney in writing.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Except as provided pursuant to Section 2.01 pursuant to a Board Resolution, and set forth in an Officer&#8217;s Certificate, or
      established in one or more indentures supplemental to this Indenture, no service charge shall be made for any exchange or registration of transfer of Securities, or issue of new Securities in case of partial redemption of any series or repurchase,
      conversion or exchange of less than the entire principal amount of a Security, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge in relation thereto, other than exchanges pursuant to Section 2.06,
      Section 3.03(b) and Section 9.04 not involving any transfer.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company and the Security Registrar shall not be required (i) to issue, exchange or register the transfer of any Securities
      during a period beginning at the opening of business 15 days before the day of the sending of a notice of redemption of less than all the Outstanding Securities of the same series and ending at the close of business on the day of such sending, nor
      (ii) to register the transfer of or exchange any Securities of any series or portions thereof called for redemption or surrendered for repurchase, but not validly withdrawn, other than the unredeemed portion of any such Securities being redeemed in
      part or not surrendered for repurchase, as the case may be.&#160; The provisions of this Section 2.05 are, with respect to any Global Security, subject to Section&#160;2.11 hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed under this Indenture or under applicable
      law with respect to any transfer of any interest in any Security (including any transfers between or among Depositary participants or beneficial owners of interests in any Global Security) other than to require delivery of such certificates and other
      documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance as to form with the express requirements hereof.</div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.06</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Temporary Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Pending the preparation of definitive Securities of any series, the Company may execute, and the Trustee shall authenticate and deliver, temporary Securities (printed, lithographed
      or typewritten) of any authorized denomination.&#160; Such temporary Securities shall be substantially in the form of the definitive Securities in lieu of which they are issued, but with such omissions, insertions and variations as may be appropriate for
      temporary Securities, all as may be determined by the Company.&#160; Every temporary Security of any series shall be executed by the Company and be authenticated by the Trustee upon the same conditions and in substantially the same manner, and with like
      effect, as the definitive Securities of such series.&#160; Without unnecessary delay the Company will execute and will furnish definitive Securities of such series and thereupon any or all temporary Securities of such series may be surrendered in exchange
      therefor (without charge to the Securityholders), at the office or agency of the Company designated for the purpose, and the Trustee shall authenticate and such office or agency shall deliver in exchange for such temporary Securities an equal
      aggregate principal amount of definitive Securities of such series, unless the Company advises the Trustee to the effect that definitive Securities need not be executed and furnished until further notice from the Company.&#160; Until so exchanged, the
      temporary Securities of such series shall be entitled to the same benefits under this Indenture as definitive Securities of such series authenticated and delivered hereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.07</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Mutilated, Destroyed, Lost or Stolen Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In case any temporary or definitive Security shall become mutilated or be destroyed, lost or stolen, the Company (subject to the next succeeding sentence) shall execute, and upon
      the Company&#8217;s request the Trustee (subject as aforesaid) shall authenticate and deliver, a new Security of the same series, bearing a number not contemporaneously outstanding, in exchange and substitution for the mutilated Security, or in lieu of and
      in substitution for the Security so destroyed, lost or stolen.&#160; In every case the applicant for a substituted Security shall furnish to the Company and the Trustee such security or indemnity as may be required by them to save each of them harmless,
      and, in every case of destruction, loss or theft, the applicant shall also furnish to the Company and the Trustee evidence to their satisfaction of the destruction, loss or theft of the applicant&#8217;s Security and of the ownership thereof.&#160; The Trustee
      may authenticate any such substituted Security and deliver the same upon the written request or authorization of any officer of the Company.&#160; Upon the issuance of any substituted Security, the Company may require the payment of a sum sufficient to
      cover any tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Trustee) connected therewith.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In case any Security that has matured or is about to mature shall become mutilated or be destroyed, lost or stolen, the Company may, instead of issuing a substitute Security, pay
      or authorize the payment of the same (without surrender thereof except in the case of a mutilated Security) if the applicant for such payment shall furnish to the Company and the Trustee such security or indemnity as they may require to save them
      harmless, and, in case of destruction, loss or theft, evidence to the satisfaction of the Company and the Trustee of the destruction, loss or theft of such Security and of the ownership thereof.</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Every replacement Security issued pursuant to the provisions of this Section shall constitute an additional contractual obligation of the Company whether or not the mutilated,
      destroyed, lost or stolen Security shall be found at any time, or be enforceable by anyone, and shall be entitled to all the benefits of this Indenture equally and proportionately with any and all other Securities of the same series duly issued
      hereunder.&#160; All Securities shall be held and owned upon the express condition that the foregoing provisions are exclusive with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities, and shall preclude (to the extent
      lawful) any and all other rights or remedies, notwithstanding any law or statute existing or hereafter enacted to the contrary with respect to the replacement or payment of negotiable instruments or other securities without their surrender.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.08</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Cancellation</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All Securities surrendered for the purpose of payment, redemption, repurchase, exchange, registration of transfer or conversion shall, if surrendered to the Company or any paying
      agent (or any other applicable agent), be delivered to the Trustee for cancellation, or, if surrendered to the Trustee, shall be cancelled by it, and no Securities shall be issued in lieu thereof except as expressly required or permitted by any of
      the provisions of this Indenture.&#160; On request of the Company at the time of such surrender, the Trustee shall deliver to the Company canceled Securities held by the Trustee.&#160; In the absence of such request the Trustee may dispose of canceled
      Securities in accordance with its standard procedures and deliver a certificate of disposition to the Company.&#160; If the Company shall otherwise acquire any of the Securities, however, such acquisition shall not operate as a redemption or satisfaction
      of the indebtedness represented by such Securities unless and until the same are delivered to the Trustee for cancellation.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.09</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Benefits of Indenture</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Nothing in this Indenture or in the Securities, express or implied, shall give or be construed to give to any Person, other than the parties hereto and the holders of the
      Securities any legal or equitable right, remedy or claim under or in respect of this Indenture, or under any covenant, condition or provision herein contained; all such covenants, conditions and provisions being for the sole benefit of the parties
      hereto and of the holders of the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.10</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Authenticating Agent</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">So long as any of the Securities of any series remain Outstanding there may be an Authenticating Agent for any or all such series of Securities which the Trustee shall have the
      right to appoint.&#160; Said Authenticating Agent shall be authorized to act on behalf of the Trustee to authenticate Securities of such series issued upon exchange, transfer or partial redemption, repurchase or conversion thereof, and Securities so
      authenticated shall be entitled to the benefits of this Indenture and shall be valid and obligatory for all purposes as if authenticated by the Trustee hereunder.&#160; All references in this Indenture to the authentication of Securities by the Trustee
      shall be deemed to include authentication by an Authenticating Agent for such series.&#160; Each Authenticating Agent shall be acceptable to the Company and shall be a corporation that has a combined capital and surplus, as most recently reported or
      determined by it, sufficient under the laws of any jurisdiction under which it is organized or in which it is doing business to conduct a trust business, and that is otherwise authorized under such laws to conduct such business and is subject to
      supervision or examination by federal or state authorities.&#160; If at any time any Authenticating Agent shall cease to be eligible in accordance with these provisions, it shall resign immediately.</div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any Authenticating Agent may at any time resign by giving written notice of resignation to the Trustee and to the Company.&#160; The Trustee may at any time (and upon request by the
      Company shall) terminate the agency of any Authenticating Agent by giving written notice of termination to such Authenticating Agent and to the Company.&#160; Upon resignation, termination or cessation of eligibility of any Authenticating Agent, the
      Trustee may appoint an eligible successor Authenticating Agent acceptable to the Company.&#160; Any successor Authenticating Agent, upon acceptance of its appointment hereunder, shall become vested with all the rights, powers and duties of its predecessor
      hereunder as if originally named as an Authenticating Agent pursuant hereto.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.11</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Global Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If the Company shall establish pursuant to Section 2.01 that the Securities of a particular series are to be issued as a Global
      Security, then the Company shall execute and the Trustee shall, in accordance with Section 2.04, authenticate and deliver, a Global Security that (i) shall represent, and shall be denominated in an amount equal to the aggregate principal amount of,
      all of the Outstanding Securities of such series, (ii) shall be registered in the name of the Depositary or its nominee, (iii) shall be delivered by the Trustee to the Depositary or pursuant to the Depositary&#8217;s instruction (or if the Depositary names
      the Trustee as its custodian, retained by the Trustee), and (iv) shall bear a legend substantially to the following effect: &#8220;Except as otherwise provided in Section 2.11 of the Indenture, this Security may be transferred, in whole but not in part,
      only to another nominee of the Depositary or to a successor Depositary or to a nominee of such successor Depositary.&#8221;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Notwithstanding the provisions of Section 2.05, the Global Security of a series may be transferred, in whole but not in part
      and in the manner provided in Section 2.05, only to another nominee of the Depositary for such series, or to a successor Depositary for such series selected or approved by the Company or to a nominee of such successor Depositary.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If at any time the Depositary for a series of the Securities notifies the Company that it is unwilling or unable to continue as
      Depositary for such series or if at any time the Depositary for such series shall no longer be registered or in good standing under the Exchange Act, or other applicable statute or regulation, and a successor Depositary for such series is not
      appointed by the Company within 90 days after the Company receives such notice or becomes aware of such condition, as the case may be, or if an Event of Default has occurred and is continuing and the Company has received a request from the Depositary
      or from the Trustee, this Section 2.11 shall no longer be applicable to the Securities of such series and the Company will execute, and subject to Section 2.04, the Trustee will authenticate and deliver the Securities of such series in definitive
      registered form without coupons, in authorized denominations, and in an aggregate principal amount equal to the principal amount of the Global Security of such series in exchange for such Global Security.&#160; In addition, the Company may at any time
      determine that the Securities of any series shall no longer be represented by a Global Security and that the provisions of this Section 2.11 shall no longer apply to the Securities of such series.&#160; In such event the Company will execute and, subject
      to Section 2.04, the Trustee, upon receipt of an Officer&#8217;s Certificate evidencing such determination by the Company, will authenticate and deliver the Securities of such series in definitive registered form without coupons, in authorized
      denominations, and in an aggregate principal amount equal to the principal amount of the Global Security of such series in exchange for such Global Security.&#160; Upon the exchange of the Global Security for such Securities in definitive registered form
      without coupons, in authorized denominations, the Global Security shall be canceled by the Trustee.&#160; Such Securities in definitive registered form issued in exchange for the Global Security pursuant to this Section 2.11(c) shall be registered in such
      names and in such authorized denominations as the Depositary, pursuant to instructions from its direct or indirect participants or otherwise, shall instruct the Trustee.&#160; The Trustee shall deliver such Securities to the Depositary for delivery to the
      Persons in whose names such Securities are so registered.</div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 2.12</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">CUSIP Numbers</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company in issuing the Securities may use &#8220;CUSIP&#8221; numbers (if then generally in use), and, if so, the Trustee shall use &#8220;CUSIP&#8221; numbers in notices of redemption as a
      convenience to Holders; provided that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Securities or as contained in any notice of a redemption and that reliance may be placed
      only on the other elements of identification printed on the Securities, and any such redemption shall not be affected by any defect in or omission of such numbers.&#160; The Company will promptly notify the Trustee of any change in the &#8220;CUSIP&#8221; numbers.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 3<br>
      <br>
      REDEMPTION OF SECURITIES AND SINKING FUND PROVISIONS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 3.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Redemption</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company may redeem the Securities of any series issued hereunder on and after the dates and in accordance with the terms established for such series pursuant to Section 2.01
      hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 3.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Notice of Redemption</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case the Company shall desire to exercise such right to redeem all or, as the case may be, a portion of the Securities of
      any series in accordance with any right the Company reserved for itself to do so pursuant to Section&#160;2.01 hereof, the Company shall, or shall cause the Trustee to, give notice of such redemption to holders of the Securities of such series to be
      redeemed by mailing, first class postage prepaid (or with regard to any Global Security held in book entry form, by electronic mail in accordance with the applicable procedures of the Depositary), a notice of such redemption not less than 30 days and
      not more than 90 days before the date fixed for redemption of that series to such Securityholders, unless a shorter period is specified in the Securities to be redeemed.&#160; Any notice that is mailed in the manner herein provided shall be conclusively
      presumed to have been duly given, whether or not the registered holder receives the notice.&#160; In any case, failure duly to give such notice to the holder of any Security of any series designated for redemption in whole or in part, or any defect in the
      notice, shall not affect the validity of the proceedings for the redemption of any other Securities of such series or any other series.&#160; In the case of any redemption of Securities prior to the expiration of any restriction on such redemption
      provided in the terms of such Securities or elsewhere in this Indenture, the Company shall furnish the Trustee with an Officer&#8217;s Certificate evidencing compliance with any such restriction.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Each such notice of redemption shall identify the Securities to be redeemed (including CUSIP numbers, if any), specify the date fixed for redemption and the redemption price at
      which Securities of that series are to be redeemed, and shall state that payment of the redemption price of such Securities to be redeemed will be made at the office or agency of the Company, upon presentation and surrender of such Securities, that
      interest accrued to the date fixed for redemption will be paid as specified in said notice, that from and after said date interest will cease to accrue and that the redemption is from a sinking fund, if such is the case.&#160; If less than all the
      Securities of a series are to be redeemed, the notice to the holders of Securities of that series to be redeemed in part shall specify the particular Securities to be so redeemed.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In case any Security is to be redeemed in part only, the notice that relates to such Security shall state the portion of the principal amount thereof to be redeemed, and shall
      state that on and after the redemption date, upon surrender of such Security, a new Security or Securities of such series in principal amount equal to the unredeemed portion thereof will be issued.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If less than all the Securities of a series are to be redeemed, the Company shall give the Trustee at least 45 days&#8217; notice
      (unless a shorter notice shall be satisfactory to the Trustee) in advance of the date fixed for redemption as to the aggregate principal amount of Securities of the series to be redeemed, and thereupon the Securities to be redeemed shall be selected,
      by lot, on a pro rata basis, or in such other manner as the Company shall deem appropriate and fair in its discretion and that may provide for the selection of a portion or portions (equal to one thousand U.S. dollars ($1,000) or any integral
      multiple thereof) of the principal amount of such Securities of a denomination larger than $1,000, the Securities to be redeemed and shall thereafter promptly notify the Company in writing of the numbers of the Securities to be redeemed, in whole or
      in part.&#160; The Company may, if and whenever it shall so elect, by delivery of instructions signed on its behalf by an Officer, instruct the Trustee or any paying agent to call all or any part of the Securities of a particular series for redemption and
      to give notice of redemption in the manner set forth in this Section, such notice to be in the name of the Company or its own name as the Trustee or such paying agent may deem advisable.&#160; In any case in which notice of redemption is to be given by
      the Trustee or any such paying agent, the Company shall deliver or cause to be delivered to, or permit to remain with, the Trustee or such paying agent, as the case may be, such Security Register, transfer books or other records, or suitable copies
      or extracts therefrom, sufficient to enable the Trustee or such paying agent to give any notice by mail that may be required under the provisions of this Section.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 3.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Payment Upon Redemption</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If the giving of notice of redemption shall have been completed as above provided, the Securities or portions of Securities of
      the series to be redeemed specified in such notice shall become due and payable on the date and at the place stated in such notice at the applicable redemption price, together with interest accrued to, but excluding, the date fixed for redemption and
      interest on such Securities or portions of Securities shall cease to accrue on and after the date fixed for redemption, unless the Company shall default in the payment of such redemption price and accrued interest with respect to any such Security or
      portion thereof.&#160; On presentation and surrender of such Securities on or after the date fixed for redemption at the place of payment specified in the notice, said Securities shall be paid and redeemed at the applicable redemption price for such
      series, together with interest accrued thereon to, but excluding, the date fixed for redemption (but if the date fixed for redemption is an Interest Payment Date, the interest installment payable on such date shall be payable to the registered holder
      at the close of business on the applicable record date pursuant to Section 2.03).</div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Upon presentation of any Security of such series that is to be redeemed in part only, the Company shall execute and the Trustee
      shall authenticate and the office or agency where the Security is presented shall deliver to the Securityholder thereof, at the expense of the Company, a new Security of the same series of authorized denominations in principal amount equal to the
      unredeemed portion of the Security so presented.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 3.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Sinking Fund</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The provisions of Sections 3.04, 3.05 and 3.06 shall be applicable to any sinking fund for the retirement of Securities of a series, except as otherwise specified as contemplated
      by Section&#160;2.01 for Securities of such series.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The minimum amount of any sinking fund payment provided for by the terms of Securities of any series is herein referred to as a &#8220;mandatory sinking fund payment,&#8221; and any payment in
      excess of such minimum amount provided for by the terms of Securities of any series is herein referred to as an &#8220;optional sinking fund payment&#8221;.&#160; If provided for by the terms of Securities of any series, the cash amount of any sinking fund payment
      may be subject to reduction as provided in Section 3.05.&#160; Each sinking fund payment shall be applied to the redemption of Securities of any series as provided for by the terms of Securities of such series.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 3.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Satisfaction of Sinking Fund Payments with Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company (i) may deliver Outstanding Securities of a series and (ii) may apply as a credit Securities of a series that have been redeemed either at the election of the Company
      pursuant to the terms of such Securities or through the application of permitted optional sinking fund payments pursuant to the terms of such Securities, in each case in satisfaction of all or any part of any sinking fund payment with respect to the
      Securities of such series required to be made pursuant to the terms of such Securities as provided for by the terms of such series, provided that such Securities have not been previously so credited.&#160; Such Securities shall be received and credited
      for such purpose by the Trustee at the redemption price specified in such Securities for redemption through operation of the sinking fund and the amount of such sinking fund payment shall be reduced accordingly.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 3.06</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Redemption of Securities for Sinking Fund</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Not less than 45 days prior to each sinking fund payment date for any series of Securities (unless a shorter period shall be satisfactory to the Trustee), the Company will deliver
      to the Trustee an Officer&#8217;s Certificate specifying the amount of the next ensuing sinking fund payment for that series pursuant to the terms of the series, the portion thereof, if any, that is to be satisfied by delivering and crediting Securities of
      that series pursuant to Section 3.05 and the basis for such credit and will, together with such Officer&#8217;s Certificate, deliver to the Trustee any Securities to be so delivered.&#160; Not less than 30 days before each such sinking fund payment date the
      Securities to be redeemed upon such sinking fund payment date shall be selected in the manner specified in Section 3.02 and the Company shall cause notice of the redemption thereof to be given in the name of and at the expense of the Company in the
      manner provided in Section 3.02.&#160; Such notice having been duly given, the redemption of such Securities shall be made upon the terms and in the manner stated in Section 3.03.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">17</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 4<br>
      <br>
      COVENANTS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 4.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Payment of Principal, Premium and Interest</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company will duly and punctually pay or cause to be paid the principal of (and premium, if any) and interest on the Securities of that series at the time and place and in the
      manner provided herein and established with respect to such Securities. Payments of principal on the Securities may be made at the time provided herein and established with respect to such Securities by U.S. dollar check drawn on and mailed to the
      address of the Securityholder entitled thereto as such address shall appear in the Security Register, or U.S. dollar wire transfer to, a U.S. dollar account if such Securityholder shall have furnished wire instructions to the Trustee no later than 15
      days prior to the relevant payment date. Payments of interest on the Securities may be made at the time provided herein and established with respect to such Securities by U.S. dollar check mailed to the address of the Securityholder entitled thereto
      as such address shall appear in the Security Register, or U.S. dollar wire transfer to, a U.S. dollar account if such Securityholder shall have furnished wire instructions in writing to the Security Registrar and the Trustee no later than 15 days
      prior to the relevant payment date.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 4.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Maintenance of Office or Agency</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">So long as any series of the Securities remain Outstanding, the Company agrees to maintain an office or agency with respect to each such series and at such other location or
      locations as may be designated as provided in this Section 4.02, where (i) Securities of that series may be presented for payment, (ii) Securities of that series may be presented as herein above authorized for registration of transfer and exchange,
      and (iii) notices and demands to or upon the Company in respect of the Securities of that series and this Indenture may be given or served, such designation to continue with respect to such office or agency until the Company shall, by written notice
      signed by any officer authorized to sign an Officer&#8217;s Certificate and delivered to the Trustee, designate some other office or agency for such purposes or any of them.&#160; If at any time the Company shall fail to maintain any such required office or
      agency or shall fail to furnish the Trustee with the address thereof, such presentations, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Company hereby appoints the Trustee as its agent to receive all
      such presentations, notices and demands.&#160; The Company initially appoints the Corporate Trust Office of the Trustee as its paying agent with respect to the Securities.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">18</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 4.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Paying Agents</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If the Company shall appoint one or more paying agents for all or any series of the Securities, other than the Trustee, the
      Company will cause each such paying agent to execute and deliver to the Trustee an instrument in which such agent shall agree with the Trustee, subject to the provisions of this Section:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;that it will hold all sums held by it as such agent for the payment of the principal of (and premium, if any) or interest on
      the Securities of that series (whether such sums have been paid to it by the Company or by any other obligor of such Securities) in trust for the benefit of the Persons entitled thereto;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(2)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;that it will give the Trustee notice of any failure by the Company (or by any other obligor of such Securities) to make any
      payment of the principal of (and premium, if any) or interest on the Securities of that series when the same shall be due and payable;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(3)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;that it will, at any time during the continuance of any failure referred to in the preceding paragraph (a)(2) above, upon the
      written request of the Trustee, forthwith pay to the Trustee all sums so held in trust by such paying agent; and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(4)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;that it will perform all other duties of paying agent as set forth in this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If the Company shall act as its own paying agent with respect to any series of the Securities, it will on or before each due
      date of the principal of (and premium, if any) or interest on Securities of that series, set aside, segregate and hold in trust for the benefit of the Persons entitled thereto a sum sufficient to pay such principal (and premium, if any) or interest
      so becoming due on Securities of that series until such sums shall be paid to such Persons or otherwise disposed of as herein provided and will promptly notify the Trustee of such action, or any failure (by it or any other obligor on such Securities)
      to take such action.&#160; Whenever the Company shall have one or more paying agents for any series of Securities, it will, prior to each due date of the principal of (and premium, if any) or interest on any Securities of that series, deposit with the
      paying agent a sum sufficient to pay the principal (and premium, if any) or interest so becoming due, such sum to be held in trust for the benefit of the Persons entitled to such principal, premium or interest, and (unless such paying agent is the
      Trustee) the Company will promptly notify the Trustee of this action or failure so to act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Notwithstanding anything in this Section to the contrary, (i) the agreement to hold sums in trust as provided in this Section
      is subject to the provisions of Section 11.05, and (ii) the Company may at any time, for the purpose of obtaining the satisfaction and discharge of this Indenture or for any other purpose, pay, or direct any paying agent to pay, to the Trustee all
      sums held in trust by the Company or such paying agent, such sums to be held by the Trustee upon the same terms and conditions as those upon which such sums were held by the Company or such paying agent; and, upon such payment by the Company or any
      paying agent to the Trustee, the Company or such paying agent shall be released from all further liability with respect to such money.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">19</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 4.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Appointment to Fill Vacancy in Office of Trustee</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company, whenever necessary to avoid or fill a vacancy in the office of Trustee, will appoint, in the manner provided in Section 7.10, a Trustee, so that there shall at all
      times be a Trustee hereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 5<br>
      <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> SECURITYHOLDERS&#8217; LISTS AND REPORTS BY THE COMPANY AND </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">THE&#160;TRUSTEE</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 5.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Company to Furnish Trustee Names and Addresses of Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company will furnish or cause to be furnished to the Trustee (a) within 15 days after each regular record date (as defined in Section 2.03) a list, in such form as the Trustee
      may reasonably require, of the names and addresses of the holders of each series of Securities as of such regular record date, provided that the Company shall not be obligated to furnish or cause to furnish such list at any time that the list shall
      not differ in any respect from the most recent list furnished to the Trustee by the Company and (b) at such other times as the Trustee may request in writing within 30 days after the receipt by the Company of any such request, a list of similar form
      and content as of a date not more than 15 days prior to the time such list is furnished; provided, however, that, in either case, no such list need be furnished for any series for which the Trustee shall be the Security Registrar.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 5.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Preservation of Information; Communications With Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall preserve, in as current a form as is reasonably practicable, all information as to the names and addresses of
      the holders of Securities contained in the most recent list furnished to it as provided in Section 5.01 and as to the names and addresses of holders of Securities received by the Trustee in its capacity as Security Registrar (if acting in such
      capacity).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee may destroy any list furnished to it as provided in Section&#160;5.01 upon receipt of a new list so furnished.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Securityholders may communicate as provided in Section 312(b) of the Trust Indenture Act with other Securityholders with
      respect to their rights under this Indenture or under the Securities, and, in connection with any such communications, the Trustee shall satisfy its obligations under Section 312(b) of the Trust Indenture Act in accordance with the provisions of
      Section 312(b) of the Trust Indenture Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 5.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Reports by the Company</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company will at all times comply with Section 314(a) of the Trust Indenture Act.&#160; The Company covenants and agrees to
      provide (which delivery may be via electronic mail) to the Trustee within 30 days, after the Company files the same with the Commission, copies of the annual reports and of the information, documents and other reports (or copies of such portions of
      any of the foregoing as the Commission may from time to time by rules and regulations prescribe) that the Company is required to file with the Commission pursuant to Section 13 or Section 15(d) of the Exchange Act; provided, however, the Company
      shall not be required to deliver to the Trustee any correspondence filed with the Commission or any materials for which the Company has sought and received confidential treatment by the Commission; and provided further, that so long as such filings
      by the Company are available on the Commission&#8217;s Electronic Data Gathering, Analysis and Retrieval System (EDGAR), or any successor system, such filings shall be deemed to have been filed with the Trustee for purposes hereof without any further
      action required by the Company. For the avoidance of doubt, a failure by the Company to file annual reports, information and other reports with the Commission within the time period prescribed thereof by the Commission shall not be deemed a breach of
      this Section 5.03.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">20</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Delivery of reports, information and documents to the Trustee under Section 5.03 is for informational purposes only and the
      information and the Trustee&#8217;s receipt of the foregoing shall not constitute constructive notice of any information contained therein, or determinable from information contained therein including the Company&#8217;s compliance with any of their covenants
      thereunder (as to which the Trustee is entitled to rely exclusively on an Officer&#8217;s Certificate).&#160; The Trustee is under no duty to examine any such reports, information or documents delivered to the Trustee or filed with the Commission via EDGAR to
      ensure compliance with the provision of this Indenture or to ascertain the correctness or otherwise of the information or the statements contained therein.&#160; The Trustee shall have no responsibility or duty whatsoever to ascertain or determine whether
      the above referenced filings with the Commission on EDGAR (or any successor system) has occurred.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 5.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Reports by the Trustee</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If required by Section 313(a) of the Trust Indenture Act, the Trustee, within sixty (60) days after each May 1, shall send to
      the Securityholders a brief report dated as of such May 1, which complies with Section 313(a) of the Trust Indenture Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall comply with Section 313(b) and 313(c) of the Trust Indenture Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;A copy of each such report shall, at the time of such transmission to Securityholders, be filed by the Trustee with the
      Company, with each securities exchange upon which any Securities are listed (if so listed) and also with the Commission.&#160; The Company agrees to notify the Trustee when any Securities become listed on any securities exchange.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 6<br>
      <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">REMEDIES OF THE TRUSTEE AND SECURITYHOLDERS ON EVENT OF </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">DEFAULT</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Events of Default</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Whenever used herein with respect to Securities of a particular series, &#8220;Event of Default&#8221; means any one or more of the
      following events that has occurred and is continuing:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;">
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company defaults in
          the payment of any installment of interest upon any of the Securities of that series, as and when the same shall become due and payable, and such default continues for a period of 90 days; provided, however, that a valid extension or deferral of an interest payment period by the Company in accordance with the terms of any indenture supplemental hereto shall not constitute a default in the
          payment of interest for this purpose;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(2)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company defaults in
          the payment of the principal of (or premium, if any, on) any of the Securities of that series as and when the same shall become due and payable whether at maturity, upon redemption, by declaration or otherwise, or in any payment required by any
          sinking or analogous fund established with respect to that series; provided, however, that a valid extension or delay of the maturity of such Securities in
          accordance with the terms of any indenture supplemental hereto shall not constitute a default in the payment of principal or premium, if any;</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-indent: 108pt;"><font style="font-weight: bold;">(3)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company fails to
          observe or perform any other of its covenants or agreements with respect to that series contained in this Indenture or otherwise established with respect to that series of Securities pursuant to Section 2.01 hereof (other than a covenant or
          agreement that has been expressly included in this Indenture solely for the benefit of one or more series of Securities other than such series) for a period of 90 days after the date on which written notice of such failure, requiring the same to
          be remedied and stating that such notice is a &#8220;Notice of Default&#8221; hereunder, shall have been received by the Company from the Trustee, by registered or certified mail, or by the Company and the Trustee by the holders of at least a
          majority in aggregate principal amount of the Securities of that series at the time Outstanding;</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(4)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company pursuant to or within the meaning of any Bankruptcy Law (i) commences a voluntary case, (ii) consents to the entry
      of an order for relief against it in an involuntary case, (iii) consents to the appointment of a Custodian of it or for all or substantially all of its property or (iv) makes a general assignment for the benefit of its creditors; or</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(5)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;a court of competent jurisdiction enters an order under any Bankruptcy Law that (i) is for relief against the Company in an
      involuntary case, (ii) appoints a Custodian of the Company for all or substantially all of its property or (iii) orders the liquidation of the Company, and the order or decree remains unstayed and in effect for 90 days.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25">
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In each and every such
          case (other than an Event of Default specified in clause (4) or clause (5) above), unless the principal of all the Securities of that series shall have already become due and payable, either the Trustee or the holders of at least a majority in aggregate principal amount of the Securities of that series then Outstanding hereunder, by notice in writing to the Company (and to the Trustee if given by such
          Securityholders), may declare the principal of (and premium, if any, on) and accrued and unpaid interest on all the Securities of that series to be due and payable immediately, and upon any such declaration the same shall become and shall be
          immediately due and payable.&#160; If an Event of Default specified in clause (4) or clause (5) above occurs, the principal of and accrued and unpaid interest on all the Securities of that series shall automatically be immediately due and payable
          without any declaration or other act on the part of the Trustee or the holders of the Securities.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25">
      <div style="text-indent: 72pt;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;At any time after the
          principal of (and premium, if any, on) and accrued and unpaid interest on the Securities of that series shall have been so declared due and payable, and before any judgment or decree for the payment of the moneys due shall have been obtained or
          entered as hereinafter provided, the holders of a majority in aggregate principal amount of the Securities of that series then Outstanding hereunder (or, at a meeting of
            holders of such amount of the Securities of that series then Outstanding at which a quorum is present, the holders of a majority in principal amount of the Securities of that series then Outstanding hereunder represented at such meeting),
          by written notice to the Company and the Trustee, may rescind and annul such declaration and its consequences if: (i) the Company has paid or deposited with the Trustee a sum sufficient to pay all matured installments of interest upon all the
          Securities of that series and the principal of (and premium, if any, on) any and all Securities of that series that shall have become due otherwise than by acceleration (with interest upon such principal and premium, if any, and, to the extent
          that such payment is enforceable under applicable law, upon overdue installments of interest, at the rate per annum expressed in the Securities of that series to the date of such payment or deposit) and the amount payable to the Trustee under
          Section 7.06, and (ii) any and all Events of Default under the Indenture with respect to such series, other than the nonpayment of principal on (and premium, if any, on) and accrued and unpaid interest on Securities of that series that shall not
          have become due by their terms, shall have been remedied or waived as provided in Section 6.06.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">No such rescission and annulment shall extend to or shall affect any subsequent default or impair any right consequent thereon.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case the Trustee shall have proceeded to enforce any right with respect to Securities of that series under this Indenture
      and such proceedings shall have been discontinued or abandoned because of such rescission or annulment or for any other reason or shall have been determined adversely to the Trustee, then and in every such case, subject to any determination in such
      proceedings, the Company and the Trustee shall be restored respectively to their former positions and rights hereunder, and all rights, remedies and powers of the Company and the Trustee shall continue as though no such proceedings had been taken.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Collection of Indebtedness and Suits for Enforcement by Trustee</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Company covenants that (i)&#160;in case it shall default in the payment of any installment of interest on any of the Securities
      of a series, or in any payment required by any sinking or analogous fund established with respect to that series as and when the same shall have become due and payable, and such default shall have continued for a period of 90 days, or (ii)&#160;in case it
      shall default in the payment of the principal of (or premium, if any, on) any of the Securities of a series when the same shall have become due and payable, whether upon maturity of the Securities of a series or upon redemption or upon declaration or
      otherwise then, upon demand of the Trustee, the Company will pay to the Trustee, for the benefit of the holders of the Securities of that series, the whole amount that then shall have been become due and payable on all such Securities for principal
      (and premium, if any) or interest, or both, as the case may be, with interest upon the overdue principal (and premium, if any) and (to the extent that payment of such interest is enforceable under applicable law) upon overdue installments of interest
      at the rate per annum expressed in the Securities of that series; and, in addition thereto, such further amount as shall be sufficient to cover the costs and expenses of collection, and the amount payable to the Trustee under Section 7.06.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">23</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;If the Company shall fail to pay such amounts forthwith upon such demand, the Trustee, in its own name and as trustee of an
      express trust, shall be entitled and empowered to institute any action or proceedings at law or in equity for the collection of the sums so due and unpaid, and may prosecute any such action or proceeding to judgment or final decree, and may enforce
      any such judgment or final decree against the Company or other obligor upon the Securities of that series and collect the moneys adjudged or decreed to be payable in the manner provided by law or equity out of the property of the Company or other
      obligor upon the Securities of that series, wherever situated.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case of any receivership, insolvency, liquidation, bankruptcy, reorganization, readjustment, arrangement, composition or
      judicial proceedings affecting the Company, or its creditors or property, the Trustee shall have power to intervene in such proceedings and take any action therein that may be permitted by the court and shall (except as may be otherwise provided by
      law) be entitled to file such proofs of claim and other papers and documents as may be necessary or advisable in order to have the claims of the Trustee and of the holders of Securities of such series allowed for the entire amount due and payable by
      the Company under the Indenture at the date of institution of such proceedings and for any additional amount that may become due and payable by the Company after such date, and to collect and receive any moneys or other property payable or
      deliverable on any such claim, and to distribute the same after the deduction of the amount payable to the Trustee under Section 7.06; and any receiver, assignee or trustee in bankruptcy or reorganization is hereby authorized by each of the holders
      of Securities of such series to make such payments to the Trustee, and, in the event that the Trustee shall consent to the making of such payments directly to such Securityholders, to pay to the Trustee any amount due it under Section 7.06.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;All rights of action and of asserting claims under this Indenture, or under any of the terms established with respect to
      Securities of that series, may be enforced by the Trustee without the possession of any of such Securities, or the production thereof at any trial or other proceeding relative thereto, and any such suit or proceeding instituted by the Trustee shall
      be brought in its own name as trustee of an express trust, and any recovery of judgment shall, after provision for payment to the Trustee of any amounts due under Section 7.06, be for the ratable benefit of the holders of the Securities of such
      series.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In case of an Event of Default hereunder, the Trustee may in its discretion proceed to protect and enforce the rights vested in it by this Indenture by such appropriate judicial
      proceedings as the Trustee shall deem most effectual to protect and enforce any of such rights, either at law or in equity or in bankruptcy or otherwise, whether for the specific enforcement of any covenant or agreement contained in the Indenture or
      in aid of the exercise of any power granted in this Indenture, or to enforce any other legal or equitable right vested in the Trustee by this Indenture or by law.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Nothing contained herein shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Securityholder any plan of reorganization,
      arrangement, adjustment or composition affecting the Securities of that series or the rights of any Securityholder thereof or to authorize the Trustee to vote in respect of the claim of any Securityholder in any such proceeding.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Application of Moneys Collected</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any moneys collected by the Trustee pursuant to this Article with respect to a particular series of Securities shall be applied in the following order, at the date or dates fixed
      by the Trustee and, in case of the distribution of such moneys on account of principal (or premium, if any) or interest, upon presentation of the Securities of that series, and notation thereon of the payment, if only partially paid, and upon
      surrender thereof if fully paid:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">FIRST: To the payment of costs and expenses of collection and of all amounts payable to the Trustee under Section 7.06;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">SECOND: To the payment of the amounts then due and unpaid upon Securities of such series for principal (and premium, if any) and interest, in respect of which or for the benefit of
      which such money has been collected, ratably, without preference or priority of any kind, according to the amounts due and payable on such Securities for principal (and premium, if any) and interest, respectively; and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">THIRD: To the payment of the remainder, if any, to the Company or any other Person lawfully entitled thereto.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Limitation on Suits</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">
      <div style="text-indent: 36pt; line-height: 1.25;">No holder of any Security of any series shall have any right by virtue or by availing of any provision of this
        Indenture to institute any suit, action or proceeding in equity or at law upon or under or with respect to this Indenture or for the appointment of a receiver or trustee, or for any other remedy hereunder, unless (i) such Securityholder previously
        shall have given to the Trustee written notice of an Event of Default and of the continuance thereof with respect to the Securities of such series specifying such Event of Default, as hereinbefore provided; (ii) the holders of at least a majority in aggregate principal amount of the Securities of such series then Outstanding shall have made written request upon the Trustee to institute such
        action, suit or proceeding in its own name as Trustee hereunder; (iii) such Securityholder or Securityholders shall have offered to the Trustee indemnity satisfactory to it against the costs, expenses and liabilities to be incurred in compliance
        with such request; (iv) the Trustee for 60 days after its receipt of such notice, request and offer of indemnity, shall have failed to institute any such action,
        suit or proceeding and (v) during such 60 day period, the holders of a majority in principal amount of the Securities of that series (or at a meeting of holders of such series at which a quorum is present, the holders of a majority in principal amount of the Securities of such series represented at such meeting) do not
        give the Trustee a direction inconsistent with the request.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Notwithstanding anything contained herein to the contrary or any other provisions of this Indenture, the right of any holder of any Security to receive payment of the principal of
      (and premium, if any) and interest on such Security, as therein provided, on or after the respective due dates expressed in such Security (or in the case of redemption, on the redemption date), or to institute suit for the enforcement of any such
      payment on or after such respective dates or redemption date, shall not be impaired or affected without the consent of such holder and by accepting a Security hereunder it is expressly understood, intended and covenanted by the taker and holder of
      every Security of such series with every other such taker and holder and the Trustee, that no one or more holders of Securities of such series shall have any right in any manner whatsoever by virtue or by availing of any provision of this Indenture
      to affect, disturb or prejudice the rights of the holders of any other of such Securities, or to obtain or seek to obtain priority over or preference to any other such holder, or to enforce any right under this Indenture, except in the manner herein
      provided and for the equal, ratable and common benefit of all holders of Securities of such series.&#160; For the protection and enforcement of the provisions of this Section, each and every Securityholder and the Trustee shall be entitled to such relief
      as can be given either at law or in equity.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">25</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Rights and Remedies Cumulative; Delay or Omission Not Waiver</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Except as otherwise provided in Section 2.07, all powers and remedies given by this Article to the Trustee or to the
      Securityholders shall, to the extent permitted by law, be deemed cumulative and not exclusive of any other powers and remedies available to the Trustee or the holders of the Securities, by judicial proceedings or otherwise, to enforce the performance
      or observance of the covenants and agreements contained in this Indenture or otherwise established with respect to such Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;No delay or omission of the Trustee or of any holder of any of the Securities to exercise any right or power accruing upon any
      Event of Default occurring and continuing as aforesaid shall impair any such right or power, or shall be construed to be a waiver of any such default or an acquiescence therein; and, subject to the provisions of Section 6.04, every power and remedy
      given by this Article or by law to the Trustee or the Securityholders may be exercised from time to time, and as often as shall be deemed expedient, by the Trustee or by the Securityholders.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.06</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Control by Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">
      <div style="text-indent: 36pt; line-height: 1.25;">The holders of a majority in aggregate principal amount of the Securities of any series at the time Outstanding,
        determined in accordance with Section 8.04, shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee with respect to
        such series; provided, however, that such direction shall not be in conflict with any rule of law or with this Indenture or subject the Trustee in its sole discretion to personal liability.&#160; Subject to the provisions of Section 7.01, the Trustee
        shall have the right to decline to follow any such direction if the Trustee in good faith shall, by a Responsible Officer or officers of the Trustee, determine that the proceeding so directed, subject to the Trustee&#8217;s duties under the Trust
        Indenture Act, would involve the Trustee in personal liability or might be unduly prejudicial to the Securityholders not involved in the proceeding.&#160; The holders of a majority in aggregate principal amount of the Securities of any series at the
        time Outstanding affected thereby, determined in accordance with Section 8.04, may on behalf of the holders of all of the Securities of such series waive any past default in the performance of any of the covenants contained herein or established
        pursuant to Section 2.01 with respect to such series and its consequences, except a default in the payment of the principal of, or premium, if any, or interest on, any of the Securities of that series as and when the same shall become due by the
        terms of such Securities otherwise than by acceleration (unless such default has been cured and a sum sufficient to pay all matured installments of interest and principal and any premium has been deposited with the Trustee (in accordance with
        Section 6.01(c)), provided, however, that the holders of a majority in aggregate principal amount of the Securities of any series at the time Outstanding may rescind an
          acceleration and its consequences, including any related payment default that resulted from the acceleration.&#160; Upon any such waiver, the default covered thereby shall be deemed to be cured for all purposes of this Indenture and the
        Company, the Trustee and the holders of the Securities of such series shall be restored to their former positions and rights hereunder, respectively; but no such waiver shall extend to any subsequent or other default or impair any right consequent
        thereon.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">26</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 6.07</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Undertaking to Pay Costs</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All parties to this Indenture agree, and each holder of any Securities by such holder&#8217;s acceptance thereof shall be deemed to have agreed, that any court may in its discretion
      require, in any suit for the enforcement of any right or remedy under this Indenture, or in any suit against the Trustee for any action taken or omitted by it as Trustee, the filing by any party litigant in such suit of an undertaking to pay the
      costs of such suit, and that such court may in its discretion assess reasonable costs, including reasonable attorneys&#8217; fees and expenses, against any party litigant in such suit, having due regard to the merits and good faith of the claims or
      defenses made by such party litigant; but the provisions of this Section shall not apply to any suit instituted by the Trustee, to any suit instituted by any Securityholder, or group of Securityholders, holding more than 10% in aggregate principal
      amount of the Outstanding Securities of any series, or to any suit instituted by any Securityholder for the enforcement of the payment of the principal of (or premium, if any) or interest on any Security of such series, on or after the respective due
      dates expressed in such Security or established pursuant to this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 7<br>
      <br>
      CONCERNING THE TRUSTEE</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Certain Duties and Responsibilities of Trustee</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee, prior to the occurrence of an Event of Default with respect to the Securities of a series and after the curing of
      all Events of Default with respect to the Securities of that series that may have occurred, shall undertake to perform with respect to the Securities of such series such duties and only such duties as are specifically set forth in this Indenture, and
      no implied covenants shall be read into this Indenture against the Trustee.&#160; In case an Event of Default with respect to the Securities of a series has occurred (that has not been cured or waived), the Trustee shall exercise with respect to
      Securities of that series such of the rights and powers vested in it by this Indenture, and use the same degree of care and skill in their exercise, as a prudent man would exercise or use under the circumstances in the conduct of his or her own
      affairs.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;No provision of this Indenture shall be construed to relieve the Trustee from liability for its own negligent action, its own
      negligent failure to act, or its own willful misconduct, except that:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;prior to the occurrence of an Event of Default with respect to the Securities of a series and after the curing or waiving of
      all such Events of Default with respect to that series that may have occurred:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(A)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the duties and obligations of the Trustee shall with respect to the Securities of such series be determined solely by the
      express provisions of this Indenture, and the Trustee shall not be liable with respect to the Securities of such series except for the performance of such duties and obligations as are specifically set forth in this Indenture, and no implied
      covenants or obligations shall be read into this Indenture against the Trustee; and</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">27</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(B)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;in the absence of bad faith on the part of the Trustee, the Trustee may with respect to the Securities of such series
      conclusively rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon any certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture; but in the case of any such
      certificates or opinions that by any provision hereof are specifically required to be furnished to the Trustee, the Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Indenture;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(ii)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Trustee shall not be liable to any Securityholder or to any other Person for any error of judgment made in good faith by a
      Responsible Officer or Responsible Officers of the Trustee, unless it shall be proved that the Trustee was negligent in ascertaining the pertinent facts;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(iii)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Trustee shall not be liable with respect to any action taken or omitted to be taken by it in good faith in accordance
      with the direction of the holders of not less than a majority in principal amount of the Securities of any series at the time Outstanding relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or
      exercising any trust or power conferred upon the Trustee under this Indenture with respect to the Securities of that series;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(iv)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;none of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise
      incur personal financial liability in the performance of any of its duties or in the exercise of any of its rights or powers if there is reasonable ground for believing that the repayment of such funds or liability is not reasonably assured to it
      under the terms of this Indenture or adequate indemnity against such risk is not reasonably assured to it;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(v)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall not be required to give any bond or surety in respect of the performance of its powers or duties hereunder;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(vi)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The permissive right of the Trustee to do things enumerated in this Indenture shall not be construed as a duty of the Trustee;
      and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(vii)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;No Trustee shall have any duty or responsibility for any act or omission of any other Trustee appointed with respect to a
      series of Securities hereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Certain Rights of Trustee</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Except as otherwise provided in Section 7.01:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee may conclusively rely and shall be protected in acting or refraining from acting upon any resolution, certificate,
      statement, instrument, opinion, report, notice, request, consent, order, approval, bond, security or other paper or document believed by it to be genuine and to have been signed or presented by the proper party or parties;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Any request, direction, order or demand of the Company mentioned herein shall be sufficiently evidenced by a Board Resolution
      or an instrument signed in the name of the Company by any authorized Officer of the Company (unless other evidence in respect thereof is specifically prescribed herein);</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">28</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee may consult with counsel and the opinion or written advice of such counsel or, if requested, any Opinion of Counsel
      shall be full and complete authorization and protection in respect of any action taken or suffered or omitted hereunder in good faith and in reliance thereon;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request,
      order or direction of any of the Securityholders pursuant to the provisions of this Indenture, unless such Securityholders shall have offered to the Trustee security or indemnity reasonably acceptable to the Trustee against the costs, expenses and
      liabilities that may be incurred therein or thereby; nothing contained herein shall, however, relieve the Trustee of the obligation, upon the occurrence of an Event of Default with respect to a series of the Securities (that has not been cured or
      waived), to exercise with respect to Securities of that series such of the rights and powers vested in it by this Indenture, and to use the same degree of care and skill in their exercise, as a prudent man would exercise or use under the
      circumstances in the conduct of his or her own affairs;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall not be liable for any action taken or omitted to be taken by it in good faith and believed by it to be
      authorized or within the discretion or rights or powers conferred upon it by this Indenture;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate,
      statement, instrument, opinion, report, notice, request, consent, order, approval, bond, security, or other papers or documents or inquire as to the performance by the Company of one of its covenants under this Indenture, unless requested in writing
      so to do by the holders of not less than a majority in principal amount of the Outstanding Securities of the particular series affected thereby (determined as provided in Section 8.04); provided, however, that if the payment within a reasonable time
      to the Trustee of the costs, expenses or liabilities likely to be incurred by it in the making of such investigation is, in the opinion of the Trustee, not reasonably assured to the Trustee by the security afforded to it by the terms of this
      Indenture, the Trustee may require security or indemnity reasonably acceptable to the Trustee against such costs, expenses or liabilities as a condition to so proceeding.&#160; The reasonable expense of every such examination shall be paid by the Company
      or, if paid by the Trustee, shall be repaid by the Company upon demand;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through
      agents or attorneys and the Trustee shall not be responsible for any misconduct or negligence on the part of any agent or attorney appointed with due care by it hereunder;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(h)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its obligations hereunder
      arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of
      God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which are consistent with accepted practices in the banking
      industry to resume performance as soon as practicable under the circumstances;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">29</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In no event shall the Trustee be responsible or liable for special, indirect, punitive or consequential loss or damage of any
      kind whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action; and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(j)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee agrees to accept and act upon instructions or directions pursuant to this Indenture sent by unsecured e-mail,
      facsimile transmission or other similar unsecured electronic methods; provided, however, that such instructions or directions shall be signed by an authorized representative of the party providing such instructions or directions.&#160; If the party elects
      to give the Trustee e-mail or facsimile instructions (or instructions by a similar electronic method) and the Trustee in its discretion elects to act upon such instructions, the Trustee&#8217;s understanding of such instructions shall be deemed
      controlling.&#160; The Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee&#8217;s reliance upon and compliance with such instructions notwithstanding such instructions conflict or are inconsistent with
      a subsequent written instruction.&#160; The party providing electronic instructions agrees to assume all risks arising out of the use of such electronic methods to submit instructions and directions to the Trustee, including without limitation the risk of
      the Trustee acting on unauthorized instructions, and the risk or interception and misuse by third parties.&#160; The Trustee may request that the Company deliver an Officer&#8217;s Certificate setting forth the names of individuals and/or titles of officers
      authorized at such time to furnish the Trustee with Officer&#8217;s Certificates, Company Orders and any other matters or directions pursuant to this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(k)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to
      be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder and under the Securities, and each agent, custodian or other person employed to act under this Indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(l)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall not be deemed to have knowledge of any Default or Event of Default (other than an Event of Default
      constituting the failure to pay the interest on, or the principal of, the Securities if the Trustee also serves the paying agent for such Securities) until the Trustee shall have received written notification in the manner set forth in this Indenture
      or a Responsible Officer of the Trustee shall have obtained actual knowledge.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; <font style="font-weight: bold;">Trustee Not Responsible for Recitals or Issuance or Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The recitals contained herein and in the Securities shall be taken as the statements of the Company, and the Trustee assumes no
      responsibility for the correctness of the same.&#160; The Trustee shall not be responsible for any statement in any registration statement, prospectus, or any other document in connection with the sale of Securities. The Trustee shall not be responsible
      for any rating on the Securities or any action or omission of any rating agency.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee makes no representations as to the validity or sufficiency of this Indenture or of the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee shall not be accountable for the use or application by the Company of any of the Securities or of the proceeds of
      such Securities, or for the use or application of any moneys paid over by the Trustee in accordance with any provision of this Indenture or established pursuant to Section 2.01, or for the use or application of any moneys received by any paying agent
      other than the Trustee.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">30</font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">May Hold Securities</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Trustee or any paying agent or Security Registrar, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if
      it were not Trustee, paying agent or Security Registrar.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Moneys Held in Trust</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Subject to the provisions of Section 11.05, all moneys received by the Trustee shall, until used or applied as herein provided, be held in trust for the purposes for which they
      were received, but need not be segregated from other funds except to the extent required by law.&#160; The Trustee shall be under no liability for interest on any moneys received by it hereunder except such as it may agree with the Company to pay thereon.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.06</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Compensation and Reimbursement</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; The Company shall pay to the Trustee for each of its capacities hereunder from time to time compensation for its services as
      the Company and the Trustee shall from time to time agree upon in writing.&#160; The Trustee&#8217;s compensation shall not be limited by any law on compensation of a trustee of an express trust.&#160; The Company shall reimburse the Trustee upon request for all
      reasonable out-of-pocket expenses incurred by it.&#160; Such expenses shall include the reasonable compensation and expenses of the Trustee&#8217;s agents and counsel.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; The Company shall indemnify each of the Trustee in each of its capacities hereunder against any loss, liability or expense
      (including the cost of defending itself and including the reasonable compensation and expenses of the Trustee&#8217;s agents and counsel) incurred by it except as set forth in Section 7.06(c) in the exercise or performance of its powers, rights or duties
      under this Indenture as Trustee or Agent.&#160; The Trustee shall notify the Company promptly of any claim for which it may seek indemnity.&#160; The Company shall defend the claim and the Trustee shall cooperate in the defense.&#160; The Trustee may have one
      separate counsel and the Company shall pay the reasonable fees and expenses of such counsel.&#160; The Company need not pay for any settlement made without its consent, which consent shall not be unreasonably withheld.&#160; This indemnification shall apply to
      officers, directors, employees, shareholders and agents of the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; The Company need not reimburse any expense or indemnify against any loss or liability incurred by the Trustee or by any
      officer, director, employee, shareholder or agent of the Trustee through negligence or bad faith.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;To ensure the Company&#8217;s payment obligations in this Section, the Trustee shall have a lien prior to the Securities on all funds
      or property held or collected by the Trustee, except that held in trust to pay principal of or interest on particular Securities.&#160; When the Trustee incurs expenses or renders services in connection with an Event of Default specified in Section
      6.01(4) or (5), the expenses (including the reasonable fees and expenses of its counsel) and the compensation for services in connection therewith are to constitute expenses of administration under any bankruptcy law.&#160; The provisions of this Section
      7.06 shall survive the termination of this Indenture and the resignation or removal of the Trustee.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">31</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.07</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Reliance on Officer&#8217;s Certificate</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Except as otherwise provided in Section 7.01, whenever in the administration of the provisions of this Indenture the Trustee shall deem it reasonably necessary or desirable that a
      matter be proved or established prior to taking or suffering or omitting to take any action hereunder, such matter (unless other evidence in respect thereof be herein specifically prescribed) may, in the absence of negligence or bad faith on the part
      of the Trustee, be deemed to be conclusively proved and established by an Officer&#8217;s Certificate delivered to the Trustee and such certificate, in the absence of negligence or bad faith on the part of the Trustee, shall be full warrant to the Trustee
      for any action taken, suffered or omitted to be taken by it under the provisions of this Indenture upon the faith thereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.08</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Disqualification; Conflicting Interests</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If the Trustee has or shall acquire any &#8220;conflicting interest&#8221; within the meaning of Section 310(b) of the Trust Indenture Act, the Trustee and the Company shall in all respects
      comply with the provisions of Section 310(b) of the Trust Indenture Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.09</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Corporate Trustee Required; Eligibility</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">There shall at all times be a Trustee with respect to the Securities issued hereunder which shall at all times be a corporation organized and doing business under the laws of the
      United States of America or any state or territory thereof or of the District of Columbia, or a corporation or other Person permitted to act as trustee by the Commission, authorized under such laws to exercise corporate trust powers, having a
      combined capital and surplus of at least fifty million U.S. dollars ($50,000,000), and subject to supervision or examination by federal, state, territorial, or District of Columbia authority.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If such corporation or other Person publishes reports of condition at least annually, pursuant to law or to the requirements of the aforesaid supervising or examining authority,
      then for the purposes of this Section, the combined capital and surplus of such corporation or other Person shall be deemed to be its combined capital and surplus as set forth in its most recent report of condition so published.&#160; The Company may not,
      nor may any Person directly or indirectly controlling, controlled by, or under common control with the Company, serve as Trustee.&#160; In case at any time the Trustee shall cease to be eligible in accordance with the provisions of this Section, the
      Trustee shall resign immediately in the manner and with the effect specified in Section 7.10.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.10</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Resignation and Removal; Appointment of Successor</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Trustee or any successor hereafter appointed may at any time resign with respect to the Securities of one or more series by
      giving written notice thereof to the Company and the Securityholders of such series.&#160; Upon receiving such notice of resignation, the Company shall promptly appoint a successor trustee with respect to Securities of such series by written instrument,
      in duplicate, executed by order of the Board of Directors, one copy of which instrument shall be delivered to the resigning Trustee and one copy to the successor trustee.&#160; If no successor trustee shall have been so appointed and have accepted
      appointment within 30 days after the sending of such notice of resignation, the resigning Trustee may petition any court of competent jurisdiction for the appointment of a successor trustee with respect to Securities of such series, or any
      Securityholder of that series who has been a bona fide holder of a Security or Securities for at least six months may on behalf of himself and all others similarly situated, petition any such court for the appointment of a successor trustee.&#160; Such
      court may thereupon after such notice, if any, as it may deem proper and prescribe, appoint a successor trustee.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case at any time any one of the following shall occur:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Trustee shall fail to comply with the provisions of Section 7.08 after written request therefor by the Company or by any
      Securityholder who has been a bona fide holder of a Security or Securities for at least six months; or</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(ii)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; the Trustee shall cease to be eligible in accordance with the provisions of Section 7.09 and shall fail to resign after
      written request therefor by the Company or by any such Securityholder; or</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 108pt; line-height: 1.25;"><font style="font-weight: bold;">(iii)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; the Trustee shall become incapable of acting, or shall be adjudged a bankrupt or insolvent, or commence a voluntary bankruptcy
      proceeding, or a receiver of the Trustee or of its property shall be appointed or consented to, or any public officer shall take charge or control of the Trustee or of its property or affairs for the purpose of rehabilitation, conservation or
      liquidation;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">then, in any such case, the Company may remove the Trustee with respect to all Securities and appoint a successor trustee by written instrument, in duplicate, executed by order of
      the Board of Directors, one copy of which instrument shall be delivered to the Trustee so removed and one copy to the successor trustee, or any Securityholder who has been a bona fide holder of a Security or Securities for at least six months may, on
      behalf of that holder and all others similarly situated, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor trustee.&#160; Such court may thereupon after such notice, if any, as it may deem
      proper and prescribe, remove the Trustee and appoint a successor trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The holders of a majority in aggregate principal amount of the Securities of any series at the time Outstanding may at any time
      remove the Trustee with respect to such series by so notifying the Trustee and the Company and may appoint a successor Trustee for such series with the consent of the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Any resignation or removal of the Trustee and appointment of a successor trustee with respect to the Securities of a series
      pursuant to any of the provisions of this Section shall become effective upon acceptance of appointment by the successor trustee as provided in Section 7.11.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Any successor trustee appointed pursuant to this Section may be appointed with respect to the Securities of one or more series
      or all of such series, and at any time there shall be only one Trustee with respect to the Securities of any particular series.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">33</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.11</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Acceptance of Appointment By Successor</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case of the appointment hereunder of a successor trustee with respect to all Securities, every such successor trustee so
      appointed shall execute, acknowledge and deliver to the Company and to the retiring Trustee an instrument accepting such appointment, and thereupon the resignation or removal of the retiring Trustee shall become effective and such successor trustee,
      without any further act, deed or conveyance, shall become vested with all the rights, powers, trusts and duties of the retiring Trustee; but, on the request of the Company or the successor trustee, such retiring Trustee shall, upon payment of any
      amounts due to it pursuant to the provisions of Section 7.06, execute and deliver an instrument transferring to such successor trustee all the rights, powers, and trusts of the retiring Trustee and shall duly assign, transfer and deliver to such
      successor trustee all property and money held by such retiring Trustee hereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case of the appointment hereunder of a successor trustee with respect to the Securities of one or more (but not all) series,
      the Company, the retiring Trustee and each successor trustee with respect to the Securities of one or more series shall execute and deliver an indenture supplemental hereto wherein each successor trustee shall accept such appointment and which (i)
      shall contain such provisions as shall be necessary or desirable to transfer and confirm to, and to vest in, each successor trustee all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities of that or those
      series to which the appointment of such successor trustee relates, (ii) shall contain such provisions as shall be deemed necessary or desirable to confirm that all the rights, powers, trusts and duties of the retiring Trustee with respect to the
      Securities of that or those series as to which the retiring Trustee is not retiring shall continue to be vested in the retiring Trustee, and (iii) shall add to or change any of the provisions of this Indenture as shall be necessary to provide for or
      facilitate the administration of the trusts hereunder by more than one Trustee, it being understood that nothing herein or in such supplemental indenture shall constitute such Trustees co-trustees of the same trust, that each such Trustee shall be
      trustee of a trust or trusts hereunder separate and apart from any trust or trusts hereunder administered by any other such Trustee and that no Trustee shall be responsible for any act or failure to act on the part of any other Trustee hereunder; and
      upon the execution and delivery of such supplemental indenture the resignation or removal of the retiring Trustee shall become effective to the extent provided therein, such retiring Trustee shall with respect to the Securities of that or those
      series to which the appointment of such successor trustee relates have no further responsibility for the exercise of rights and powers or for the performance of the duties and obligations vested in the Trustee under this Indenture, and each such
      successor trustee, without any further act, deed or conveyance, shall become vested with all the rights, powers, trusts and duties of the retiring Trustee with respect to the Securities of that or those series to which the appointment of such
      successor trustee relates; but, on request of the Company or any successor trustee, such retiring Trustee shall duly assign, transfer and deliver to such successor trustee, to the extent contemplated by such supplemental indenture, the property and
      money held by such retiring Trustee hereunder with respect to the Securities of that or those series to which the appointment of such successor trustee relates.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Upon request of any such successor trustee, the Company shall execute any and all instruments for more fully and certainly
      vesting in and confirming to such successor trustee all such rights, powers and trusts referred to in paragraph (a) or (b) of this Section, as the case may be.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">34</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;No successor trustee shall accept its appointment unless at the time of such acceptance such successor trustee shall be
      qualified and eligible under this Article.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Upon acceptance of appointment by a successor trustee as provided in this Section, the Company shall send notice of the
      succession of such trustee hereunder to the Securityholders.&#160; If the Company fails to transmit such notice within ten days after acceptance of appointment by the successor trustee, the successor trustee shall cause such notice to be transmitted at
      the expense of the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.12</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Merger, Conversion, Consolidation or Succession to Business</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any corporation into which the Trustee may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to
      which the Trustee shall be a party, or any corporation succeeding to all or substantially all the corporate trust business of the Trustee, including the administration of the trust created by this Indenture, shall be the successor of the Trustee
      hereunder, provided that such corporation shall be qualified under the provisions of Section 7.08 and eligible under the provisions of Section 7.09, without the execution or filing of any paper or any further act on the part of any of the parties
      hereto, anything herein to the contrary notwithstanding.&#160; In case any Securities shall have been authenticated, but not delivered, by the Trustee then in office, any successor by merger, conversion or consolidation to such authenticating Trustee may
      adopt such authentication and deliver the Securities so authenticated with the same effect as if such successor Trustee had itself authenticated such Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 7.13</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Preferential Collection of Claims Against the Company</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Trustee shall comply with Section 311(a) of the Trust Indenture Act, excluding any creditor relationship described in Section 311(b) of the Trust Indenture Act.&#160; A Trustee who
      has resigned or been removed shall be subject to Section 311(a) of the Trust Indenture Act to the extent included therein.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold;">Section 7.14</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Notice of Default</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If any Event of Default occurs and is continuing and if such Event of Default is known to a Responsible Officer of the Trustee, the Trustee shall send to each Securityholder in the
      manner and to the extent provided in Section 313(c) of the Trust Indenture Act notice of the Event of Default within the earlier of 90 days after it occurs and 30 days after it is known to a Responsible Officer of the Trustee or written notice of it
      is received by the Trustee, unless such Event of Default has been cured; <font style="font-style: italic;">provided, however</font>, that, except in the case of a default in the payment of the principal of (or premium, if any) or interest on any
      Security, the Trustee shall be protected in withholding such notice if and so long as the Responsible Officers of the Trustee in good faith determine that the withholding of such notice is in the interest of the Securityholders.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">35</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 8<br>
      <br>
      CONCERNING THE SECURITYHOLDERS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 8.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Evidence of Action by Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Whenever in this Indenture it is provided that the holders of a majority or specified percentage in aggregate principal amount of the Securities of a particular series may take any
      action (including the making of any demand or request, the giving of any notice, consent or waiver or the taking of any other action), the fact that at the time of taking any such action the holders of such majority or specified percentage of that
      series have joined therein may be evidenced by any instrument or any number of instruments of similar tenor executed by such holders of Securities of that series in person or by agent or proxy appointed in writing.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If the Company shall solicit from the Securityholders of any series any request, demand, authorization, direction, notice, consent, waiver or other action, the Company may, at its
      option, as evidenced by an Officer&#8217;s Certificate, fix in advance a record date for such series for the determination of Securityholders entitled to give such request, demand, authorization, direction, notice, consent, waiver or other action, but the
      Company shall have no obligation to do so.&#160; If such a record date is fixed, such request, demand, authorization, direction, notice, consent, waiver or other action may be given before or after the record date, but only the Securityholders of record
      at the close of business on the record date shall be deemed to be Securityholders for the purposes of determining whether Securityholders of the requisite proportion of Outstanding Securities of that series have authorized or agreed or consented to
      such request, demand, authorization, direction, notice, consent, waiver or other action, and for that purpose the Outstanding Securities of that series shall be computed as of the record date; provided, however, that no such authorization, agreement
      or consent by such Securityholders on the record date shall be deemed effective unless it shall become effective pursuant to the provisions of this Indenture not later than six months after the record date.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 8.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Proof of Execution by Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Subject to the provisions of Section 7.01, proof of the execution of any instrument by a Securityholder (such proof will not require notarization) or his or her agent or proxy and
      proof of the holding by any Person of any of the Securities shall be sufficient if made in the following manner:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The fact and date of the execution by any such Person of any instrument may be proved in any reasonable manner acceptable to
      the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The ownership of Securities shall be proved by the Security Register of such Securities or by a certificate of the Security
      Registrar thereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">The Trustee may require such additional proof of any matter referred to in this Section as it shall deem necessary.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">36</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 8.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Who May be Deemed Owners</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Prior to the due presentment for registration of transfer of any Security, the Company, the Trustee, any paying agent and any Security Registrar may deem and treat the Person in
      whose name such Security shall be registered upon the books of the Security Registrar as the absolute owner of such Security (whether or not such Security shall be overdue and notwithstanding any notice of ownership or writing thereon made by anyone
      other than the Security Registrar) for the purpose of receiving payment of or on account of the principal of, premium, if any, and (subject to Section 2.03) interest on such Security and for all other purposes; and neither the Company nor the Trustee
      nor any paying agent nor any Security Registrar shall be affected by any notice to the contrary.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 8.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Certain Securities Owned by Company Disregarded</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In determining whether the holders of the requisite aggregate principal amount of Securities of a particular series have concurred in any direction, consent or waiver under this
      Indenture, the Securities of that series that are owned by the Company or any other obligor on the Securities of that series or by any Person directly or indirectly controlling or controlled by or under common control with the Company or any other
      obligor on the Securities of that series shall be disregarded and deemed not to be Outstanding for the purpose of any such determination, except that for the purpose of determining whether the Trustee shall be protected in relying on any such
      direction, consent or waiver, only Securities of such series that the Trustee actually knows are so owned shall be so disregarded.&#160; The Securities so owned that have been pledged in good faith may be regarded as Outstanding for the purposes of this
      Section, if the pledgee shall establish to the satisfaction of the Trustee the pledgee&#8217;s right so to act with respect to such Securities and that the pledgee is not a Person directly or indirectly controlling or controlled by or under direct or
      indirect common control with the Company or any such other obligor.&#160; In case of a dispute as to such right, any decision by the Trustee taken upon the advice of counsel shall be full protection to the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 8.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Actions Binding on Future Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">At any time prior to (but not after) the evidencing to the Trustee, as provided in Section 8.01, of the taking of any action by the holders of the majority or percentage in
      aggregate principal amount of the Securities of a particular series specified in this Indenture in connection with such action, any holder of a Security of that series that is shown by the evidence to be included in the Securities the holders of
      which have consented to such action may, by filing written notice with the Trustee, and upon proof of holding as provided in Section 8.02, revoke such action so far as concerns such Security.&#160; Except as aforesaid any such action taken by the holder
      of any Security shall be conclusive and binding upon such holder and upon all future holders and owners of such Security, and of any Security issued in exchange therefor, on registration of transfer thereof or in place thereof, irrespective of
      whether or not any notation in regard thereto is made upon such Security.&#160; Any action taken by the holders of the majority or percentage in aggregate principal amount of the Securities of a particular series specified in this Indenture in connection
      with such action shall be conclusively binding upon the Company, the Trustee and the holders of all the Securities of that series.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">37</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 9<br>
      <br>
      SUPPLEMENTAL INDENTURES</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 9.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Supplemental Indentures Without the Consent of Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In addition to any supplemental indenture otherwise authorized by this Indenture, the Company and the Trustee may from time to time and at any time enter into an indenture or
      indentures supplemental hereto (which shall conform to the provisions of the Trust Indenture Act as then in effect), without the consent of the Securityholders, for one or more of the following purposes:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to cure any ambiguity, defect, or inconsistency herein or in the Securities of any series;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to comply with Article Ten;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to provide for uncertificated Securities in addition to or in place of certificated Securities;</div>
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    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to add to the covenants, restrictions, conditions or provisions relating to the Company for the benefit of the holders of all
      or any series of Securities (and if such covenants, restrictions, conditions or provisions are to be for the benefit of less than all series of Securities, stating that such covenants, restrictions, conditions or provisions are expressly being
      included solely for the benefit of such series), to make the occurrence, or the occurrence and the continuance, of a default in any such additional covenants, restrictions, conditions or provisions an Event of Default, or to surrender any right or
      power herein conferred upon the Company;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to add to, delete from, or revise the conditions, limitations, and restrictions on the authorized amount, terms, or purposes of
      issue, authentication, and delivery of Securities, as herein set forth;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to make any change that does not adversely affect the rights of any Securityholder in any material respect;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to provide for the issuance of and establish the form and terms and conditions of the Securities of any series as provided in
      Section 2.01, to establish the form of any certifications required to be furnished pursuant to the terms of this Indenture or any series of Securities, or to add to the rights of the holders of any series of Securities;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(h)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to evidence and provide for the acceptance of appointment hereunder by a successor trustee; or</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;to comply with any requirements of the Commission or any successor in connection with the qualification of this Indenture under
      the Trust Indenture Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Trustee is hereby authorized to join with the Company in the execution of any such supplemental indenture, and to make any further appropriate agreements and stipulations that
      may be therein contained, but the Trustee shall not be obligated to enter into any such supplemental indenture that affects the Trustee&#8217;s own rights, duties or immunities under this Indenture or otherwise.</div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any supplemental indenture authorized by the provisions of this Section may be executed by the Company and the Trustee without the consent of the holders of any of the Securities
      at the time Outstanding, notwithstanding any of the provisions of Section 9.02.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 9.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Supplemental Indentures With Consent of Securityholders</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">
      <div style="text-indent: 36pt; line-height: 1.25;">With the consent (evidenced as provided in Section 8.01) of the holders of not less than a majority in aggregate
        principal amount of the Securities of each series (or, at a meeting of holders of such series at which a quorum is present, the holders of a majority in principal amount
          of the Securities of each such series represented at such meeting) affected by such supplemental indenture or indentures at the time Outstanding, the Company, when authorized by a Board Resolution, and the Trustee may from time to time and
        at any time enter into an indenture or indentures supplemental hereto (which shall conform to the provisions of the Trust Indenture Act as then in effect) for the purpose of adding any provisions to or changing in any manner or eliminating any of
        the provisions of this Indenture or of any supplemental indenture or of modifying in any manner not covered by Section 9.01 the rights of the holders of the Securities of such series under this Indenture; provided, however, that no such
        supplemental indenture shall, without the consent of the holders of each Security then Outstanding and affected thereby, (a) extend the fixed maturity of any Securities of any series, or reduce the principal amount thereof, or reduce the rate or
        extend the time of payment of interest thereon, or reduce any premium payable upon the redemption thereof or (b) reduce the aforesaid percentage of Securities, the holders of which are required to consent to any such supplemental indenture.</div>
      <div style="line-height: 1.25">&#160;</div>
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">It shall not be necessary for the consent of the Securityholders of any series affected thereby under this Section to approve the particular form of any proposed supplemental
      indenture, but it shall be sufficient if such consent shall approve the substance thereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 9.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Effect of Supplemental Indentures</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Upon the execution of any supplemental indenture pursuant to the provisions of this Article or of Section 10.01, this Indenture shall, with respect to such series, be and be deemed
      to be modified and amended in accordance therewith and the respective rights, limitations of rights, obligations, duties and immunities under this Indenture of the Trustee, the Company and the holders of Securities of the series affected thereby
      shall thereafter be determined, exercised and enforced hereunder subject in all respects to such modifications and amendments, and all the terms and conditions of any such supplemental indenture shall be and be deemed to be part of the terms and
      conditions of this Indenture for any and all purposes.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 9.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Securities Affected by Supplemental Indentures</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Securities of any series affected by a supplemental indenture, authenticated and delivered after the execution of such supplemental indenture pursuant to the provisions of this
      Article or of Section 10.01, may bear a notation in form approved by the Company, provided such form meets the requirements of any securities exchange upon which such series may be listed, as to any matter provided for in such supplemental
      indenture.&#160; If the Company shall so determine, new Securities of that series so modified as to conform, in the opinion of the Board of Directors, to any modification of this Indenture contained in any such supplemental indenture may be prepared by
      the Company, authenticated by the Trustee and delivered in exchange for the Securities of that series then Outstanding.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">39</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 9.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Execution of Supplemental Indentures</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Upon the request of the Company, accompanied by its Board Resolutions authorizing the execution of any such supplemental indenture, and upon the filing with the Trustee of evidence
      of the consent of Securityholders required to consent thereto as aforesaid, the Trustee shall join with the Company in the execution of such supplemental indenture unless such supplemental indenture affects the Trustee&#8217;s own rights, duties or
      immunities under this Indenture or otherwise, in which case the Trustee may in its discretion but shall not be obligated to enter into such supplemental indenture. The Trustee, subject to the provisions of Section 7.01, shall receive an Officer&#8217;s
      Certificate or an Opinion of Counsel as conclusive evidence that any supplemental indenture executed pursuant to this Article is authorized or permitted by the terms of this Article and that all conditions precedent to the execution of the
      supplemental indenture have been complied with; provided, however, that such Officer&#8217;s Certificate or Opinion of Counsel need not be provided in connection with the execution of a supplemental indenture that establishes the terms of a series of
      Securities pursuant to Section 2.01 hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Promptly after the execution by the Company and the Trustee of any supplemental indenture pursuant to the provisions of this Section, the Company shall (or shall direct the Trustee
      to) send a notice, setting forth in general terms the substance of such supplemental indenture, to the Securityholders of all series affected thereby .as their names and addresses appear upon the Security Register. Any failure of the Company to send,
      or cause the sending of, such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such supplemental indenture.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 10<br>
      <br>
      SUCCESSOR ENTITY</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold;">Section 10.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Company May Consolidate, Etc.</font></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Nothing contained in this Indenture shall prevent any consolidation or merger of the Company with or into any other Person (whether or not affiliated with the Company) or
      successive consolidations or mergers in which the Company or its successor or successors shall be a party or parties, or shall prevent any sale, conveyance, transfer or other disposition of the property of the Company or its successor or successors
      as an entirety, or substantially as an entirety, to any other Person (whether or not affiliated with the Company or its successor or successors); provided, however, the Company hereby covenants and agrees that, upon any such consolidation or merger
      (in each case, if the Company is not the survivor of such transaction) or any such sale, conveyance, transfer or other disposition (other than a sale, conveyance, transfer or other disposition to a Subsidiary of the Company), the due and punctual
      payment of the principal of (premium, if any) and interest on all of the Securities of all series in accordance with the terms of each series, according to their tenor, and the due and punctual performance and observance of all the covenants and
      conditions of this Indenture with respect to each series or established with respect to such series pursuant to Section 2.01 to be kept or performed by the Company shall be expressly assumed, by supplemental indenture (which shall conform to the
      provisions of the Trust Indenture Act, as then in effect) reasonably satisfactory in form to the Trustee executed and delivered to the Trustee by the entity formed by such consolidation, or into which the Company shall have been merged, or by the
      entity which shall have acquired such property.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">40</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 10.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Successor Entity Substituted</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case of any such consolidation, merger, sale, conveyance, transfer or other disposition and upon the assumption by the
      successor entity by supplemental indenture, executed and delivered to the Trustee and satisfactory in form to the Trustee, of the obligations set forth under Section 10.01 on all of the Securities of all series Outstanding, such successor entity
      shall succeed to and be substituted for the Company with the same effect as if it had been named as the Company herein, and thereupon the predecessor corporation shall be relieved of all obligations and covenants under this Indenture and the
      Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;In case of any such consolidation, merger, sale, conveyance, transfer or other disposition, such changes in phraseology and
      form (but not in substance) may be made in the Securities thereafter to be issued as may be appropriate.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Nothing contained in this Article shall require any action by the Company in the case of a consolidation or merger of any
      Person into the Company where the Company is the survivor of such transaction, or the acquisition by the Company, by purchase or otherwise, of all or any part of the property of any other Person (whether or not affiliated with the Company).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 11<br>
      <br>
      SATISFACTION AND DISCHARGE</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 11.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Satisfaction and Discharge of Indenture</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If at any time: (a) the Company shall have delivered to the Trustee for cancellation all Securities of a series theretofore authenticated and not delivered to the Trustee for
      cancellation (other than any Securities that shall have been destroyed, lost or stolen and that shall have been replaced or paid as provided in Section 2.07 and Securities for whose payment money or Governmental Obligations have theretofore been
      deposited in trust or segregated and held in trust by the Company and thereupon repaid to the Company or discharged from such trust, as provided in Section 11.05); or (b) all such Securities of a particular series not theretofore delivered to the
      Trustee for cancellation shall have become due and payable, or are by their terms to become due and payable within one year or are to be called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of
      redemption, and the Company shall deposit or cause to be deposited with the Trustee as trust funds the entire amount in moneys or Governmental Obligations or a combination thereof, sufficient in the opinion of a nationally recognized firm of
      independent public accountants expressed in a written certification thereof delivered to the Trustee, to pay at maturity or upon redemption all Securities of that series not theretofore delivered to the Trustee for cancellation, including principal
      (and premium, if any) and interest due or to become due to such date of maturity or date fixed for redemption, as the case may be, and if the Company shall also pay or cause to be paid all other sums payable hereunder with respect to such series by
      the Company then this Indenture shall thereupon cease to be of further effect with respect to such series except for the provisions of Sections 2.03, 2.05, 2.07, 4.01, 4.02, 4.03, 7.10, 11.5 and 13.04, that shall survive until the date of maturity or
      redemption date, as the case may be, and Sections 7.06 and 11.05, that shall survive to such date and thereafter, and the Trustee, on demand of the Company and at the cost and expense of the Company shall execute proper instruments acknowledging
      satisfaction of and discharging this Indenture with respect to such series.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 11.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Discharge of Obligations</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If at any time all such Securities of a particular series not heretofore delivered to the Trustee for cancellation or that have not become due and payable as described in Section
      11.01 shall have been paid by the Company by depositing irrevocably with the Trustee as trust funds moneys or an amount of Governmental Obligations sufficient to pay at maturity or upon redemption all such Securities of that series not theretofore
      delivered to the Trustee for cancellation, including principal (and premium, if any) and interest due or to become due to such date of maturity or date fixed for redemption, as the case may be, and if the Company shall also pay or cause to be paid
      all other sums payable hereunder by the Company with respect to such series, then after the date such moneys or Governmental Obligations, as the case may be, are deposited with the Trustee the obligations of the Company under this Indenture with
      respect to such series shall cease to be of further effect except for the provisions of Sections 2.03, 2.05, 2.07, 4,01, 4.02, 4,03, 7.06, 7.10, 11.05 and 13.04 hereof that shall survive until such Securities shall mature and be paid.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Thereafter, Sections 7.06 and 11.05 shall survive.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 11.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Deposited Moneys to be Held in Trust</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All moneys or Governmental Obligations deposited with the Trustee pursuant to Sections 11.01 or 11.02 shall be held in trust and shall be available for payment as due, either
      directly or through any paying agent (including the Company acting as its own paying agent), to the holders of the particular series of Securities for the payment or redemption of which such moneys or Governmental Obligations have been deposited with
      the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 11.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Payment of Moneys Held by Paying Agents</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In connection with the satisfaction and discharge of this Indenture all moneys or Governmental Obligations then held by any paying agent under the provisions of this Indenture
      shall, upon demand of the Company, be paid to the Trustee and thereupon such paying agent shall be released from all further liability with respect to such moneys or Governmental Obligations.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 11.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Repayment to Company</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any moneys or Governmental Obligations deposited with any paying agent or the Trustee, or then held by the Company, in trust for payment of principal of or premium, if any, or
      interest on the Securities of a particular series that are not applied but remain unclaimed by the holders of such Securities for at least two years after the date upon which the principal of (and premium, if any) or interest on such Securities shall
      have respectively become due and payable, or such other shorter period set forth in applicable escheat or abandoned or unclaimed property law, shall be repaid to the Company on May 31 of each year or upon the Company&#8217;s request or (if then held by the
      Company) shall be discharged from such trust; and thereupon the paying agent and the Trustee shall be released from all further liability with respect to such moneys or Governmental Obligations, and the holder of any of the Securities entitled to
      receive such payment shall thereafter, as a general creditor, look only to the Company for the payment thereof.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">42</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 12<br>
      <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> IMMUNITY OF INCORPORATORS, STOCKHOLDERS, OFFICERS AND </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">DIRECTORS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 12.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">No Recourse</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">No recourse under or upon any obligation, covenant or agreement of this Indenture, or of any Security, or for any claim based thereon or otherwise in respect thereof, shall be had
      against any incorporator, stockholder, officer or director, past, present or future as such, of the Company or of any predecessor or successor corporation, either directly or through the Company or any such predecessor or successor corporation,
      whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that this Indenture and the obligations issued hereunder are solely corporate obligations,
      and that no such personal liability whatever shall attach to, or is or shall be incurred by, the incorporators, stockholders, officers or directors as such, of the Company or of any predecessor or successor corporation, or any of them, because of the
      creation of the indebtedness hereby authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities or implied therefrom; and that any and all such personal liability of every name
      and nature, either at common law or in equity or by constitution or statute, of, and any and all such rights and claims against, every such incorporator, stockholder, officer or director as such, because of the creation of the indebtedness hereby
      authorized, or under or by reason of the obligations, covenants or agreements contained in this Indenture or in any of the Securities or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration for, the
      execution of this Indenture and the issuance of such Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">ARTICLE 13<br style="line-height: 1.25;">
      <br>
      MISCELLANEOUS PROVISIONS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.01</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Effect on Successors and Assigns</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">All the covenants, stipulations, promises and agreements in this Indenture made by or on behalf of the Company shall bind its successors and assigns, whether so expressed or not.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.02</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Actions by Successor</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Any act or proceeding by any provision of this Indenture authorized or required to be done or performed by any board, committee or officer of the Company shall and may be done and
      performed with like force and effect by the corresponding board, committee or officer of any corporation that shall at the time be the lawful successor of the Company.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.03</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Surrender of Company Powers</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company by instrument in writing executed by authority of its Board of Directors and delivered to the Trustee may surrender any of the powers reserved to the Company, and
      thereupon such power so surrendered shall terminate both as to the Company and as to any successor corporation.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.04</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Notices</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Except as otherwise expressly provided herein, any notice, request or demand that by any provision of this Indenture is required or permitted to be given, made or served by the
      Trustee, the Security Registrar, any paying or other agent under this Indenture or by the holders of Securities or by any other Person pursuant to this Indenture to or on the Company may be given or served by being deposited in first class mail,
      postage prepaid, addressed (until another address is filed in writing by the Company with the Trustee), as follows:<u>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</u>.&#160; Any notice,
      election, request or demand by the Company or any Securityholder or by any other Person pursuant to this Indenture to or upon the Trustee shall be deemed to have been sufficiently given or made, for all purposes, if given or made in writing at the
      Corporate Trust Office of the Trustee.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.05</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Governing Law; Jury Trial Waiver</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This Indenture and each Security shall be governed by, and construed in accordance with, the internal laws of the State of New York, except to the extent that the Trust Indenture
      Act is applicable.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">EACH PARTY HERETO, AND EACH HOLDER OF A SECURITY BY ACCEPTANCE THEREOF, HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY
      IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS INDENTURE.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.06</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Treatment of Securities as Debt</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">It is intended that the Securities will be treated as indebtedness and not as equity for federal income tax purposes.&#160; The provisions of this Indenture shall be interpreted to
      further this intention.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.07</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Certificates and Opinions as to Conditions Precedent</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Upon any application or demand by the Company to the Trustee to take any action under any of the provisions of this Indenture,
      the Company shall furnish to the Trustee an Officer&#8217;s Certificate stating that all conditions precedent provided for in this Indenture (other than the certificate to be delivered pursuant to Section 13.12) relating to the proposed action have been
      complied with and, if requested, an Opinion of Counsel stating that in the opinion of such counsel all such conditions precedent have been complied with, except that in the case of any such application or demand as to which the furnishing of such
      documents is specifically required by any provision of this Indenture relating to such particular application or demand, no additional certificate or opinion need be furnished.</div>
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      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">44</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-weight: bold;">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Each certificate or opinion provided for in this Indenture and delivered to the Trustee with respect to compliance with a
      condition or covenant in this Indenture (other than the certificate to be delivered pursuant to Section 13.12 of this Indenture or Section 314(a)(1) of the Trust Indenture Act) shall include (i) a statement that the Person making such certificate or
      opinion has read such covenant or condition; (ii) a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based; (iii) a statement that, in
      the opinion of such Person, he has made such examination or investigation as is reasonably necessary to enable him to express an informed opinion as to whether or not such covenant or condition has been complied with; and (iv) a statement as to
      whether or not, in the opinion of such Person, such condition or covenant has been complied with.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.08</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Payments on Business Days</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Except as provided pursuant to Section 2.01 pursuant to a Board Resolution, and set forth in an Officer&#8217;s Certificate, or established in one or more indentures supplemental to this
      Indenture, in any case where the date of maturity of interest or principal of any Security or the date of redemption of any Security shall not be a Business Day, then payment of interest or principal (and premium, if any) may be made on the next
      succeeding Business Day with the same force and effect as if made on the nominal date of maturity or redemption, and no interest shall accrue for the period after such nominal date.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.09</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Conflict with Trust Indenture Act</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">If and to the extent that any provision of this Indenture limits, qualifies or conflicts with the duties imposed by Section 318(c) of the Trust Indenture Act, such imposed duties
      shall control.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.10</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Counterparts</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This Indenture may be executed in any number of counterparts, each of which shall be an original, but such counterparts shall together constitute but one and the same instrument.&#160;
      The exchange of copies of this Indenture and of signature pages by facsimile or PDF transmission shall constitute effective execution and delivery of this Indenture as to the parties hereto and may be used in lieu of the original Indenture for all
      purposes. Signatures of the parties hereto transmitted by facsimile or PDF shall be deemed to be their original signatures for all purposes.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.11</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Separability</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In case any one or more of the provisions contained in this Indenture or in the Securities of any series shall for any reason be held to be invalid, illegal or unenforceable in any
      respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Indenture or of such Securities, but this Indenture and such Securities shall be construed as if such invalid or illegal or unenforceable provision
      had never been contained herein or therein.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.12</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Compliance Certificates</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Company shall deliver to the Trustee, within 120 days after the end of each fiscal year during which any Securities of any series were outstanding, an officer&#8217;s certificate
      stating whether or not the signers know of any Event of Default that occurred during such fiscal year.&#160; Such certificate shall contain a certification from the principal executive officer, principal financial officer or principal accounting officer
      of the Company that a review has been conducted of the activities of the Company and the Company&#8217;s performance under this Indenture and that the Company has complied with all conditions and covenants under this Indenture.&#160; For purposes of this
      Section 13.12, such compliance shall be determined without regard to any period of grace or requirement of notice provided under this Indenture.&#160; If the officer of the Company signing such certificate has knowledge of such an Event of Default, the
      certificate shall describe any such Event of Default and its status.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">45</font></div>
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        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.13</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">U.S.A Patriot Act</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The parties hereto acknowledge that in accordance with Section 326 of the U.S.A. Patriot Act, the Trustee, like all financial institutions and in order to help fight the funding of
      terrorism and money laundering, is required to obtain, verify, and record information that identifies each person or legal entity that establishes a relationship or opens an account with the Trustee.&#160; The parties to this Indenture agree that they
      will provide the Trustee with such information as it may request in order for the Trustee to satisfy the requirements of the U.S.A. Patriot Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.14</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Force Majeure</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In no event shall the Trustee, the Security Registrar, any paying agent or any other agent under this Indenture be responsible or liable for any failure or delay in the performance
      of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or
      natural catastrophes or acts of God, and interruptions, loss or malfunctions or utilities, communications or computer (software and hardware) services; it being understood that the Trustee, the Security Registrar, any paying agent or any other agent
      under this Indenture shall use reasonable efforts which are consistent with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Section 13.15</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Table of Contents; Headings</font>.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The table of contents and headings of the articles and sections of this Indenture have been inserted for convenience of reference only, are not intended to be considered a part
      hereof, and will not modify or restrict any of the terms or provisions hereof.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold; font-variant: small-caps;">In Witness Whereof</font>, the parties hereto have caused this Indenture to be duly executed all as of the day and year
      first above written.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25">
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" id="z9dd6170f77d04362876946e339764507">

          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>
                <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps; font-weight: bold;">Compugen Ltd.</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;" rowspan="1">&#160;</td>
            <td style="width: 50%;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>By: ______________________________ <br>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>Name:____________________________</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>Title: _____________________________</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold; font-variant: small-caps;">[Trustee]</font>, as Trustee</div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>
                <div>By: ______________________________ </div>
              </div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>Name:____________________________</div>
            </td>
          </tr>
          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50.00%;">
              <div>Title: _____________________________</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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    </div>
    <div style="text-align: justify; margin-left: 216pt; line-height: 1.25;">&#160;&#160; <br>
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">CROSS-REFERENCE TABLE (1)</div>
    <div style="line-height: 1.25">&#160;</div>
    <table cellspacing="0" cellpadding="0" id="za1650ebf6a2e4ccda065d549bf1e15b9" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 70%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Section of Trust Indenture Act of 1939, as Amended</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom; padding-bottom: 2px;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Section of Indenture</div>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">310(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.09</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
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          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.08</div>
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        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.10</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">310(c)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">Inapplicable</div>
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        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">311(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.13</div>
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        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">311(b)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.13</div>
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        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">311(c)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">Inapplicable</div>
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        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">312(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.01</div>
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        <tr>
          <td style="width: 70%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.02(a)</div>
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        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">312(b)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
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        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">312(c)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.02(c)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">313(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.04(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">313(b)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.04(b)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">313(c)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.04(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.04(b)</div>
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        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">313(d)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.04(c)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">314(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">5.03</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">13.12</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">314(b)</div>
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          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
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            <div style="text-align: justify; line-height: 1.25;">Inapplicable</div>
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        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
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          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">13.07(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">314(d)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">Inapplicable</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">314(e)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
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        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">314(f)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">Inapplicable</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">315(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.01(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.01(b)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">315(b)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">315(c)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.01</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">315(d)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">7.01(b)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">315(e)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">6.07</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">316(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">6.06</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">8.04</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">316(b)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">6.04</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">316(c)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">8.01</div>
          </td>
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          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">317(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">6.02</div>
          </td>
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        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">317(b)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">4.03</div>
          </td>
        </tr>
        <tr>
          <td style="width: 70%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">318(a)</div>
          </td>
          <td style="width: 1%; vertical-align: top;" colspan="1">&#160;</td>
          <td style="width: 29%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25;">13.09</div>
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    <div style="text-align: justify; line-height: 1.25;">_________________</div>
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          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>This Cross-Reference Table does not constitute part of the Indenture and shall not have any bearing on the interpretation of any of its terms or provisions.</div>
          </td>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>exhibit_5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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        <div>
          <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
        <div style="text-align: right;"><u><font style="font-weight: bold;"> <br>
            </font></u></div>
        <div style="text-align: right;"><u><font style="font-weight: bold;">Exhibit 5.1</font></u><br>
        </div>
        <div><br>
        </div>
        <img width="172" height="74" src="image00001.jpg"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="text-align: center; line-height: 1.25;">Tel Aviv, July 30, 2020</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Compugen Ltd.</div>
    <div style="line-height: 1.25;">Azrieli Center, 26 Harokmim Street, Building D</div>
    <div style="line-height: 1.25;">Holon 5885849</div>
    <div style="line-height: 1.25;"><u>Israel</u></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Re: <u>Compugen Ltd. - Registration Statement on Form F-3 for the Offer and Sale of Securities</u></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">We have acted as Israeli counsel to Compugen Ltd., a company limited by shares organized under the laws of the state of Israel (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;),
      in connection with the Registration Statement on Form F-3 (the &#8220;<font style="font-weight: bold;">Registration</font>&#160;<font style="font-weight: bold;">Statement</font>&#8221;) to be filed by the Company with the Securities and Exchange Commission under the
      Securities Act of 1933 (the &#8220;<font style="font-weight: bold;">Act</font>&#8221;), as amended, on or about the date hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">The Registration Statement contains (i) a base prospectus which relates to the proposed offer and sale by the Company from
        time to time, as set forth in the base prospectus contained in the Registration Statement (the &#8220;<font style="font-weight: bold;">Base Prospectus</font>&#8221;) and as shall be set
        forth in one or more supplements to the Base Prospectus (each, a &#8220;<font style="font-weight: bold;">Base Prospectus Supplement</font>&#8221;), of an aggregate amount of any or all of
        the following securities (the &#8220;<font style="font-weight: bold;">Securities</font>&#8221;): (a) ordinary shares, nominal (par) value NIS 0.01 per share, of the Company (the &#8220;<font style="font-weight: bold;">Ordinary Shares</font>&#8221;); (b) senior or subordinated debt securities of the Company (the &#8220;<font style="font-weight: bold;">Debt Securities</font>&#8221;) to be issued by the Company pursuant to an indenture (an &#8220;<font style="font-weight: bold;">Indenture</font>&#8221;)
        to be executed by the Company and the relevant trustee under the Indenture; (c) rights to purchase any of the Company&#8217;s Securities or any combination thereof (the &#8220;<font style="font-weight: bold;">Rights</font>&#8221;); (d) warrants to purchase Ordinary Shares (the &#8220;<font style="font-weight: bold;">Warrants</font>"); and (e) units to purchase Ordinary
        Shares, Debt Securities, Rights, Warrants or any combination of such Securities (the &#8220;<font style="font-weight: bold;">Units</font>&#8221;); and (ii) a warrant share prospectus
        covering the offering, issuance and sale by the Company of up to 749,104 Ordinary Shares (the &#8220;<font style="font-weight: bold;">Warrant Shares</font>&#8221;) that may be issued and sold upon the exercise of certain outstanding warrants (the &#8220;<font style="font-weight: bold;">Outstanding Warrants</font>&#8221;) for an aggregate exercise price of up to US$ 3,550,753, as set forth in the warrant share prospectus
        contained in the Registration Statement (the &#8220;<font style="font-weight: bold;">Warrant Prospectus</font>&#8221;) and as shall be set forth in one or more supplements to the Warrant
        Prospectus (each, a &#8220;<font style="font-weight: bold;">Warrant Prospectus Supplement</font>&#8221;).</div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="background-color: #FFFFFF;">All Securities that may be offered, issued and sold by the Company under the Base Prospectus and the Warrant Prospectus have all together
        an aggregate offering price of up to $350,000,000.</font></div>
    <div style="background-color: #FFFFFF; line-height: 1.25;">
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The Rights may be issued under a standby underwriting arrangement between the Company and one or more underwriters pursuant to which such underwriters will purchase any offered
        Securities remaining unsubscribed for after such Rights offering (the &#8220;<font style="font-weight: bold;">Rights</font>&#160;<font style="font-weight: bold;">Agreement</font>&#8221;), and a Rights agent that may act solely as the Company&#8217;s agent in connection
        with the Rights offering may be appointed (the &#8220;<font style="font-weight: bold;">Rights</font>&#160;<font style="font-weight: bold;">Agent</font>&#8221;). Any series of Warrants covered by the Base Prospectus may be issued under a separate warrant agreement
        (the &#8220;<font style="font-weight: bold;">Warrant</font>&#160;<font style="font-weight: bold;">Agreement</font>&#8221;) which may be entered into between the Company and a warrant agent (the &#8220;<font style="font-weight: bold;">Warrant</font>&#160;<font style="font-weight: bold;">Agent</font>&#8221;). The Units may be issued under a unit agreement (the &#8220;<font style="font-weight: bold;">Unit</font>&#160;<font style="font-weight: bold;">Agreement</font>&#8221;) between the Company and a unit agent (the &#8220;<font style="font-weight: bold;">Unit</font>&#160;<font style="font-weight: bold;">Agent</font>&#8221;).</div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This opinion is being furnished in accordance with the requirements of Item 601(b)(5)(i) of Regulation S-K.</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">In our capacity as your Israeli counsel in connection with your preparation and filing of the Registration Statement, we have examined and relied without investigation as to
      matters of fact upon the Registration Statement and the exhibits thereto, and upon such certificates, statements and results of inquiries of public officials and office holders and representatives of the Company and originals or copies, certified or
      otherwise identified to our satisfaction, of such other documents, corporate records, certificates and instruments as we have deemed necessary or appropriate to enable us to render the opinions expressed herein. We have assumed the genuineness of all
      signatures on all documents examined by us, the legal competence and capacity of all natural persons, the correctness and completeness of certificates of public officials and the representations set forth therein, the authenticity of all documents
      submitted to us as originals and the conformity to authentic original documents of all documents submitted to us as copies. As to any facts material to the opinions expressed herein which were not independently established or verified, we have relied
      upon oral or written statements and representations of officers and other representatives of the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="background-color: #FFFFFF;">We have further assumed that: (i) at the time of execution, issuance and delivery of any Rights, the related Rights Agreement will have
        been duly authorized, executed and delivered by the parties thereto and will be the valid and legally binding obligation of the Rights Agent, enforceable against such party in accordance with its terms; (ii) at the time of execution, issuance and
        delivery of any Warrants covered by the Registration Statement, the related Warrant Agreement will have been duly authorized, executed and delivered by the Company and the Warrant Agent and will be the valid and legally binding obligation of the
        Warrant Agent, enforceable against such party in accordance with its terms; </font>(iii)<font style="background-color: #FFFFFF;"> at the time of execution, issuance and delivery of the Units, the Unit Agreement will have been duly authorized,
        executed and delivered by the Company and the Unit Agent and will be the valid and legally binding obligation of the Unit Agent, enforceable against such party in accordance with its terms; (iv) at the time of issuance and delivery of any Ordinary
        Shares upon exercise of the warrants covered by the Warrant Prospectus, the warrants will be in full force and effect and the holders thereof shall have the legal right to exercise them pursuant to their terms; (v) at the time of the issuance and
        sale of any of the Securities, the terms of such Securities, and their issuance and sale, will have been established so as not to violate any applicable law or result in a default under or breach of any agreement or instrument binding upon the
        Company and so as to comply with any requirement or restriction imposed by any court or governmental body having jurisdiction over the Company; (vi) at the time of execution, issuance and delivery of any of the Securities, this Registration
        Statement shall be effective under the Securities Act; and (vii) at the time of execution, issuance and delivery of any of the Securities, an appropriate Prospectus Supplement with respect to the offering of such Securities will have been delivered
        and filed in compliance with the Securities Act and the applicable rules and regulations thereunder.</font></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="background-color: #FFFFFF;">For the purpose of the opinions expressed below, we have assumed further that after the issuance of the Ordinary Shares pursuant to the
        Registration Statement, the total number of issued Ordinary Shares, together with the total number of Ordinary Shares reserved for issuance upon the exercise, exchange or conversion, as the case may be, of any exercisable, exchangeable or
        convertible security then outstanding, will not exceed the authorized share capital under the Company&#8217;s Articles of Association.</font></div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;"><font style="background-color: #FFFFFF;">Based upon the foregoing, in reliance thereon and subject to the assumptions, comments, qualifications, limitations and exceptions stated
        herein and the effectiveness of the Registration Statement under the Act, we are of the opinion that:</font></div>
    <div style="background-color: #FFFFFF; line-height: 1.25;">
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;With respect to the Ordinary Shares, assuming the taking of all necessary corporate action to authorize and approve the issuance of any Ordinary Shares, the terms
        of the offering thereof and related matters, upon payment of the consideration therefor provided for in the applicable definitive purchase, underwriting or similar agreement approved by the board of directors and otherwise in accordance with the
        provisions of the applicable convertible Securities, if any, such Ordinary Shares will be validly issued, fully paid and non-assessable.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">2.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; With respect to the Rights, assuming the: (a) taking of all necessary corporate action to authorize and approve the issuance and terms of any Rights, the terms of
        the offering thereof and related matters; and (b) due authorization, execution, issuance and delivery, in accordance with the terms of the applicable underwriting or other agreement&#160;approved&#160;by the Board of Directors and otherwise in accordance with the provisions of the applicable Rights Agreement, the
          Rights will constitute valid and binding obligations of the Company.</div>
      <div style="text-align: center;"><br>
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      <div style="text-align: center;"><font style="font-family: 'Times New Roman',Times,serif;">2<br>
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      <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">3.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; With respect to the Warrants, assuming the (a) taking of all necessary corporate action to authorize and approve the issuance and terms of any Warrants, the terms
        of the offering thereof and related matters; and (b) due execution, authentication, issuance and delivery of such Warrants upon payment of the consideration therefor provided for in the applicable definitive purchase, underwriting or similar
        agreement approved by the board of directors and otherwise in accordance with the provisions of the applicable Warrant Agreement, such Warrants will constitute valid and binding obligations of the Company.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">4.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; With respect to the Units, assuming the: (a) taking of all necessary corporate action to authorize and approve the issuance and the terms of the Units, the related
        Unit Agreement and any Securities which are components of the Units, the terms of the offering thereof and related matters; and (b) due execution, countersignature (where applicable), authentication, issuance and delivery of the Units and the
        Securities that are components of such Units in each case upon the payment of the consideration therefore provided for in the applicable definitive purchase, underwriting or similar agreement approved by the board of directors, and otherwise in
        accordance with the provisions of the applicable Unit Agreement, such Units will constitute valid and binding obligations of the Company.</div>
      <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;"> <br>
      </div>
      <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">5.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; With respect to the Warrant Shares underlying the Outstanding Warrants, to be
            issued upon the exercise of such Outstanding Warrants, upon the due exercise of the Outstanding Warrants&#160;in accordance with their terms&#160;and when
            issued and sold by the Company and delivered by the Company against receipt of the exercise price therefor in accordance with and in the manner described in the applicable Outstanding Warrants, the Warrant Shares will be validly issued, fully paid and non-assessable.&#160;&#160;&#160;&#160;&#160; </div>
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    <br>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">In addition to the assumptions, comments, qualifications, limitations and exceptions set forth above, the opinions set forth herein are further limited by, subject to and based
      upon the following assumptions, comments, qualifications, limitations and exceptions:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="line-height: 1.25"> </div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">1.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; We are opining herein as to the effect on the subject transaction only of the internal laws of the State of Israel, and have assumed that the laws of the State of Israel would be chosen as the governing law of each applicable Rights Agreement,
        Warrant Agreement and Unit Agreement. We&#160;express no opinion with respect to the
        applicability thereto, or the effect thereon, of the laws of any other jurisdiction. In rendering our opinions, we have not considered, and hereby disclaim any opinion as to, the application or impact of any laws, cases, decisions, rules or
        regulations of any other jurisdiction, court or administrative agency. This opinion is expressly limited to the matters set forth above, and we render no opinion, whether by implication or otherwise, as to any other matters.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">2.&#160;&#160;&#160;&#160;&#160;&#160; &#160; &#160; Our opinions herein are subject to and may be limited by: (i) applicable bankruptcy, insolvency, reorganization, receivership, moratorium and other similar laws
      affecting or relating to the rights and remedies of creditors generally including, without limitation, laws relative to fraudulent conveyances, preference and equitable subordination; (ii) general principles of equity (regardless of whether
      considered in a proceeding in equity or at law); and (iii) principles of good faith and fair dealing.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">3.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Our opinions are further subject to the effect of generally applicable rules of law arising from statutes, judicial and administrative decisions, and the rules and
      regulations of governmental authorities that: (i) limit or affect the enforcement of provisions of a contract that purport to require waiver of the obligations of good faith, fair dealing, diligence and reasonableness; (ii) limit the availability of
      a remedy under certain circumstances where another remedy has been elected; (iii) limit the enforceability of provisions releasing, exculpating or exempting a party from, or requiring indemnification of a party for, liability for its own action or
      inaction, to the extent the action or inaction involves negligence, recklessness, willful misconduct or unlawful conduct; (iv) may, where less than all of the contract may be unenforceable, limit the enforceability of the balance of the contract to
      circumstances in which the unenforceable portion is not an essential part of the agreed exchange; and (v) govern and afford judicial discretion regarding the determination of damages and entitlement to attorneys&#8217; fees.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">4.&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; You have informed us that you intend to issue the Securities from time to time on a delayed or continuous basis, and this opinion is limited to the laws, including
      the rules and regulations, as in effect on the date hereof. We understand that prior to issuing any Securities you will afford us an opportunity to review the operative documents pursuant to which such Securities are to be issued (including the
      applicable Base Prospectus Supplement and Warrant Prospectus Supplement) and any required governmental approvals with respect thereto, and will file such supplement or amendment to this opinion (if any) as we may reasonably consider necessary or
      appropriate by reason of the terms of such Securities.</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;"> <br>
    </div>
    <div style="text-align: center;"><font style="font-family: 'Times New Roman',Times,serif;"> 3<br>
      </font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">We consent to the filing of this opinion letter as Exhibit 5.1 to the Registration Statement and to the use of our name under the caption &#8220;Legal Matters&#8221; in the Prospectuses
      included in the Registration Statement. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations promulgated thereunder.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 21.3pt; line-height: 1.25;">This opinion letter is rendered as of the date first written above and we disclaim any obligation to advise you of facts, circumstances, events or developments, including,
      without limitation, in the law, which hereafter may be brought to our attention and which may alter, affect or modify the opinion expressed herein.&#160;&#160;Our opinion is expressly limited to the matters set forth above and we render no opinion, whether by
      implication or otherwise, as to any other matters relating to the Company or the Securities, except as set forth above.</div>
    <div style="line-height: 1.25">&#160;</div>
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            <div style="text-align: center; line-height: 1.25;">Very truly yours,</div>
          </td>
          <td style="width: 12%; vertical-align: top;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
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            <div style="line-height: 1.25;">&#160;</div>
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          <td style="width: 35%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;"><u>/s/ Shibolet &amp; Co., Law Firm</u></div>
            <div style="text-align: center; line-height: 1.25;">Shibolet &amp; Co., Law Firm</div>
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<TYPE>EX-5.2
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<DESCRIPTION>EXHIBIT 5.2
<TEXT>
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      <div style="text-align: right;"><font style="font-weight: bold;"> <u>Exhibit 5.2</u></font><br>
      </div>
      <div style="text-align: right;"><font style="font-weight: bold;"> <br>
        </font></div>
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              <div>&#160;<img src="image00003.jpg"></div>
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    </div>
    <div style="line-height: 1.25;">July 30, 2020</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Compugen Ltd.</div>
    <div style="line-height: 1.25;">26 Harokmim Street</div>
    <div style="line-height: 1.25;">Holon 5885849</div>
    <div style="line-height: 1.25;">Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Ladies and Gentlemen:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">We have acted as special U.S. counsel to Compugen Ltd., a company organized under the laws of the State of Israel (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221;), in
      connection with the filing of a Registration Statement on Form F-3 (the &#8220;<font style="font-weight: bold; font-style: italic;">Registration Statement</font>&#8221;) with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold; font-style: italic;">SEC</font>&#8221;) under the Securities Act of 1933, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Securities Act</font>&#8221;). The Registration Statement includes a base prospectus (the &#8220;<font style="font-weight: bold; font-style: italic;">Base Prospectus</font>&#8221;), which forms part of the Registration Statement and provides that it may be supplemented in the future by one or more prospectus supplements (each, a &#8220;<font style="font-weight: bold; font-style: italic;">Prospectus Supplement</font>&#8221;). The Registration Statement, as amended from time to time, including the Base Prospectus (as supplemented from time to time by one or more Prospectus Supplements), provides for the registration by the Company
      of:</div>
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          <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>ordinary shares, par value NIS0.01 per share, of the Company (the &#8220;<font style="font-weight: bold; font-style: italic;">Ordinary Shares</font>&#8221;);</div>
          </td>
        </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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          </td>
          <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>debt securities, in one or more series (the &#8220;<font style="font-weight: bold; font-style: italic;">Debt Securities</font>&#8221;), which may be issued pursuant to an indenture to be dated on or about the date of the first issuance of Debt
              Securities thereunder, by and between a trustee to be selected by the Company (the &#8220;<font style="font-weight: bold; font-style: italic;">Trustee</font>&#8221;) and the Company, in the form filed as Exhibit 4.2 to the Registration Statement and one
              or more indentures supplemental thereto with respect to any particular series of Debt Securities (the &#8220;<font style="font-weight: bold; font-style: italic;">Indenture</font>&#8221;);</div>
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          </td>
          <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
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            <div>warrants for the purchase of Ordinary Shares, in one or more series (the &#8220;<font style="font-weight: bold; font-style: italic;">Warrants</font>&#8221;);</div>
          </td>
        </tr>

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          <td style="width: 18pt; vertical-align: top; align: right;">&#8226;</td>
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            <div>rights to purchase any other securities of the Company (&#8220;<font style="font-weight: bold; font-style: italic;">Rights</font>&#8221;); and</div>
          </td>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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            <div>units comprised of one or more of the other securities of the Company.</div>
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    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">The Debt Securities plus any additional Debt Securities that may be registered pursuant to any registration statement that the Company may hereafter file with the SEC pursuant to Rule 462(b) under
      the Securities Act in connection with an offering by the Company pursuant to the Registration Statement, are collectively referred to herein as the &#8220;<font style="font-weight: bold; font-style: italic;">Securities</font>.&#8221; The Securities are being
      registered for offer and sale from time to time pursuant to Rule 415 under the Securities Act.</div>
    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">In connection with this opinion, we have examined and relied upon the originals, or copies certified to our satisfaction, of such records, documents, certificates, opinions, memoranda and other
      instruments as in our judgment are necessary or appropriate to enable us to render the opinion expressed below. As to certain factual matters, we have relied upon a certificate of an officer of the Company and have not independently verified such
      matters.</div>
    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
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    <div style="text-align: justify; line-height: 1.25;">In rendering this opinion, we have assumed the legal capacity of all natural persons; the genuineness and authenticity of all signatures on original documents; the authenticity of all documents
      submitted to us as originals; the conformity to originals of all documents submitted to us as copies and the authenticity of the originals of such copies; the accuracy, completeness and authenticity of certificates of public officials; the valid
      existence of the Company under the laws of the State of Israel; that the Company has the corporate power to enter into and perform its obligations under the Debt Securities and the Indenture in accordance with their respective terms and has duly
      authorized, executed and delivered the Debt Securities and the Indenture in accordance with its organizational documents and the laws of the State of Israel; that any Ordinary Shares issued upon conversion of the Debt Securities will be duly
      authorized, validly issued, fully paid and nonassessable; and that the execution, delivery and performance by the Company of its obligations under the Debt Securities and the Indenture do not and will not violate the laws of the State of Israel or
      any other applicable laws (excepting from such assumption the laws of the State of New York). We have also assumed that any Debt Securities offered under the Registration Statement, and the related Indenture will be executed in the form filed as an
      exhibit to the Registration Statement. We have also assumed that with respect to any Securities being issued upon conversion of any convertible Debt Securities, the applicable convertible Debt Securities will be valid and legally binding obligations
      of the Company, enforceable against the Company in accordance with their terms, except as enforcement may be limited by applicable bankruptcy, insolvency, reorganization, arrangement, moratorium or other similar laws affecting creditors&#8217; rights, and
      subject to general equity principles and to limitations on availability of equitable relief, including specific performance.</div>
    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">Our opinion herein is expressed solely with respect to the laws of the State of New York. Our opinion is based on these laws as in effect on the date hereof. We express no opinion as to whether the
      laws of any particular jurisdiction are applicable to the subject matter hereof. We are not rendering any opinion as to compliance with any federal or state law, rule or regulation relating to securities, or to the sale or issuance thereof.</div>
    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">On the basis of the foregoing and in reliance thereon, and subject to the qualifications herein stated, we are of the opinion that:</div>
    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-weight: bold;">1.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: Arial, sans-serif; font-size: 3pt;">&#160;</font>With respect to any series of Debt Securities issued under
      the Indenture and offered under the Registration Statement, provided that; (i) the Registration Statement and any required post-effective amendment thereto have all become and remain effective under the Securities Act and the Base Prospectus and any
      and all Prospectus Supplement(s) required by applicable laws have been delivered and filed as required by such laws; (ii) the Indenture has been duly authorized by the Company and the Trustee by all necessary corporate action; (iii) the Indenture, in
      substantially the form filed as an exhibit to the Registration Statement, has been duly executed and delivered by the Company and the Trustee; (iv) the terms of the Debt Securities and their issuance and sale, including as to any Ordinary Shares to
      be issued on the exercise thereof, have been duly authorized by the Company by all necessary corporate action and the Indenture has been qualified under the Trust Indenture Act of 1939, as amended; (v) the terms of the Debt Securities and of their
      issuance and sale have been duly established in conformity with the Indenture so as not to violate any applicable law or result in a default under or breach of any agreement or instrument binding upon the Company, so as to be in conformity with the
      Company&#8217;s then operative articles of association (the &#8220;<font style="font-weight: bold; font-style: italic;">Articles of Association</font>&#8221;), and so as to comply with any requirement or restriction imposed by any court or governmental body having
      jurisdiction over the Company; and (vi) the notes representing the Debt Securities have been duly executed and delivered by the Company and authenticated by the Trustee pursuant to the Indenture and delivered against payment therefor, then the Debt
      Securities, when issued and sold as contemplated in the Registration Statement, the Base Prospectus and the related Prospectus Supplement(s) and in accordance with the Indenture and a duly authorized, executed and delivered purchase, underwriting or
      similar agreement, or upon exercise of any Warrants or Rights in accordance with their terms, will be valid and legally binding obligations of the Company, enforceable against the Company in accordance with their terms, except as enforcement thereof
      may be limited by bankruptcy, insolvency, reorganization, moratorium or other similar laws relating to or affecting creditors&#8217; rights generally, and by general equitable principles (regardless of whether such enforceability is considered in a
      proceeding at law or in equity).</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: justify; line-height: 1.25;">
      <div style="line-height: 1.25;"><br>
      </div>
    </div>
    <div style="text-align: justify; line-height: 1.25;">We hereby consent to the filing of this opinion as an exhibit to the Registration Statement and to the reference to our firm under the caption &#8220;Legal Matters&#8221; in the Base Prospectus. We further
      consent to the incorporation by reference of this opinion into any registration statement filed pursuant to Rule 462(b) under the Securities Act with respect to additional Securities.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Our opinion set forth above is limited to the matters expressly set forth in this letter, and no opinion is implied or may be inferred beyond the matters expressly stated.&#160; This opinion speaks only
      as to law and facts in effect or existing as of the date hereof, and we undertake no obligation or responsibility to update or supplement this opinion to reflect any facts or circumstances that may hereafter come to our attention or any changes in
      law that may hereafter occur.</div>
    <div style="text-align: justify; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Sincerely,</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25; font-variant: small-caps;">Cooley LLP</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">By:&#160; &#160;<u></u><font style="font-style: italic;"><u>/s/ Daniel I. Goldberg</u></font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
    <div style="text-align: justify; text-indent: 22.5pt; line-height: 1.25;">Daniel I. Goldberg</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>exhibit_23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
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          <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><u>Exhibit 23.1</u></div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold; font-size: 11pt;"><u>Consent of Independent Registered Public Accounting Firm</u></div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">We consent to the reference to our firm under the caption "Experts"&#160; in the Registration Statements on Form F-3 and related Prospectus of Compugen Ltd. for the registration of
          its securities and to the incorporation by reference therein of our report dated February 24, 2020, with respect to the consolidated financial statements of Compugen Ltd. and the effectiveness of Compugen Ltd.&#8217;s internal control over financial
          reporting, included in its Annual Report (Form 20-F) for the year ended December 31, 2019, filed with the Securities and Exchange Commission.</div>
        <div style="line-height: 1.25">&#160;</div>
        <div style="line-height: 1.25">
          <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" id="zb49d8c8d342c4d45aa7b24471d005a6d">

              <tr>
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                  <div>
                    <div style="line-height: 1.25;">July 30, 2020&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
                    </div>
                  </div>
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                <td style="width: 50.00%;">
                  <div>&#160;/S/ KOST FORER GABBAY &amp; KASIERER</div>
                </td>
              </tr>
              <tr>
                <td style="width: 50.00%;" rowspan="1">&#160;</td>
                <td style="width: 50.00%;" rowspan="1">&#160;</td>
              </tr>
              <tr>
                <td style="width: 50.00%;" rowspan="1">
                  <div style="line-height: 1.25;">Tel-Aviv, Israel&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <br>
                  </div>
                </td>
                <td style="width: 50.00%;" rowspan="1">&#160;A Member of Ernst &amp; Young Global</td>
              </tr>

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        </div>
        <div style="line-height: 1.25;">
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