<SEC-DOCUMENT>0001178913-21-003501.txt : 20211112
<SEC-HEADER>0001178913-21-003501.hdr.sgml : 20211112
<ACCEPTANCE-DATETIME>20211112070523
ACCESSION NUMBER:		0001178913-21-003501
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		5
CONFORMED PERIOD OF REPORT:	20211112
FILED AS OF DATE:		20211112
DATE AS OF CHANGE:		20211112

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		211399492

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2126802.htm
<DESCRIPTION>6-K
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: ZKG
         Document created using EDGARfilings PROfile 7.7.0.0
         Copyright 1995 - 2021 Broadridge -->
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
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    <div style="line-height: 1.25;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">UNITED STATES</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Form 6-K</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">For the month of November 2021</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">Commission File Number 000-30902</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">COMPUGEN LTD.</div>
    <div style="text-align: center; line-height: 1.25;">(Translation of registrant&#8217;s name into English)</div>
    <table cellspacing="0" cellpadding="0" id="zbd5bf55ecb5c46089cab15f636a0b7a6" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: middle;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">26&#160;Harokmim Street</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Holon 5885849, Israel</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">(Address of Principal Executive Offices)&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:</div>
    <div style="line-height: 1.25;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Form 20-F &#9746;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Form 40-F &#9744;&#160; <br>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): &#9744; &#160; &#160; &#160; <br>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): &#9744; &#160; &#160; &#160; <br>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
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    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">On November 10, 2021, Compugen Ltd. (&#8220;<font style="font-weight: bold;">Compugen</font>&#8221; or the &#8220;<font style="font-weight: bold;">Company</font>&#8221;) entered into a securities purchase agreement (&#8220;<font style="font-weight: bold;">SPA</font>&#8221;) with Bristol-Myers Squibb Company (&#8220;<font style="font-weight: bold;">BMS</font>&#8221;) pursuant to which BMS purchased 2,332,815 ordinary shares of Compugen at a purchase price of $8.57333
        per share for total consideration of $20.0 million.&#160; The share price represents a 33% premium over the closing price of Compugen&#8217;s ordinary shares on the
        last trading day immediately prior to the execution of the SPA. The transaction closed on November 10, 2021. &#160;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Simultaneously with the signing and closing of the SPA,
        Compugen and BMS entered into Amendment No. 3 (the &#8220;<font style="font-weight: bold;">Amendment</font>&#8221;) to the Master Clinical Trial Collaboration Agreement dated October 10, 2018, as
        amended by and between the parties.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Among other terms of the Amendment, a joint steering committee has been formed to facilitate strategic oversight and guidance for the
        clinical programs run under the collaboration. The joint steering committee will run alongside the existing joint development committee which acts at an operational level.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">The information contained in this Report on Form 6-K is hereby incorporated by reference into the Company&#8217;s Registration Statement on
        Form F-3, File No. 333-240183.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">A copy of the press release announcing the SPA and the Amendment is furnished as Exhibit 99.1 to this Report on Form 6-K.</div>
      <div style="line-height: 1.25;">&#160;</div>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Exhibits</div>
    &#160;<br>
    <table cellspacing="0" cellpadding="0" id="zde68b56008384132beca19f4d5caf449" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 72pt; vertical-align: top; align: right;">
            <div>
              <div style="line-height: 1.25; font-weight: bold;">Exhibit</div>
              <div style="line-height: 1.25;"><font style="font-weight: bold;"><u>Number</u></font></div>
            </div>
            <div> <br>
            </div>
            <div><a href="exhibit_10-1.htm">10.1</a></div>
          </td>
          <td style="width: auto; vertical-align: top;">
            <div><font style="font-weight: bold;"><u> <br>
                </u></font></div>
            <div> <font style="font-weight: bold;"><u>Description of Exhibit</u></font></div>
            <div> <br>
            </div>
            <div><a href="exhibit_10-1.htm">Securities Purchase Agreement, dated November
                10, 2021, by and between the Company and BMS.</a></div>
          </td>
        </tr>

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        <tr>
          <td style="width: 72pt; vertical-align: top; align: right;"><a href="exhibit_10-2.htm">10.2#</a></td>
          <td style="width: auto; vertical-align: top;">
            <div><a href="exhibit_10-2.htm">Amendment No. 3 to Master Clinical Trial
                Collaboration Agreement, dated November 10, 2021, by and between Compugen Ltd. and Bristol-Myers Squibb Company.</a></div>
          </td>
        </tr>

    </table>
    <table cellspacing="0" cellpadding="0" id="z4a77011392164ad989c32a8fd5bb6d42" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 72pt; vertical-align: top; align: right;"><a href="exhibit_99-1.htm">99.1</a></td>
          <td style="width: auto; vertical-align: top;">
            <div><a href="exhibit_99-1.htm">Press Release dated November 11, 2021.</a></div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">#</td>
            <td style="width: auto; vertical-align: top;">
              <div>Pursuant to Item 601(b)(10) of Regulation S-K, certain confidential portions of this exhibit were omitted by means of marking such portions with an asterisk because
                the identified confidential portions (i) are not material and (ii) are the type that the registrant treats as private or confidential.</div>
            </td>
          </tr>

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    </div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signatures</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
      by the undersigned thereunto duly authorized.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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        <tr>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="vertical-align: bottom;" colspan="3">
            <div style="line-height: 1.25; font-weight: bold;">COMPUGEN LTD.</div>
          </td>
        </tr>
        <tr>
          <td style="vertical-align: middle;" colspan="4">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Date: November 12, 2021</div>
          </td>
          <td style="width: 3%; vertical-align: bottom;">
            <div style="line-height: 1.25;">By:&#160;</div>
          </td>
          <td style="width: 38.3%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><u>/s/ Eran Ben Dor</u></div>
          </td>
          <td style="width: 9.59%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 46%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 3%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 38.3%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Eran Ben Dor</div>
            <div style="line-height: 1.25;">General Counsel</div>
          </td>
          <td style="width: 9.59%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
          </td>
        </tr>

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<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>exhibit_10-1.htm
<DESCRIPTION>EXHIBIT 10.1
<TEXT>
<html>
  <head>
    <title></title>
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         Copyright 1995 - 2021 Broadridge -->
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
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    <div style="text-align: right; text-indent: -36pt; margin-left: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;"><u> Exhibit 10.1</u><br>
    </div>
    <div style="text-align: center; text-indent: -36pt; margin-left: 36pt; line-height: 1.25; font-weight: bold;"> <br>
    </div>
    <div style="text-align: center; text-indent: -36pt; margin-left: 36pt; line-height: 1.25; font-weight: bold;">SECURITIES PURCHASE AGREEMENT</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This Securities Purchase Agreement (this &#8220;<u>Agreement</u>&#8221;) is dated as of November&#160;10, 2021, between Compugen Ltd., a corporation organized under the laws of the State of Israel
      (the &#8220;<u>Company</u>&#8221;), and Bristol-Myers Squibb Company (the &#8220;<u>Purchaser</u>&#8221;), a Delaware corporation.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">WHEREAS, concurrently with the entering into of this Agreement, the Company and Purchaser are entering into that certain Amendment No. 3 (the &#8220;<u>Amendment No. 3</u>&#8221;) to a Master
      Clinical Trial Collaboration Agreement dated October 10, 2018 (the Master Clinical Trial as amended immediately prior to the date hereof shall be referred to as &#8220;<u>Collaboration Agreement</u>&#8221;).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">WHEREAS, subject to the terms and conditions set forth in this Agreement, the Company desires to issue and sell to Purchaser, and Purchaser desires to purchase from the Company,
      securities of the Company pursuant to an exemption from registration under the Securities Act (as defined below), as more fully described in this Agreement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">NOW, THEREFORE, in consideration of the mutual covenants contained in this Agreement, and for other good and valuable consideration the receipt and adequacy of which are hereby
      acknowledged, the Company and Purchaser agree as follows:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">ARTICLE I.</font><br>
      DEFINITIONS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">1.1&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Definitions</u>.&#160; In addition to the terms defined elsewhere in this Agreement, for all purposes of this Agreement, the following terms have the meanings set forth
      in this Section 1.1:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">&#8220;<u>Acquiring Person</u>&#8221; shall have the meaning ascribed to such term in Section 4.6.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Action</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(j).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Affiliate</u>&#8221; means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common control with
      a Person as such terms are used in and construed under Rule 405 under the Securities Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Amendment No. 3</u>&#8221; has the meaning set forth in the recitals.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>BHCA</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(gg).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Board of Directors</u>&#8221; means the board of directors of the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Business Day</u>&#8221; means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or Israel or any day on which
      banking institutions in the State of New York or the State of Israel are authorized or required by law or other governmental action to close.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Closing</u>&#8221; means the closing of the purchase and sale of the Securities pursuant to Section 2.1.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Closing Date</u>&#8221; means the Trading Day on or after the date hereof on which all of the Transaction Documents have been executed and delivered by the
      applicable parties thereto, and all conditions precedent to (i) Purchaser&#8217;s obligations to pay the Subscription Amount and (ii) the Company&#8217;s obligations to deliver the Securities, in each case, have been satisfied or waived, but in no event later
      than the second (2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup>) Trading Day following the date hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Code</u>&#8221; shall have the meaning ascribed to such term in Section 4.10.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Collaboration Agreement</u>&#8221; has the meaning set forth in the recitals.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Commission</u>&#8221; means the United States Securities and Exchange Commission.</div>
    <div style="line-height: 1.25">&#160;</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Common Stock Equivalents</u>&#8221; means any securities of the Company or the Subsidiaries which would entitle the holder thereof to acquire at any time Common
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      no later than 9:01 a.m. (New York City time) on the Trading Day immediately following the date hereof, or (ii) if this Agreement is signed between midnight (New York City time) and 9:00 a.m. (New York City time) on any Trading Day, no later than 9:01
      a.m. (New York City time) on the date hereof.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>FDCA</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(cc).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Federal Reserve</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(gg).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Fundamental Representations</u>&#8221; shall have the meaning ascribed to such term in Section 4.7.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>GAAP</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(h).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Governmental Authority</u>&#8221; means any applicable government authority, court, tribunal, arbitrator, agency, department, legislative body, commission or other
      instrumentality of (a) any government of any country or territory, (b) any nation, state, province, county, city or other political subdivision thereof or (c) any supranational body.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Indebtedness</u>&#8221; means (i) any liabilities for borrowed money or amounts owed (other than accounts payable incurred in the ordinary course of business),
      (ii) all guaranties, endorsements and other contingent obligations in respect of indebtedness of others, whether or not the same are or should be reflected in the Company&#8217;s balance sheet (or the notes thereto); and (iii) the present value of any
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Innovation Law</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(mm).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Intellectual Property Rights</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(p).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>ISA</u>&#8221; means the Israel Securities Authority.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Israeli Securities Law</u>&#8221; shall have the meaning assigned to such term in Section 3.1(f).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Law</u>&#8221; or &#8220;<u>Laws</u>&#8221; means all applicable laws, statutes, rules, codes, regulations, orders, judgments, decrees, injunctions, awards, rulings and/or
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Liens</u>&#8221; means a lien, charge, pledge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Material Adverse Effect</u>&#8221; shall have the meaning assigned to such term in Section 3.1(b).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Material Permits</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(n).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Money Laundering Laws</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(hh).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Nasdaq</u>&#8221; shall have the meaning ascribed to such term in Section 2.3(b)(vi).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Non-Fundamental Representations</u>&#8221; shall have the meaning ascribed to such term in Section 4.7.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
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    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Organizational Documents</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(b).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>PFIC</u>&#8221; shall have the meaning ascribed to such term in Section 4.10.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Person</u>&#8221; means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company,
      joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Pharmaceutical Product</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(cc).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Proceeding</u>&#8221; means an action, claim, suit, investigation or proceeding (including, without limitation, an informal investigation or partial proceeding,
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Purchase Price Per Share</u>&#8221; shall mean the product of (i) the closing price per share of the Common Stock on the NASDAQ Global Market on the last Trading
      Day immediately prior to the date hereof multiplied by (ii) the fraction 4/3.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Purchaser Party</u>&#8221; shall have the meaning ascribed to such term in Section 4.7.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Required Approvals</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(e).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Rule 144</u>&#8221; means Rule 144 promulgated by the Commission pursuant to the Securities Act, as such Rule may be amended or interpreted from time to time, or
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>SEC Reports</u>&#8221; shall have the meaning ascribed to such term in Section 3.1(h).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Securities</u>&#8221; means the Shares.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Securities Act</u>&#8221; means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Shares</u>&#8221; means a number of shares of Common Stock to be issued to Purchaser pursuant to this Agreement equal to the quotient of (i) the Subscription
      Amount divided by (ii) the Purchase Price Per Share, rounded down to the nearest whole number; provided, however, that in the event of any stock dividend, stock split, combination of shares or recapitalization with respect to the Common Stock after
      the date of this Agreement and on or prior to the Closing, the number of Shares shall be adjusted proportionately.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Short Sales</u>&#8221; means all &#8220;short sales&#8221; as defined in Rule 200 of Regulation SHO under the Exchange Act (but shall not be deemed to include locating and/or
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">4</font></div>
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Subscription Amount</u>&#8221; means $20,000,000.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Subsidiary</u>&#8221; means any direct or indirect subsidiary of the Company, and shall, where applicable, also include any direct or indirect subsidiary of the
      Company formed or acquired after the date hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>TASE</u>&#8221; shall have the meaning ascribed to such term in Section 2.3(b)(vi).</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Trading Day</u>&#8221; means a day on which the principal Trading Market is open for trading.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Trading Market</u>&#8221; means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date in question: the
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Transaction Documents</u>&#8221; means this Agreement, all exhibits and schedules hereto and any other documents or agreements executed in connection with the
      transactions contemplated hereunder.&#160; For clarity, Transaction Documents shall not include the Collaboration Agreement, nor Amendment No. 3.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">&#8220;<u>Transfer Agent</u>&#8221; means American Stock Transfer &amp; Trust Company, LLC, the current transfer agent of the Company, with a mailing address of 6201 15<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup>
      Avenue, Brooklyn, NY 11219 and a facsimile number of (718) 765-8717, and any successor transfer agent of the Company.</div>
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    <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">ARTICLE II.</font><br>
      PURCHASE AND SALE</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">2.1&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Closing</u>.&#160; On the Closing Date, upon the terms and subject to the conditions set forth herein, the Company agrees to sell, and Purchaser agrees to purchase, the
      Shares against payment by Purchaser of an aggregate purchase price equal to the Subscription Amount to the Company. The Company shall deliver to Purchaser the Shares, and the Company and Purchaser shall deliver the other items set forth in Section
      2.2 deliverable at the Closing.&#160; Upon satisfaction (or waiver in accordance hereof) of the covenants and conditions set forth in Sections 2.2 and 2.3, the Closing shall occur at 10:00 a.m. New York time at the offices of Cooley LLP, 55 Hudson Yards,
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25;">2.2&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Deliveries</u>.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;On or prior to the Closing Date, the Company shall deliver or cause to be delivered to Purchaser:</div>
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    <div style="text-indent: 72pt; margin-left: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;a copy of the irrevocable instructions to the Transfer Agent instructing the Transfer Agent to make book-entry notations representing the Shares, against delivery of the
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    <div style="text-indent: 72pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
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    <div style="text-indent: 72pt; margin-left: 36pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;a legal opinion from Cooley LLP, United States legal counsel to the Company, in form and substance reasonably acceptable to Purchaser; and</div>
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    <div style="text-indent: 72pt; margin-left: 36pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;a legal opinion from Shibolet &amp; Co. Law Firm, Israeli legal counsel to the Company, in form and substance reasonably acceptable to Purchaser.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;On or prior to the Closing Date, Purchaser shall deliver or cause to be delivered the Purchaser&#8217;s Subscription Amount, by wire transfer of
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">2.3&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Closing Conditions</u>.</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The obligations of the Company hereunder in connection with the Closing are subject to the following conditions being met (or waived by Company):</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the representations and warranties made by the Purchaser in <u>Section </u><u>3.2</u> shall be true and correct in all material respects as of the
      date when made and as of the Closing Date (unless any such representation or warranty speaks as of a specific date therein, in which case such representation or warranty shall be true and correct in all material respects as of such date), except for
      those representations and warranties that are qualified as to materiality, in which case such representations and warranties shall be true and correct in all respects as of the date when made and as of the Closing Date (unless any such representation
      or warranty speaks as of a specific date therein, in which case such representation or warranty shall be true and correct as of such date);</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;all obligations, covenants and agreements of Purchaser required to be performed at or prior to the Closing Date shall have been performed in all
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the delivery by Purchaser of the items set forth in Section 2.2(b) of this Agreement; and</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;each of the Company and Purchaser shall have executed and delivered the Amendment No. 3, and the Collaboration Agreement, as amended by Amendment
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    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The obligations of Purchaser hereunder in connection with the Closing are subject to the following conditions being met (or waived by Purchaser):</div>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(A) The representations and warranties made by the Company (a) in <u>Section </u><u>3.1</u> (other than the representations and warranties set
      forth in <u>Sections 3.1(a)-(g)</u>), without regard to materiality or Material Adverse Effect qualifiers contained within such representations and warranties, shall be true and correct in all respects as of the Closing Date, except for any failure
      of such representations and warranties to be true and correct that would not reasonably be expected to have a Material Adverse Effect, and (b) in <u>Sections 3.1(a)-(g)</u> shall be true and correct in all respects as of the Closing Date;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">6</font></div>
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;all obligations, covenants and agreements of the Company required to be performed at or prior to the Closing Date shall have been performed in all
      material respects (or, to the extent obligations, covenants and agreements are qualified by materiality or Material Adverse Effect, in all respects);</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the delivery by the Company of the items set forth in Section 2.2(a) of this Agreement;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company shall have delivered to the Purchaser evidence, in form and substance reasonably satisfactory to the Purchaser, that each of the
      Required Approvals was received as of the Closing;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;there shall have been no Material Adverse Effect with respect to the Company since the date hereof;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(vi)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Shares shall be duly listed, and admitted and authorized for trading, on the Nasdaq Global Market (&#8220;<u>Nasdaq</u>&#8221;) and an application for
      listing shall have been filed with the Tel Aviv Stock Exchange (the &#8220;<u>TASE</u>&#8221;) (subject to official notice of issuance, if required);</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(vii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company shall have delivered a certificate, executed on behalf of the Company by its Secretary, dated as of the Closing Date, certifying the
      Board of Directors of the Company has approved the transactions contemplated by this Agreement and the other Transaction Documents and the issuance of the Securities and that they remain in effect, certifying the current versions of the
      Organizational Documents of the Company and certifying as to the signatures and authority of persons signing the Transaction Documents and related documents on behalf of the Company;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(viii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the sale of the Shares by the Company to the Purchaser hereunder shall not be prohibited by any Law;</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(ix)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;from the date hereof to the Closing Date, trading in the Common Stock shall not have been suspended, nor shall a suspension have been threatened in
      writing, by the Commission, the ISA, the Nasdaq, or the TASE and, at any time prior to the Closing Date, trading in securities shall not have been limited in any material respect or suspended, or minimum prices shall not have been established on
      securities whose trades are reported by such service, or on any Trading Market, nor shall a banking moratorium have been declared by any of the United States, New York State or Israeli authorities nor shall there have occurred any material outbreak
      or escalation of hostilities or other national or international calamity of such magnitude in its effect on, or any material adverse change in, any financial market which, in each case, in the reasonable judgment of Purchaser, makes it impracticable
      or inadvisable to purchase the Securities at the Closing; and</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;">(x)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;each of the Company and Purchaser shall have executed and delivered the Amendment No. 3, and the Collaboration Agreement, as amended by Amendment
      No. 3 shall not have been terminated and shall be effective in accordance with its terms.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 72pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">7</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">ARTICLE III.</font><br>
      REPRESENTATIONS AND WARRANTIES</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">3.1&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Representations and Warranties of the Company</u>.&#160; Except as set forth in the Disclosure Schedules, which Disclosure Schedules shall be deemed a part hereof and
      shall qualify any representation or otherwise made herein to the extent of the disclosure contained in the corresponding section of the Disclosure Schedules, the Company hereby represents and warrants as of the date hereof and as of the Closing Date
      to the Purchaser as follows (unless as of a specific date therein, in which case they shall be accurate as of such date):</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Subsidiaries</u>.&#160; All of Subsidiaries of the Company are set forth on <u>Schedule 3.1(a)</u>.&#160; The Company owns, directly or indirectly, all of
      the share capital or other equity interests of each Subsidiary free and clear of any Liens, and all of the issued and outstanding share capital of each Subsidiary are validly issued and are fully paid, non-assessable and free of preemptive and
      similar rights to subscribe for or purchase securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Organization and Qualification</u>.&#160; The Company and each of the Subsidiaries is an entity duly incorporated or otherwise organized, validly
      existing and in good standing under the laws of the jurisdiction of its incorporation or organization, with the requisite power and authority to own and use its properties and assets and to carry on its business as currently conducted and described
      in the SEC Reports.&#160; Neither the Company nor any Subsidiary is in violation nor default of any of the provisions of its respective certificate or articles of incorporation, bylaws or other organizational or charter documents (collectively, the &#8220;<u>Organizational
        Documents</u>&#8221;).&#160; True and correct copies of the Company&#8217;s Organizational Documents, as in effect on the date of this Agreement, are each filed or incorporated by reference as exhibits to the SEC Reports.&#160; Each of the Company and the Subsidiaries
      is duly qualified to conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except where the
      failure to be so qualified or in good standing, as the case may be, would not have or reasonably be expected to result in: (i) a material adverse effect on the legality, validity or enforceability of any Transaction Document, (ii) a material adverse
      effect on the results of operations, assets, business, prospects or condition (financial or otherwise) of the Company and the Subsidiaries, taken as a whole, or (iii) a material adverse effect on the Company&#8217;s ability to perform in any material
      respect on a timely basis its obligations under any Transaction Document (any of (i), (ii) or (iii), a &#8220;<u>Material Adverse Effect</u>&#8221;) and no Proceeding has been instituted in any such jurisdiction revoking, limiting or curtailing or seeking to
      revoke, limit or curtail such power and authority or qualification.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Authorization; Enforcement</u>.&#160; The Company has the requisite corporate power and authority to enter into and to consummate the transactions
      contemplated by this Agreement and each of the other Transaction Documents and otherwise to carry out its obligations hereunder and thereunder.&#160; The execution and delivery of this Agreement and each of the other Transaction Documents by the Company
      and the consummation by it of the transactions contemplated hereby and thereby have been duly authorized by all necessary corporate action on the part of the Company and no further action is required by the Company, the Board of Directors or the
      Company&#8217;s shareholders in connection herewith or therewith other than in connection with the Required Approvals.&#160; This Agreement and each other Transaction Document to which it is a party has been (or upon delivery will have been) duly executed by
      the Company and, when delivered in accordance with the terms hereof and thereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except (i) as limited by applicable
      bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors' rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other
      equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by Law.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">8</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Conflicts</u>.&#160; The execution, delivery and performance by the Company of this Agreement and the other Transaction Documents to which it is a
      party, the issuance and sale of the Securities and the consummation by it of the transactions contemplated hereby and thereby do not and will not (i) conflict with or violate any provision of the Company&#8217;s or any Subsidiary&#8217;s Organizational
      Documents, or (ii) conflict with, constitute a default (or an event that with notice or lapse of time or both would become a default) under, or result in the creation of any Lien upon the Shares or any of the properties or assets of the Company or
      any Subsidiary, or give to others any rights of termination, amendment, acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument (evidencing a Company or Subsidiary debt
      or otherwise) or other understanding to which the Company or any Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound or affected, or (iii) subject to the Required Approvals, conflict with or result in a
      violation of any Law to which the Company or a Subsidiary is subject (including, without limitation, local, foreign, federal and state securities laws and regulations and the rules and regulations of the Nasdaq and the TASE), or by which any property
      or asset of the Company or a Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii), such as would not have or reasonably be expected to result in a Material Adverse Effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Filings, Consents and Approvals</u>.&#160; The Company is not required to obtain any consent, waiver, authorization or order of, give any notice to,
      or make any filing or registration with, any court or other federal, state, local, foreign or other governmental authority or other Person in connection with the execution, delivery and performance by the Company of the Transaction Documents, other
      than: (i) the filing and approval of an application for the listing of the Shares with Nasdaq for trading thereon in the time and manner required thereby, (ii) the approval of the listing of the Shares on the TASE, (iii) such filings as are required
      to be made with the Commission or under applicable state securities laws, which filings shall be made in a timely manner in accordance with all Laws (iv) a notice to be filed by the Company with the Israeli Innovation Authority (the &#8220;<u>IIA</u>&#8221;) in
      connection with the issuance of the Shares pursuant to the terms hereof, and (v) an undertaking by the Purchaser to the IIA, with respect to the observance by the Purchaser, as a shareholder of the Company, of the requirements of the Israeli Law for
      the Encouragement of Industrial Research and Development of 1984 and regulations promulgated thereunder, in the form of <u>Exhibit B</u> executed by the Purchaser and delivered to the Company immediately prior to the Closing (collectively, the &#8220;<u>Required
        Approvals</u>&#8221;).</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">9</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Issuance of the Securities; Registration</u>.&#160; The Securities are duly authorized and, when issued and paid for in accordance with the applicable
      Transaction Documents, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens or restrictions on transfer, including preemptive rights, rights of first refusal, purchase option, call option, subscription right or
      other similar rights, other than as arising pursuant to the Transaction Documents, as a result of any action by the Purchaser or under local, federal, state or foreign securities Laws.&#160; The Company has reserved from its duly authorized share capital
      the maximum number of shares of Common Stock issuable pursuant to this Agreement. Assuming the accuracy of the representations and warranties of the Purchaser in this Agreement and subject to the Required Approvals, the Shares will be issued in
      compliance with all applicable local, federal, state and foreign securities laws.&#160; No stop order or suspension of trading of Common Stock has been imposed by Nasdaq, the SEC, the TASE or the ISA and remains in effect.&#160; The Common Stock is registered
      pursuant to Section 12(b) of the Exchange Act.&#160; The Company has taken no action designed to terminate the registration of the Common Stock under the Exchange Act and the Company has not received any written notification that the Commission is
      contemplating terminating such registration.&#160; The Common Stock is listed on the Nasdaq and the TASE, and there are no proceedings pending or, to the knowledge of the Company, threatened to revoke or suspend the listing of the Shares on Nasdaq and the
      TASE.&#160; The Company is in compliance in all material respects with the requirements of the Nasdaq and TASE for continued listing of Common Stock thereon, and the Company has not received any notice of, nor to the Company&#8217;s knowledge is there any basis
      for, the delisting of the Common Stock from Nasdaq or the TASE. The Shares are not, or upon issuance will not be, subject to any transfer restrictions under Israeli law except for restrictions on resale of such securities on the TASE pursuant to the
      Israeli Securities Law, 5728-1968 and the regulations promulgated thereunder (the &#8220;<u>Israeli Securities Law</u>&#8221;).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Capitalization</u>.&#160; As of the date hereof, the capitalization of the Company is as set forth on <u>Schedule 3.1(g)</u>, which <u>Schedule
        3.1(g)</u> shall also include the number of shares of Common Stock owned beneficially, and of record, by Affiliates of the Company as of the date hereof.&#160; Except as set forth in <u>Schedule 3.1(g)</u>, no other shares of Common Stock, or any
      securities convertible into any capital stock of the Company, were issued, reserved for issuance or outstanding, and the Company does not have outstanding any options to purchase, any preemptive rights or other rights to subscribe for or to purchase,
      or any written contracts, leases, licenses, indentures, agreements, commitments or other legally binding arrangements to issue or sell, shares of its capital stock or any such options, rights, convertible securities or warrants other than those
      granted or reserved for grant under the Equity Incentive Plans.&#160; No Person has any right of first refusal, preemptive right, right of participation, or any similar right to participate in the transactions contemplated by the Transaction Documents.&#160;
      Except as set forth on <u>Schedule 3.1(g)</u> and except a result of the purchase and sale of the Securities, there are no outstanding options, warrants, scrip rights to subscribe to, calls or commitments of any character whatsoever relating to, or
      securities, rights or obligations convertible into or exercisable or exchangeable for, or giving any Person any right to subscribe for or acquire, any shares of Common Stock or the share capital of any Subsidiary, or contracts, commitments,
      understandings or arrangements by which the Company or any Subsidiary is or may become bound to issue additional shares of Common Stock or Common Stock Equivalents or share capital of any Subsidiary.&#160; The issuance and sale of the Securities will not
      obligate the Company or any Subsidiary to issue shares of Common Stock or other securities to any Person (other than Purchaser) and will not result in a right of any holder of Company securities to adjust the exercise, conversion, exchange or reset
      price under any of such securities. There are no outstanding securities or instruments of the Company or any Subsidiary that contain any redemption or similar provisions, and there are no contracts, commitments, understandings or arrangements by
      which the Company or any Subsidiary is or may become bound to redeem a security of the Company or such Subsidiary. The Company does not have any stock appreciation rights or &#8220;phantom stock&#8221; plans or agreements or any similar plan or agreement. All of
      the outstanding share capital of the Company are duly authorized, validly issued, fully paid and nonassessable, have been issued in compliance with all foreign, federal and state securities laws, and none of such outstanding shares was issued in
      violation of any preemptive rights or similar rights to subscribe for or purchase securities.&#160; No further approval or authorization of any shareholder, the Board of Directors or others is required for the issuance and sale of the Securities.&#160; There
      are no shareholders&#8217; agreements, voting agreements or other similar agreements with respect to the Company&#8217;s share capital to which the Company is a party or, to the knowledge of the Company, between or among any of the Company&#8217;s shareholders.&#160; Other
      than as set forth on <u>Schedule 3.1(g)</u>, the Company does not have any outstanding Indebtedness and is not a party to any contract, agreement or instrument relating to any Indebtedness.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">10</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>SEC Reports; Financial Statements</u>.&#160; The Company has timely filed or furnished all reports, schedules, forms, statements and other documents
      required to be filed or furnished by the Company under the Securities Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the date hereof (or such shorter period as the Company was required by
      law or regulation to file such material) (the foregoing materials, including the exhibits thereto and documents incorporated by reference therein, and financial statements notes and schedules thereto being collectively referred to herein as the &#8220;<u>SEC
        Reports</u>&#8221;) on a timely basis or has received a valid extension of such time of filing or furnishing and has filed or furnished any such SEC Reports prior to the expiration of any such extension.&#160; As of their respective dates, the SEC Reports
      complied in all material respects with the requirements of the Securities Act and the Exchange Act, and the applicable portions of the Sarbanes-Oxley Act of 2002, and none of the SEC Reports, when filed or furnished, contained any untrue statement of
      a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.&#160; True and complete copies of the SEC
      Reports are available for public access via the Commission&#8217;s EDGAR system. The Company has never been an issuer subject to Rule 144(i) under the Securities Act. The financial statements of the Company included in the SEC Reports comply in all
      material respects with applicable accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing.&#160; Such financial statements have been prepared in accordance with United States
      generally accepted accounting principles (&#8220;<u>GAAP</u>&#8221;) applied on a consistent basis during the periods involved, except as may be otherwise specified in such financial statements or the notes thereto and except that unaudited interim financial
      statements may not contain all footnotes required by GAAP, and fairly present in all material respects the financial position of the Company and its consolidated Subsidiaries as of and for the dates thereof and the results of operations and, if
      applicable, cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, immaterial, year-end audit adjustments, which will not be material, either individually or in the aggregate.&#160; All material Contracts that were
      required to be filed or furnished by the Company as exhibits to the SEC Reports to which the Company is a party or the property or assets of the Company is subject (collectively, the &#8220;<u>Material Agreements</u>&#8221;), have been filed or furnished as
      exhibits to the SEC Reports.&#160; All Material Agreements are valid and binding obligations of the Company, enforceable against the Company in accordance with their respective terms, and, to the knowledge of the Company, are valid and binding obligations
      of the other party thereto, enforceable against each other party thereto in accordance with their respective terms.<font style="font-weight: bold;">&#160; </font>The Company is not in default under or in violation of (and no event has occurred that with
      notice or lapse of time or both, would result in a default by the Company under), nor has the Company received notice of a claim that it is in default under or that it is in violation of Material Agreements.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">11</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25"> <br>
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    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Material Changes; Undisclosed Events, Liabilities or Developments</u>.&#160; Since the date of the latest audited financial statements included within
      the SEC Reports, except as set forth on <u>Schedule 3.1(i)(a)</u>, (i) there has been no event, fact, circumstance, occurrence or development that has had or that would reasonably be expected to result in a Material Adverse Effect, (ii) the Company
      has not incurred any liabilities (contingent or otherwise) other than (A) trade payables, other accounts payable, accrued expenses and accrued severance pay incurred in the ordinary course of business consistent with past practice and (B) liabilities
      not required to be reflected in the Company&#8217;s financial statements pursuant to GAAP or disclosed in filings made with the Commission, (iii) the Company has not altered its method of accounting in any material respect, (iv) the Company has not
      declared or made any dividend or distribution of cash or other property to its shareholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its share capital, (v) the Company has not sold any assets or made any
      capital expenditures outside the ordinary course of business, (vi) the Company has not issued any equity securities to any officer, director or Affiliate, except pursuant to existing Company Equity Incentive Plans; and (vii) the Company has not made
      any change or amendment to the Organizational Documents.&#160; The Company has not taken any steps to seek protection pursuant to any Law relating to bankruptcy, insolvency, reorganization, receivership, liquidation or winding up, nor does the Company
      have any knowledge or reason to believe that any of their respective creditors intend to initiate involuntary bankruptcy proceedings or any actual knowledge of any fact which would reasonably lead a creditor to do so. Except for the issuance of the
      Securities contemplated by this Agreement, or information provided to the Purchaser pursuant to the Collaboration Agreement as amended by Amendment No. 3 or as set forth on <u>Schedule 3.1(i)(b)</u>, no event, liability, fact, circumstance,
      occurrence or development has occurred or exists or is reasonably expected to occur or exist with respect to the Company or its Subsidiaries or their respective businesses, prospects, properties, operations, assets or financial condition that (i)
      would be required to be disclosed by the Company under applicable securities laws or Trading Market rules at the time this representation is made or deemed made that has not been publicly disclosed at least 1 Trading Day prior to the date that this
      representation is made or (ii) could reasonably be expected to have a Material Adverse Effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">12</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Litigation</u>.&#160; Except as set forth on <u>Schedule 3.1(j)</u>, there is no action, suit, inquiry, notice of violation, proceeding or
      investigation pending or, to the knowledge of the Company, threatened against or affecting the Company, any Subsidiary or any of their respective properties before or by Nasdaq or the TASE or any court, arbitrator, governmental or administrative
      agency or regulatory authority (federal, state, county, local or foreign) (collectively, an &#8220;<u>Action</u>&#8221;).&#160; None of the Actions set forth on <u>Schedule 3.1(j)</u> (i) adversely affects or challenges the legality, validity or enforceability of
      any of the Transaction Documents or the Securities or (ii) would, if there were an unfavorable decision, have or reasonably be expected to result in a Material Adverse Effect.&#160; Neither the Company nor any Subsidiary, nor any director or officer
      thereof, is or, to the Company&#8217;s knowledge has been, the subject of any Action involving a claim of violation of or liability under Israeli or United States federal or state securities laws or a claim of breach of fiduciary duty.&#160; There has not been,
      and to the knowledge of the Company, there is not pending or contemplated, any investigation by the Commission or the ISA involving the Company or any current or former director or officer of the Company.&#160; The Commission has not issued any stop order
      or other order suspending the effectiveness of any registration statement filed by the Company or any Subsidiary under the Exchange Act or the Securities Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Labor Relations</u>.&#160; No labor dispute exists or, to the knowledge of the Company, is imminent with respect to any of the employees of the
      Company, which would reasonably be expected to result in a Material Adverse Effect.&#160; The Company believes that its relations with its employees are good. None of the Company&#8217;s or its Subsidiaries&#8217; employees is a member of a union that relates to such
      employee&#8217;s relationship with the Company or such Subsidiary, and neither the Company nor any of its Subsidiaries is a party to a collective bargaining agreement, and the Company and its Subsidiaries believe that their relationships with their
      employees are good.&#160; To the knowledge of the Company, no executive officer of the Company or any Subsidiary, is, or is now expected to be, in violation of any material term of any employment contract, confidentiality, disclosure or proprietary
      information agreement or non-competition agreement, or any other contract or agreement or any restrictive covenant in favor of any third party, and the continued employment of each such executive officer does not subject the Company or any of its
      Subsidiaries to any liability with respect to any of the foregoing matters.&#160; The Company and its Subsidiaries are in compliance with all federal, state, local and foreign laws and regulations relating to employment (including laws relating to
      classification of employees and independent contractors) and employment practices and benefits, terms and conditions of employment and wages and hours, except where the failure to be in compliance would not, individually or in the aggregate,
      reasonably be expected to have a Material Adverse Effect.&#160; There are no claims pending against the Company or any Subsidiary before any Governmental Authority asserting any violation of labor laws or regulations.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">13</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Compliance</u>.&#160; Neither the Company nor any Subsidiary: (i) is in default under or in violation of (and no event has occurred that has not been
      waived that, with notice or lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the Company or any Subsidiary received notice of a claim that it is in default under or that it is in violation of, any
      indenture, loan or credit agreement or any other agreement or instrument to which it is a party or by which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation of any judgment, decree
      or order of any court, arbitrator or other governmental authority or (iii) is or has been in violation of any statute, rule, ordinance or regulation of any governmental authority, including without limitation all foreign, federal, state and local
      Laws, except in each case in clauses (i), (ii) and (iii) as would not have or reasonably be expected to result in a Material Adverse Effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(m)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Environmental Laws</u>. The Company and its Subsidiaries (i) are in compliance with all federal, state, local and foreign laws relating to
      pollution or protection of human health or the environment (including ambient air, surface water, groundwater, land surface or subsurface strata), including laws relating to emissions, discharges, releases or threatened releases of chemicals,
      pollutants, contaminants, or toxic or hazardous substances or wastes (collectively, &#8220;<u>Hazardous Materials</u>&#8221;) into the environment, or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport
      or handling of Hazardous Materials, as well as all authorizations, codes, decrees, demands, or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits, plans or regulations, issued, entered, promulgated or
      approved thereunder (&#8220;<u>Environmental Laws</u>&#8221;); (ii) have received all permits licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses; and (iii) are in compliance with all terms and
      conditions of any such permit, license or approval where in each clause (i), (ii) and (iii), the failure to so comply would be reasonably expected to have, individually or in the aggregate, a Material Adverse Effect.&#160; Neither the Company nor any
      Subsidiary is subject to any claim relating to any Environmental Laws, which violation, contamination, liability or claim has had or could reasonably be reasonably expected to have, individually or in the aggregate, a Material Adverse Effect; and,
      there is no pending or, to the Company&#8217;s knowledge, threatened investigation that might lead to such a claim.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(n)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Regulatory Permits</u>.&#160; The Company and each of the Subsidiaries possess all certificates, authorizations and permits issued by the appropriate
      federal, state, local or foreign regulatory authorities necessary to conduct their respective businesses as described in the SEC Reports, except where the failure to possess such permits would not reasonably be expected to have, individually or in
      the aggregate, a Material Adverse Effect (&#8220;<u>Material Permits</u>&#8221;), and neither the Company nor any Subsidiary has received any notice of proceedings relating to the revocation or modification in any material respect of any Material Permit.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(o)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Title to Assets</u>.&#160; The Company and the Subsidiaries have good and marketable title in fee simple to all real property owned by them and good
      and marketable title in all personal property owned by them that is material to the business of the Company and the Subsidiaries, in each case free and clear of all Liens, except for (i) Liens as do not materially affect the value of such property
      and do not materially interfere with the use made and proposed to be made of such property by the Company and the Subsidiaries and (ii) Liens for the payment of local, federal, state, foreign or other taxes, for which appropriate reserves have been
      made therefor in accordance with GAAP and, the payment of which is neither delinquent nor subject to penalties.&#160; Any real property and facilities held under lease by the Company and the Subsidiaries are held by them under valid, subsisting and
      enforceable leases with which the Company and the Subsidiaries are in compliance in all material respects.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">14</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(p)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Intellectual Property</u>.&#160; The Company and the Subsidiaries have, or have rights to use, all patents, patent applications, trademarks, trademark
      applications, service marks, trade names, trade secrets, inventions, copyrights, licenses and other intellectual property rights and similar rights necessary or required for use in connection with their respective businesses as currently conducted
      and as described in the SEC Reports and which the failure to so have would reasonably be expected to have a Material Adverse Effect (collectively, the &#8220;<u>Intellectual Property Rights</u>&#8221;).&#160; None of, and neither the Company nor any Subsidiary has
      received a notice (written or otherwise) that any of, the Intellectual Property Rights has expired, terminated or been abandoned, or is expected to expire or terminate or be abandoned, within two (2) years from the date of this Agreement.&#160; Neither
      the Company nor any Subsidiary has received a written notice of a claim or otherwise has knowledge that the Intellectual Property Rights violate or infringe upon the rights of any Person.&#160; To the knowledge of the Company, all such Intellectual
      Property Rights are enforceable and there is no existing infringement by another Person of any of the Intellectual Property Rights, except where such enforceability issues or infringement would not, individually or in the aggregate, reasonably be
      expected to have a Material Adverse Effect.&#160; The Company and its Subsidiaries have taken reasonable security measures to protect the secrecy, confidentiality and value of all of their Intellectual Property Rights, except where failure to do so would
      not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(q)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Insurance</u>.&#160; The Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and
      in such amounts as are reasonably prudent and customary in the businesses in which the Company and the Subsidiaries are engaged, including, but not limited to, directors and officers insurance coverage at least equal to the aggregate Subscription
      Amount.&#160; Neither the Company nor any Subsidiary has any reasonable basis to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from another recognized insurance
      provider of similar standing as may be necessary to continue its business without a significant increase in cost.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(r)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Transactions With Affiliates and Employees</u>.&#160; Except as set forth on <u>Schedule 3.1(r)</u>, none of the officers, directors, employees or
      affiliates of the Company or any Subsidiary is presently a party to any transaction with the Company or any Subsidiary (other than for services as employees, officers or directors), including any contract, agreement or other arrangement providing for
      the furnishing of services to or by, providing for rental of real or personal property to or from, providing for the borrowing of money from or lending of money to or otherwise requiring payments to or from any officer, director, employee or
      affiliate or, to the knowledge of the Company, any entity in which any officer, director, employee or affiliate has a substantial interest or is an employee, officer, director, trustee, shareholder, member or partner, in each case in excess of
      $120,000 other than for (i) payment of salary or consulting fees for services rendered, (ii) reimbursement for expenses incurred on behalf of the Company and (iii) other employee benefits, including share option grants under any share option plan of
      the Company and participation in the Company&#8217;s employee share purchase plan.&#160; All transactions among the Company or any Subsidiary, on the one hand, and any officer, director, employees or shareholder of the Company or any Subsidiary, on the other
      hand, have been approved in accordance with Laws and the rules of any Trading Market.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">15</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(s)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Sarbanes-Oxley; Internal Accounting Controls</u>.&#160; The Company and the Subsidiaries are in compliance in all material respects with any and all
      applicable requirements of the Sarbanes-Oxley Act of 2002 that are effective as of the date hereof with respect to the Company, and any and all applicable rules and regulations promulgated by the Commission thereunder that are effective with respect
      to the Company as of the date hereof and as of the Closing Date.&#160; The Company and the Subsidiaries maintain a system of internal accounting controls designed to provide reasonable assurance that: (i) transactions are executed in accordance with
      management&#8217;s general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and to maintain asset accountability, (iii) access to assets is permitted only in
      accordance with management&#8217;s general or specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company
      and the Subsidiaries have established disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Company and the Subsidiaries and designed such disclosure controls and procedures to ensure that information
      required to be disclosed by the Company in the reports it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the Commission&#8217;s rules and forms.&#160; The Company&#8217;s certifying
      officers have evaluated the effectiveness of the disclosure controls and procedures of the Company and the Subsidiaries as of the end of its most recently completed fiscal year (such date, the &#8220;<u>Evaluation Date</u>&#8221;).&#160; The Company presented in its
      most recently filed annual report under the Exchange Act the conclusions of the certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date.&#160; Since the Evaluation Date,
      there have been no changes in the internal control over financial reporting (as such term is defined in the Exchange Act) of the Company and its Subsidiaries that have materially affected, or is reasonably likely to materially affect, the internal
      control over financial reporting of the Company and its Subsidiaries. The Company has not received any notice or correspondence from any accountant or other Person relating to any potential material weakness or significant deficiency in any part of
      the internal controls over financial reporting of the Company that has not been cured or otherwise resolved prior to the date hereof.&#160; There is no transaction, arrangement, or other relationship between the Company and an unconsolidated or other off
      balance sheet entity that is required to be disclosed by the Company in its Exchange Act filings and is not so disclosed or that otherwise could be reasonably likely to have a Material Adverse Effect.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">16</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(t)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Certain Fees</u>.&#160; No brokerage or finder&#8217;s fees or commissions are or will be payable by the Company or any Subsidiary to any broker, financial
      advisor or consultant, finder, placement agent, investment banker, bank or other Person with respect to the transactions contemplated by the Transaction Documents.&#160; Purchaser shall have no obligation with respect to any fees or with respect to any
      claims made by or on behalf of other Persons for fees of a type contemplated in this Section that may be due in connection with the transactions contemplated by the Transaction Documents.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(u)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Investment Company</u>. The Company is not, and is not an Affiliate of, and immediately after receipt of payment for the Securities, will not be
      or be an Affiliate of, an &#8220;investment company&#8221; within the meaning of the Investment Company Act of 1940, as amended.&#160; The Company shall conduct its business in a manner so that it will not become an &#8220;investment company&#8221; subject to registration under
      the Investment Company Act of 1940, as amended.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Listing and Maintenance Requirements</u>.&#160; The Common Stock is registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and the Company
      has taken no action designed to, or which to its knowledge is likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act nor has the Company received any notification that the Commission is contemplating
      terminating such registration.&#160; The Company has not, in the 12 months preceding the date hereof, received notice from any Trading Market on which the Common Stock is or has been listed or quoted to the effect that the Company is not in compliance in
      any material respect with the listing or maintenance requirements of such Trading Market. The Company is, and has no reason to believe that it will not in the foreseeable future continue to be, in compliance in all material respects with all such
      listing and maintenance requirements. The Common Stock is currently eligible for electronic transfer through the Depository Trust Company or another established clearing corporation and the Company is current in payment of the fees to the Depository
      Trust Company (or such other established clearing corporation) in connection with such electronic transfer.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(w)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Application of Takeover Protections</u>.&#160; The Company and the Board of Directors of the Company have taken all necessary action, if any, in order
      to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti&#8209;takeover provision under the Company&#8217;s articles of association (or similar charter
      documents) or the laws of the State of Israel that is or would become applicable to Purchaser as a result of Purchaser and the Company fulfilling their obligations or exercising their rights under the Transaction Documents, including without
      limitation as a result of the Company&#8217;s issuance of the Securities and Purchaser&#8217;s ownership of the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">17</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(x)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Disclosure</u>.&#160; The Company has provided, in all material respects, Purchaser with information regarding all the matters that Purchaser has
      requested.&#160; Neither the Company nor any Person acting on its behalf has provided the Purchaser or its agents or counsel with any information that constitutes material, non-public information, other than the terms of the transactions contemplated
      hereby and such information provided pursuant to the Collaboration Agreement and amendments thereto (including Amendment No. 3).&#160;&#160;No representations and warranties and written statements by the Company contained in this Agreement and the other
      Transaction Documents and in the documents delivered to the Purchaser in connection with its due diligence investigation of the Company in connection herewith contain any untrue statement of a material fact or omit to state any material fact
      necessary in order to make these representations and warranties and statements, in light of the circumstances under which they were made, not misleading.&#160; The Company acknowledges and agrees that (i) the&#160;&#160;Purchaser has not made nor does it make any
      representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in Section 3.2 hereof, and (ii) the representations contained in Section 3.2 shall not modify, amend or affect the Purchaser&#8217;s
      right to rely on the Company&#8217;s representations and warranties contained in this Agreement or any representations and warranties contained in any other Transaction Document.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(y)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Tax Status</u>.&#160; Except for matters that would not, individually or in the aggregate, have or reasonably be expected to result in a Material
      Adverse Effect, the Company and its Subsidiaries each (i) has timely made or filed with all appropriate Government Authorities all tax returns, reports and declarations required by any jurisdiction to which it is subject, (ii) has timely paid all
      taxes and other governmental assessments and charges that are shown or determined to be due on such returns, reports and declarations and (iii) has set aside on its books provision reasonably adequate for the payment of all taxes for periods
      subsequent to the periods to which such returns, reports or declarations apply.&#160; There are no unpaid taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company or of any Subsidiary know
      of no basis for any such claim. All taxes and other assessments and levies that the Company or any Subsidiary is required to withhold or to collect for payment have been duly withheld and collected and paid to the proper Governmental Authority or
      third party when due, other than taxes that the Company or any Subsidiary is contesting in good faith and for which adequate reserves have been established.&#160;&#160;There are no material tax liens or claims pending or, to the Company&#8217;s knowledge, threatened
      against the Company or any Subsidiary or any of their respective assets or property.&#160;&#160;Except as set forth on <u>Schedule 3.1(y)</u>, there are no outstanding tax sharing agreements or other such arrangements between the Company and any Subsidiary or
      other corporation or entity.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(z)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Foreign Corrupt Practices</u>.&#160; Neither the Company nor any Subsidiary, nor to the knowledge of the Company or any Subsidiary, any director,
      officer, agent, employee or other person acting on behalf of the Company or any Subsidiary, has (i) <u>directly</u> or indirectly, used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or
      domestic political activity, (ii) made any unlawful payment to foreign or domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution
      made by the Company or any Subsidiary (or made by any Person acting on its behalf of which the Company is aware) which is in violation of law, or (iv) violated in any material respect any provision of any anti-bribery law or regulations, including
      the FCPA.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(aa)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Accountants</u>.&#160; The Company&#8217;s accounting firm is set forth in the SEC Reports.&#160; To the knowledge and belief of the Company, such accounting
      firm (i) is an independent registered public accounting firm with respect to the Company as required by the Securities Act and the Exchange Act and (ii) shall express its opinion with respect to the financial statements to be included in the
      Company&#8217;s annual report to be filed under the Exchange Act for the fiscal year ending December 31, 2021.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">18</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(bb)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Regulation M Compliance</u>.&#160; The Company has not, and to its knowledge no one acting on its behalf has, (i) taken, directly or indirectly, any
      action designed to cause or to result in the stabilization or manipulation of the price of any security of the Company to facilitate the sale or resale of any of the Securities, (ii) sold, bid for, purchased, or, paid any compensation for soliciting
      purchases of, any of the Securities, or (iii) paid or agreed to pay to any Person any compensation for soliciting another to purchase any other securities of the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(cc)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>FDA</u>.&#160; As to each product subject to the jurisdiction of the U.S. Food and Drug Administration (&#8220;<u>FDA</u>&#8221;) under the Federal Food, Drug
      and Cosmetic Act, as amended, and the regulations thereunder (&#8220;<u>FDCA</u>&#8221;) that is developed, manufactured, packaged, labeled, tested, distributed, sold, and/or marketed by the Company or any of its Subsidiaries (each such product, a &#8220;<u>Pharmaceutical

        Product</u>&#8221;), such Pharmaceutical Product is being developed, manufactured, packaged, labeled, tested, distributed, sold and/or marketed by the Company in compliance in all material respects with all applicable requirements under FDCA and similar
      laws, rules and regulations relating to registration, investigational use, premarket clearance, licensure, or application approval, good manufacturing practices, good laboratory practices, good clinical practices, product listing, quotas, labeling,
      advertising, record keeping and filing of reports.&#160; Except as set forth on <u>Schedule 3.1(cc)</u>, there is no pending, completed or, to the Company&#8217;s knowledge, threatened, action (including any lawsuit, arbitration, or legal or administrative or
      regulatory proceeding, charge, complaint, or investigation) against the Company or any of its Subsidiaries, and none of the Company or any of its Subsidiaries has received any notice, warning letter or other communication from the FDA or any other
      governmental entity, which (i) contests the premarket clearance, licensure, registration, or approval of, the uses of, the distribution of, the manufacturing or packaging of, the testing of, the sale of, or the labeling and promotion of any
      Pharmaceutical Product, (ii) withdraws its approval of, requests the recall, suspension, or seizure of, or withdraws or orders the withdrawal of advertising or sales promotional materials relating to, any Pharmaceutical Product, (iii) imposes a
      clinical hold on any clinical investigation by the Company or any of its Subsidiaries, (iv) enjoins production at any facility of the Company or any of its Subsidiaries, (v) enters or proposes to enter into a consent decree of permanent injunction
      with the Company or any of its Subsidiaries, or (vi) otherwise alleges any violation of any laws, rules or regulations by the Company or any of its Subsidiaries, and which, either individually or in the aggregate, would have a Material Adverse
      Effect.&#160; The properties, business and operations of the Company have been and are being conducted in all material respects in accordance with all applicable laws, rules and regulations of the FDA.&#160; Except as set forth on Schedule 3.1(cc), the Company
      has not been informed by the FDA that the FDA will prohibit the marketing, sale, license or use in the United States of any product proposed to be developed, produced or marketed by the Company nor has the FDA expressed any concern as to approving or
      clearing for marketing any product being developed or proposed to be developed by the Company.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">19</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(dd)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Equity Incentive Plans</u>. Each share option or other Common Stock Equivalents granted by the Company under the Company&#8217;s Equity Incentive
      Plans was granted in accordance with the terms of the Company&#8217;s Equity Incentive Plans and Law. No share option or other Common Stock Equivalents granted under the Company&#8217;s Equity Incentive Plans has been backdated.&#160; The Company has not knowingly
      granted, and there is no and has been no Company policy or practice to knowingly grant, share options or other Common Stock Equivalents prior to, or otherwise knowingly coordinate the grant of share options or other Common Stock Equivalents with, the
      release or other public announcement of material information regarding the Company or its Subsidiaries or their financial results or prospects.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ee)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Office of Foreign Assets Control</u>.&#160; Neither the Company nor any Subsidiary nor, to the Company&#8217;s knowledge, any director, officer, agent,
      employee or affiliate of the Company or any Subsidiary is currently subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Treasury Department (&#8220;<u>OFAC</u>&#8221;). The Company will not directly or indirectly use
      the proceeds of the offering of the Securities hereunder, or lend, contribute or otherwise make available such proceeds to any joint venture partner or other person or entity for the purpose of financing the activities of any person that, to the
      Company&#8217;s knowledge, is currently subject to any U.S. sanctions administered by OFAC.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ff)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>U.S. Real Property Holding Corporation</u>.&#160; The Company is not and has never been a U.S. real property holding corporation within the meaning
      of Section 897 of the Internal Revenue Code of 1986, as amended (the &#8220;<u>Code</u>&#8221;), and the Company shall so certify upon Purchaser's request.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(gg)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Bank Holding Company Act</u>.&#160; Neither the Company nor any of its Subsidiaries or Affiliates is subject to the Bank Holding Company Act of 1956,
      as amended (the &#8220;<u>BHCA</u>&#8221;), and to regulation by the Board of Governors of the Federal Reserve System (the &#8220;<u>Federal Reserve</u>&#8221;).&#160; Neither the Company nor any of its Subsidiaries or Affiliates under the Company&#8217;s control owns or controls,
      directly or indirectly, five percent (5%) or more of the outstanding shares of any class of voting securities or twenty-five percent or more of the total equity of a bank or any entity that is subject to the BHCA and to regulation by the Federal
      Reserve.&#160; Neither the Company nor any of its Subsidiaries or Affiliates under the Company&#8217;s control exercises a controlling influence over the management or policies of a bank or any entity that is subject to the BHCA and to regulation by the Federal
      Reserve.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(hh)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Money Laundering</u>.&#160; The operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with applicable
      financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the &#8220;<u>Money
        Laundering Laws</u>&#8221;), and no Action or Proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge
      of the Company or any Subsidiary, threatened.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">20</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Offering</u>.&#160; Subject to the accuracy of the Purchaser&#8217;s representations and warranties set forth in <u>Section 3.2 </u>hereof, the offer,
      sale and issuance of the Shares to be issued in conformity with the terms of this Agreement constitute transactions which are exempt from the registration requirements of the Securities Act and from all applicable state registration or qualification
      requirements and are exempt from the requirement to publish a prospectus in Israel under the Israeli Securities Law.&#160; Neither the Company nor, to the Company&#8217;s knowledge, any Person acting on behalf of the Company has either directly or indirectly,
      including through a broker or finder, engaged in any general solicitation or published any advertisement in connection with the offer and sale of Shares.&#160; The issuance and sale of the Securities hereunder does not contravene the rules and regulations
      of the Trading Markets on which the Common Stock are admitted to trading on the date hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(jj)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Integration</u>.&#160; Neither the Company nor any of its Affiliates under its control nor, to the Company&#8217;s knowledge, any Person acting on its
      behalf has, directly or indirectly, made any offers or sales of any Company security or solicited any offers to buy any security under circumstances that would cause the offering of the Shares to be integrated with prior offerings by the Company in a
      manner that would (i) require the registration of the Shares under the Securities Act; (ii) require the publication of a prospectus in Israel under the Israeli Securities Law; or (iii) cause this offering of the Shares to require approval of
      shareholders of the Company under any applicable shareholder approval provisions, including, without limitation, under the rules and regulations of NASDAQ or the TASE or the Israeli Companies Law. None of the Company, any of its affiliates or, to the
      knowledge of the Company, any Person acting on their behalf will take any action or steps that would require registration of the issuance of any of the Shares under the Securities Act or the publication of a prospectus under the Israeli Securities
      Law or otherwise or cause the offering of any of the Shares to be integrated with other offerings of securities of the Company in such a manner as to require registration of the issuance of any of the Shares under the Securities Act or the
      publication of a prospectus under the Israeli Securities Law.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(kk)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Transfer Taxes</u>. There are no transfer taxes or other similar fees or charges under Israeli law, U.S. federal law or the laws of any state,
      or any political subdivision thereof, required to be paid in connection with the execution and delivery of this Agreement or the issuance or sale by the Company of the Securities.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(ll)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Acknowledgement Regarding Purchaser&#8217;s Trading Activity</u>. Excluding the Israeli resale restrictions described in Section 3.2(h), it is
      understood and acknowledged by the Company that, following the public disclosure of the transactions contemplated by this Agreement and Amendment No. 3 in accordance with the terms hereof, the Purchaser has not been asked by the Company to agree, nor
      has the Purchaser agreed with the Company to desist from effecting any transactions in or with respect to any securities of the Company, or &#8220;derivative&#8221; securities based on securities issued by the Company or to hold any of the Securities for any
      specified term.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;">(mm)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Innovation Law</u>.&#160; The Company has received grants from the Israeli Innovation Authority under the Encouragement of Research, Development and
      Technological Innovation in the Industry Law 5744-1984 (the &#8220;<u>Innovation Law</u>&#8221;). The Company is in compliance, in all material respects, with the terms and conditions of the grants and the laws and guidelines applicable thereto (including,
      without limitation, the Innovation Law and the applicable regulations, rules, procedures thereof), and has fully fulfilled all the undertakings and obligations relating thereto including under the Innovation Law and the applicable regulations, rules,
      procedures thereof.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">21</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">3.2&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Representations and Warranties of Purchaser</u>.&#160; Purchaser hereby represents and warrants as of the date hereof and as of the Closing Date to the Company as
      follows (unless as of a specific date therein, in which case they shall be accurate as of such date):</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(a)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Organization; Authority</u>.&#160; Purchaser is an entity duly incorporated or formed, validly existing and in good standing under the laws of the
      jurisdiction of its incorporation or formation with full right, corporate power and authority to enter into and to consummate the transactions contemplated by the Transaction Documents and otherwise to carry out its obligations hereunder and
      thereunder. The execution and delivery of the Transaction Documents and performance by Purchaser of the transactions contemplated by the Transaction Documents have been duly authorized by all necessary corporate action on the part of Purchaser.&#160; Each
      Transaction Document to which it is a party has been duly executed by Purchaser, and when delivered by Purchaser in accordance with the terms hereof, will constitute the valid and legally binding obligation of Purchaser, enforceable against it in
      accordance with its terms, except: (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors' rights generally, (ii) as limited by laws relating to the
      availability of specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by Law.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(b)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Understandings or Arrangements</u>.&#160; Purchaser is acquiring the Securities as principal for its own account and has no direct or indirect
      arrangement or understandings with any other persons to distribute or regarding the distribution of such Securities (this representation and warranty not limiting Purchaser&#8217;s right to sell the Securities in compliance with applicable federal and
      state securities laws).&#160; Purchaser is acquiring the Securities hereunder in the ordinary course of its business.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(c)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Purchaser Status</u>.&#160; At the time Purchaser was offered the Securities, it was, and as of the date hereof it is an &#8220;accredited investor&#8221; as
      defined in Rule 501 of Regulation D under the Securities Act.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(d)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Experience of Purchaser</u>.&#160; Purchaser, either alone or together with its representatives, has such knowledge, sophistication and experience in
      business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Securities, and has so evaluated the merits and risks of such investment.&#160; Purchaser is able to bear the economic risk of an
      investment in the Securities and, at the present time, is able to afford a complete loss of such investment.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(e)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Investment Representations and Warranties</u>. Purchaser understands and agrees that the offering and sale of the Securities have not been
      registered under the Securities Act or the Israeli Securities Laws or any applicable state securities laws and is being made in reliance upon federal and state exemptions for transactions not involving a public offering which depend upon, among other
      things, the bona fide nature of the investment intent and the accuracy of Purchaser&#8217;s representations as expressed herein.</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">22</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(f)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Access to Information</u>. Purchaser acknowledges that it has been furnished by the Company with information regarding the Company which it has
      requested,&#160;has had the opportunity to review the Transaction Documents (including all exhibits and schedules thereto) and the SEC Reports and has been afforded, (i) the opportunity to ask such questions as it has deemed necessary of, and to receive
      answers from, representatives of the Company concerning the Company; (ii) access to information about the Company and its financial condition, results of operations, business, properties, management and prospects as it deemed sufficient to enable it
      to evaluate its investment; and (iii) the opportunity to obtain such additional information that the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed investment decision with respect to the
      investment.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(g)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Certain Transactions and Confidentiality</u>.&#160; Other than consummating the transactions contemplated hereunder, Purchaser has not, directly or
      indirectly, executed any purchases or sales, including Short Sales,&#160;of the securities of the Company during the period commencing as of the time that Purchaser first discussed with the Company the material pricing terms of the transactions
      contemplated hereunder and ending immediately prior to the execution hereof.&#160; Other than to Purchaser&#8217;s representatives, including, without limitation, its officers, directors, partners, legal and other advisors, employees, agents and Affiliates,
      Purchaser has maintained the confidentiality of all disclosures made to it in connection with this transaction (including the existence and terms of this transaction).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 55.5pt; margin-left: 21pt; line-height: 1.25;">(h)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Israeli Resale Restrictions</u>. Purchaser is aware of the fact that the resale of the Shares may be subject to certain restrictions under the
      Israeli Securities Law and the regulations promulgated thereunder, and therefore the resale of such Shares on the TASE may be subject to such restrictions. Purchaser undertakes to comply with such restrictions with respect to the resale of Securities
      on the TASE.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 55.5pt; margin-left: 21pt; line-height: 1.25;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Voting Agreements</u>. Purchaser is not a party to any agreement or arrangement, whether written or oral, between Purchaser and any of the
      Company&#8217;s shareholders as of the date hereof regulating the management of the Company, the shareholders&#8217; rights in the Company, the transfer of shares in the Company, including any voting agreements, shareholder agreements or any other similar
      agreement even if its title is different or has any other relations or agreements with any of the Company&#8217;s shareholders, directors or officers.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(j)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Governmental Review</u>. Purchaser understands that no Israeli or United States federal or state agency or any other government or
      governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the Securities nor have such authorities passed upon or endorsed the merits of the offering of the
      Securities.</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">23</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(k)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Brokers</u>. No agent, broker, investment banker, person or firm acting in a similar capacity on behalf of or under the authority of Purchaser is
      or will be entitled to any broker&#8217;s or finder&#8217;s fee or any other commission or similar fee, directly or indirectly, for which the Company or any of its Affiliates after the Closing would have any liabilities in connection with this Agreement, any of
      the transactions contemplated by this Agreement, or on account of any action taken by Purchaser in connection with the transactions contemplated by this Agreement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(l)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Independent Advice</u>. Purchaser understands that nothing in this Agreement or any other materials presented by or on behalf of the Company to
      Purchaser in connection with the purchase of the Securities constitutes legal, tax or investment advice.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(m)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No General Solicitation</u>. Purchaser is not subscribing for Securities as a result of or subsequent to any advertisement, article, notice or
      other communication, published in any newspaper, magazine or similar media or broadcast over television, radio, or the internet, or presented at any seminar or meeting, or any solicitation of a subscription by a person not previously known to
      Purchaser in connection with&#160;investments in securities generally.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 51pt; margin-left: 21pt; line-height: 1.25;">(n)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Restricted Securities</u>.&#160; Purchaser understands that the Securities will be characterized as &#8220;restricted securities&#8221; under the federal
      securities laws inasmuch as they are being acquired from the Company in a private placement under Section 4(a)(2) of the Securities Act and that under such laws and applicable regulations such Securities may be resold without registration under the
      Securities Act only in certain limited circumstances.&#160; Purchaser acknowledges that the Securities must be held indefinitely unless subsequently registered under the Securities Act and under applicable state securities laws or an exemption from such
      registration is available;&#160;provided,&#160;however, that by making the representations herein, Purchaser does not agree to hold any of the Securities for any minimum or other specific term and reserves the right to dispose of the Securities at any time in
      compliance&#160; with applicable Israeli or United States securities laws.&#160; Purchaser is aware of the provisions of Rule 144 under the Securities Act, which permits, as provided therein, limited resale of securities purchased in a private placement.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">ARTICLE IV.</font><br>
      OTHER AGREEMENTS OF THE PARTIES</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.1&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Furnishing of Information</u>.&#160; With a view to making available to the Purchaser the benefits of Rule 144 and any other rule or regulation of the Commission that
      may at any time permit the Purchaser to sell securities of the Company to the public without registration, the Company agrees, for so long as the Purchaser holds the Shares or, if shorter, 12 months&#160; from the Closing Date, to use its commercially
      reasonable efforts to (i) make and keep public information available, as those terms are understood and defined in Rule 144, at all times on and after the date hereof; (ii) file with the Commission in a timely manner all reports and other documents
      required of the Company under the Securities Act and the Exchange Act and (iii) furnish to the Purchaser promptly upon request (A) a written statement by the Company that it has complied with the reporting requirements of Rule 144, the Securities Act
      and the Exchange Act and (B) such other information as may be reasonably requested to avail the Purchaser of any rule or regulation of the Commission that permits the selling of any such securities without registration.</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">24</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.2&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Integration</u>.&#160; The Company shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of
      the Securities Act) that would be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any Trading Market such that it would require shareholder approval prior to the closing of such other transaction
      unless shareholder approval is obtained before the closing of such subsequent transaction.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.3&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Securities Laws Disclosure; Publicity</u>.&#160; The Company shall (a) by the Disclosure Time on the Trading Day immediately following the date hereof issue a press
      release disclosing the material terms of the transactions contemplated hereby including, but not limited to, the name of Purchaser, and (b) file a Report on Form 6-K, including the Transaction Documents as exhibits thereto, with the Commission within
      the time required by the Exchange Act (the &#8220;<u>6-K Filing</u>&#8221;).&#160; The Company and Purchaser shall consult with each other in issuing any press releases with respect to the transactions contemplated hereby, and neither the Company nor Purchaser shall
      issue any such press release nor otherwise make any such public statement without the prior consent of the Company, with respect to any press release of Purchaser, or without the prior consent of Purchaser, with respect to any press release of the
      Company, which consent shall not unreasonably be withheld or delayed, <font style="font-style: italic;">provided</font>&#160;<font style="font-style: italic;">that</font> either party shall be permitted to publicly disclose information that such party
      determines in good faith is necessary to be disclosed to comply with Law or the rules or regulations of any securities exchange on which such party&#8217;s stock may be listed, or pursuant to an order of a court or governmental entity, in which case the
      disclosing party shall promptly provide the other party with prior notice of such public statement or communication.&#160; Furthermore, notwithstanding the foregoing, information contained in press releases previously approved by the parties may be
      included in subsequent press releases and external communications, by either party without review by, or the necessity to obtain prior approval from, the other party.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.4&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>MNPI</u>.&#160; The Company shall not, and shall cause each of its Subsidiaries and each of their respective officers, directors, employees and agents, not to, provide
      Purchaser with any material, nonpublic information regarding the Company or any of its Subsidiaries from and after the filing of the 6-K Filing with the Commission without the express prior written consent of Purchaser, except such information
      provided pursuant to the Collaboration Agreement as amended by Amendment No. 3. To the extent that the Company delivers any material, non-public information to Purchaser without Purchaser&#8217;s consent (except information delivered pursuant to the
      Collaboration Agreement as amended by Amendment No. 3), the Company hereby covenants and agrees that Purchaser shall not have any duty of confidentiality with respect to, or a duty not to trade on the basis of, such material, non-public information,
      provided the parties shall remain subject to Law.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.5&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Use of Proceeds</u>. The Company shall use the proceeds from the sale of the Securities hereunder solely as permitted pursuant to the terms of Section 10.14(a) of
      the Collaboration Agreement. Without limiting the foregoing, none of such proceeds shall be used, directly or indirectly, (i) for the satisfaction of any debt of the Company (other than payment of trade payables incurred in the ordinary course of
      business of the Company and consistent with prior practices), (ii) for the redemption of any securities of the Company or (iii) with respect to any litigation involving the Company (including, without limitation, (A) the settlement thereof or (B) the
      payment of any costs or expenses related thereto).</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">25</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.6&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Shareholder Rights Plan</u>.&#160; No claim will be made or enforced by the Company or, with the consent of the Company, any other Person, that Purchaser is an &#8220;<u>Acquiring
        Person</u>&#8221; under any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or similar anti-takeover plan or arrangement in effect or hereafter adopted by the Company, or that Purchaser
      would be deemed to trigger the provisions of any such plan or arrangement, by virtue of receiving Securities under the Transaction Documents or under any other agreement between the Company and Purchaser.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.7&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Indemnification of Purchaser</u>.&#160; Subject to the provisions of this Section 4.7, the Company will indemnify and hold Purchaser, its Affiliates and their respective
      directors, officers, shareholders, members, partners, employees and agents (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title), each Person who controls
      Purchaser (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, shareholders, agents, members, partners or employees (and any other Persons with a functionally equivalent role of a
      Person holding such titles notwithstanding a lack of such title or any other title) of such controlling persons (each, a &#8220;<u>Purchaser Party</u>&#8221;) harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and
      expenses, including all judgments, amounts paid in settlements, court costs and reasonable attorneys&#8217; fees and costs of investigation (together referred to as &#8220;<u>Loss</u>&#8221;) that any such Purchaser Party may suffer or incur as a result of or relating
      to (a) any breach of any of the representations, warranties, covenants or agreements made by the Company in this Agreement or in the other Transaction Documents or (b) any action instituted against the Purchaser Parties in any capacity, or any of
      them or their respective Affiliates, by any shareholder of the Company who is not an Affiliate of such Purchaser Party, with respect to any of the transactions contemplated by the Transaction Documents (unless such action is solely based upon a
      material breach of such Purchaser Party&#8217;s representations, warranties or covenants under the Transaction Documents or any agreements or understandings such Purchaser Party may have with any such shareholder or any violations by such Purchaser Party
      of state or federal securities laws or any conduct by such Purchaser Party which is finally judicially determined to constitute fraud, gross negligence, willful misconduct or willful malfeasance).&#160; If any action shall be brought against any Purchaser
      Party in respect of which indemnity may be sought pursuant to this Agreement, such Purchaser Party shall promptly notify the Company in writing, and the Company shall have the right to assume the defense thereof with counsel of its own choosing
      reasonably acceptable to the Purchaser Party.&#160; Any Purchaser Party shall have the right to employ separate counsel in any such action and participate in the defense thereof, but the fees and expenses of such counsel shall be at the expense of such
      Purchaser Party except to the extent that (i) the employment thereof has been specifically authorized by the Company in writing, (ii) the Company has failed after a reasonable period of time to assume such defense and to employ counsel or (iii) in
      such action there is, in the reasonable opinion of Purchaser Party&#8217;s counsel, a material conflict on any material issue between the position of the Company and the position of such Purchaser Party, in which case the Company shall be responsible for
      the reasonable fees and expenses of no more than one such separate counsel.&#160; The Company will not be liable to any Purchaser Party under this Agreement (y) for any settlement by a Purchaser Party effected without the Company&#8217;s prior written consent,
      which shall not be unreasonably withheld or delayed; or (z) to the extent, but only to the extent that a loss, claim, damage or liability is attributable to any Purchaser Party&#8217;s breach of any of the representations, warranties, covenants or
      agreements made by such Purchaser Party in this Agreement or in the other Transaction Documents. The indemnification required by this Section 4.7 shall be made, subject to the procedure set forth above, by periodic payments of the amount thereof, as
      and when documented bills are received by the Company or Losses are otherwise incurred and notified in writing to the Company.&#160; Notwithstanding the foregoing, the maximum aggregate monetary liability of the Company for any and all breaches of
      representations and warranties under this Agreement and as to any indemnification pursuant to clause (b) of this Section 4.7 solely to the extent such indemnification does not result from a breach of the Company&#8217;s covenants or other obligations under
      the Transaction Documents, as to any Purchaser Party and all Purchaser Parties together, shall not exceed the Subscription Amount; provided however, that in no event shall such aggregate monetary liability of the Company, as to any Purchaser Party
      and all Purchaser Parties together, for any and all breaches of Non-Fundamental Representations, exceed 50% of the Subscription Amount.&#160; Representations and warranties regarding Organization and Qualification (Section 3.1(b)), Authorization;
      Enforcement (Section 3.1(c)), No Conflicts (Section 3.1(d)), Filings, Consents and Approvals (Section 3.1(e)), Issuance of the Securities; Registration (Section 3.1(f)), and Capitalization (Section 3.1(g)) shall be referred to as &#8220;<u>Fundamental
        Representations</u>&#8221;, and all other representations and warranties shall be referred to as &#8220;<u>Non-Fundamental Representations</u>&#8221;.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">26</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.8&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>L</u><u>isting of Common Stock</u>. The Company hereby agrees to use reasonable best efforts to maintain the listing or quotation of the Common Stock on the Nasdaq,
      and promptly following the date hereof, the Company shall apply to list or quote all of the Shares on Nasdaq and the TASE and promptly secure the listing of all of the Shares on each such Trading Market no later than the Closing Date. The Company
      further agrees, if the Company applies to have the Common Stock traded on any other Trading Market, it will then include in such application all of the Shares, and will take such other action as is necessary to cause all of the Shares to be listed or
      quoted on such other Trading Market as promptly as possible.&#160; The Company will take all action reasonably necessary to continue the listing and trading of its Common Stock on a Trading Market and will comply in all material respects with the
      Company&#8217;s reporting, filing and other obligations under the bylaws or rules of the Trading Market.&#160; The Company agrees to maintain the eligibility of the Common Stock for electronic transfer through the Depository Trust Company or another established
      clearing corporation, including, without limitation, by timely payment of fees to the Depository Trust Company or such other established clearing corporation in connection with such electronic transfer.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.9&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Transfer Restrictions.</u> It is understood that the certificates evidencing the Securities may bear substantially the following legend:</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; margin-left: 36pt; line-height: 1.25;">&#8220;<u>THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR ANY APPLICABLE STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
        HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES UNDER SUCH ACT OR APPLICABLE STATE SECURITIES LAWS OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED OR
        UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT</u>.&#8221;</div>
    <div style="text-align: justify; margin-left: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">27</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">If any Shares are subject to the above legend, or any stop transfer or similar instruction or restriction, the Company shall, upon the request of the holder of such Shares, promptly cause such
      legends, stop transfer or similar instructions to be removed (and, if certificated, new certificates without such legends, stop transfer or similar instructions to be issued) if (a) such Shares have been, or are being substantially contemporaneously,
      resold pursuant to an effective registration statement with the Commission or (b) the holder of such Shares provides the Company a customary certification regarding its satisfaction of the holding period and its non-affiliate status under Rule 144
      and, if within the first twelve (12) months of Closing, at the holder&#8217;s election, a letter by the holder&#8217;s broker or a certification from the holder regarding the substantially contemporaneous sale of the Shares in connection with the removal of such
      legends, stock transfer or similar instructions (which may be relied upon by the Company and its counsel and transfer agent).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.10&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Information for Tax Purposes</u>. Not later than one hundred twenty (120) days after the end of the Company&#8217;s fiscal year, the Company will determine whether it
      and each of its non-U.S. subsidiaries constitutes a &#8220;passive foreign investment company&#8221; (&#8220;<u>PFIC</u>&#8221;) or a &#8220;controlled foreign corporation&#8221; as defined for U.S. tax purposes under Section 1298 of the Code for such fiscal year and will so advise
      Purchaser. For each fiscal year of the Company beginning with the tax year ending December 31, 2021, commencing with the first fiscal year for which it is determined to be a PFIC, the Company and each of its non-U.S. subsidiaries shall no later than
      one hundred twenty (120) day after the end of such fiscal year, furnish Purchaser with all information necessary for them to make a qualified electing fund election, including: (a) a PFIC Annual Information Statement under Section 1295(b) of the
      Code; and (b) all information necessary for it to complete IRS Form 8621 (or successor form). Additionally, to the extent additional information is required to meet U.S. tax reporting requirements, the Company agrees to furnish all necessary
      documentation to comply, to the extent legally permissible.&#160; All information shall be provided in English.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">4.11&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Innovation Law</u>. The Company will (i) fulfil all the undertakings and obligations relating to any grants it has received or may receive in the future from the
      Israeli Innovation Authority under the Innovation Law and (ii) comply with the terms and conditions of the grants and the laws and guidelines applicable thereto (including, without limitation, the Innovation Law and the applicable regulations, rules,
      procedures thereof).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">ARTICLE V.</font><br>
      MISCELLANEOUS</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.1&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Termination</u>.&#160; This Agreement may be terminated by Purchaser by written notice to the Company if the Closing has not been consummated on or before fifth Trading
      Day following the date hereof; <u>provided</u>, <u>however</u>, that no such termination will affect the right of any party to sue for any breach by any other party (or parties).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.2&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Fees and Expenses</u>.&#160; Each party shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred
      by such party incident to the negotiation, preparation, execution, delivery and performance of this Agreement.&#160; The Company shall pay all Transfer Agent fees, stamp taxes and other taxes and duties levied in connection with the delivery of any
      Securities to Purchaser.</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">28</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.3&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Entire Agreement</u>.&#160; The Transaction Documents, together with the exhibits and schedules thereto, contain the entire understanding of the parties with respect to
      the subject matter hereof and thereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into such documents, exhibits and schedules.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.4&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Notices</u>.&#160; Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given
      and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered via facsimile at the facsimile number or email attachment at the email address as set forth on the signature pages attached hereto at or
      prior to 5:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such notice or communication is delivered via facsimile at the facsimile number or email attachment at the email address as set
      forth on the signature pages attached hereto on a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (c) the second (2<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">nd</sup>) Trading Day following the date of mailing, if sent by U.S. nationally
      recognized overnight courier service or (d) upon actual receipt by the party to whom such notice is required to be given.&#160; The address for such notices and communications shall be as set forth on the signature pages attached hereto.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.5&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Amendments; Waivers</u>.&#160; No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed, in the case of an
      amendment, by the Company and Purchaser or, in the case of a waiver, by the party against whom enforcement of any such waived provision is sought.&#160; No waiver of any default with respect to any provision, condition or requirement of this Agreement
      shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any
      manner impair the exercise of any such right. Any amendment effected in accordance with this Section 5.5 shall be binding upon Purchaser, any holder of Securities and the Company.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.6&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Headings</u>.&#160; The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the
      provisions hereof.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.7&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Successors and Assigns</u>.&#160; This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns.&#160; The Company
      may not assign this Agreement or any rights or obligations hereunder without the prior written consent of Purchaser.&#160; Purchaser may assign any or all of its rights under this Agreement to any Person to whom Purchaser assigns or transfers any
      Securities, provided that such transferee agrees in writing to be bound, with respect to the transferred Securities, by the provisions of the Transaction Documents that apply to Purchaser.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.8&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>No Third-Party Beneficiaries</u>.&#160; This Agreement is intended for the benefit of the parties hereto and their respective successors and permitted assigns and is not
      for the benefit of, nor may any provision hereof be enforced by, any other Person, except as otherwise set forth in Section 4.7 and this Section 5.8.</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">29</font></div>
      <div id="DSPFPageBreak" style="page-break-after: always;">
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    </div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.9&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Governing Law</u>.&#160; All questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall be governed by and
      construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof.&#160; Each party agrees that all legal Proceedings concerning the interpretations, enforcement and defense
      of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees or agents) shall be commenced
      exclusively in the state and federal courts sitting in the City of New York, Borough of Manhattan.&#160; Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of
      Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction Documents), and hereby irrevocably
      waives, and agrees not to assert in any Action or Proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such Action or Proceeding is improper or is an inconvenient venue for such Proceeding.&#160; Each party
      hereby irrevocably waives personal service of process and consents to process being served in any such Action or Proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such party at
      the address in effect for notices to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and notice thereof.&#160; Nothing contained herein shall be deemed to limit in any way any right to serve
      process in any other manner permitted by law.&#160;&#160; If any party shall commence an Action or Proceeding to enforce any provisions of the Transaction Documents, then, in addition to the obligations of the Company under Section 4.7, the prevailing party in
      such Action or Proceeding shall be reimbursed by the non-prevailing party for its reasonable attorneys&#8217; fees and other costs and expenses incurred with the investigation, preparation and prosecution of such Action or Proceeding.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.10&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Survival</u>.&#160; The representations and warranties contained herein shall survive the Closing and the delivery of the Securities until: (1) for Non-Fundamental
      Representations, 12 months after the Closing, and (2) for Fundamental Representations, the expiration of the applicable statute of limitation.&#160; The covenants contained herein shall survive until fully performed.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.11&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Execution</u>.&#160; This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute
      one and the same instrument, and may be delivered by facsimile transmission or by electronic delivery of a portable document format (PDF) file (including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic
      Transactions Act, the Electronic Signatures and Records Act or other applicable law, e.g., www.docusign.com).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.12&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Severability</u>.&#160; If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal, void or
      unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially
      reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the
      parties that they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid, illegal, void or unenforceable.</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"> <br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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      Company of such loss, theft or destruction.&#160; The applicant for a new certificate or instrument under such circumstances shall also pay any reasonable third-party costs (including customary indemnity) associated with the issuance of such replacement
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      required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any other Person under any law (including, without limitation, any bankruptcy law, state or federal law, common law or equitable cause of action), then to
      the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred.</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">5.18&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<u>Construction</u>. The parties agree that each of them and/or their respective counsel have reviewed and had an opportunity to revise the Transaction Documents and,
      therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of the Transaction Documents or any amendments thereto. In addition, each and
      every reference to share prices and shares of Common Stock in any Transaction Document shall be subject to adjustment for reverse and forward stock splits, stock dividends, stock combinations and other similar transactions of the Common Stock that
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    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;">IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as of the date first indicated
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            <div style="line-height: 1.25;">By: <u>/s/ Ari Krashin</u></div>
            <div style="line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;Name: Ari Krashin</div>
            <div style="line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;Title: CFO &amp; COO</div>
            <div style="line-height: 1.25;">With a copy to (which shall not constitute notice):</div>
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            <div style="text-align: justify; line-height: 1.25;">Azrieli Center</div>
            <div style="text-align: justify; line-height: 1.25;">26 Harokmim Street, Bldg D</div>
            <div style="text-align: justify; line-height: 1.25;">Holon, Israel 5885849</div>
            <div style="line-height: 1.25;">Attention:&#160;&#160;CFO and General Counsel</div>
            <div style="line-height: 1.25;">Fax:&#160; +972-73-376-6703</div>
            <div style="line-height: 1.25;">Email: <u>Arik@cgen.com</u>; legal@cgen.com</div>
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            <div style="text-align: justify; line-height: 1.25;">Cooley LLP</div>
            <div style="text-align: justify; line-height: 1.25;">55 Hudson Yards, New York</div>
            <div style="text-align: justify; line-height: 1.25;">NY 10001-2157Attention:&#160;&#160;Daniel I. Goldberg</div>
            <div style="text-align: justify; line-height: 1.25;">Facsimile:&#160;&#160;(212) 479-6275</div>
            <div style="text-align: justify; line-height: 1.25;">Email: dgoldberg@cooley.com</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase Agreement to be duly executed by their respective authorized signatories as of the date first indicated
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            <div style="line-height: 1.25;">By: <u>/s/ Daniel O&#8217;Connell</u></div>
            <div style="line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;Name: Daniel O&#8217;Connell</div>
            <div style="line-height: 1.25;">&#160;&#160;&#160;&#160;&#160;Title: Executive Director, Corporate Development</div>
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              Attention:&#160; Executive Vice President and General Counsel<br>
              Facsimile No.: (212) 546-9562</div>
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            <div style="line-height: 1.25;">Bristol-Myers Squibb Company<br>
              Route 206 &amp; Province Line Road<br>
              Princeton, New Jersey&#160; 08543<br>
              Attention: Senior Vice President Transactions Law<br>
              Facsimile: (609) 252-7680</div>
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<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>3
<FILENAME>exhibit_10-2.htm
<DESCRIPTION>EXHIBIT 10.2
<TEXT>
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        <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;"><u><font style="font-weight: bold;"> Exhibit 10.2</font></u><br>
        </div>
        <div style="text-align: justify; line-height: 1.25;"> <font style="font-variant: normal;"><br>
          </font></div>
        <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">Certain confidential information contained in this document, marked by [*], has been omitted because
          Compugen Ltd. has determined that the information is (i) not material and (ii) would likely cause competitive harm to Compugen Ltd. if publicly disclosed.</div>
      </div>
      <div style="line-height: 1.25; font-variant: normal;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">EXECUTION VERSION</div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">CONIFDENTIAL</div>
      <div style="line-height: 1.25; font-variant: normal;"><br style="line-height: 1.25;">
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal; font-weight: bold;">Amendment No. 3 to Master Clinical Trial Collaboration Agreement</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">This
        Amendment No. 3 to Master Clinical Trial Collaboration Agreement</font><font style="font-variant: normal;"> (this &#8220;<font style="font-weight: bold; font-style: italic;">Amendment No. 3</font>&#8221;)
        is effective as of November 10, 2021 (&#8220;<font style="font-weight: bold; font-style: italic;">Amendment No. 3 Effective Date</font>&#8221;) by and between <font style="font-weight: bold;">Compugen Ltd.</font>, an Israeli corporation with a place of business at Azrieli Center, 26 Harokmim Street, Building D, Holon 5885849, Israel&#160;(&#8220;<font style="font-weight: bold; font-style: italic;">Compugen</font>&#8221;), and <font style="font-weight: bold;">Bristol-Myers Squibb Company</font>, a Delaware corporation, headquartered at 430 E. 29th Street, 14FL, New York, N.Y. 10016 (&#8220;<font style="font-weight: bold; font-style: italic;">BMS</font>&#8221;).</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal; font-weight: bold;">Background</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">A.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;BMS and Compugen entered into that certain Master Clinical Trial Collaboration Agreement, dated as of October 10, 2018, as amended (the &#8220;<font style="font-weight: bold; font-style: italic;">Agreement</font>&#8221;).</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">B.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The Parties have mutually agreed to amend the Agreement as follows in accordance with Section 13.7 of the Agreement.</font></div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">Now,
        therefore</font><font style="font-variant: normal;">, in consideration of the mutual covenants and undertakings contained herein, and on the terms and subject to the conditions set forth herein, the Parties hereby agree as follows:</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">1.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Capitalized terms used and not otherwise defined herein shall have the meaning given to such terms in the Agreement.</font></div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">2.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Section 2.8 shall be deleted in its entirety, and replaced with the following:</font></div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">2.8</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">JDC Dispute Resolution</font>.&#160; The representatives of the JDC shall attempt in good faith to reach consensus on all matters properly brought before the JDC. If, after a good faith reasonable, and open discussion among the members of the JDC, and
            the Alliance Managers, the JDC is unable to agree on a matter that has been properly brought before it for a period of [*], and that calls for a decision, either Party may refer the dispute (a &#8220;<font style="font-weight: bold;">JDC Dispute</font>&#8221;) to the JSC for resolution.</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">3.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The following shall be added to the Agreement as Section 2.9:</font></div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">2.9</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Joint Steering Committee. </font>By no later than [*] after the Amendment No. 3 Effective Date, the Parties will establish a Joint Steering Committee (&#8220;<font style="font-weight: bold;">JSC</font>&#8221;) to provide strategic oversight to all Combined Therapy Studies, and to be the advisory body for the Combined Therapy Studies, the Monotherapy Arm and, if requested by Compugen, other clinical studies involving
          the Compugen Compound.&#160; The responsibilities of the JSC are described in Section 2.10(c) of this Agreement.</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">(a)</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Membership</font>.&#160; Each Party will initially appoint [*] voting representatives with appropriate seniority and expertise required to fulfill the responsibilities of the JSC to serve as members of the JSC. For clarity, members of the JDC
          may also serve as members of the JSC, as long as they meet the foregoing requirements. Members of the JDC, as well as employees or consultants of a Party who are not members of the JSC for either Party may be invited, subject to agreement (which
          agreement must be in writing and may be by email) by both Parties, to attend meetings of the JSC on an ad hoc basis if their attendance would helpful to the JSC in fulfilling its responsibilities. Such ad hoc attendees, however (i)&#160;shall not vote
          or otherwise participate in the decision-making process of the JSC, and (ii)&#160;shall be bound by obligations of confidentiality and non-disclosure at least as protective of the Confidential Information of both Parties as those set forth in Article
          9 of this Agreement. The JSC may change its size from time to time by mutual consent of its members, provided that the JSC will consist of an equal number of representatives from each of Compugen and BMS.&#160; Each Party may replace, on a temporary
          or permanent basis, any or all of its JSC representatives by providing written notice to the other Party; provided that any such replacement member shall have the appropriate seniority and expertise to serve as a member of the JSC.</font></div>
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      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">Certain confidential information contained in this document, marked by [*], has been omitted because
        Compugen Ltd. has determined that the information is (i) not material and (ii) would likely cause competitive harm to Compugen Ltd. if publicly disclosed.</div>
    </div>
    <div style="line-height: 1.25; font-variant: normal;"> <br>
    </div>
    <div style="line-height: 1.25; font-variant: normal;">
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">EXECUTION VERSION</div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">CONIFDENTIAL</div>
    </div>
    <div style="line-height: 1.25; font-variant: normal;"> <br>
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    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">(b)</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Meetings</font>.&#160; The JSC will hold meetings at such times and places as the
          Parties may determine.&#160; The JSC will meet at least once quarterly during the Term unless the Parties agree otherwise.&#160; Meetings of the JSC need not be in person and may be by telephone or any other method determined by the JSC.&#160; Each Party will
          bear its own costs associated with attending such meetings.</font></div>
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    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">(c)</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Responsibilities</font>.</font></div>
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          authority of JSC shall not replace the responsibilities and authority assigned to the JDC under Section 2.4, and Section 2.5, except to the extent that such matters also fall under the responsibilities and authority that are expressly designated
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    <div style="text-align: justify; text-indent: 72pt; margin-right: 1.3pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">(v)</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Upon a request from the JSC, preparing a report regarding the progress of any or all of the Combined Therapy Studies, to be used by
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">5.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Section 8.11(a) (<font style="font-style: italic;">Access</font>) of the Agreement is hereby deleted in its
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      <div style="text-indent: 72pt; margin-right: 1.3pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">(a)</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Access</font>.&#160;&#160; BMS shall have
            access to all interim clinical and translational data analyses, and the final clinical and translational data analysis made by, or provided to Compugen with respect to the Monotherapy Arm (the &#8220;<font style="font-weight: bold;">Monotherapy Study Data</font>&#8221;) promptly following the completion of any such analysis. In addition, Compugen shall provide updates with respect to the Monotherapy Arm, including: (i) reports
            requested by the JSC, provided that such information is relevant to the Combined Therapy or the Combined Therapy Studies, and (ii) all interim Monotherapy Study Data that is available at such time of each JSC meeting. Compugen shall also
            provide BMS all Monotherapy Study Data produced, after the most recent JSC meeting,
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    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">6.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The following shall be added to the Agreement as Section 10.14:</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">10.14</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;
        <font style="font-weight: bold;">Additional Funding</font>.</font></div>
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    <div style="text-align: justify; text-indent: 72pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-variant: normal;">&#160;(a)</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-weight: bold;">Use of Funds</font>.&#160; The entire net proceeds from the issuance of equity shares by Compugen under the Share Purchase Agreement dated October 15, 2021 shall be utilized by Compugen for the conduct of the Initial Studies and the
          Triple Study, provided that if all of such studies are completed in a manner reasonably satisfactory to BMS, then any remaining portion of the net proceeds of the issuance may be allocated to other &#8220;general working capital and research and development activities&#8221;. For clarity, notwithstanding the foregoing, neither the Initial Studies nor the Triple Study shall be deemed a Jointly-Funded Study.<br>
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      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25; font-variant: normal;">
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">Certain confidential information contained in this document, marked by [*], has been omitted because
        Compugen Ltd. has determined that the information is (i) not material and (ii) would likely cause competitive harm to Compugen Ltd. if publicly disclosed.</div>
      &#160;</div>
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      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">EXECUTION VERSION</div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">CONIFDENTIAL</div>
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          Studies and the Triple Study, or (ii) such time that the entire net proceeds from the issuance of equity shares by Compugen pursuant to the foregoing shall have been utilized by Compugen to conduct the Initial Studies and the Triple Study,
          Compugen shall provide the JSC, on an annual basis, a report summarizing in reasonable detail the activities performed to conduct the Initial Studies, and the Triple Study, and setting forth the actual amounts spent on the Initial Studies and the
          Triple Study (including reasonably related direct and indirect expenses) during the immediately preceding calendar year. Such reports shall also include a forecast of the activities to be performed to conduct the Initial Studies and the Triple
          Study over the following year, and a good faith estimate of the amount of funding required to perform such activities (including reasonably related direct and indirect expenses) over the following year. Such report shall be provided [*]. In addition, the first annual report will include all of the actual amounts spent on the Initial Studies and the Triple Study as of the Amendment No. 3 Effective
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    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">8.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;This Amendment No. 3 may be executed in two (2) or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one (1) and the
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    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">9.</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;This Amendment No. 3 shall be governed and construed in accordance with the internal laws of the State of New York, USA, excluding any choice of law rules that may direct the
          application of the laws of another jurisdiction.</font></div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-style: italic; font-variant: normal;">[Signature page follows]</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-style: italic; font-variant: normal;"> <br>
    </div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
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    </div>
    <div style="line-height: 1.25; font-variant: normal;">
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">Certain confidential information contained in this document, marked by [*], has been omitted because
        Compugen Ltd. has determined that the information is (i) not material and (ii) would likely cause competitive harm to Compugen Ltd. if publicly disclosed.</div>
    </div>
    <div style="line-height: 1.25; font-variant: normal;">&#160;<br>
    </div>
    <div style="line-height: 1.25; font-variant: normal;">
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">EXECUTION VERSION</div>
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: normal;">CONIFDENTIAL</div>
    </div>
    <div style="text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;"> <br>
      </font></div>
    <div style="text-indent: 36pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; font-variant: normal;">In witness
        whereof</font><font style="font-variant: normal;">, BMS and Compugen have duly executed this Amendment No.3 as of the Amendment No. 3 Effective Date.</font></div>
    <div style="line-height: 1.25; font-variant: normal;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z095fdb0290664c7d8ba9d5322457c5fa" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 50%; vertical-align: top; font-variant: normal;">
            <div style="line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
            <div style="line-height: 1.25; font-weight: bold;"> <br>
            </div>
          </td>
          <td style="width: 50%; vertical-align: top; font-variant: normal;">
            <div style="line-height: 1.25; font-weight: bold;">Bristol-Myers Squibb Company</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="line-height: 1.25;"><font style="font-variant: normal;">By: </font><u><font style="font-variant: normal;">/s/ Ari Krashin</font></u></div>
          </td>
          <td style="width: 50%; vertical-align: top; font-variant: normal;">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">By: <u>/s/ Jonathan Cheng, MD</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div style="line-height: 1.25;"><font style="font-variant: normal;">Name: </font><font style="font-variant: normal;">Ari Krashin</font><font style="font-variant: normal;">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font></div>
          </td>
          <td style="width: 50%; vertical-align: top; font-variant: normal;">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Name: Jonathan Cheng, MD</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; font-variant: normal;">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Title: CFO &amp; COO</div>
          </td>
          <td style="width: 50%; vertical-align: top; font-variant: normal;">
            <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Title: SVP, Head of Oncology Development</div>
          </td>
        </tr>

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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>4
<FILENAME>exhibit_99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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      <div style="line-height: 1.25;">
        <div style="text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.1</font></u><br>
        </div>
        <br>
        <br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><img width="125" height="53" src="image0.jpg">
        <div><br>
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    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">FOR IMMEDIATE RELEASE</div>
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      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Compugen Announces Collaboration Expansion</font><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;"> with Bristol Myers </font><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;"></font></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><font style="font-size: 12pt; font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Squibb alongside $20 Million Equity Investment</font></div>
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          <tr>
            <td style="width: 17.85pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Investment is intended to enhance the strategic collaboration between Compugen and Bristol Myers Squibb and support the continued execution of the clinical programs</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
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          <tr>
            <td style="width: 17.85pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div>Ongoing clinical programs aimed at testing Compugen&#8217;s DNAM axis hypothesis, targeting PVRIG, TIGIT and PD-1 include cohort expansion studies in selected tumor types
                of the dual combination of COM701 with nivolumab and the triple combination of COM701 with nivolumab and BMS investigational anti-TIGIT antibody BMS- 986207</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">HOLON, ISRAEL November 11, 2021&#8211; <u>Compugen Ltd.</u>
      (Nasdaq: CGEN), a clinical-stage cancer immunotherapy company and a leader in
      predictive target discovery, announced today that Bristol Myers Squibb (NYSE: BMY)&#160;completed its $20&#160;million investment in Compugen&#160; in consideration for the issuance of&#160;2,332,815
      shares of Compugen purchased at $8.57333 per share, representing a 33% premium over the closing price on November 9, 2021.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">As part of the expansion of the collaboration, a joint steering committee has been formed to facilitate strategic oversight and guidance
        for the programs run under the collaboration. This will run alongside the existing joint development committee which acts at an operational level.</div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">&#8220;Bristol Myers Squibb&#8217;s strategic investment in Compugen strengthens our relationship and the goal of both companies to take forward our
      clinical studies conducted under our collaboration in bringing innovative therapies to cancer patients,&#8221; said Anat Cohen-Dayag, Ph.D., President and CEO of Compugen. &#8220;We value Bristol Myers Squibb&#8217;s continued support of Compugen and in our evaluation
      of our DNAM axis hypothesis by testing COM701 in combination with nivolumab as a dual combination and in combination with nivolumab and BMS-986207 as a triple combination targeting PVRIG, PD-1 and TIGIT.&#8221;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">About COM701</div>
    <div style="text-align: justify; line-height: 1.25;">COM701 is a humanized antibody that binds with high affinity to PVRIG, a novel immune checkpoint discovered computationally by Compugen,
      blocking the interaction with its ligand, PVRL2. In pre-clinical studies, blockade of PVRIG by COM701 has demonstrated potent, reproducible enhancement of T cell activation, consistent with the desired mechanism of action of activating T cells in the
      tumor microenvironment to generate anti-tumor immune responses. Compugen has identified PVRIG and TIGIT as key parallel and complementary inhibitory pathways in the DNAM axis, which also intersect with the well-established PD-1 pathway. Research from
      Compugen suggests that these three pathways have different dominance in different tumor types and patients, implying that to induce effective antitumor responses, certain patient populations may require the blockade of different combinations of these
      three pathways.&#160;To test this hypothesis, Compugen has established a science-driven, biomarker informed clinical program, which evaluates different combinations of these axis members across tumor types. Compugen is the only company with clinical
      assets targeting both PVRIG and TIGIT in its portfolio allowing it to explore the potential of blocking these parallel and complementary members of the&#160;DNAM&#160;axis&#160;comprehensively to drive robust immune responses.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">About&#160;Compugen&#160;</font>&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">Compugen&#160;is a clinical-stage discovery and development company utilizing its broadly applicable, predictive computational discovery
      platforms to identify novel drug targets and develop therapeutics in the field of cancer immunotherapy.&#160;Compugen&#8217;s lead product candidate, COM701, a potentially first-in-class anti-PVRIG antibody, for the treatment of solid tumors, is
      undergoing&#160;Phase 1 studies as a single agent and in&#160;dual,&#160;and triple combinations. COM902,&#160;Compugen&#8217;s second fully owned clinical&#160;antibody targeting TIGIT, for the treatment of solid and hematological tumors, is undergoing Phase 1 studies as a single
      agent and in dual combination. Partnered programs include bapotulimab, a therapeutic antibody in Phase 1 development targeting ILDR2 licensed to Bayer under a research and discovery collaboration and license agreement, and AZD2936, a TIGIT/PD-1
      bispecific in Phase 1 development derived from COM902 through a license agreement with AstraZeneca for the development of bispecific and multi-specific antibodies. Compugen&#8217;s therapeutic pipeline of early-stage&#160;immuno-oncology programs includes
      myeloid targets.&#160;Compugen&#160;is headquartered in Israel, with offices in South San Francisco, CA.&#160;Compugen&#8217;s&#160;shares are listed on Nasdaq and the Tel Aviv&#160;Stock Exchange under the ticker symbol CGEN. For additional information, please
      visit&#160;Compugen&#8217;s&#160;corporate website at&#160;www.cgen.com.&#160;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Forward-Looking Statement</div>
    <div style="text-align: justify; line-height: 1.25;">This press release contains &#8220;forward-looking statements&#8221; within the meaning of the Securities Act of 1933 and the Securities Exchange
      Act of 1934, as amended, and the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on the current beliefs, expectations, and assumptions of Compugen. Forward-looking statements
      can be identified using terminology such as &#8220;will,&#8221; &#8220;may,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;believes,&#8221; &#8220;potential,&#8221; &#8220;plan,&#8221; &#8220;goal,&#8221; &#8220;estimate,&#8221; &#8220;likely,&#8221; &#8220;should,&#8221; &#8220;confident,&#8221; and &#8220;intends,&#8221; and similar expressions that are intended to identify
      forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements include, but are not limited to, statements relating to the intention of the parties to enhance the strategic
      collaboration between Compugen and Bristol Myers Squibb to support the continued execution of the clinical studies conducted under the collaboration with Bristol Myers Squibb; or to the aim of the ongoing clinical programs at testing Compugen&#8217;s DNAM
      axis hypothesis, targeting PVRIG, TIGIT and PD-1 and to include cohort expansion studies in selected tumor types. These forward-looking statements involve known and unknown risks and uncertainties that may cause the actual results, performance, or
      achievements of Compugen to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Among these risks: the effect of the global COVID-19 pandemic may continue to negatively
      impact the global economy and may also adversely affect Compugen&#8217;s business; clinical development involves a lengthy and expensive process, with an uncertain outcome and Compugen may encounter substantial delays or even an inability to begin clinical
      trials for any specific product or may not be able to conduct or complete our trials on the timelines we expect; Compugen&#8217;s business model is substantially dependent on entering into collaboration agreements with third parties and Compugen may not be
      successful in generating adequate revenues or commercializing aspects of its business model; Compugen&#8217;s approach to the discovery of therapeutic products is based on its proprietary computational target discovery infrastructure, which is unproven
      clinically; and Compugen does not know whether it will be able to discover and develop additional potential product candidates or products of commercial value. These risks and other risks are more fully discussed in the &#8220;Risk Factors&#8221; section of
      Compugen&#8217;s most recent Annual Report on Form 20-F as filed with the Securities and Exchange Commission (SEC) as well as other documents that may be subsequently filed by Compugen from time to time with the SEC. In addition, any forward-looking
      statements represent Compugen's views only as of the date of this release and should not be relied upon as representing its views as of any subsequent date. Compugen does not assume any obligation to update any forward-looking statements unless
      required by law.&#160;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">Company Contact:&#160;</font>&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">Yvonne Naughton, PhD&#160;&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">Head of Investor Relations and Corporate Communications</div>
    <div style="text-align: justify; line-height: 1.25;">Email:&#160;ir@cgen.com&#160;&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">Tel: +1&#160;(628)&#160;241-0071&#160;&#160;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Investor Relations Contact:</div>
    <div style="text-align: justify; line-height: 1.25;">John Mullaly</div>
    <div style="text-align: justify; line-height: 1.25;">LifeSci Advisors, LLC</div>
    <div style="text-align: justify; line-height: 1.25;">Email: jmullaly@lifesciadvisors.com</div>
    <div style="text-align: justify; line-height: 1.25;">Tel: +1 (617) 429-3548</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
