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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |  |
Net loss | $ (34,203) | $ (29,698) | $ (27,337)
Adjustments required to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 4,276 | 2,772 | 2,408
Depreciation | 461 | 715 | 989
Increase (decrease) in Severance pay, net | (101) | 184 | (22)
Gain from property and equipment sales and disposals | (3) | (12) | (135)
Decrease (increase) in interest receivables from short-term bank deposits | 469 | (532) | 66
Decrease (increase) in trade receivables | 2,000 | (2,000) |
Increase in other accounts receivable and prepaid expenses | (2,802) | (1,613) | (142)
Decrease (increase) in long-term prepaid expenses | (31) | (1,187) | 83
Decrease in operating lease right of use asset | 525 | 475 | 2,165
Increase (decrease) in trade payables and other accounts payable and accrued expenses | 3,367 | 3,817 | (3,502)
Increase (decrease) in deferred participation in R&D expenses | 3,708 | (829) | (627)
Decrease in operating lease liability | (416) | (412) | (1,834)
Net cash used in operating activities | (22,750) | (28,320) | (27,888)
Cash flows from investing activities: |  |  |
Proceeds from maturity of short-term bank deposits | 136,850 | 70,300 | 59,403
Investment in short-term bank deposits | (129,945) | (152,350) | (54,300)
Purchase of property and equipment | (292) | (166) | (155)
Proceeds from sale of property and equipment | 3 | 44 | 382
Net cash provided by (used in) investing activities | 6,616 | (82,172) | 5,330
Cash flows from financing activities: |  |  |
Proceeds from issuance of ordinary shares, net | 14,958 | 74,147 | 22,758
Proceeds from exercise of warrants | 425 | 18,325 |
Proceeds from exercise of stock-based awards | 1,455 | 15,991 | 3,173
Net cash provided by financing activities | 16,838 | 108,463 | 25,931
Increase (decrease) in cash, cash equivalents and restricted cash | 704 | (2,029) | 3,373
Cash, cash equivalents and restricted cash at the beginning of the year | 7,810 | 9,839 | 6,466
Cash and cash equivalents and restricted cash at the end of the year | 8,514 | 7,810 | 9,839
Supplemental disclosure of non-cash investing and financing activities: |  |  |
Purchase of property and equipment | 116 | 16 | 47
Receivables on account of shares |  |  | 76
Right-of-use asset obtained in exchange for operating lease liability |  | (194) | 363
Cash paid (received) during the year for: |  |  |
Interest payments received from short-term bank deposits and cash equivalents | 1,364 | 1,232 | 1,002
Reconciliation of cash, cash equivalents and restricted cash: |  |  |
Cash and cash equivalents | 7,801 | 7,143 | 9,187
Restricted cash | 713 | 667 | 652
Cash and cash equivalents and restricted cash at the end of the year | $ 8,514 | $ 7,810 | $ 9,839

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