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STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY - USD ($) $ in Thousands | Ordinary shares [Member] | Additional paid-in capital [Member] | Accumulated deficit [Member] | Total
--- | --- | --- | --- | ---
Balance at Dec. 31, 2018 | $ 164 |  | $ 367,920 | $ (330,841) | $ 37,243
Balance, shares at Dec. 31, 2018 | 59,849,784 |  |  |  |
Options exercised | $ 3 |  | 3,246 |  | 3,249
Options exercised, shares | 878,378 |  |  |  |
Issuance of shares and warrants, net | $ 20 |  | 22,738 |  | 22,758
Issuance of shares and warrants, net, shares | 7,194,674 |  |  |  |
Stock-based compensation relating to options issued to employees, directors and non-employees |  |  | 2,408 |  | 2,408
Net loss |  |  |  | (27,337) | (27,337)
Balance at Dec. 31, 2019 | $ 187 |  | 396,312 | (358,178) | 38,321
Balance, shares at Dec. 31, 2019 | 67,922,836 |  |  |  |
Options exercised | $ 9 |  | 15,906 |  | 15,915
Options exercised, shares | 3,070,542 |  |  |  |
Warrants exercised | $ 11 |  | 18,314 |  | 18,325
Warrants exercised, shares | 3,866,139 |  |  |  |
Issuance of shares, net | $ 24 |  | 74,123 |  | 74,147
Issuance of shares, net, shares | 8,816,339 |  |  |  |
Stock-based compensation relating to options issued to employees, directors and non-employees |  |  | 2,772 |  | 2,772
Net loss |  |  |  | (29,698) | (29,698)
Balance at Dec. 31, 2020 | $ 231 |  | 507,427 | (387,876) | $ 119,782
Balance, shares at Dec. 31, 2020 | 83,675,856 |  |  |  | 83,675,856
Exercise of options and ESPP shares | $ 1 |  | 1,454 |  | $ 1,455
Exercise of options and ESPP shares, shares | 335,204 |  |  |  |
Warrants exercised |  | [1] | 425 |  | 425
Warrants exercised, shares | 89,557 |  |  |  |
Issuance of shares, net | $ 7 |  | 14,951 |  | 14,958
Issuance of shares, net, shares | 2,332,815 |  |  |  |
Stock-based compensation relating to options issued to employees, directors and non-employees |  |  | 4,276 |  | 4,276
Net loss |  |  |  | (34,203) | (34,203)
Balance at Dec. 31, 2021 | $ 239 |  | $ 528,533 | $ (422,079) | $ 106,693
Balance, shares at Dec. 31, 2021 | 86,433,432 |  |  |  | 86,433,432
[1] | Representing amount lower than $1.

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