<SEC-DOCUMENT>0001178913-22-002931.txt : 20220804
<SEC-HEADER>0001178913-22-002931.hdr.sgml : 20220804
<ACCEPTANCE-DATETIME>20220804074103
ACCESSION NUMBER:		0001178913-22-002931
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20220804
DATE AS OF CHANGE:		20220804
EFFECTIVENESS DATE:		20220804

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-266508
		FILM NUMBER:		221134737

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">As filed with the U.S. Securities and Exchange Commission on August 4, 2022.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Registration No. 333-&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
    <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> <br>
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">WASHINGTON, D.C. 20549</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <hr align="center" style="height: 1px; width: 10%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">FORM S-8</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">REGISTRATION STATEMENT</div>
    <div style="text-align: center; line-height: 1.25; font-family: Arial;"><font style="font-family: 'Times New Roman',Times,serif; font-weight: bold;">UNDER</font><font style="font-family: 'Times New Roman',Times,serif;">&#160;<font style="font-weight: bold;">THE</font></font></div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">SECURITIES ACT OF 1933</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <hr align="center" style="height: 1px; width: 10%; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold;">COMPUGEN LTD.</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z21d15bc3538a462da3c994b683db860b">

        <tr>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25;">(Exact name of registrant as specified in its charter)</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Israel</div>
          </td>
          <td style="width: 33%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td style="width: 33%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">N/A</div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25;">(State or other jurisdiction of</div>
          </td>
          <td style="width: 33%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td style="width: 33%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25;">(I.R.S. Employer</div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25;">incorporation or organization)</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25;">Identification No.)</div>
          </td>
        </tr>

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    </div>
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        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Azrieli Center, 26 Harokmim Street, Building D</div>
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Holon, 5885849</div>
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td style="width: 33%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Not Applicable</div>
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(Zip Code)</div>
          </td>
        </tr>

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    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Compugen Ltd. 2010 Share Incentive Plan</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;(<font style="font-style: italic;">Full title of the plan</font>)</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Anat Cohen-Dayag, Ph.D.</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">President and Chief Executive Officer</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Compugen Ltd.</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Azrieli Center, 26 Harokmim Street, Building D</div>
    <div style="text-align: center; line-height: 1.25; font-family: Arial; font-weight: bold;"><font style="font-family: 'Times New Roman',Times,serif;">Holon, 5885849 Israel</font></div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Phone: +972-3-765-8585</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Fax: +972-3-765-8555</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Compugen USA, Inc.</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">395 Oyster Point Boulevard<br>
      Suite 307<br>
      South San Francisco, CA 94080</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">415-373-0556</div>
    <div style="text-align: center; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif;">(Name, address and telephone number, including area code, of agent for service)<br>
        <br style="line-height: 1.25;">
      </font></div>
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        <tr>
          <td colspan="3" style="vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Copies to:</div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Ari Krashin</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Daniel I. Goldberg</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Eran Ben Dor</div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Cooley LLP</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">26 Harokmim Street</div>
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">&#160;Building D</div>
          </td>
          <td style="width: 33%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">55 Hudson Yards</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
          <td style="width: 33%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">26 Harokmim Street</div>
            <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">&#160;Building D</div>
          </td>
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        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; font-family: Arial; font-weight: bold;"><font style="font-family: 'Times New Roman',Times,serif;">Holon, 5885849, Israel</font></div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">New York, NY 10001-2157</div>
          </td>
          <td style="width: 33%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; font-family: Arial; font-weight: bold;"><font style="font-family: 'Times New Roman',Times,serif;">Holon, 5885849, Israel</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Tel: 972-3-765-8585</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Tel: 212-479-6000</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Tel: 972-3-765-8585</div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Fax: 972-3-765-8555</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Fax: 212 479 6275</div>
          </td>
          <td style="width: 33%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Fax: 972-3-765-8555</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth
        company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act. (Check one):</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
      </div>
    </div>
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          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Large accelerated filer &#9744;</div>
          </td>
          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Accelerated filer &#9745;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Non-accelerated filer &#9744;</div>
          </td>
          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Smaller reporting company &#9744;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: Arial;"><font style="font-family: 'Times New Roman',Times,serif;">Emerging growth company</font>&#9744;</div>
          </td>
        </tr>

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    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial
      accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. &#9744;</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">EXPLANATORY NOTE</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">This Registration Statement relates to an increase of an additional 2,000,000 ordinary shares, NIS 0.01 par value per share (the &#8220;Ordinary Shares&#8221;), of
      Compugen Ltd. (the &#8220;Registrant&#8221;) that are being issued and sold, or may be issued and sold, upon exercise of options or other awards granted by the Registrant to participants in the Compugen Ltd. 2010 Share Incentive Plan, as amended (the &#8220;2010
      Plan&#8221;) as approved by the Registrant&#8217;s Board of Directors on March 24, 2022.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Reference is made to the Registrant&#8217;s Registration Statements on Form S-8 filed with the Securities and Exchange Commission (the &#8220;Commission&#8221;) on September
      7, 2010 (Registration No. 333-169239), June 11, 2015 (Registration No. 333-204869), March 27, 2018 (Registration No. 333-&#160;223937) and July 30,2022 (Registration No.&#160;333-240182) (together, the &#8220;Prior Registration Statements&#8221;), pursuant to which a
      total of 18,345,436 Ordinary Shares issuable under the 2010 Plan were previously registered under the Securities Act of 1933, as amended.&#160; Pursuant to General Instruction E to Form S-8, the contents of the Prior Registration Statements are hereby
      incorporated by reference in their entirety, except as otherwise updated or modified by this Registration Statement.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">PART II</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">The following documents filed by the Registrant with the Commission pursuant to the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;) are
      hereby incorporated herein by reference and made a part hereof:</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
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          <td style="width: 36pt; font-family: 'Times New Roman',Times,serif;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; font-family: 'Times New Roman',Times,serif;">(i)</td>
          <td style="width: auto; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div>The Registrant&#8217;s Annual Report on Form 20-F for the fiscal year ended December 31, 2021, filed with the Commission on February 28, 2022, as amended on February 28, 2022 (File No. 000-30902);</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
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          </td>
          <td style="width: 36pt; vertical-align: top; font-family: 'Times New Roman',Times,serif;">(ii)</td>
          <td style="width: auto; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div>The Registrant&#8217;s Reports of Foreign Private Issuer on Form 6-K, as filed with the Commission on February 24, 2022, May 10, 22, May 16, 2022 and August 4, 2022 (File No.&#160;000-30902); and</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb39c2124e08442109a08ffcb14a1e9cb">

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          <td style="width: 36pt; font-family: 'Times New Roman',Times,serif;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; font-family: 'Times New Roman',Times,serif;">(iii)</td>
          <td style="width: auto; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div>The description of the Registrant&#8217;s Ordinary Shares in the Registrant&#8217;s Registration Statement on Form 8-A (File No.&#160;000-30902) filed with the Commission under the Exchange Act on August 2, 2000, including any amendment or report filed for
              the purpose of updating such description.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">All documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, after the date of
      this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold, and all Reports of Foreign Private Issuer on Form
      6-K submitted by the Registrant to the Commission during such period, or portions thereof that are identified in such forms as being incorporated into this Registration Statement, shall be deemed to be incorporated by reference in this Registration
      Statement and to be a part hereof from the date of filing such documents. Any document, or any statement contained in a document, incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes
      of this Registration Statement to the extent that a document or statement contained herein, or in any other subsequently filed document that also is deemed to be incorporated by reference herein, modifies or supersedes such document or statement. Any
      statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Subject to the foregoing, all information appearing in this Registration Statement is qualified in its
      entirety by the information appearing in the documents incorporated by reference.</div>
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    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">ITEM 8. EXHIBITS.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">The following is a list of exhibits filed as a part of this Registration Statement which are incorporated herein:</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <table cellspacing="0" cellpadding="2" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z679dbe09ad0f4ecfbcbd060caaa6a3a2">

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            <div style="line-height: 1.25; font-weight: bold;">EXHIBIT NO.</div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25; font-weight: bold;">EXHIBIT</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891319002031/exhibit_99-4.htm">1.1</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891319002031/exhibit_99-4.htm">Articles of Association of Compugen, as amended (incorporated by reference to Annex A3 of Exhibit 99.4 to Compugen&#8217;s
                report on Form 6-K filed with the SEC on August 5, 2019 (File No. 000-30902)).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891319002031/exhibit_99-4.htm">1.2</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891319002031/exhibit_99-4.htm">Memorandum of Association of Compugen, as amended (incorporated by reference to Annex A2 of Exhibit 99.4 to Compugen&#8217;s
                report on Form 6-K filed with the SEC on August 5, 2019 (File No. 000-30902)).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891320002176/exhibit_4-1.htm">4.1</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891320002176/exhibit_4-1.htm">Compugen Ltd. 2010 Share Incentive Plan, as amended&#160;(incorporated by reference to Exhibit 4.1 to Compugen&#8217;s
                Registration Statement on Form S-8, filed with the SEC on July 30, 2020 (File No.333-240182)).</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_5-1.htm">5.1*</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_5-1.htm">Opinion of Shibolet &amp; Co., Law Firm</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_23-1.htm">23.1*</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_23-1.htm">Consent of Kost Forer Gabbay &amp; Kasierer, a Member of Ernst &amp; Young Global</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_5-1.htm">23.2*</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_5-1.htm">Consent of Shibolet &amp; Co., Law Firm (included in Exhibit 5.1)</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="#SIGNATURES">24.1*</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="#SIGNATURES">Powers of Attorney (included in the signature pages to this Registration Statement)</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 16.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_107-1.htm">107.1*</a></div>
          </td>
          <td style="width: 83.04%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="line-height: 1.25;"><a href="exhibit_107-1.htm">Filing Fee Table</a></div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -18pt; margin-left: 18pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">* Filed herein.</div>
    <div style="margin-left: 18pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
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    </div>
    <div style="text-align: center; text-indent: -18pt; margin-left: 18pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;"><a name="SIGNATURES"><!--Anchor--></a>SIGNATURES</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: Arial;"><font style="font-family: 'Times New Roman',Times,serif; font-style: italic;">The Registrant.</font><font style="font-family: 'Times New Roman',Times,serif;">&#160; Pursuant to the
        requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf
        by the undersigned, thereunto duly authorized, in City of Holon, State of Israel, on August 4, 2022.</font></div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <table cellspacing="0" cellpadding="0" border="0" id="ze219f5dd9b2f40929aaa6384d965ce59" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

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              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>
                <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-variant: small-caps;">Compugen Ltd.</div>
                <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> <br>
                </div>
                <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">By: <u>/s/ Anat Cohen-Dayag, Ph.D.</u></div>
                <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160; &#160;&#160; Anat Cohen-Dayag, Ph.D.</div>
                <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;&#160;&#160; &#160; Chief Executive Officer and President</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Each person whose signature appears below constitutes and appoints Anat Cohen-Dayag, Ph.D., Ari Krashin and Eran Ben Dor, and each of them singly, his true
      and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them singly, for him and in his name, place and stead, and in any and all capacities, to sign any and all amendments (including post-effective
      amendments) to this Registration Statement of Compugen Ltd. and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting to the attorneys-in-fact and agents, and
      each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in or about the premises, as full to all intents and purposes as he might or could do in person, hereby ratifying and confirming
      all that the attorneys-in-fact and agents or any or each of them or their substitute may lawfully do or cause to be done by virtue hereof.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the
      dates indicated.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z8054721d66b542848930fdaeac1fbfd1">

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            <div style="text-align: center; margin-right: 9pt; margin-left: 9pt; line-height: 1.25; font-weight: bold;"><u>Signature</u></div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; margin-right: 9pt; margin-left: 9pt; line-height: 1.25; font-weight: bold;"><u>Title(s)</u></div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="text-align: center; margin-right: 9pt; margin-left: 9pt; line-height: 1.25; font-weight: bold;"><u>Date</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;" rowspan="1">&#160;</td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;" rowspan="1">&#160;</td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;" rowspan="1">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Anat Cohen-Dayag, Ph.D.</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Anat Cohen-Dayag, Ph.D.</div>
          </td>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Chief Executive Officer and President and Director</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(principal executive officer)</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Ari Krashin</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Mr. Ari Krashin</div>
          </td>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Chief Financial Officer</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(principal financial and accounting officer)</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Paul Sekhri</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;Mr. Paul Sekhri</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Chairman of the Board</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Sandy Zweifach</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;Mr. Sandy Zweifach</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Director</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Dr. Mathias Hukkelhoven</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;Dr. Mathias Hukkelhoven</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Director</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Eran Perry</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Mr. Eran Perry</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Director</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Gilead Halevy</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;Mr. Gilead Halevy</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Director</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Dr. Kinneret Livnat Savitzky</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;Dr. Kinneret Livnat Savitzky</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Director</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 33%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
          <td rowspan="1" style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 33%; vertical-align: top;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Compugen USA, Inc.</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">By: <u>/s/ Julia Decker</u></div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Name: Julia Decker</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Title: Treasurer and Director of Finance of Compugen USA, Inc.</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Authorized U.S. Representative</div>
          </td>
          <td style="width: 33%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25; text-align: center;">August 4, 2022</div>
          </td>
        </tr>

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    <div> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>exhibit_5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <!--PROfilePageNumberReset%Num%2%%%--><font style="font-family: 'Times New Roman',Times,serif;"> </font>
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    <div id="DSPFPageHeader">
      <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
        <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><u><font style="font-weight: bold;">Exhibit 5.1</font></u><br>
      </div>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> <img src="image00002.jpg"></div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> <br>
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Tel Aviv, August 4, 2022</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Compugen Ltd.<br>
      Azrieli Center</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">26 Harokmim Street, Building D</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Holon, 5885849</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>Israel</u></div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="text-align: center; margin-left: 35.45pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Re:&#160;&#160;&#160;<u>Compugen Ltd. - Registration Statement on Form&#160;S-8</u></div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Ladies and Gentlemen:</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: Arial;"><font style="font-family: 'Times New Roman',Times,serif;">We refer to the registration statement on Form S-8 (the &#8220;<u>Registration Statement</u>&#8221;), to be filed
        by Compugen Ltd., a company organized under the laws of the State of Israel (the &#8220;<u>Registrant</u>&#8221;), with the United States Securities and Exchange Commission under the Securities Act of 1933, as amended (the &#8220;<u>Act</u>&#8221;), relating to the
        registration of 2,000,000 of the Registrant&#8217;s Ordinary Shares, nominal value NIS 0.01 each (the &#8220;<u>Shares</u>&#8221;), authorized for issuance under the Compugen Ltd. 2010 Share Incentive Plan, as amended (the &#8220;<u>Plan</u>&#8221;).</font></div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">This opinion is being furnished in accordance with the requirements of Item 8 of Form&#160;S-8 and Item 601(b)(5)(i) of Regulation S-K.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">In our capacity as the Registrant&#8217;s Israeli external legal counsel in connection with the registering of the Shares pursuant to the
      Registration Statement, we have examined copies of the Registrant&#8217;s Articles of Association, as amended, the Plan, protocols of meetings of the Board of Directors of the Registrant with respect to the reservation of the Shares for issuance under the
      Plan which were presented to us, and other corporate records, instruments and documents we have considered necessary or appropriate for the purpose of this opinion, which were presented to us by the Registrant, and such matters of Israeli law as we
      have considered necessary or appropriate for the purpose of rendering this opinion. We have assumed that the Registrant presented to us all such protocols and documents relating to or having any bearing on the Plan.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">In our examination, we have assumed the genuineness of all signatures, the legal capacity of all natural persons, the correctness and
      completeness of certificates of public officials and the representations set forth therein, the authenticity of all documents submitted to us as originals and the conformity to authentic original documents of all documents submitted to us as copies.
      We have assumed the same to have been properly given and to be accurate and we have assumed the truth of all facts communicated to us by the Registrant. We have also assumed that all protocols of meetings of the Registrant&#8217;s Board of Directors which
      have been provided to us are true and accurate and have been properly prepared in accordance with the Registrant&#8217;s incorporation documents and all applicable laws. We have also assumed that each individual grant of an option to purchase Shares under
      the Plan pursuant to the terms and conditions thereof to be made after the date hereof will be duly authorized by all necessary corporate action in accordance with the Israeli Companies Law, 5759-1999.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Based upon and subject to the foregoing, we are of the opinion that the Shares being registered pursuant to this Registration Statement
      have been duly and validly authorized for registration under the Registration Statement, and if, and when, issued and paid for upon the exercise of an option to purchase Shares granted under the Plan&#160;pursuant to the terms and conditions thereof, such
      Shares will be validly issued, fully paid and nonassessable.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">We are members of the Israeli Bar and we are opining herein as to the effect on the subject matter only of the internal laws of the
      State of Israel, and we express no opinion with respect to the applicability thereto, or the effect thereon, of the laws of any other jurisdiction.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">This opinion letter is rendered as of the date first written above and we disclaim any obligation to advise the Registrant of facts,
      circumstances, events or developments, including, without limitation, in the law, which hereafter may be brought to our attention and which may alter, affect or modify the opinion expressed herein. Our opinion is expressly limited to the matters set
      forth above and we render no opinion, whether by implication or otherwise, as to any other matters relating to the Registrant, the Plan or the Shares.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">We consent to the filing of this opinion letter as Exhibit&#160;5.1 to the Registration Statement. This consent is not to be construed as an
      admission that we are a party whose consent is required to be filed with the Registration Statement under Section 7 of the Act or the rules and regulations promulgated thereunder.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <table cellspacing="0" cellpadding="0" border="0" id="ze98232b12056442b9dc255657b2d536b" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

          <tr>
            <td style="width: 50.00%;">
              <div>&#160;</div>
            </td>
            <td style="width: 50%;">
              <div>
                <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Very truly yours,</div>
                <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
                </div>
                <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><u>/s/ Shibolet &amp; Co., Law Firm</u></div>
                <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Shibolet &amp; Co., Law Firm</div>
              </div>
            </td>
          </tr>

      </table>
    </div>
    <div><br>
    </div>
  </div>
  <font style="font-family: 'Times New Roman',Times,serif;"></font>
  <div id="DSPFPageNumberArea" style="text-align: center;">
    <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>exhibit_23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
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  <head>
    <title></title>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <font style="font-family: 'Times New Roman',Times,serif;">
  </font>
  <div>
    <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-style: italic; font-weight: bold;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><font style="font-style: normal;"><u>Exhibit 23.1</u></font></div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 of Compugen
      Ltd. pertaining to the Compugen Ltd. 2010 Share Incentive Plan, as amended, of our reports dated February 28, 2022, with respect to the consolidated financial statements of Compugen Ltd., and the effectiveness of internal control over financial
      reporting of Compugen Ltd. included in its Annual Report on Form 20-F and Form 20-F/A for the year ended December 31, 2021, filed with the Securities and Exchange Commission.</div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" border="0" id="z165488db3d594b34b4c0c28dcfd0477a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">Tel Aviv, Israel</div>
          </td>
          <td style="width: 50%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;"><u>/s/ KOST FORER GABBAY &amp; KASIERER</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
            <div style="line-height: 1.25;">August 4, 2022</div>
          </td>
          <td style="width: 50%; vertical-align: middle;">
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">KOST FORER GABBAY &amp; KASIERER</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">A Member of Ernst &amp; Young&#160;Global</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
  </div>
  <font style="font-family: 'Times New Roman',Times,serif;">
  </font>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>exhibit_107-1.htm
<DESCRIPTION>FILING FEES TABLE
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Z-K Global
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="text-align: right; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">
      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"><u>Exhibit 107.1</u></div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">CALCULATION OF FILING FEE TABLE</div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">FORM S-8</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(Form Type)</div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">COMPUGEN LTD.</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(Exact Name of Registrant as Specified in its Charter)</div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><u>Table 1: Newly Registered Securities</u></div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <table cellspacing="0" cellpadding="2" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);">

        <tr>
          <td style="width: 9.05%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Security</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Type</div>
          </td>
          <td style="width: 15.19%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Security Class</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Title</div>
          </td>
          <td style="width: 13.9%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Fee Calculation</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Rule</div>
          </td>
          <td style="width: 14.7%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Amount</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Registered <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div>
          </td>
          <td style="width: 11.4%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Proposed Maximum Offering Price Per Unit <sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div>
          </td>
          <td style="width: 11.9%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Maximum Aggregate</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Offering Price</div>
          </td>
          <td style="width: 11.89%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Fee Rate</div>
          </td>
          <td style="width: 11.96%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Amount of</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Registration Fee</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.05%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">Equity</div>
          </td>
          <td style="width: 15.19%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">Ordinary shares, New Israeli Shekel 0.01 par value per share</div>
          </td>
          <td style="width: 13.9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">Rule 457(c)<br>
              and 457(h)</div>
          </td>
          <td style="width: 14.7%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">2,000,000<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(3)</sup></div>
          </td>
          <td style="width: 11.4%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">$1.59</div>
          </td>
          <td style="width: 11.9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">
              <div style="line-height: 1.25;">$3,180,000</div>
            </div>
          </td>
          <td style="width: 11.89%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">$92.70 per million dollars</div>
          </td>
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            <div style="text-align: center; line-height: 1.25;"><font style="background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">$2</font>94.80</div>
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            <div style="line-height: 1.25; font-weight: bold;">Total Offering Amounts</div>
          </td>
          <td style="width: 11.4%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
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          <td style="width: 11.9%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;">$3,180,000</div>
          </td>
          <td style="width: 11.89%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.96%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;"><font style="background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">$2</font>94.80</div>
          </td>
        </tr>
        <tr>
          <td style="width: 52.84%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="line-height: 1.25; font-weight: bold;">Total Fee Offsets</div>
          </td>
          <td style="width: 11.4%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.9%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.89%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.96%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">__</div>
          </td>
        </tr>
        <tr>
          <td style="width: 52.84%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);" colspan="4">
            <div style="line-height: 1.25; font-weight: bold;">Net Fee Due</div>
          </td>
          <td style="width: 11.4%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.9%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.89%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 11.96%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25;"><font style="background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">$2</font>94.80</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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    <div style="line-height: 1.25;">
      <div style="text-align: justify; line-height: 1.25; font-family: Arial;"><font style="font-family: 'Times New Roman',Times,serif;">(1) Pursuant to Rule 416(a) under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), this Registration
          Statement also covers such indeterminate number of Ordinary Shares as may be offered or issued to prevent dilution resulting from stock splits, stock dividends, or similar transactions pursuant to the terms of the Compugen Ltd. 2010 Share
          Incentive Plan, as amended the &#8220;2010 Plan&#8221;).</font></div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="text-align: justify; line-height: 1.25;">(2) For purposes of computing the registration fee only. Calculated in accordance with Rule 457(h)(1) promulgated under the Securities Act, based on the average of the high and low sale prices per
        share of the Registrant&#8217;s Ordinary Shares as reported by The Nasdaq Global Market on August 1, 2022.</div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">
      <div style="text-align: justify; line-height: 1.25;">(3) Represents 2,000,000 additional Ordinary Shares authorized for issuance under the 2010 Plan.</div>
      <div style="text-align: justify; line-height: 1.25;"> <br>
      </div>
      <div style="text-align: justify; line-height: 1.25;">
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
