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SHAREHOLDERS' EQUITY (Tables) | 12 Months Ended
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Dec. 31, 2022
Stockholders' Equity Note [Abstract] |
Schedule of stock-based compensation expenses | Transactions related to the grant of options to employees, directors and non-employees under the above Plan during the year ended December 31, 2022, were as follows:
|  | Number of options |  |  | Weighted average exercise price |  |  | Weighted average remaining contractual life |  |  | Aggregate intrinsic value |
|  |  |  |  | $ |  |  | Years |  |  | $ |
Options outstanding at beginning of year |  |  | 6,976,104 |  |  |  | 6.39 |  |  |  | 6.69 |  |  |  | 3,323 |
Options granted |  |  | 2,186,400 |  |  |  | 2.58 |  |  |  |  |  |  |  |  |
Options exercised |  |  | (33,186 | ) |  |  | 3.14 |  |  |  |  |  |  |  |  |
Options forfeited |  |  | (778,069 | ) |  |  | 6.42 |  |  |  |  |  |  |  |  |
Options expired |  |  | (193,500 | ) |  |  | 4.21 |  |  |  |  |  |  |  |  |
Options outstanding at end of year |  |  | 8,157,749 |  |  |  | 5.43 |  |  |  | 6.32 |  |  |  | - |
Exercisable at end of year |  |  | 4,635,040 |  |  |  | 5.68 |  |  |  | 4.52 |  |  |  | - |
Schedule of option activity | e.The stock-based compensation expenses related to stock options and ESPP are included as follows in the expense categories:
|  | Year ended December 31, |
|  | 2022 |  |  | 2021 |  |  | 2020 |
Research and development expenses |  | $ | 2,158 |  |  | $ | 1,971 |  |  | $ | 1,123 |
Marketing and business development expenses |  |  | 269 |  |  |  | 215 |  |  |  | 172 |
General and administrative expenses |  |  | 1,901 |  |  |  | 2,090 |  |  |  | 1,477 |
|  | $ | 4,328 |  |  | $ | 4,276 |  |  | $ | 2,772 |

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- Definition Tabular disclosure of cost recognized for award under share-based payment arrangement by plan. Includes, but is not limited to, related tax benefit. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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