<SEC-DOCUMENT>0001178913-23-002268.txt : 20230622
<SEC-HEADER>0001178913-23-002268.hdr.sgml : 20230622
<ACCEPTANCE-DATETIME>20230622070009
ACCESSION NUMBER:		0001178913-23-002268
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20230622
FILED AS OF DATE:		20230622
DATE AS OF CHANGE:		20230622

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		231031484

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2329904.htm
<DESCRIPTION>6-K
<TEXT>
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      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold; color: #000000;">Washington, D.C. 20549<br>
          </font><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-size: 14pt; font-weight: bold;">Form 6-K</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16</div>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; color: #000000;">For the month of June 2023</div>
      <div style="text-align: center; line-height: 1.25; color: #000000;">Commission File Number 000-30902</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold;">COMPUGEN LTD.</div>
      <div style="text-align: center; line-height: 1.25; color: #000000;">(Translation of registrant's name into English)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">26 Harokmim Street</div>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Holon 5885849, Israel</div>
      <div style="text-align: center; line-height: 1.25; color: #000000;">(Address of Principal Executive Offices)</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; color: #000000;">Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; color: #000000;">Form 20-F &#9746;&#8195;&#8195;Form 40-F &#9744;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; color: #000000;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule
        101(b)(1): &#9744;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; color: #000000;">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule
        101(b)(7): &#9744;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
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      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Compugen Ltd.</div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="text-align: justify; line-height: 1.25; color: #000000;">On June 22, 2023, Compugen Ltd. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;) issued a press release, a copy of which is furnished as Exhibit 99.1 (the &#8220;<font style="font-weight: bold;">Press Release</font>&#8221;) to this Report
        on Form 6-K and incorporated by reference herein.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25; color: #000000;">With the exception of the second and third paragraphs in the Press Release, the information incorporated by reference
          in this Report on Form 6-K is hereby incorporated by reference into the Company&#8217;s Registration Statements on Form F-3, File Nos. 333-240183 and 333-270985.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="z2efbd333ce9744ada3db3d673df188c4" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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              <div style="line-height: 1.25; color: #000000; font-weight: bold;">Exhibit</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 92%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top; border-bottom: 2px solid black;">
              <div style="line-height: 1.25; color: #000000; font-weight: bold;">Number</div>
            </td>
            <td style="width: 2%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
            <td style="width: 92%; vertical-align: top; border-bottom: 2px solid black;">
              <div style="line-height: 1.25; color: #000000; font-weight: bold;">Description of Exhibit</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 92%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 6%; vertical-align: top;">
              <div style="line-height: 1.25;"><a href="exhibit_99-1.htm">99.1</a></div>
            </td>
            <td style="width: 2%; vertical-align: top;">&#160;</td>
            <td style="width: 92%; vertical-align: top;">
              <div style="line-height: 1.25;"><a href="exhibit_99-1.htm">Compugen Doses First
                  Patient in Triple Immunotherapy Combination COM701, COM902 and Pembrolizumab Platinum Resistant Ovarian Cancer Proof-of-Concept Study</a></div>
            </td>
          </tr>

      </table>
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      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Signatures</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; color: #000000;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be
        signed on its behalf by the undersigned thereunto duly authorized.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" border="0" id="z96576d33247448dd9b0d514e21cc5c5f" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="vertical-align: bottom;" colspan="2">
              <div style="line-height: 1.25; color: #000000; font-weight: bold;">COMPUGEN LTD.</div>
            </td>
            <td style="width: 10%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
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            <td style="vertical-align: bottom;" colspan="4">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
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            <td style="width: 50%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">Date: June 22, 2023</div>
            </td>
            <td style="width: 4%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">By:</div>
            </td>
            <td style="width: 36%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="line-height: 1.25; color: #000000;">/s/ Eran Ben Dor</div>
            </td>
            <td style="width: 10%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
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            <td style="width: 50%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 4%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 36%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">Eran Ben Dor</div>
            </td>
            <td style="width: 10%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
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              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 4%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 36%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">General Counsel</div>
            </td>
            <td style="width: 10%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>

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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>exhibit_99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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    <div style="text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.1</font></u><br>
    </div>
    <div><u><font style="font-weight: bold;"> </font></u><br>

      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;"><img width="125" height="53" src="image0.jpg"></div>
        <div style="line-height: 1.25;"><br>
        </div>
      </div>
      <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">FOR IMMEDIATE RELEASE</div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="text-align: center; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Compugen Doses First Patient in Triple Immunotherapy </div>
      <div style="text-align: center; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Combination COM701, COM902 and Pembrolizumab&#160;</div>
      <div style="text-align: center; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;"> Platinum Resistant Ovarian Cancer Proof-of-Concept Study</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z5a28ded99df0497695731603fa61482f" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-family: 'Times New Roman',Times,serif;">Study builds on clinical benefit reported in heavily pretreated platinum resistant ovarian cancer patients treated with dual and triple combination of COM701 + nivolumab &#177;
                BMS-986207</div>
            </td>
          </tr>

      </table>
      <div> <br>
        </div>
      <table cellspacing="0" cellpadding="0" id="z256fb018b846416c90c4473a009c85e4" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

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            <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#8226;</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-family: 'Times New Roman',Times,serif;">Initial findings expected by the end of 2023</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">HOLON, ISRAEL &#8211; June 22 2023 - Compugen Ltd. (Nasdaq: CGEN) (TASE: CGEN) a clinical-stage cancer immunotherapy company and a
          pioneer in computational target discovery, today&#160;announced that the first patient has been dosed in the triple immunotherapy combination proof-of-concept study evaluating COM701, Compugen&#8217;s potential first-in-class anti-PVRIG antibody, with
          COM902, Compugen&#8217;s potential best-in-class anti-TIGIT antibody and pembrolizumab in patients with platinum resistant ovarian cancer.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8220;We are very excited that the first patient with platinum resistant ovarian cancer has been dosed with the triple immunotherapy
        combination of COM701, COM902 and pembrolizumab in our proof-of-concept study. This milestone keeps us on track to report initial findings by the end of this year,&#8221; said Anat Cohen-Dayag, Ph.D., President, and CEO of Compugen. &#8220;The goal of the
        study is to build on the encouraging data previously reported by us at the ESMO Immuno-Oncology Congress 2022, with the dual and triple blockade of PVRIG and PD-1 with or without TIGIT. We expect that this study will help us to better understand
        the contribution of the components and contribute to our ongoing biomarker work to try and identify the patients most likely to respond, with the purpose of building a path to registration.&#8221;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8220;Despite recent advances in the treatment of patients with platinum resistant ovarian cancer, there remains a significant unmet
        need for new treatment options for these patients,&#8221; said Dr. Manish Sharma, Associate Director of Clinical Research at START Midwest in Grand Rapids, Michigan. &#8220;I am very excited to participate in this proof-of-concept study with the novel triple
        immunotherapy combination of COM701, COM902 and pembrolizumab. Our initial observation is that this combination is well tolerated by patients as observed in our microsatellite stable colorectal cancer proof-of-concept study initiated recently. I
        hope this differentiated approach of blocking three pathways in the DNAM-1 axis, PVRIG, TIGIT and PD-1 will result in additional treatment options for patients with platinum resistant ovarian cancer.&#8221;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Details on the study:</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">This proof-of-concept study <font style="color: rgb(0, 0, 0);">(NCT04354246) </font>is an open label study evaluating the combination of COM701 with COM902 and pembrolizumab in up to 40 patients with high grade platinum
        resistant epithelial ovarian cancer including patients with fallopian tube cancer and primary peritoneal cancer who have received up to 3 lines of prior therapy for platinum resistant ovarian cancer. The study includes patients with all
        histologies. The initiation of the study is based on Phase 1 cohort expansion data reported <font style="color: rgb(34, 34, 34);">at ESMO-IO 2022</font>, <font style="color: rgb(34, 34, 34);">showing a favorable safety and tolerability profile and durable anti-tumor activity with the combination of COM701 and nivolumab </font>&#177; BMS-986207 in platinum resistant ovarian cancer
        patients.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25; color: rgb(51, 51, 51); font-family: 'Times New Roman',Times,serif; font-weight: bold;">About&#160;Compugen</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Compugen&#160;is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable predictive
        computational discovery capabilities to identify new drug targets and biological pathways for developing cancer immunotherapies.&#160;Compugen has developed two proprietary product candidates: COM701, a potential first-in-class anti-PVRIG antibody and
        COM902,&#160;a potential best-in-class antibody targeting TIGIT for the treatment of solid tumors. Compugen also has a clinical stage partnered program, rilvegostomig (previously AZD2936), a PD-1/TIGIT bi-specific derived from COM902, in Phase 2
        development by AstraZeneca through a license agreement for the development of bi-specific and multi-specific antibodies.&#160;In addition, the Company&#8217;s therapeutic pipeline of early-stage&#160;immuno-oncology programs consists of programs aiming to address
        various mechanisms of immune resistance. The most advanced program, COM503 is in IND enabling studies. COM503 is a potential first-in-class, high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby
        freeing natural IL-18 to inhibit cancer growth in the tumor microenvironment. Compugen&#160;is headquartered in Israel, with offices in San Francisco, CA.&#160;Compugen&#8217;s&#160;shares are listed on Nasdaq and the Tel Aviv&#160;Stock Exchange under the ticker symbol
        CGEN.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; color: rgb(51, 51, 51); font-family: 'Times New Roman',Times,serif; font-weight: bold;">Forward-Looking Statement</div>
      <div style="line-height: 1.25; font-size: 12pt;"><font style="font-size: 10pt; font-family: 'Times New Roman',Times,serif; color: rgb(51, 51, 51);">This press release contains
          &#8220;forward-looking statements&#8221; within the meaning of the Securities Act of 1933 and the Securities Exchange Act of 1934, as amended, and the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking
          statements are based on the current beliefs, expectations, and assumptions of Compugen. Forward-looking statements can be identified using terminology such as &#8220;will,&#8221; &#8220;may,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;believes,&#8221; &#8220;potential,&#8221; &#8220;plan,&#8221; &#8220;goal,&#8221;
          &#8220;estimate,&#8221; &#8220;likely,&#8221; &#8220;should,&#8221; &#8220;confident,&#8221; and &#8220;intends,&#8221; and similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements
          include, but are not limited to, our expectation to report initial findings by the end of 2023; </font><font style="font-size: 10pt;">our expectation that this study will help us to better understand the contribution of the components and
          contribute to our ongoing biomarker work to try and identify the patients most likely to respond, with the purpose of building a path to registration; and statement related to the hope this differentiated approach of blocking three pathways in
          the DNAM-1 axis, PVRIG, TIGIT and PD-1 will result in additional treatment options for patients with platinum resistant ovarian cancer.<font style="font-family: 'Times New Roman',Times,serif; color: rgb(51, 51, 51);">These
            forward-looking statements involve known and unknown risks and uncertainties that may cause the actual results, performance, or achievements of Compugen to be materially different from any future results, performance or achievements expressed
            or implied by such forward-looking statements. Among these risks: In the near term, Compugen is highly dependent on the success of COM701 and of COM902; Compugen may not be able to advance its internal clinical stage programs through clinical
            development or manufacturing or successfully partner or commercialize them, or obtain marketing approval, either alone or with a collaborator, or may experience significant delays in doing so; Clinical development involves a lengthy and
            expensive process, with an uncertain outcome and Compugen may encounter substantial delays or even an inability to begin clinical trials for any specific product or may not be able to conduct or complete its trials on the timelines it expects;
            Compugen has limited experience in the development of therapeutic product candidates, and it may be unable to implement its business strategy. These risks and other risks are more fully discussed in the &#8220;Risk Factors&#8221; section of Compugen&#8217;s most
            recent Annual Report on Form 20-F as filed with the Securities and Exchange Commission (SEC) as well as other documents that may be subsequently filed by Compugen from time to time with the SEC. In addition, any forward-looking statements
            represent Compugen&#8217;s views only as of the date of this release and should not be relied upon as representing its views as of any subsequent date. Compugen does not assume any obligation to update any forward-looking statements unless required
            by law.</font></font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Company contact:</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Yvonne Naughton, Ph.D.</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Head of Investor Relations and Corporate Communications</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Email:&#160;<font style="color: rgb(64, 144, 117);">ir@cgen.com</font>&#160;&#160;</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">Tel: +1&#160;(628)&#160;241-0071&#160;</div>
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