<SEC-DOCUMENT>0001178913-23-002275.txt : 20230623
<SEC-HEADER>0001178913-23-002275.hdr.sgml : 20230623
<ACCEPTANCE-DATETIME>20230623161611
ACCESSION NUMBER:		0001178913-23-002275
CONFORMED SUBMISSION TYPE:	F-3/A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20230623
DATE AS OF CHANGE:		20230623

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		F-3/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-270985
		FILM NUMBER:		231037872

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>F-3/A
<SEQUENCE>1
<FILENAME>zk2329834.htm
<DESCRIPTION>F-3/A
<TEXT>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">
        <div style="line-height: 1.25; color: #000000; font-weight: bold;">As filed with the Securities and Exchange Commission on June 23, 2023</div>
      </div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: right; line-height: 1.25; font-weight: bold;">Registration No. 333-270985 </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">UNITED STATES</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">WASHINGTON, D.C. 20549</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">___________________________</div>
      <div style="line-height: 1.25;">&#160;
        <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">Amendment No. 2 to</div>
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">FORM F-3</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Compugen Ltd.</div>
      <div style="text-align: center; margin-right: 4.95pt; line-height: 1.25;">(Exact name of registrant as specified in its charter)</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; margin-right: 4.95pt; line-height: 1.25; font-weight: bold;">Not Applicable</div>
      <div style="text-align: center; margin-right: 4.95pt; line-height: 1.25;">(Translation of Registrant&#8217;s Name into English)</div>
      <div style="line-height: 1.25;">&#160;</div>
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              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Israel</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25; font-weight: bold;">Not Applicable</div>
            </td>
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          <tr>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25;">(State or other jurisdiction of<br>
                incorporation or organization)</div>
            </td>
            <td style="width: 50%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25;">(I.R.S. Employer Identification Number)</div>
            </td>
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      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Azrieli Center</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">26 Harokmim Street</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Building D<br>
        Holon 5885849, Israel<br>
        +972-3-765-8585</div>
      <div style="text-align: center; line-height: 1.25;">(Address and telephone number of Registrant&#8217;s principal executive offices)</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">___________________</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><br>
        Compugen USA, Inc.<br>
        225 Bush Street, Suite 348</div>
      <div style="text-align: center; line-height: 1.25;"><font style="font-weight: bold;">San Francisco, CA 94104</font><br>
        <font style="font-weight: bold;">Phone: 415-373-0556</font><br>
        <font style="font-weight: bold;">Fax: 415-373-0776</font><br>
        (Name, address, and telephone number of agent for service)</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">___________________</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Copies to:</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
      </div>
      <div style="line-height: 1.25;">
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            <tr>
              <td style="width: 33.33%; vertical-align: top;">
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Alberto Sessa<br>
                  Chief Financial Officer<br>
                  Compugen Ltd.</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Azrieli Center<br>
                  26 Harokmim Street</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Building D<br>
                  Holon 5885849, Israel<br>
                  Phone: +972-3-765-8585<br>
                  Fax: +972-3-765-8555</div>
              </td>
              <td style="width: 33.33%; vertical-align: top;">
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Daniel I. Goldberg</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Eric Blanchard</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Cooley LLP<br>
                  55 Hudson Yards<br>
                  New York, New York 10001-2157<br>
                  Tel: 212-479-6000<br>
                  Fax: 212-479-6275</div>
              </td>
              <td style="width: 33.33%; vertical-align: top;">
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Shelly Blatt Zak</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Ivor Krumholtz</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Shibolet &amp; Co., Law Firm</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Tou Towers</div>
                <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Yitzhak Sadeh 4<br>
                  Tel Aviv-Yafo 6777504, Israel<br>
                  Tel: +972-3-307-5000<br>
                  Fax: +972-3-777-8444</div>
              </td>
            </tr>

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        &#160;</div>
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      <div style="line-height: 1.25; color: #000000;">Approximate date of commencement of proposed sale to the public: From time to time after the effective date of this Registration Statement.</div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9746;</font></div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration
        statement number of the earlier effective registration statement for the same offering. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier
        effective registration statement for the same offering. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">If this Form is a registration statement pursuant to General Instruction I.C. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e)
        under the Securities Act, check the following box. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.C. filed to register additional securities or additional classes of securities pursuant to
        Rule 413(b) under the Securities Act, check the following box. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; color: #000000;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933.</div>
      <div style="text-align: right; line-height: 1.25; color: #000000;">Emerging growth company <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; color: #000000;">If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for
        complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. <font style="font-family: 'Segoe UI Symbol', sans-serif;">&#9744;</font></div>
      <div style="line-height: 1.25; color: #000000;">&#160;&#160;</div>
      <div style="line-height: 1.25; color: #000000; font-weight: bold;">The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment
        which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until this Registration Statement shall become effective on such date as the Securities
        and Exchange Commission, acting pursuant to said Section 8(a), may determine.</div>
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      <div style="text-align: center; line-height: 1.25; font-weight: bold;">EXPLANATORY NOTE</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="line-height: 1.25; color: #000000;">Compugen Ltd. is filing this Amendment No. 2 (this &#8220;Amendment No. 2&#8221;) to its registration statement on Form&#160;F-3&#160;(File&#160;No. 333-270985)&#160;previously filed on March 30, 2022, as amended on April 14, 2022, as
        an&#160;exhibit-only&#160;filing solely to file an updated (i) consent of Kost Forer Gabbay &amp; Kasierer (a Member of Ernst &amp; Young Global), filed herewith as Exhibit 23.1 (the &#8220;Consent&#8221;), and (ii) filing fee table, filed herewith as Exhibit 107 (the
        &#8220;Filing Fee Table&#8221;). Accordingly, this Amendment No. 2 consists only of the facing page, this explanatory note, Item 9 of Part II of the Registration Statement, the signature pages to the Registration Statement, the Consent filed herewith as
        Exhibit 23.1 and the Filing Fee Table filed herewith as Exhibit 107. The remainder of the Registration Statement is unchanged and has been omitted from this Amendment No. 2.</div>
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        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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        </div>
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      <br>
      <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">PART II<br>
        <br>
        INFORMATION NOT REQUIRED IN PROSPECTUS</div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
      <div style="line-height: 1.25; color: #000000; font-weight: bold;">Item 9. Exhibits</div>
      <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 9.6%; vertical-align: bottom; border-bottom: #000000 2px solid;">
              <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Exhibit<br>
                Number</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 88.56%; vertical-align: bottom; border-bottom: #000000 2px solid;">
              <div style="line-height: 1.25; color: #000000; font-weight: bold;">Description of Document</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25; color: #000000;">1.1**</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">Form of Underwriting Agreement.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891323000336/exhibit_1-1.htm">1.2</a>*</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">
              <div style="line-height: 1.25;"><br>
              </div>
            </td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891323000336/exhibit_1-1.htm">Sales Agreement, dated January 31, 2023, by and between the Company and SVB Securities LLC (incorporated by reference
                  to Exhibit 1.1 to the Registrant&#8217;s Report on Form 6-K filed with the SEC on January 31, 2023 (File No. 000-30902)).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25; color: #000000;">4.1*</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">Specimen Certificate for Ordinary Shares (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Registration Statement on Form F-1/A filed with the SEC on August 2, 2000 (File. No
                333-12316)).</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891323001227/exhibit_4-2.htm">4.2*</a></div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">
              <div style="line-height: 1.25;"><br>
              </div>
            </td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891323001227/exhibit_4-2.htm">Form of Indenture between the Registrant and one or more trustees to be named.</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25; color: #000000;">4.3**</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">Form of Debt Securities.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25; color: #000000;">4.4*</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891318001935/exhibit_4-1.htm">Form of Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.1 to the Registrant&#8217;s Report on Form
                  6-K filed with the SEC on June 19, 2018 (File No. 000-30902)).</a></div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25; color: #000000;">4.5**</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">Form of Warrant.</div>
            </td>
          </tr>
          <tr>
            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
            </td>
            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
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            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
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              <div style="text-align: center; line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891323001227/exhibit_5-1.htm">5.1*</a></div>
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            <td style="width: 9.6%; vertical-align: top;">
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            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
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            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
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            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 1.84%; vertical-align: bottom;">&#160;</td>
            <td style="width: 88.56%; vertical-align: top;">
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            <td style="width: 9.6%; vertical-align: top;">
              <div style="text-align: center; line-height: 1.25;"><a href="https://www.sec.gov/Archives/edgar/data/1119774/000117891323001227/exhibit_5-2.htm">23.3*</a></div>
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            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 1.84%; vertical-align: bottom;"><br>
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            <td style="width: 88.56%; vertical-align: top;">
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            <td style="width: 9.6%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 9.6%; vertical-align: top;">
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              <div style="text-align: center; line-height: 1.25;"><a href="exhibit_107.htm">107</a></div>
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      <div style="line-height: 1.25; color: #000000;">_____________</div>
      <div style="line-height: 1.25; color: #000000;">* Previously filed.</div>
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        incorporated herein by reference.</div>
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            <td style="width: 30.07%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.12%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
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              <div style="line-height: 1.25; color: #000000;">/s/ Anat Cohen-Dayag</div>
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              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.07%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.12%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.07%; vertical-align: top;">
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.12%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.12%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.07%; vertical-align: top;">
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 30.12%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 3%; vertical-align: top;">
              <div style="line-height: 1.25; color: #000000;">&#160;</div>
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            <td style="width: 19.96%; vertical-align: top;">
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            <td style="width: 3%; vertical-align: top;">
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            <td style="width: 3%; vertical-align: top;">
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            <td style="width: 3%; vertical-align: top;">
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            <td style="width: 30.12%; vertical-align: top;">
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<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>2
<FILENAME>exhibit_23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
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    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM</div>
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    <div style="text-align: justify; line-height: 1.25; text-indent: 18pt;">We hereby consent to the reference to our firm under the caption &#8220;Experts&#8221; in <font style="color: rgb(0, 0, 0);">&#160;Amendment No. 2 to </font>the Registration Statements on Form
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            <div style="line-height: 1.25;">Tel Aviv, Israel</div>
            <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">June 23, 2023</div>
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<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>3
<FILENAME>exhibit_107.htm
<DESCRIPTION>FILING FEES TABLE
<TEXT>
<html>
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<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
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    <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">Calculation of Filing Fee Tables</div>
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    <div style="text-align: center; line-height: 1.25; color: #000000; font-weight: bold;">COMPUGEN LTD.</div>
    <div style="text-align: center; line-height: 1.25; color: #000000;">(Exact Name of Registrant as Specified in its Charter)</div>
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              Maximum<br>
              Offering<br>
              Price Per<br>
              Unit (2)</div>
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          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Maximum<br>
              Aggregate<br>
              Offering<br>
              Price</div>
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          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 9%;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Fee<br>
              Rate</div>
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          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0);">
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              Registration<br>
              Fee</div>
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          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
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        <tr>
          <td style="width: 9.14%; vertical-align: middle;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 18%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 7%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
          <td style="width: 7.2%; vertical-align: top;">&#160;</td>
          <td style="width: 2%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: #000000;">Fees to Be Paid</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Equity</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td colspan="2" style="vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Ordinary Shares, par value NIS 0.01 per share</div>
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          <td style="width: 9%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7.2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 2%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Debt</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Debt Securities</div>
          </td>
          <td style="width: 9%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.2%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Equity</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td colspan="2" style="vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Warrants</div>
          </td>
          <td style="width: 9%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7.2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 2%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Other</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 18%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Rights</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.2%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Equity</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td colspan="2" style="vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Units</div>
          </td>
          <td style="width: 9%; vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7.2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 2%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: top;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Unallocated (Shelf)</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td colspan="2" style="vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 9%; vertical-align: middle;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">(2)</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">350,000,000</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">0.0001102</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7.2%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">38,570</div>
          </td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td colspan="8" style="vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">Total Offering Amounts</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">350,000,000</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7.2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">38,570</div>
          </td>
          <td style="width: 2%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td colspan="7" style="vertical-align: middle;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">Total Fees Previously Paid</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7.2%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#8212;</div>
          </td>
          <td style="width: 2%; vertical-align: middle;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td colspan="7" style="vertical-align: middle; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">Total Fee Offsets</div>
          </td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 7%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 9%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: middle; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7.2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: #000000;">38,570</div>
          </td>
          <td style="width: 2%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: #000000;">(3)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 9.14%; vertical-align: top;">&#160;</td>
          <td colspan="8" style="vertical-align: middle;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">Net Fee Due</div>
          </td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 7%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 9%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: middle;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 7.2%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">0</div>
          </td>
          <td style="width: 2%; vertical-align: middle;">
            <div style="line-height: 1.25; color: #000000;">(3)</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="za52c9e0840314df8a15bfa298dea35e6">

        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25; color: #000000;">(1)</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25; color: #000000;">There are being registered hereunder such indeterminate number of the securities of each identified class being registered as may be sold by the registrant from time to time
              at indeterminate prices, with the maximum aggregate public offering price not to exceed $350 million. Also includes such indeterminate number of securities of Compugen Ltd. (the &#8220;Registrant&#8221;) as may be issued upon exercise, conversion or
              exchange of these securities. Separate consideration may or may not be received for securities that are issuable upon exercise, conversion or exchange of other securities.</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
          </td>
        </tr>
        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25; color: #000000;">(2)</div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div style="text-align: justify; line-height: 1.25; color: #000000;">The proposed maximum offering price per unit of each class of securities will be determined from time to time by the Registrant in connection with the issuance by the
              Registrant of the securities registered hereunder and is not specified as to each class of security pursuant to General Instruction II.C. of Form F-3 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;).</div>
          </td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 4%; vertical-align: top;">&#160;</td>
          <td rowspan="1" style="width: 96%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td rowspan="1" style="width: 4%; vertical-align: top;">(3)<br>
          </td>
          <td rowspan="1" style="width: 96%; vertical-align: top;">
            <div style="color: rgb(0, 0, 0); text-align: justify;">The Registrant previously filed a Registration Statement on Form F-3 with the Securities and Exchange Commission on July 30, 2020 (File No. 333-240183), which was declared effective on
              August 7, 2020 (the &#8220;<font style="font-weight: bold;">Prior Registration Statement</font>&#8221;), that registered an aggregate of $350,000,000 of an indeterminate number of securities to be offered by the Registrant from time to time. Of the
              $350,000,000 of securities registered on the Prior Registration Statement, for which the Registrant paid a filing fee of $45,430 in connection therewith, $346,246,838.25 of the securities remain unsold, leaving $44,942.84 in previously paid
              fees available for future offset (calculated at the fee rate in effect on the filing date of the Prior Registration Statement). In accordance with Rule 457(p) under the Securities Act, the Registrant is using $38,570 of the unused filing fees
              to offset the filing fee payable in connection with this filing. Accordingly, no additional registration fee is due to be paid at this time. Concurrently with the effectiveness of this registration statement, any offering of unsold securities
              pursuant to the Prior Registration Statement is hereby terminated.</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: center; line-height: 1.25; color: #000000;"><u>Table 2: Fee Offset Claims and Sources</u></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z8f0a415e7b3e4176a2b93e86fbdbcc64">

        <tr>
          <td style="width: 6%; vertical-align: top;">&#160;</td>
          <td colspan="1" style="width: 1.04%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Registrant<br>
              or Filer<br>
              Name</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Form<br>
              or<br>
              Filing<br>
              Type</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">File<br>
              Number</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Initial<br>
              Filing<br>
              Date</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Filing<br>
              Date</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Fee Offset<br>
              Claimed</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Security<br>
              Type<br>
              Associated<br>
              with Fee<br>
              Offset<br>
              Claimed</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); width: 8%; text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Security<br>
              Title<br>
              Associated<br>
              with Fee<br>
              Offset<br>
              Claimed</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Unsold<br>
              Securities<br>
              Associated<br>
              with Fee<br>
              Offset<br>
              Claimed</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td colspan="2" rowspan="1" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Unsold<br>
              Aggregate<br>
              Offering<br>
              Amount<br>
              Associated<br>
              with Fee<br>
              Offset<br>
              Claimed</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; text-align: center;">&#160;</td>
          <td colspan="2" style="vertical-align: bottom; border-bottom: 2px solid rgb(0, 0, 0); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Fee Paid<br>
              with Fee<br>
              Offset<br>
              Source</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td colspan="26" rowspan="1" style="width: 6%; vertical-align: top; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Rule 457(p)</div>
          </td>
          <td rowspan="1" style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: bottom; text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Fee Offset Claims</div>
          </td>
          <td colspan="1" style="width: 1.04%; vertical-align: top;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Compugen Ltd.</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">F-3</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; color: #000000;">333-240183</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">July 30, 2020</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">$</td>
          <td style="width: 5.58%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">38, 570</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">Unallocated (Universal) Shelf</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">(1)</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 8%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25; color: #000000;">&#160;Unallocated (Universal) Shelf</div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td colspan="1" style="width: 6%; vertical-align: bottom; text-align: right;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman';">
              <div style="line-height: 1.25;">346,246,838.25</div>
            </div>
          </td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
          <td style="width: 2%; vertical-align: bottom;">&#160;</td>
          <td style="width: 6%; vertical-align: bottom;">&#160;</td>
          <td style="width: 1%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255); text-align: center;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Fee Offset Sources</div>
          </td>
          <td colspan="1" style="width: 1.04%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">Compugen Ltd.</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">F-3</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">333-240183</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: center; line-height: 1.25; color: #000000;">July 30, 2020</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 5.58%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 8%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td colspan="1" style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
          <td style="width: 2%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">$</div>
          </td>
          <td style="width: 6%; vertical-align: bottom; background-color: rgb(204, 238, 255);">
            <div style="text-align: right; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">38,570</div>
          </td>
          <td style="width: 1%; vertical-align: bottom; background-color: rgb(204, 238, 255);">&#160;</td>
        </tr>

    </table>
    <div style="text-align: justify; line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;"><br>
      (1) Pursuant to Rule 457(p) under the Securities Act, the Registrant is offsetting the registration fee due under this registration statement by $38,570, which represents the portion of the registration fee previously paid with respect to
      $346,246,838.25 of unsold securities (the &#8220;<font style="font-weight: bold;">Unsold Offset Securities</font>&#8221;) previously registered on the 2020 Registration Statement. The offering of the Unsold Offset Securities pursuant to the Prior Registration
      Statement associated with the claimed fee offset pursuant to Rule 457(p) have been completed or terminated.</div>
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