<SEC-DOCUMENT>0001178913-24-000094.txt : 20240108
<SEC-HEADER>0001178913-24-000094.hdr.sgml : 20240108
<ACCEPTANCE-DATETIME>20240108071006
ACCESSION NUMBER:		0001178913-24-000094
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		4
CONFORMED PERIOD OF REPORT:	20240108
FILED AS OF DATE:		20240108
DATE AS OF CHANGE:		20240108

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COMPUGEN LTD
		CENTRAL INDEX KEY:			0001119774
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30902
		FILM NUMBER:		24518309

	BUSINESS ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
		BUSINESS PHONE:		011-972-3-765-8585

	MAIL ADDRESS:	
		STREET 1:		26 HAROKMIM STREET
		STREET 2:		BUILDING D
		CITY:			HOLON
		STATE:			L3
		ZIP:			5885849
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2430750.htm
<DESCRIPTION>6-K
<TEXT>
<html>
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        <font style="background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-style: normal; font-variant: normal; text-transform: none;">UNITED STATES</font></div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">SECURITIES AND EXCHANGE COMMISSION</div>
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; background-color: rgb(255, 255, 255); font-weight: bold; color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-style: normal; font-variant: normal; text-transform: none;">
      <div style="text-align: center; line-height: 1.25;">Form 6-K</div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNDER THE SECURITIES EXCHANGE ACT OF 1934</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">For the month of January 2024</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">Commission File Number 000-30902</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; font-size: 16pt;">
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;">COMPUGEN LTD.</div>
    </div>
    <div style="text-align: center; line-height: 1.25;">(Translation of registrant&#8217;s name into English)</div>
    <table cellspacing="0" cellpadding="0" id="z06cf0c5847054a319bc978e246fcd590" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: middle;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">26&#160;Harokmim Street</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Holon 5885849, Israel</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;">
            <div style="text-align: center; line-height: 1.25;">(Address of Principal Executive Offices)&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">Form 20-F &#9746;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; Form 40-F &#9744;&#160;</div>
    <div style="text-align: center; line-height: 1.25;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Compugen Ltd.</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">On January 8, 2024, Compugen Ltd. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;)
      issued a press release, a copy of which is furnished as Exhibit 99.1 (the &#8220;<font style="font-weight: bold;">Press Release</font>&#8221;), and incorporated herein by reference, announcing that
      the Company had regained compliance with Nasdaq Listing Rule 5550(a)(2).</div>
    <div style="line-height: 1.25">&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">On January 8, 2024, the Company issued a press release, a copy of which is furnished as Exhibit 99.2 (the &#8220;<font style="font-weight: bold;">Milestone Press Release</font>&#8221;), and incorporated herein by reference, announcing that a $10 million milestone payment to the Company from AstraZeneca was triggered after the first
      patient was dosed in AstraZeneca&#8217;s ARTEMIDE-Bil01 trial with rilvegostomig.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">With the exception of the quotes attributable to Anat Cohen-Dayag, Ph.D., in the Milestone Press Release, information incorporated by reference in this Report on Form 6-K is hereby incorporated by reference into the Company&#8217;s Registration Statements on Form F-3, File No. 333-270985.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="line-height: 1.25; font-weight: bold;">Exhibit</div>
          </td>
          <td style="width: 90%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="line-height: 1.25; font-weight: bold;"><u>Number</u></div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="line-height: 1.25; font-weight: bold;"><u>Description of Exhibit</u></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">&#160;</td>
          <td style="width: 90%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="line-height: 1.25;"><a href="exhibit_99-1.htm"><u>99.1</u></a></div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="line-height: 1.25;"><a href="exhibit_99-1.htm">Press Release dated
                January 8, 2024 &#8211; &#8220;Compugen Regains Compliance with Nasdaq Minimum Bid Price Requirement.&#8221;</a></div>
          </td>
        </tr>
        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="line-height: 1.25;"><a href="exhibit_99-2.htm">99.2</a></div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="line-height: 1.25;"><a href="exhibit_99-2.htm">Press Release dated
                January 8, 2024 &#8211; &#8220;Compugen to Receive $10 Million Milestone Payment Following Dosing of First Patient in AstraZeneca Phase 3 Rilvegostomig Trial in Biliary Tract Cancer.&#8221;</a></div>
          </td>
        </tr>

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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signatures</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its
      behalf by the undersigned thereunto duly authorized.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" id="z19712aa74ce84a569d5e5920726567bf" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 51.26%; vertical-align: bottom;">&#160;</td>
          <td style="width: 40.07%; vertical-align: bottom;" colspan="2">
            <div style="line-height: 1.25; font-weight: bold;">COMPUGEN LTD.</div>
          </td>
          <td style="width: 8.66%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;" colspan="4">&#160;</td>
        </tr>
        <tr>
          <td style="width: 51.26%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Date: January 8, 2024</div>
          </td>
          <td style="width: 4.52%; vertical-align: bottom;">
            <div style="line-height: 1.25;">By:</div>
          </td>
          <td style="width: 35.56%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="line-height: 1.25;">/s/ Eran Ben Dor</div>
          </td>
          <td style="width: 8.66%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 51.26%; vertical-align: bottom;">&#160;</td>
          <td style="width: 4.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 35.56%; vertical-align: bottom;">
            <div style="line-height: 1.25;">Eran Ben Dor</div>
          </td>
          <td style="width: 8.66%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 51.26%; vertical-align: bottom;">&#160;</td>
          <td style="width: 4.52%; vertical-align: bottom;">&#160;</td>
          <td style="width: 35.56%; vertical-align: bottom;">
            <div style="line-height: 1.25;">General Counsel</div>
          </td>
          <td style="width: 8.66%; vertical-align: bottom;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <br>
    <div style="line-height: 1.25;">
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>exhibit_99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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      <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
    <div style="line-height: 1.25; text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.1</font></u><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
  </div>
  <div style="line-height: 1.25;"><img width="128" height="53" src="image0.jpg"></div>
  <div style="line-height: 1.25;">
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
  </div>
  <div style="line-height: 1.25; font-weight: bold;">FOR IMMEDIATE RELEASE</div>
  <div style="line-height: 1.25;"><br style="line-height: 1.25;">
  </div>
  <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Compugen
    Regains Compliance with Nasdaq Minimum Bid </div>
  <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Price
    Requirement</div>
  <div style="line-height: 1.25">&#160;</div>
  <div style="line-height: 1.25;">HOLON, ISRAEL,&#160;Jan 8, 2024&#160;- Compugen Ltd. (Nasdaq: CGEN) (TASE: CGEN) a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, announced today that on January 4, 2024, it received a
    notification letter (the &#8220;Notification Letter&#8221;) from the Listing Qualifications Department of The Nasdaq Stock Market LLC (&#8220;Nasdaq&#8221;) notifying the Company that it had regained compliance with the minimum bid price requirement set forth in the Nasdaq
    Listing Rule 5550(a)(2) (the &#8220;Minimum Bid Price Requirement&#8221;).</div>
  <div style="line-height: 1.25">&#160;</div>
  <div style="line-height: 1.25;">As announced on November 3, 2023, the Company was notified that its ordinary shares failed to maintain a minimum bid price of $1.00 over the previous 30 consecutive business days as required by the Minimum Bid Price
    Requirement. To regain compliance with the Minimum Bid Price Requirement, the closing bid of the Company&#8217;s ordinary shares&#160;needed to be at least $1.00 for a minimum of 10 consecutive business days.</div>
  <div style="line-height: 1.25">&#160;</div>
  <div style="line-height: 1.25;">The Notification Letter confirmed that the Company evidenced a closing bid price at or greater than the $1.00 per ordinary share minimum requirement for the last 10 consecutive business days from December 19, 2023 to
    January 3, 2024 and that the Company has regained compliance with the Minimum Bid Price Requirement.</div>
  <div style="line-height: 1.25">&#160;</div>
  <div style="line-height: 1.25; font-weight: bold;">About Compugen</div>
  <div style="line-height: 1.25;">Compugen&#160;is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable predictive computational discovery capabilities to identify new drug targets and biological pathways for
    developing cancer immunotherapies.&#160;Compugen has developed two proprietary product candidates: COM701, a potential first-in-class anti-PVRIG antibody and COM902,&#160;a potential best-in-class antibody targeting TIGIT for the treatment of solid tumors.
    Compugen also has a clinical stage partnered program, rilvegostomig (previously AZD2936), a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from Compugen&#8217;s clinical stage anti-TIGIT antibody, COM902, in Phase 3 development by
    AstraZeneca through a license agreement for the development of bispecific and multispecific antibodies.&#160;In addition, the Company&#8217;s therapeutic pipeline of early-stage&#160;immuno-oncology programs consists of programs aiming to address various mechanisms of
    immune resistance, of which the most advanced program, in IND enabling studies is COM503, which is licensed to Gilead.</div>
  <div style="line-height: 1.25;">COM503 is a potential first-in-class, high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby freeing natural IL-18 in the tumor microenvironment to inhibit cancer growth.
    Compugen&#160;is headquartered in Israel, with offices in San Francisco, CA. Compugen&#8217;s shares are listed on Nasdaq and the Tel Aviv&#160;Stock Exchange under the ticker symbol CGEN.&#160;</div>
  <div style="line-height: 1.25;"><br style="line-height: 1.25;">
  </div>
  <div style="line-height: 1.25; font-weight: bold;">Company contact:</div>
  <div style="line-height: 1.25;">Yvonne Naughton, Ph.D.</div>
  <div style="line-height: 1.25;">Head of Investor Relations and Corporate Communications</div>
  <div style="line-height: 1.25;">Email:&#160;ir@cgen.com</div>
  <div style="line-height: 1.25;">Tel: +1&#160;(628)&#160;241-0071&#160;&#160;</div>
  <div style="line-height: 1.25;"> <br>
  </div>
  <div style="line-height: 1.25;">
    <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"> </div>
  <div style="line-height: 1.25;"><br style="line-height: 1.25;">
  </div>
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<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>exhibit_99-2.htm
<DESCRIPTION>EXHIBIT 99.2
<TEXT>
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        <div style="line-height: 1.25;">
          <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
        <div style="line-height: 1.25; text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.2</font></u><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
      <div style="line-height: 1.25;"><img width="128" height="53" src="image0.jpg"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">FOR IMMEDIATE RELEASE</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Compugen to Receive $10 Million Milestone Payment Following </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Dosing of First Patient in AstraZeneca Phase 3 Rilvegostomig </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">Trial in Biliary Tract Cancer</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">HOLON, ISRAEL,&#160;January 8, 2024&#160;- <u>Compugen Ltd.</u>
        (Nasdaq: CGEN) (TASE: CGEN) a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, today announced that Compugen is entitled to receive a $10 million milestone payment from AstraZeneca (LSE/STO/Nasdaq: AZN),
        after the first patient was dosed in AstraZeneca&#8217;s ARTEMIDE-Bil01 trial with rilvegostomig. Rilvegostomig is a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from Compugen&#8217;s clinical-stage anti-TIGIT antibody, COM902. The
        ARTEMIDE-Bil01 trial is expected to recruit about 750 subjects in more than 20 countries with biliary tract cancer who will be randomized to receive rilvegostomig or placebo with investigator choice chemotherapy as adjuvant treatment after
        resection with curative intent.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">&#8220;I am delighted to see the advancement of the rilvegostomig Phase 3 trial by AstraZeneca, a global leader in oncology, which has dosed
        the first patient triggering a $10 million milestone payment to Compugen,&#8221; said Anat Cohen-Dayag, Ph.D., President, and Chief Executive Officer of Compugen. &#8220;Our license agreement with AstraZeneca is part of our strategy to broaden
        commercialization opportunities for our pipeline and specifically capitalize on the potentially emerging promise of bispecific therapies while maintaining our focus on the development of COM902 as part of the combination with COM701, our potential
        first-in-class anti-PVRIG antibody.&#8221;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">About the Compugen-AstraZeneca license agreement</div>
      <div style="line-height: 1.25;">In 2018, Compugen and AstraZeneca entered into an agreement by which Compugen provided an exclusive license to AstraZeneca to use
        Compugen&#8217;s monospecific antibodies that bind to TIGIT, including COM902, for the development of bispecific and multispecific antibody products, excluding such bispecific and multispecific antibodies that also bind to PVRIG, PVRL2 and/or TIGIT.
        AstraZeneca is responsible for all research, development, and commercial activities. AstraZeneca has the right to create multiple products under this license. In addition to the $10 million milestone payment described in this press release,
        Compugen has received a $10 million upfront payment, and an additional $15.5 million in milestone payments to date, all out of up to an aggregate milestone amount of $200 million that the Company is eligible to receive in development, regulatory
        and commercial milestones for the first product, as well as tiered royalties on future product sales. If additional bi- or multi-specific therapies are developed based on Compugen&#8217;s monospecific antibodies that bind to TIGIT, additional milestones
        and royalties would be due to Compugen.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Further details about ARTEMIDE-Bil01 trial are available on ClinicalTrials.gov, identifier: <u>NCT06109779</u></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">About&#160;Compugen</div>
      <div style="line-height: 1.25;">Compugen&#160;is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable predictive computational
        discovery capabilities to identify new drug targets and biological pathways for developing cancer immunotherapies.&#160;Compugen has developed two proprietary product candidates: COM701, a potential first-in-class anti-PVRIG antibody and COM902,&#160;a
        potential best-in-class antibody targeting TIGIT for the treatment of solid tumors. Compugen also has a clinical stage partnered program, rilvegostomig (previously AZD2936), a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from
        Compugen&#8217;s clinical stage anti-TIGIT antibody, COM902, in Phase 3 development by AstraZeneca through a license agreement for the development of bispecific and multispecific antibodies.&#160;In addition, the Company&#8217;s therapeutic pipeline of
        early-stage&#160;immuno-oncology programs consists of programs aiming to address various mechanisms of immune resistance, of which the most advanced program, COM503, is in IND enabling studies is licenced to Gilead. COM503 is a potential first-in-class,
        high affinity antibody which blocks the interaction between IL-18 binding protein and IL-18, thereby freeing natural IL-18 in the tumor microenvironment to inhibit cancer growth. Compugen&#160;is headquartered in Israel, with offices in San Francisco,
        CA. Compugen&#8217;s shares are listed on Nasdaq and the Tel Aviv&#160;Stock Exchange under the ticker symbol CGEN.&#160;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Forward-Looking Statement</div>
      <div style="line-height: 1.25;">This press release contains &#8220;forward-looking statements&#8221; within the meaning of the Securities Act of 1933 and the Securities Exchange Act
        of 1934, as amended, and the safe-harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on the current beliefs, expectations, and assumptions of Compugen. Forward-looking statements can
        be identified using terminology such as &#8220;will,&#8221; &#8220;may,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;believes,&#8221; &#8220;potential,&#8221; &#8220;plan,&#8221; &#8220;goal,&#8221; &#8220;estimate,&#8221; &#8220;likely,&#8221; &#8220;should,&#8221; &#8220;confident,&#8221; and &#8220;intends,&#8221; and similar expressions that are intended to identify
        forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements include, but are not limited to, statements relating to the recruitment of subjects to the ARTEMIDE-Bil01 trial.
        These forward-looking statements involve known and unknown risks and uncertainties that may cause the actual results, performance, or achievements of Compugen to be materially different from any future results, performance or achievements expressed
        or implied by such forward-looking statements. Among these risks: Compugen&#8217;s business model is substantially dependent on entering into collaboration agreements with third parties and Compugen may not be successful in generating adequate revenues
        or commercializing aspects of its business model; Compugen&#8217;s approach to the discovery of therapeutic products is based on its proprietary computational target discovery infrastructure, which is unproven clinically; Compugen does not know whether
        it will be able to discover and develop additional potential product candidates or products of commercial value; and the general market, political and economic conditions in the countries in which Compugen operates, including Israel; and the effect
        of the evolving nature of the recent war in Gaza between Israel and Hamas. These risks and other risks are more fully discussed in the &#8220;Risk Factors&#8221; section of Compugen&#8217;s most recent Annual Report on Form 20-F as filed with the Securities and
        Exchange Commission (SEC) as well as other documents that may be subsequently filed by Compugen from time to time with the SEC. In addition, any forward-looking statements represent Compugen&#8217;s views only as of the date of this release and should
        not be relied upon as representing its views as of any subsequent date. Compugen does not assume any obligation to update any forward-looking statements unless required by law.&#160;</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Company contact:</div>
      <div style="line-height: 1.25;">Yvonne Naughton, Ph.D.</div>
      <div style="line-height: 1.25;">Head of Investor Relations and Corporate Communications</div>
      <div style="line-height: 1.25;">Email:&#160;ir@cgen.com</div>
      <div style="line-height: 1.25;">Tel: +1&#160;(628)&#160;241-0071&#160;&#160;</div>
      <div style="line-height: 1.25;"> <br>
      </div>
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</SEC-DOCUMENT>
