v3.25.4

Commitments and Contingencies - Additional Information (Details) $ in Thousands, € in Millions, £ in Millions |  | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Jan. 08, 2025 USD ($) | Mar. 31, 2025 USD ($) | Dec. 31, 2025 USD ($) | Dec. 31, 2024 USD ($) | Jan. 31, 2024 GBP (£) | Jan. 11, 2024 USD ($) | Feb. 28, 2021 EUR (€)
Other Commitments [Line Items] |  |  |  |  |  |  |
Research and development expense |  |  | $ 46,713 | $ 14,336 |  |  |
Acelyrin Asset Purchase Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments Due |  |  | 0 |  |  |  |
Mabworks Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Upfront Payment Paid | $ 9,000 |  |  |  |  |  |
Development and Regulatory Milestones [Member] | Mabworks Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments | 30,000 |  |  |  |  |  |
Commercial Milestones [Member] | Mabworks Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments | $ 832,000 |  |  |  |  |  |
Milestone [Member] | CRH Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Research and development expense |  |  | 1,000 |  |  |  |
Milestone [Member] | ProBioGen Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Research and development expense |  |  | 2,700 |  |  |  |
Milestone [Member] | Mabworks Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Research and development expense |  |  | 1,000 |  |  |  |
Manufacturing Services [Member] | ProBioGen Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payment, Amount Reduced |  |  | 1,200 |  |  |  | € 1.1
Upfront Payment [Member] | Mabworks Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Research and development expense |  | $ 9,000 |  |  |  |  |
Maximum [Member] | Development Regulatory and Commercial Milestones [Member] | Acelyrin Asset Purchase Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments |  |  |  |  |  | $ 157,500 |
Maximum [Member] | Development Regulatory Commercial and Sales Milestones [Member] | CRH Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments |  |  | 143,600 |  | £ 106.8 |  |
Maximum [Member] | Development Manufacturing and Commercial [Member] | ProBioGen Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments |  |  | 11,700 |  |  |  | 10.0
Maximum [Member] | Sales Milestones [Member] | ProBioGen Agreement [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone Payments |  |  | $ 8,200 |  |  |  | € 7.0

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