v3.25.4

Segments - Schedule of Forth Disaggregated Research and Development Expenses (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024
Segment Reporting Information [Line Items] |  |  |
Research and development expense |  | $ 46,713 | $ 14,336
Operating Segments [Member] |  |  |
Segment Reporting Information [Line Items] |  |  |
Research and development expense |  | 46,713 | 14,336
Operating Segments [Member] | Direct Expense [Member] | Budoprutug |  |  |
Segment Reporting Information [Line Items] |  |  |
Research and development expense |  | 25,045 | 5,982
Operating Segments [Member] | Direct Expense [Member] | CLYM1161 |  |  |
Segment Reporting Information [Line Items] |  |  |
Research and development expense | [1] | 11,964 | 0
Operating Segments [Member] | Direct Expense [Member] | Legacy programs |  |  |
Segment Reporting Information [Line Items] |  |  |
Research and development expense | [2] | 107 | 201
Operating Segments [Member] | Unallocated Expense [Member] | Personnel-related (including stock-based compensation) |  |  |
Segment Reporting Information [Line Items] |  |  |
Research and development expense |  | 8,232 | 7,990
Operating Segments [Member] | Unallocated Expense [Member] | Other research and development expenses |  |  |
Segment Reporting Information [Line Items] |  |  |
Research and development expense |  | $ 1,365 | $ 163
[1] | Includes the upfront payment and the associated direct transaction costs incurred in connection with the Mabworks Agreement for the year ended December 31, 2025.
[2] | Includes direct expenses related to the Company's legacy product candidates ETX-123 and ETX-155.

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- Definition Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 220 -SubTopic 40 -Name Accounting Standards Codification -Section 55 -Paragraph 18 -Publisher FASB -URI https://asc.fasb.org/1943274/2147476153/220-40-55-18 Reference 2: http://www.xbrl.org/2003/role/exampleRef -Topic 220 -SubTopic 40 -Name Accounting Standards Codification -Section 55 -Paragraph 14 -Publisher FASB -URI https://asc.fasb.org/1943274/2147476153/220-40-55-14 Reference 3: http://www.xbrl.org/2003/role/exampleRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 48 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482785/280-10-55-48 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 985 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481283/985-20-50-2 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Topic 730 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482916/730-10-50-1 Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 912 -SubTopic 730 -Name Accounting Standards Codification -Section 25 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479532/912-730-25-1 + Details
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