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Accrued Expenses (Detail) (USD $) | Dec. 31, 2012 | Dec. 31, 2011
--- | --- | ---
Schedule of Accrued Liabilities [Line Items] |  |
Payroll and benefits | $ 2,477,833 | $ 2,366,412
Professional fees | 642,853 | 793,430
Clinical trial costs | 102,414 |
SRL research grants | 110,350 | 989,556
Restructuring costs | 933,732 |
Other | 1,569,862 | 1,172,196
Total | $ 5,837,044 | $ 5,321,594

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