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Revenue by Product Group, by Significant Customer and by Geographic Region; Geographic Information (Tables) | 12 Months Ended
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Dec. 31, 2012
Product Revenue by Product Group | Product revenue by product group is as follows:
|  | Year Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
|  | Revenue |  |  | Percentage of Product Revenue |  |  | Revenue |  |  | Percentage of Product Revenue |  |  | Revenue |  |  | Percentage of Product Revenue |
Orthobiologics |  | $ | 49,954,112 |  |  |  | 73.5 | % |  | $ | 39,858,139 |  |  |  | 64.3 | % |  | $ | 30,741,305 |  |  |  | 58.3 | %
Dermal |  |  | 1,384,403 |  |  |  | 2.0 | % |  |  | 3,681,166 |  |  |  | 5.9 | % |  |  | 3,564,616 |  |  |  | 6.8 | %
Surgical |  |  | 5,022,456 |  |  |  | 7.4 | % |  |  | 4,976,261 |  |  |  | 8.1 | % |  |  | 3,883,444 |  |  |  | 7.3 | %
Ophthalmic |  |  | 8,784,011 |  |  |  | 12.9 | % |  |  | 10,963,822 |  |  |  | 17.7 | % |  |  | 11,971,787 |  |  |  | 22.7 | %
Veterinary |  |  | 2,865,187 |  |  |  | 4.2 | % |  |  | 2,476,998 |  |  |  | 4.0 | % |  |  | 2,574,578 |  |  |  | 4.9 | %
|  | $ | 68,010,169 |  |  |  | 100.0 | % |  | $ | 61,956,386 |  |  |  | 100.0 | % |  | $ | 52,735,730 |  |  |  | 100.0 | %
Percentage of Product Revenue by Significant Customers | Product revenue by significant customers as a percent of product revenues is as follows:
|  | Percent of Product Revenue
|  | Year Ended December 31,
|  | 2012 |  | 2011 |  | 2010
DePuy Mitek |  | 61.2% |  | 47.1% |  | 42.7%
Bausch & Lomb Inc. |  | 11.4% |  | 15.8% |  | 21.2%
Boehringer |  | 4.2% |  | 4.0% |  | 4.9%
Medtronic |  | 3.1% |  | 5.6% |  | 10.2%
Rivex Pharma |  | 2.0% |  | 1.3% |  | 1.5%
|  | 81.9% |  | 73.8% |  | 80.5%
Product Revenue by Geographic Location and Percentage of Total Product Revenue | Revenues by geographic location in total and as a percentage of total revenues are as follows:
|  | Year Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
|  | Revenue |  |  | Percentage of Total Revenue |  | Revenue |  |  | Percentage of Total Revenue |  | Revenue |  |  | Percentage of Total Revenue |
United States |  | $ | 57,904,290 |  |  |  | 81.1 | % |  | $ | 48,366,140 |  |  |  | 74.7 | % |  | $ | 38,313,594 |  |  |  | 69.0 | %
Europe |  |  | 6,267,830 |  |  |  | 8.8 | % |  |  | 10,988,664 |  |  |  | 16.9 | % |  |  | 12,976,985 |  |  |  | 23.3 | %
Other |  |  | 7,186,385 |  |  |  | 10.1 | % |  |  | 5,423,831 |  |  |  | 8.4 | % |  |  | 4,266,015 |  |  |  | 7.7 | %
Total |  | $ | 71,358,505 |  |  |  | 100.0 | % |  | $ | 64,778,635 |  |  |  | 100.0 | % |  | $ | 55,556,594 |  |  |  | 100.0 | %
Net Tangible Long Lived Assets by Principal Geographic Areas | Net tangible long-lived assets by principal geographic areas were as follows:
|  | Years Ended December 31, |
|  | 2012 |  |  | 2011 |
United States |  | $ | 33,792,325 |  |  | $ | 34,565,770 |
Italy |  |  | 1,320,656 |  |  |  | 1,904,108 |
Total |  | $ | 35,112,981 |  |  | $ | 36,469,878 |

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- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -URI http://asc.fasb.org/extlink&oid=6534315&loc=d3e8736-108599 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -URI http://asc.fasb.org/extlink&oid=6534315&loc=d3e8813-108599 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=14024403&loc=d3e13816-109267 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 131 -Paragraph 27, 28 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -URI http://asc.fasb.org/extlink&oid=6534315&loc=d3e8906-108599 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 21 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6534315&loc=d3e8721-108599 + Details
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