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Consolidated Statements of Operations and Comprehensive Income (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Product revenue $ 68,010,169 $ 61,956,386 $ 52,735,730
Licensing, milestone and contract revenue 3,348,336 2,822,249 2,820,864
Total revenue 71,358,505 64,778,635 55,556,594
Operating expenses:      
Cost of product revenue 28,988,621 26,783,738 23,826,604
Research & development 5,388,036 6,168,937 6,874,633
Selling, general & administrative 14,728,662 17,858,558 17,317,671
Restructuring charges 2,537,988    
Total operating expenses 51,643,307 50,811,233 48,018,908
Income from operations 19,715,198 13,967,402 7,537,686
Interest income (expense), net (187,777) (182,388) (194,620)
Income before income taxes 19,527,421 13,785,014 7,343,066
Provision for income taxes 7,769,961 5,318,334 3,027,071
Net income 11,757,460 8,466,680 4,315,995
Basic net income per share:      
Net income $ 0.89 $ 0.65 $ 0.34
Basic weighted average common shares outstanding 13,260,739 13,064,051 12,624,495
Diluted net income per share:      
Net income $ 0.82 $ 0.62 $ 0.32
Diluted weighted average common shares outstanding 14,344,577 13,747,813 13,646,533
Net income 11,757,460 8,466,680 4,315,995
Other comprehensive income (loss)      
Foreign currency translation adjustment 412,551 (519,405) (2,547,776)
Comprehensive income $ 12,170,011 $ 7,947,275 $ 1,768,219