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Note 7 - Accrued Expenses
 12 Months Ended
Dec. 31, 2013
Payables and Accruals [Abstract]  
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
7. Accrued Expenses

Accrued expenses consist of the following:

   
December 31,
 
   
2013
   
2012
 
Payroll and benefits
  $ 2,728,616     $ 2,477,833  
Professional fees
    383,231       642,853  
Clinical trial costs
    882,651       102,414  
Research grants
    610,498       844,803  
Restructuring costs
    24,638       933,732  
Other
    908,247       835,409  
Total
  $ 5,537,881     $ 5,837,044