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Note 9 - Accrued Expenses | 12 Months Ended
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Dec. 31, 2014
Payables and Accruals [Abstract] |
Accounts Payable and Accrued Liabilities Disclosure [Text Block] | 9. Accrued Expenses Accrued expenses consist of the following:
|  | December 31, |
|  | 2014 |  |  | 2013 |
Compensation and related expenses |  | $ | 2,791,935 |  |  | $ | 2,870,147 |
Professional fees |  |  | 553,630 |  |  |  | 383,231 |
Clinical trial costs |  |  | 508,042 |  |  |  | 882,651 |
Research grants |  |  | 539,053 |  |  |  | 610,498 |
Restructuring costs |  |  | 8,384 |  |  |  | 24,638 |
Other |  |  | 346,482 |  |  |  | 766,716 |
Total |  | $ | 4,747,526 |  |  | $ | 5,537,881 |

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- Definition The entire disclosure for accounts payable and accrued liabilities at the end of the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.19(a),20,24) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 19 -Subparagraph a -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20, 24 -Article 5 + Details
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