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Note 15 - Revenue by Product Group, by Significant Customer and by Geographic Region; Geographic Information (Tables)

12 Months Ended

Dec. 31, 2014

Segment Reporting [Abstract]

Schedule of Segment Reporting Information, by Segment [Table Text Block]

		Years Ended December 31,
		2014								2013								2012
		Revenue				Percentage of Product Revenue				Revenue				Percentage of Product Revenue				Revenue				Percentage of Product Revenue
Orthobiologics		$	61,956,870				82	%		$	55,956,068				78	%		$	49,954,112				74	%
Dermal			1,334,295				2	%			1,816,602				3	%			1,384,403				2	%
Surgical			5,854,876				8	%			5,445,715				8	%			5,022,456				7	%
Ophthalmic			3,153,435				4	%			4,656,560				6	%			8,784,011				13	%
Veterinary			3,174,522				4	%			3,898,785				5	%			2,865,187				4	%
		$	75,473,998				100	%		$	71,773,730				100	%		$	68,010,169				100	%

Schedule of Revenue by Major Customers [Table Text Block]

		Percentage of Product Revenue Years Ended December 31,
		2014				2013				2012
DePuy Mitek			72	%			63	%			61	%
Boehringer			4	%			5	%			4	%
Medtronic XoMEd			4	%			3	%			3	%
Bausch & Lomb			3	%			5	%			12	%
Nordic Pharma			2	%			2	%			1	%
			85	%			78	%			81	%

Schedule of Revenue from External Customers Attributed to Foreign Countries by Geographic Area [Table Text Block]

		Years Ended December 31,
		2014								2013								2012
		Revenue				Percentage of Total Revenue				Revenue				Percentage of Total Revenue				Revenue				Percentage of Total Revenue
United States		$	92,259,139				87	%		$	58,490,142				78	%		$	57,976,667				81	%
Europe			6,214,441				6	%			7,411,568				10	%			6,218,890				9	%
Other			7,121,259				7	%			9,179,444				12	%			7,162,948				10	%
Total		$	105,594,839				100	%		$	75,081,154				100	%		$	71,358,505				100	%

Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas [Table Text Block]

		Years Ended December 31,
		2014				2013
United States		$	31,058,617			$	31,999,468
Italy			610,266				939,243
Total		$	31,668,883			$	32,938,711

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Tabular disclosure of the names of foreign countries from which revenue is material and the amount of revenue from external customers attributed to those countries. An entity may also provide subtotals of geographic information about groups of countries.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

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Tabular disclosure of information concerning material long-lived assets (excluding financial instruments, customer relationships with financial institutions, mortgage and other servicing rights, deferred policy acquisition costs, and deferred taxes assets) located in identified geographic areas and/or the amount of revenue from external customers attributed to that country from which revenue is material. An entity may also provide subtotals of geographic information about groups of countries.

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Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

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