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Note 10 - Accrued Expenses - Accrued Expenses (Details) - USD ($)	Sep. 30, 2015	Dec. 31, 2014
Compensation and related expenses	$ 2,806,699	$ 2,791,935
Facility construction costs	2,073,561
Professional fees	524,938	$ 553,630
Clinical trial costs	240,987	508,042
Research grants	393,085	539,053
Other	508,505	354,866
Total	$ 6,547,775	$ 4,747,526

X

- Definition

Represents accrued clinical trial costs current.

+ References

No definition available.

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X

- Definition

Represents accrued research grants current.

+ References

No definition available.

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X

- Definition

Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



-SubTopic 10



-Section S99



-Paragraph 1



-Subparagraph (SX 210.5-02.20)



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X

- Definition

Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



-SubTopic 10



-Section 45



-Paragraph 6



-URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e6911-107765



Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Glossary Current Liabilities



-URI http://asc.fasb.org/extlink&oid=6509677



Reference 3: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



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-Section 45



-Paragraph 8



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-Name Accounting Standards Codification



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-Section S99



-Paragraph 1



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- Definition

Carrying value as of the balance sheet date of obligations incurred and payable for the acquisition of merchandise, materials, supplies and services pertaining to construction projects such as a housing development or factory expansion not classified as trade payables. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

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-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



-SubTopic 10



-Section S99



-Paragraph 1



-Subparagraph (SX 210.5-02.19(a))



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- Definition

Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

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-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



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-Section S99



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- Definition

Carrying value as of the balance sheet date of obligations incurred through that date and payable arising from transactions not otherwise specified in the taxonomy. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



-SubTopic 10



-Section 45



-Paragraph 9



-URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e7018-107765



Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Glossary Current Liabilities



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Reference 3: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 210



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-URI http://asc.fasb.org/extlink&oid=28358313&loc=d3e6911-107765



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-Publisher FASB



-Name Accounting Standards Codification



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