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Note 17 - Quarterly Financial Data (Unaudited) - Quarterly Financial Data (Unaudited) (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Product revenue | $ 28,296 | $ 25,783 | $ 26,575 | $ 22,278 | $ 25,607 | $ 23,676 | $ 22,898 | $ 15,515 | $ 102,932 | $ 87,696 | $ 75,474
Total revenue | 28,726 | 25,789 | 26,581 | 22,283 | 30,894 | 23,681 | 22,904 | 15,520 | 103,379 | 92,999 | 105,595
Cost of product revenue | 7,539 | 4,998 | 6,065 | 5,425 | 6,290 | 5,176 | 5,274 | 4,313 | 24,027 | 21,053 | 20,930
Gross profit on product revenue | 20,757 | 20,785 | 20,510 | 16,853 | 19,317 | 18,500 | 17,624 | 11,202 |  |  |
Net income | $ 8,085 | $ 8,952 | $ 8,615 | $ 6,895 | $ 11,042 | $ 8,380 | $ 7,820 | $ 3,516 | $ 32,547 | $ 30,758 | $ 38,319
Basic net income per share (in dollars per share) | $ 0.56 | $ 0.61 | $ 0.59 | $ 0.46 | $ 0.74 | $ 0.56 | $ 0.52 | $ 0.24 | $ 2.22 | $ 2.06 | $ 2.61
Basic common shares outstanding (in shares) | 14,538 | 14,625 | 14,679 | 14,875 | 14,965 | 14,967 | 14,961 | 14,905 |  |  |
Diluted net income per share (in dollars per share) | $ 0.54 | $ 0.59 | $ 0.57 | $ 0.45 | $ 0.72 | $ 0.55 | $ 0.51 | $ 0.23 | $ 2.15 | $ 2.01 | $ 2.51
Diluted common shares outstanding (in shares) | 14,979 | 15,077 | 15,111 | 15,307 | 15,353 | 15,316 | 15,336 | 15,330 | 15,116 | 15,321 | 15,269

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- Definition Total costs related to goods produced and sold during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.2(a)) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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