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Note 18 - Quarterly Financial Data (Unaudited) - Quarterly Financial Data (Unaudited) (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Product revenue | $ 28,884 | $ 27,178 | $ 28,340 | $ 23,381 | $ 28,296 | $ 25,783 | $ 26,575 | $ 22,278 | $ 107,783 | $ 102,932 | $ 87,696
Total revenue | 29,388 | 27,184 | 33,462 | 23,386 | 28,726 | 25,789 | 26,581 | 22,283 | 113,420 | 103,379 | 92,999
Cost of product revenue | 8,716 | 6,250 | 6,315 | 6,083 | 7,539 | 4,998 | 6,065 | 5,425 | 27,364 | 24,027 | 21,053
Gross profit on product revenue | 20,168 | 20,928 | 22,025 | 17,298 | 20,757 | 20,785 | 20,510 | 16,853 |  |  |
Net income | $ 8,067 | $ 6,887 | $ 11,369 | $ 5,493 | $ 8,085 | $ 8,952 | $ 8,615 | $ 6,895 | $ 31,816 | $ 32,547 | $ 30,758
Net income (in dollars per share) | $ 0.55 | $ 0.47 | $ 0.78 | $ 0.38 | $ 0.56 | $ 0.61 | $ 0.59 | $ 0.46 | $ 2.18 | $ 2.22 | $ 2.06
Basic common shares outstanding (in shares) | 14,596 | 14,579 | 14,588 | 14,576 | 14,538 | 14,625 | 14,679 | 14,875 |  |  |
Diluted net income per share (in dollars per share) | $ 0.53 | $ 0.46 | $ 0.76 | $ 0.37 | $ 0.54 | $ 0.59 | $ 0.57 | $ 0.45 | $ 2.11 | $ 2.15 | $ 2.01
Diluted common shares outstanding (in shares) | 15,141 | 15,115 | 15,044 | 15,043 | 14,979 | 15,077 | 15,111 | 15,307 | 15,068 | 15,116 | 15,321

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