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Note 11 - Accrued Expenses (Tables)
 6 Months Ended
Jun. 30, 2018
Notes Tables  
Schedule of Accrued Liabilities [Table Text Block]
    June 30,
2018		   December 31,
2017
Compensation and related expenses   $
3,633
     $
2,893
  
Clinical trial costs    
867
      
2,318
  
Accrued liabilities related to product recall    
1181
      
-
  
Research grants    
408
      
419
  
Professional fees    
1,213
      
448
  
Deferred income    
74
      
-
  
Other    
83
      
248
  
Total   $
7,459
     $
6,326