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Note 6 - Equity Incentive Plan (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
    Nine Months Ended September 30,
    2018   2017
Risk free interest rate    
2.15%
-
2.82%
     
1.60%
-
1.78%
 
Expected volatility    
37.12%
-
45.61%
     
41.36%
-
44.30%
 
Expected life (years)    
4.0
-
4.5
     
 
4.0
 
 
Expected dividend yield    
 
0.00%
 
     
 
0.00%
 
 
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
    Three Months Ended September 30,   Nine Months Ended September 30,
    2018   2017   2018   2017
Cost of product revenue   $
39
    $
107
    $
(205
)   $
306
 
Research and development    
239
     
177
     
690
     
340
 
Selling, general and administrative    
899
     
1,190
     
9,579
     
3,294
 
Total stock-based compensation expense   $
1,177
    $
1,474
    $
10,064
    $
3,940
 
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
    Three Months Ended September 30,   Nine Months Ended September 30,
    2018   2017   2018   2017
Grants:                
Stock options    
18,500
     
60,609
     
228,300
     
470,744
 
RSAs    
-
     
14,506
     
64,578
     
14,506
 
RSUs    
3,624
     
-
     
11,754
     
9,970
 
Exercises:                                
Stock options    
-
     
3,329
     
284,548
     
12,766
 
SARs    
-
     
-
     
-
     
5,000