<SEC-DOCUMENT>0001171843-18-001789.txt : 20180308
<SEC-HEADER>0001171843-18-001789.hdr.sgml : 20180308
<ACCEPTANCE-DATETIME>20180308171745
ACCESSION NUMBER:		0001171843-18-001789
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		4
CONFORMED PERIOD OF REPORT:	20180302
ITEM INFORMATION:		Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers
ITEM INFORMATION:		Other Events
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20180308
DATE AS OF CHANGE:		20180308

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Anika Therapeutics, Inc.
		CENTRAL INDEX KEY:			0000898437
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				043145961
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-14027
		FILM NUMBER:		18677440

	BUSINESS ADDRESS:	
		STREET 1:		32 WIGGINS AVENUE
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730
		BUSINESS PHONE:		(781) 457-9000

	MAIL ADDRESS:	
		STREET 1:		32 WIGGINS AVENUE
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANIKA THERAPEUTICS INC
		DATE OF NAME CHANGE:	19970114

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANIKA RESEARCH INC
		DATE OF NAME CHANGE:	19930309
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>f8k_030818.htm
<DESCRIPTION>FORM 8-K
<TEXT>
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-size: 12pt">UNITED STATES</FONT><BR>
<FONT STYLE="font-size: 12pt">SECURITIES AND EXCHANGE COMMISSION</FONT><BR>
<FONT STYLE="font-size: 10pt">Washington, D.C. 20549</FONT><BR>
<BR>
<FONT STYLE="font-size: 12pt">FORM 8-K</FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-size: 10pt">CURRENT REPORT</FONT><BR>
<FONT STYLE="font-size: 10pt">PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934</FONT><BR>
<BR>
<FONT STYLE="font-size: 10pt">Date of Report (Date of earliest event reported): March 2, 2018</FONT><BR>
<BR>
<FONT STYLE="font-size: 12pt">Anika Therapeutics, Inc.</FONT><BR>
<FONT STYLE="font-size: 10pt">(<I>Exact name of registrant as specified in its charter</I>)</FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
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    <TD STYLE="width: 33%">&nbsp;</TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
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    <TD STYLE="text-align: center"><BR STYLE="clear: both">
<FONT STYLE="font-size: 10pt">Massachusetts</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">000-21326</FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt">04-3145961</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><I>(State or other jurisdiction of</I></FONT><BR>
<FONT STYLE="font-size: 10pt"><I>incorporation or organization)</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><I>Commission file number</I></FONT></TD>
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><I>(I.R.S. Employer</I></FONT><BR>
<FONT STYLE="font-size: 10pt"><I>Identification No.)</I></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 100%; text-align: center"><FONT STYLE="font-size: 10pt">32 Wiggins Avenue, Bedford, MA 01730</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><I>(Address of principal executive offices) (Zip code)</I></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><BR>
(781)-457-9000<BR>
<I>Registrant&rsquo;s telephone number, including area code: </I><BR>
<BR>
</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Check the appropriate box below if the Form 8-K filing is intended to simultaneously
satisfy the filing obligation of the registrant under any of the following provisions:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><BR>
 &#9744; Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<BR>
 &#9744; Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<BR>
 &#9744; Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<BR>
 &#9744; Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Indicate by check mark whether the registrant is an emerging growth company as defined
in Rule 405 of the Securities Act of 1933 (17 CFR &sect;230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR &sect;240.12b-2).<BR>
Emerging growth company &#9744;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">If an emerging growth company, indicate by check mark if the registrant has elected not
to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to
Section 13(a) of the Exchange Act. &#9744;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0"><B>Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment
of Certain Officers; Compensatory Arrangements of Certain Officers.</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><I>Retirement of Chief Executive Officer and Director</I></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">On March 2, 2018, Charles H. Sherwood, Ph.D. notified us of his intention to retire from
his positions as our Chief Executive Officer and one of our directors effective as of 5 p.m., Eastern standard time, on March 9,
2018. On March&nbsp;5, 2018, we issued a press release announcing Dr. Sherwood&rsquo;s retirement.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">We are parties to an employment agreement with Dr. Sherwood dated October 17, 2008, as
amended by Amendment No. 1 thereto dated December 8, 2010. Under his employment agreement, Dr. Sherwood is entitled, as the result
of his retirement, to receive, in substantially equal installments payable over the 18 months following his retirement, a total
of $1,691,640, which represents 1.5 times the sum of his base salary and target annual bonus for 2018. He also has the right to
continue health, dental and vision plan coverage, subject to COBRA.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">In accordance with the terms of Dr. Sherwood&rsquo;s outstanding equity incentive awards,
all unvested equity awards will vest upon his retirement, following the determination by our board of directors that Dr. Sherwood
is retiring in good standing, which was a requirement outlined in his equity incentive award agreements.&nbsp; All outstanding
awards will remain exercisable until the second anniversary of his retirement or, if earlier, the original ten-year expiration
date.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">On March 8, 2018, we entered into a consulting agreement with Dr. Sherwood, pursuant
to which he has agreed to furnish us with reasonable advisory or consulting services with respect to his successor&rsquo;s transition
into the position of Chief Executive Officer for a period of one year following his retirement, up to an average of forty hours
of services per month. In compensation for his consulting services, Dr. Sherwood will receive the following:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>a total of $300,000 in cash consulting fees, payable in 12 monthly installments of $25,000 each;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>a one-time benefits continuation payment of $60,000, payable by March 31, 2018; and</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>reimbursement of up to $1,500 per month in reasonable expenses for the maintenance of an office during the one-year consulting
period.</TD></TR></TABLE>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The consulting agreement, including a related release agreement, also provides two-year
noncompetition, nonsolicitation and standstill covenants of Dr. Sherwood as well as mutual releases and nondisparagement covenants
of Dr. Sherwood and our company.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The press release announcing Dr. Sherwood&rsquo;s retirement is attached as Exhibit 99.1
to this Form 8-K. The information in the press release is intended to be furnished and shall not be deemed &ldquo;filed&rdquo;
for purposes of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section, nor
shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Securities Exchange Act of 1934,
except as expressly set forth by specific reference in such filing.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The foregoing descriptions of the terms of Dr. Sherwood&rsquo;s employment agreement,
the amendment thereto and his consulting agreement do not purport to be complete and are subject to, and qualified in their entirety
by, the full text of those agreements, which are included as Exhibits 10.1, 10.2 and 10.3, respectively, to this Form 8-K and are
incorporated herein by reference.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><I>Election of Successor Chief Executive Officer and New Director</I></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">On March 2, 2018, following the retirement of Dr. Sherwood, our board of directors elected
Joseph G. Darling to succeed Dr. Sherwood, effective upon Dr. Sherwood&rsquo;s retirement, as our Chief Executive Officer and as
one of our Class III directors, to serve until the 2020 Annual Meeting of Stockholders. Mr. Darling has served as our President
since July 27, 2017, and he will continue to hold that position. On March 5, 2018, we issued a press release announcing Mr. Darling&rsquo;s
election as Chief Executive Officer and a director.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">We are parties to an employment agreement with Mr. Darling dated July 27, 2017. On March
8, 2018, we entered into an amendment to Mr. Darling&rsquo;s employment agreement pursuant to which:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Mr. Darling&rsquo;s annual base salary will increase from $440,000 to $550,000 for the remainder of 2018, commencing March
10, 2018;</TD></TR></TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>Mr. Darling&rsquo;s annual cash bonus target for 2018 will increase from 50% to 75% of his base salary;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>on March 9, 2018, Mr. Darling will be granted restricted stock awards, with an accounting value of $400,000, of which 25% will
vest upon grant and an additional 25% will vest on March 9 of each year from 2019 through 2021;</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>in connection with his earlier relocation closer to our headquarters, Mr. Darling will receive a one-time payment of $50,000,
subject to tax gross up; and</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>in the event of a defined &ldquo;change in control,&rdquo; Mr. Darling&rsquo;s severance amount was increased from 1.5 to 2.0
times the sum of his then-current base salary and target annual bonus.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The press release announcing Mr. Darling&rsquo;s election as Chief Executive Officer
and a director is attached as Exhibit&nbsp;99.1 to this Form 8-K. The information in the press release is intended to be furnished
and shall not be deemed &ldquo;filed&rdquo; for purposes of Section 18 of the Securities Exchange Act of 1934 or otherwise subject
to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of
1933 or the Securities Exchange Act of 1934, except as expressly set forth by specific reference in such filing.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The foregoing description of the terms of the amendment to Mr. Darling&rsquo;s employment
agreement do not purport to be complete and is subject to, and qualified in its entirety by, the full text of the amendment, which
is included as Exhibit 10.4 to this Form 10-K and is incorporated herein by reference.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in"><B>Item 8.01.</B></TD><TD><B>Other Items.</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">In connection with the matters described in Item 5.02 above, we expect to record a one-time
charge of approximately $8 million in the first quarter of 2018 primarily for non-cash stock-based compensation expense associated
with the retirement of Charles H. Sherwood, Ph.D. as our Chief Executive Officer and the election of Joseph G. Darling as successor
Chief Executive Officer. This expected one-time charge was not included in our previously announced financial guidance for the
full year of 2018.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in"><B>Item 9.01.</B></TD><TD><B>Financial Statements and Exhibits.</B></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Exhibits.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 9%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Exhibit</B></FONT><BR>
<FONT STYLE="font-size: 10pt"><B>Number</B></FONT></TD>
    <TD STYLE="width: 1%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 90%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><A HREF="http://www.sec.gov/Archives/edgar/data/898437/000115752308008248/a5810432ex10_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.1&dagger;</FONT></A></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/898437/000115752308008248/a5810432ex10_1.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Employment Agreement dated October 17, 2008 between Anika Therapeutics, Inc. and Charles H. Sherwood, Ph.D. (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on October 22, 2008)</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><A HREF="http://www.sec.gov/Archives/edgar/data/898437/000115752311001610/a6645325ex10_33.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">10.2&dagger;</FONT></A></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="http://www.sec.gov/Archives/edgar/data/898437/000115752311001610/a6645325ex10_33.htm" STYLE="-sec-extract: exhibit"><FONT STYLE="font-size: 10pt">Amendment No. 1 dated December 8, 2010 to Employment Agreement dated October 17, 2008 between Anika Therapeutics, Inc. and Charles H. Sherwood, Ph.D. (incorporated by reference to Exhibit 10.33 to the Annual Report on Form 10-K for the fiscal year ended December 31, 2010)</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><A HREF="exh_103.htm"><FONT STYLE="font-size: 10pt">10.3&dagger;</FONT></A></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="exh_103.htm"><FONT STYLE="font-size: 10pt">Consulting Agreement between Anika Therapeutics, Inc. and Charles H. Sherwood, Ph.D. dated March&nbsp;8, 2018</FONT></A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><A HREF="exh_104.htm">
        10.4&dagger;</A></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="exh_104.htm">Amendment No. 1 dated March 8, 2018 to Employment Agreement dated July 27, 2017 by and between Anika Therapeutics, Inc. and Joseph G. Darling</A></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><A HREF="exh_991.htm"><FONT STYLE="font-size: 10pt">99.1</FONT></A></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><A HREF="exh_991.htm"><FONT STYLE="font-size: 10pt">Press release of Anika Therapeutics, Inc. dated March 5, 2018</FONT></A></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&dagger; Management, contract or compensatory plan or arrangement.<BR STYLE="clear: both">
</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">SIGNATURE</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has
duly caused this report to be filed on its behalf by the undersigned hereunto duly authorized.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Anika Therapeutics, Inc. </FONT></TD></TR>
<TR>
    <TD STYLE="width: 51%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 4%">&nbsp;</TD>
    <TD STYLE="width: 36%">&nbsp;</TD>
    <TD STYLE="width: 9%">&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Dated: March 8, 2018</FONT></TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">By: </FONT></TD>
    <TD STYLE="vertical-align: top; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Sylvia Cheung</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Sylvia Cheung</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Chief Financial Officer </FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

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<TYPE>EX-10.3
<SEQUENCE>2
<FILENAME>exh_103.htm
<DESCRIPTION>EXHIBIT 10.3
<TEXT>
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<P STYLE="margin: 0; text-align: right"><B>Exhibit 10.3</B></P>

<P STYLE="margin: 0; text-align: right">&nbsp;</P>

<P STYLE="margin: 0; text-align: right"></P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">CONSULTING AGREEMENT</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">This
Consulting Agreement</FONT> (this &ldquo;<I>Agreement</I>&rdquo;) is entered into as of March 8, 2018 by and between Anika Therapeutics,
Inc. (the &ldquo;<I>Company</I>&rdquo;) and Charles H. Sherwood, Ph.D. (the &ldquo;<I>Consultant</I>&rdquo;).</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">The Consultant is retiring as the Chief Executive
Officer and a director of the Company, effective as of 5 p.m., Eastern standard time, on March 9, 2018 (the &ldquo;<I>Retirement
Date</I>&rdquo;). The Company desires to have the benefit of the Consultant&rsquo;s advice and counsel for a period time after
the Retirement Date in order to assist with the transition of his role as the Company&rsquo;s Chief Executive Officer to his successor.
The Consultant is willing to provide such transitional services in accordance with the terms of this Agreement.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">Now,
Therefore</FONT>, in consideration of the premises and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the Company and the Consultant agree as follows:</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-size: 10pt">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT><U>Retirement</U>. As of the Retirement Date, the Consultant shall be considered to have retired from (a)&nbsp;his employment
with the Company, (b)&nbsp;all officer positions with the Company (including the position of Chief Executive Officer) and its subsidiaries,
(c)&nbsp;any fiduciary, administrative or other committees, including with respect to any employee benefit plans of the Company,
and (d)&nbsp;all positions as a member of the Board of Directors (or similar governing body) of the Company and its subsidiaries.
The Consultant&rsquo;s departure on the Retirement Date shall be considered by the Board of Directors of the Company to be a retirement
from the Company in good standing (as determined by the Board of Directors of the Company as administrator under the Anika Therapeutics,
Inc. 2017 Omnibus Incentive Plan and the Anika Therapeutics, Inc. Second Amended and Restated 2003 Stock Option and Incentive Plan)
for purposes of all of the Consultant&rsquo;s outstanding stock options and restricted stock awards granted under the Company&rsquo;s
equity compensation plans. As of the Retirement Date, the Consultant&rsquo;s salary shall cease, and any entitlement the Consultant
may have under a Company-provided benefit plan, program, contract or practice will terminate, except as provided in the Release
Agreement or as required by federal or state law or under the terms of the applicable plan regarding vested benefits.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-size: 10pt">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT><U>Consulting Services</U>. During the period from March 10, 2018 through February 28, 2019 (or earlier in the event of
The Consultant&rsquo;s death) (the &ldquo;<I>Consulting Period</I>&rdquo;), the Consultant shall stand ready and shall furnish
to the Company such reasonable services of an advisory or consulting nature with respect to the transition of the Consultant&rsquo;s
role as the Chief Executive Officer of the Company to his successor as the Company may reasonably call upon him to furnish and
his health and other business commitments may permit, it being understood by the parties that (a)&nbsp;the Consultant shall be
available during the Consulting Period upon reasonable written notice and at reasonable times for periodic consultations by telephone,
(b)&nbsp;the Consultant shall not be required to render such services during reasonable vacation periods or times of illness, disability
or other incapacity, and (c)&nbsp;the Consultant shall be expected to devote no more than an average of 40 hours per month to performance
of such services. The parties agree that the Consultant&rsquo;s threshold hourly commitment is less than 20% of the average level
of services the Consultant performed as an employee in the 36 months prior to his separation from employment with the Company.
It is understood that Consultant is free to engage in other consulting arrangements or become employed as long as such subsequent
consulting or employment does not conflict with the performance of the Consultant&rsquo;s obligations under this Agreement. In
providing the consulting services, the Consultant shall be an independent contractor of the Company and as such shall have no authority
to bind the Company to any agreement or obligation of any type or nature, and shall have no decision-making authority on behalf
of the Company. The Consultant shall act in accordance with such independent contractor status and not hold himself out as an officer
or employee of the Company or speak on behalf of the Company, nor shall the Consultant make any claim based on any right or privilege
applicable to the Company&rsquo;s employees. The Consultant shall be responsible for all costs of self-employment, including social
security liabilities and federal, state and local income tax payments, and shall pay such costs when and as due. Nothing herein
shall be deemed to create any form of partnership, principal-agent relationship, employer-employee relationship or joint venture
between the parties hereto with respect to the consulting services.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-size: 10pt">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT><U>Compensation for Consulting Services</U>. In consideration for the consulting services during the Consulting Period,
the Company shall provide the Consultant with the following compensation:</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(a)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>The Company shall pay to the Consultant, on the last day of each calendar month (or, if such day is not a business day,
then the immediately succeeding business day) from March&nbsp;2018 through February 2019, a cash consulting fee in the amount of
$25,000.00, <I>provided</I> that in the event of the death of the Consultant during the Consulting Period, then, upon the Chief
Executive Officer or the Chief Financial Officer of the Company becoming aware of such event, no further monthly cash consulting
fees shall be payable under this Section&nbsp;3(a) and instead the Company shall promptly pay to the Consultant&rsquo;s surviving
spouse, or if no surviving spouse to the Consultant&rsquo;s estate, an amount equal to $300,000.00 less the aggregate amount of
fees previously paid to the Consultant under this Section&nbsp;3(a).</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(b)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;
</FONT>The Company shall pay to the Consultant in cash, by March 31, 2018, a one-time benefits continuation payment in the amount
of $60,000.00.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(c)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>The Consultant shall be entitled to receive prompt reimbursement for all reasonable expenses incurred by him in performing
services hereunder during the Consulting Period, in accordance with the Company&rsquo;s standard expense reimbursement policies
and procedures as then in effect. In addition, the Company will provide the Consultant with expense reimbursement, in accordance
with the Company&rsquo;s standard expense reimbursement policies and procedures, (i)&nbsp;up to $1,500.00 per month (pro rated
for any partial month) for reasonable expenses for the maintenance of an office outside of Bedford, Massachusetts during all or
part of the Consulting Period and (ii)&nbsp;up to $10,000 for reasonable legal fees and expenses incurred by the Consultant in
March 2018 in connection with the negotiation and review of this Agreement.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In order to be eligible to receive any of such compensation, the
Consultant must first execute and not revoke the form of release attached to this Agreement as <U>Exhibit A</U> by no later than
March 30, 2018.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-size: 10pt">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT><U>Noncompetition and Nonsolicitation</U>. From the date hereof through March 9, 2020, the Consultant:</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify">will not, directly or indirectly, whether as owner, partner, shareholder, consultant, agent, employee,
co-venturer or otherwise, engage, participate, assist or invest in any business conducted anywhere in the world that develops,
manufactures or markets any products, or performs any services, that are competitive with or similar to the products or services
of the Company or the products and services that the Company has under development or that are the subject of active planning at
any time during the Consultant; <I>provided</I> that, notwithstanding the foregoing, the Consultant may own up to one percent of
the outstanding stock of a publicly held corporation that constitutes or is affiliated with such a business;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">will refrain from directly or indirectly employing, attempting to employ, recruiting or otherwise
soliciting, inducing or influencing any person to leave employment with the Company; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(c)</TD><TD STYLE="text-align: justify">will refrain from directly or indirectly calling upon, soliciting or encouraging any customer,
potential customer or supplier to terminate or otherwise modify adversely its business relationship with the Company.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The Consultant understands that the restrictions set forth in this
Section&nbsp;4 are intended to protect the Company&rsquo;s interest in its confidential and proprietary information and its established
employee, customer and supplier relationships and goodwill, and the Consultant agrees that such restrictions are reasonable and
appropriate for these purposes.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-size: 10pt">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT><U>Miscellaneous</U>.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(a)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>Except as otherwise expressly stated herein or in the release attached to this Agreement as <U>Exhibit A</U>, (i)&nbsp;this
Agreement and such release contain all the terms and conditions agreed upon by the parties hereto regarding the subject matter
of this Agreement and (ii)&nbsp;any prior agreements, promises, negotiations, or representations, either oral or written, relating
to the subject matter of this Agreement are of no force and effect.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(b)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;
</FONT>This Agreement is intended to comply, to the extent applicable, with the provisions of Section 409A of the Internal Revenue
Code of 1986, as amended (&ldquo;<I>Section 409A</I>&rdquo;), and shall, to the extent practicable, be construed in accordance
with such section. For purposes of this Agreement, each amount to be paid or benefit to be provided will be construed as a separate
identified payment for purposes of Section 409A, and any payments that are due within the &ldquo;short term deferral period&rdquo;
as defined in Section 409A will not be treated as deferred compensation unless applicable law requires otherwise.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(c)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>None of the provisions, terms, or clauses of this Agreement may be changed except if made in writing signed by both the
Consultant and the Company. Any waiver of any term or provision of this Agreement must be in writing and be signed by the party
granting the waiver. If any of the provisions, terms, or clauses of this Agreement are declared illegal, unenforceable, or ineffective,
those provisions, terms, and clauses shall be deemed severable, such that all other provisions, terms and clauses of this Agreement
shall remain valid and binding upon both parties.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(d)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;
</FONT> The Consultant acknowledges that he is currently subject to, and shall remain bound by, the post-employment covenants set
forth in his Employment Agreement with the Company dated October&nbsp;17, 2008, as amended by Amendment No. 1 thereto dated December
8, 2010 and as further modified in this Agreement.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(e)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>This Agreement may be executed in counterparts, each of which shall be deemed an original but both of which together shall
constitute one and the same instrument. Counterparts may be delivered via electronic mail (including pdf or any electronic signature
complying with the U.S. federal ESIGN Act of 2000, <I>e.g., www.docusign.com</I>) or other transmission method and any counterpart
so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(f)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>For purposes of this Agreement:</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD STYLE="text-align: justify">headings used in this Agreement are for convenience of reference only and shall not, for any purpose,
be deemed a part of this Agreement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD STYLE="text-align: justify">the words &ldquo;include&rdquo; and &ldquo;including&rdquo; shall not be construed so as to exclude
any other thing not referred to or described;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD STYLE="text-align: justify">unless the context otherwise requires, (A) references to an agreement, instrument or other document
(including this Agreement) mean such agreement, instrument or other document as amended, supplemented and modified from time to
time to the extent permitted by the provisions thereof and (B) references to a statute mean such statute as amended from time to
time and include any successor legislation thereto and any rules and regulations promulgated thereunder; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in"></TD><TD STYLE="width: 0.25in">(iv)</TD><TD STYLE="text-align: justify">this Agreement shall be construed without regard to any presumption or rule requiring construction
or interpretation against the party drafting an instrument or causing any instrument to be drafted.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">(g)<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;
</FONT>This is a Massachusetts contract and shall be construed under and be governed in all respects by the laws of the Commonwealth
of Massachusetts, without giving effect to the conflict of laws principles of such Commonwealth. With respect to any disputes concerning
federal law, such disputes shall be determined in accordance with the law as it would be interpreted and applied by the United
States Court of Appeals for the First Circuit.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">In Witness
Whereof</FONT>, the Company has caused this Agreement to be signed by its duly authorized officer and the Consultant has hereunto
set his hand, all as of the day and year first above written.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2"><FONT STYLE="font-variant: small-caps">Anika Therapeutics, Inc.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-variant: small-caps">Charles H. Sherwood, Ph.D.</FONT></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">/s/ Joseph G. Darling</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/ Charles H. Sherwood</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 27%">President</TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 16%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><BR>
</P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">EXHIBIT A</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">RELEASE AGREEMENT</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: right; text-indent: 0.5in; margin: 0pt 0 0pt 4in">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: right; text-indent: 0.5in; margin: 0pt 0 0pt 4in">&nbsp;</P>

<P STYLE="font-size: 10pt; font-style: italic; text-align: justify; margin: 0pt 0"><FONT STYLE="font-style: normal">Dr. Charles
H. Sherwood </FONT></P>

<P STYLE="font-size: 10pt; font-style: italic; text-align: justify; margin: 0pt 0"><FONT STYLE="font-style: normal">169 Marlboro
Road</FONT></P>

<P STYLE="font-size: 10pt; font-style: italic; text-align: justify; margin: 0pt 0"><FONT STYLE="font-style: normal">Sudbury, Massachusetts
01776-1347</FONT></P>

<P STYLE="font-size: 10pt; font-style: italic; text-align: justify; margin: 0pt 0"><FONT STYLE="font-style: normal">&nbsp;</FONT></P>

<P STYLE="font-size: 10pt; font-style: italic; text-align: justify; margin: 0pt 0">Re:&nbsp;Release Agreement</P>

<P STYLE="font-size: 10pt; font-style: italic; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dear Chuck:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">This letter agreement (this &ldquo;<I>Release Agreement</I>&rdquo;)
confirms your retirement as the Chief Executive Officer and a director of Anika Therapeutics, Inc. (the &ldquo;<I>Company</I>&rdquo;),
effective as of 5 p.m., Eastern standard time, on March 9, 2018 (the &ldquo;<I>Retirement Date</I>&rdquo;).</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I><U>Entitlements and Obligations</U></I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Your execution and delivery of this Release Agreement is a condition
to the effectiveness of certain provisions of the Consulting Agreement dated as of March 8, 2018 by and between the Company and
you (the &ldquo;<I>Consulting Agreement</I>&rdquo;). Without regard to the effectiveness of provisions of the Consulting Agreement,
Anika confirms that it will:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">pay you compensation that accrues to you through the Retirement Date;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">pay you for all accrued but unused vacation time due to you through the Retirement Date;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">provide you with the right to continue group health, dental and vision care coverage for 18 months
after the Retirement Date under the law known as &ldquo;COBRA,&rdquo; which will be described in a separate written notice;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">treat outstanding equity incentive awards from the Company (the &ldquo;<I>Equity Grants</I>&rdquo;)
under the terms of the applicable equity plan and award agreements; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">reimburse you for any outstanding, reasonable business expenses that you have incurred on the Company&rsquo;s
behalf through the Retirement Date, after the Company&rsquo;s timely receipt of appropriate documentation pursuant to the Company&rsquo;s
standard expense reimbursement policies and procedures.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Regardless of whether you enter into this Release Agreement with
the Company, you are subject to continuing obligations under your Employment Agreement with the Company dated October 17, 2008,
as amended (the &ldquo;<I>Employment Agreement</I>&rdquo;), including your obligations to maintain the confidentiality of Company
confidential information, return Company documents and other property, and, for eighteen months after employment ends, refrain
from certain competition and solicitation activities.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I><U>Agreement</U></I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The purpose of this Release Agreement is to establish an amicable
arrangement for the cessation of your employment relationship, including releasing the Company and related persons or entities
from any claims and permitting you to receive the severance benefits set forth in Section&nbsp;1 hereof and compensation for consulting
services and related benefits referenced in the Consulting Agreement.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 2</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">With those understandings and in exchange for the promises of you
and the Company set forth below, you and the Company agree as follows:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">1.</TD><TD STYLE="text-align: justify"><U>Severance Benefits</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">The Company shall pay you severance benefits in an amount
equal to 1.5 times the sum of your base salary and your target annual bonus for the current fiscal year, in the full amount of
$1,691,640. This amount shall be paid in substantially equal installments in accordance with the Company&rsquo;s payroll practice
over 18 months beginning at the next payroll period following the expiration of the seven-day revocation period referenced in Section&nbsp;14
hereof (the &ldquo;<I>Severance Period</I>&rdquo;). As set forth above, you shall have the right to continued health, dental and
vision plan coverage under and subject to COBRA. For the avoidance of doubt, you shall be responsible for copayment of the premium
amounts at the active employees&rsquo; rate and the Company will pay the employer portion of the premium. You understand that your
participation in all other employee benefit plans will end due to the resignation of your employment in accordance with the terms
of those plans.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">2.</TD><TD STYLE="text-align: justify"><U>Release of Claims by You</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">In consideration for, among other terms, the Consulting
Agreement, payments made under this Agreement, and other good and valuable consideration, the receipt of which you hereby acknowledge,
you and your representatives, agents, estate, heirs, successors and assigns (&ldquo;<I>You</I>&rdquo;) voluntarily, absolutely
and unconditionally hereby release, remise, discharge, indemnify and hold harmless the Company, its subsidiaries, affiliated and
related entities, its and their respective predecessors, successors and assigns, its and their respective employee benefit plans
and fiduciaries of such plans, and the current and former officers, directors, shareholders, trustees, investors, shareholders/stockholders,
employees, attorneys, accountants and agents of the Company, all of the foregoing both in their official and individual capacities
(collectively referred to as the &ldquo;<I>Releasees</I>&rdquo;) generally from any and all actions or causes of action, suits,
complaints, claims, demands, agreements, promises, contracts, torts, debts, damages, controversies, judgments, rights, and liabilities
of every name and nature, whether existing or contingent, known or unknown (&ldquo;Claims&rdquo;) that, as of the date when you
sign this Release Agreement, you have, ever had, now claim to have or ever claimed to have had against any or all of the Releasees.
This release includes any and all Claims:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">arising out of, in connection with, or relating to your employment, change in employment status,
and/or termination of employment with the Company;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">arising out of or in connection with any relationship between You and the Company;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">of wrongful discharge;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">based on any federal, state or local law, constitution or regulation regarding either securities,
employment, employment benefits, or employment discrimination and/or retaliation including those laws or regulations concerning
discrimination on the basis of race, color, creed, religion, age, sex, sexual harassment, sexual orientation, sexual/gender identity,
marital status, pregnancy or familial status, physical or mental disability or handicap, unfavorable military discharge, national
origin, ancestry, veteran status or any military service or application for military service, or any other characteristic protected
by law (including Claims of age discrimination or retaliation under the Age Discrimination in Employment Act, Claims of disability
discrimination or retaliation under the Americans with Disabilities Act, and Claims of discrimination or retaliation under Title
VII of the Civil Rights Act of 1964);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 3</P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">based on any contract whether oral or written, express or implied (including the Employment Agreement);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">under any other federal or state statute (including Claims under the Family and Medical Leave Act);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">of any torts;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">of common law statutory or equitable claims including actions in defamation, intentional infliction
of emotional distress, misrepresentation, fraud, wrongful discharge, breach of contract, breach of the covenant of good faith and
fair dealing, unfair competition and any claims to any non-vested ownership interest in the Company;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">of violation of public policy;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">for wages, bonuses, incentive compensation, stock options, vacation pay or any other compensation
or benefits, either under the Massachusetts Wage Act, M.G.L. c. 149, &sect;&sect;148-150C, or otherwise; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">for damages or other remedies of any sort, including compensatory damages, punitive damages, injunctive
relief and attorney&rsquo;s fees.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">This release is intended by you to be all encompassing
and to act as a full and total release of any Claims, whether specifically enumerated herein or not, that you may have or have
had up to the effective date of this Release Agreement as determined pursuant to Section 14 hereof, <I>provided</I> that this Release
Agreement shall not affect (a) your rights under the Company&rsquo;s Section&nbsp;401(k) Plan, the Equity Grants or this Release
Agreement, (b) your rights to any other vested benefits, (c)&nbsp;any of your rights that cannot be released by law, or (d)&nbsp;any
claims for indemnification in your capacity as an officer or director of the Company under the Company&rsquo;s Articles of Organization
or Bylaws, any written agreement to which you are a party providing for director or officer indemnification (including any director
and officer insurance policy), or applicable law.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">You agree that you shall not seek or accept damages of
any nature, other equitable or legal remedies for your own benefit, attorney&rsquo;s fees, or costs from any of the Releasees with
respect to any Claim. As a material inducement to the Company to enter into this Release Agreement, You represent that you have
not assigned to any third party and you have not filed with any agency or court any Claim released by this Release Agreement.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">Nothing in this Release Agreement shall bar or prohibit
you from contacting, seeking assistance from or participating in any proceeding before any federal or state administrative agency
to the extent permitted by applicable federal, state and/or local law. You nevertheless will be prohibited to the fullest extent
authorized by law from obtaining monetary damages in any agency proceeding in which you do so participate.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 4</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">3.</TD><TD STYLE="text-align: justify"><U>Release by Company of You</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">In consideration for, among other terms, the obligations
set forth in this Release Agreement and the Consulting Agreement, and other good and valuable consideration, the receipt of which
you hereby acknowledge, the Company and its subsidiaries, affiliated and related entities, its and their respective predecessors,
successors and assigns, and its and their representatives, agents, successors and assigns (collectively referred to as the &ldquo;<I>Releasors</I>&rdquo;)
voluntarily, absolutely and unconditionally hereby release, remise, discharge, indemnify and hold you harmless from any and all
Claims that, as of the date this Release Agreement is signed, that Releasors have, ever had, now claim to have or ever claimed
to have had against you. This release includes any and all Claims:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">arising out of, in connection with, or relating to your employment, change in employment status,
and/or termination of employment with the Company;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">arising out of or in connection with any relationship between You and the Company;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">based on any federal, state or local law, constitution or regulation regarding either securities,
employment, employment benefits, or employment discrimination and/or retaliation;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">based on any contract whether oral or written, express or implied (including the Employment Agreement);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">under any other federal or state statute;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">of any torts; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD STYLE="text-align: justify">of common law statutory or equitable claims including actions in defamation, intentional infliction
of emotional distress, misrepresentation, fraud, breach of contract, breach of the covenant of good faith and fair dealing, breach
of fiduciary duty, and unfair competition.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">It is understood that this Release Agreement does not
affect any claim of any Releasor that cannot be released by law, or claims to enforce this Agreement, or claims based on any gross
misconduct or gross negligence by you.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">4.</TD><TD STYLE="text-align: justify"><U>Accord and Satisfaction</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">The payments set forth in this Release Agreement and
the Consulting Agreement shall be complete and unconditional payment, settlement, accord and/or satisfaction with respect to all
obligations and liabilities of the Releasees to You and with respect to all Claims that could be asserted by You against the Releasees
regarding your employment with, change in employment status, and/or termination of employment from, the Company, including all
Claims for back wages, salary, vacation pay, sick pay, draws, incentive pay, bonuses, stock and stock options, equity, commissions,
severance pay, any and all other forms of compensation or benefits, attorney&rsquo;s fees, or other costs or sums.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">5.</TD><TD STYLE="text-align: justify"><U>No Liability or Wrongdoing</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">The parties hereto agree and acknowledge that this Release
Agreement is intended only to resolve any disputes between the parties and nothing contained in this Release Agreement, nor any
of its terms and provisions, nor any of the negotiations or proceedings connected with it, constitutes, will be construed to constitute,
will be offered in evidence as, received in evidence as and/or deemed to be evidence of an admission of liability or wrongdoing
by any and/or all of the parties, and any such liability or wrongdoing is hereby expressly denied by each of the parties.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 5</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">6.</TD><TD STYLE="text-align: justify"><U>Nondisparagement</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify">You agree not to take any action or make any statement, written or oral, that disparages or criticizes
the Company or any of its affiliates or current or former officers, directors, shareholders, management, employees, agents, or
any other parties involved in a business relationship with the Company, or its practices, or that disrupts or impairs its normal
operations, including actions that would (i)&nbsp;harm the reputation of the Company with its current and prospective customers,
distributors, suppliers, other business partners, or the public or (ii)&nbsp;interfere with existing contractual or employment
relationships with current and prospective customers, suppliers, distributors, other business partners or Company employees. You
further agree not to take any actions or conduct yourself in any way that would reasonably be expected to affect adversely the
reputation or goodwill of the Company or any of its affiliates or any of its current or former officers, directors, shareholders,
employees or agents.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">The Company agrees that it will instruct its directors and its officers and executive officers
(as defined in Rules 16a-1(f) and 3b-7, respectively, under the Securities Exchange Act of 1934)) not to make any statements that
could reasonably be interpreted as disparaging of or defamatory to you, personally or professionally. You understand and agree
that it will not be a violation of this Section&nbsp;6(b) for the above-referenced individuals to generally discuss for legitimate
internal business purposes the performance of the Company and individuals under your supervision during your employment with Anika.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">7.</TD><TD STYLE="text-align: justify"><U>Standstill Agreement.</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify">Unless approved in advance in writing by the Board of Directors of the Company, you agree that
neither you nor any of your representatives acting on behalf of or in concert with you will, for a period of two years after the
date of this Release Agreement, directly or indirectly:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD STYLE="text-align: justify">make any statement or proposal to the Board of Directors of the Company, any of the Company&rsquo;s
representatives or any of the Company&rsquo;s stockholders regarding, or make any public announcement, proposal or offer (including
any &ldquo;solicitation&rdquo; of &ldquo;proxies&rdquo; as such terms are defined or used in Regulation 14A of the Securities Exchange
Act of 1934) with respect to, or otherwise solicit, seek, or offer to effect (including, for the avoidance of doubt, indirectly
by means of communication with the press or media) (A) any business combination, merger, tender offer, exchange offer, or similar
transaction involving the Company or any of its subsidiaries, (B) any restructuring, recapitalization, liquidation, or similar
transaction involving the Company or any of its subsidiaries, (C) any acquisition of any of the Company's loans, debt securities,
equity securities or assets, or rights or options to acquire interests in any of the Company's loans, debt securities, equity securities,
or assets, (D) any proposal to seek representation on the Board of Directors of the Company or otherwise seek to control or influence
the management, Board of Directors, or policies of the Company, or (E) any proposal, arrangement, or other statement that is inconsistent
with the terms of this Agreement, including this Section 7(a);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD STYLE="text-align: justify">instigate, encourage, or assist any third party (including forming a &ldquo;group&rdquo; with any
such third party) to do, or enter into any discussions or agreements with any third party with respect to, any of the actions set
forth in Section 7(a);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 6</P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD STYLE="text-align: justify">take any action that would reasonably be expected to require the Company or any of its affiliates
to make a public announcement regarding any of the actions set forth in Section&nbsp;7(a); or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(iv)</TD><TD STYLE="text-align: justify">acquire (or propose or agree to acquire), of record or beneficially, by purchase or otherwise,
any loans, debt securities, equity securities, or assets of the Company or any of its subsidiaries, or rights or options to acquire
interests in any of the Company&rsquo;s loans, debt securities, equity securities, or assets, except in accordance with the exercise
or vesting of the Equity Grants, <I>provided </I>that the foregoing restrictions in this Section 7(a)(iv) shall not apply to any
of your representatives effecting or recommending transactions in securities: (A) in the ordinary course of its business as an
investment advisor, broker, dealer in securities, market maker, specialist, or block positioner; and (B) not at the direction or
request of you or any of your affiliates.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">The restrictions set forth in Section 7(a) above shall terminate and be of no further force and
effect if the Company enters into a definitive agreement with respect to, or publicly announces that it plans to enter into, a
transaction involving all or a controlling portion of the Company&rsquo;s equity securities or all or substantially all of the
Company&rsquo;s assets (whether by merger, consolidation, business combination, tender or exchange offer, recapitalization, restructuring,
sale, equity issuance, or otherwise).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">8.</TD><TD STYLE="text-align: justify"><U>Enforcement</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify">You and the Company hereby agree that the Superior Court of the Commonwealth of Massachusetts and
the United States District Court for the District of Massachusetts shall have the exclusive jurisdiction to consider any matters
related to your employment with the Company or this Release Agreement, including any Claim for violation of this Release Agreement.
With respect to any such court action, you (i)&nbsp;submit to the jurisdiction of such courts, (ii)&nbsp;consent to service of
process, and (iii)&nbsp;waive any other requirement (whether imposed by statute, rule of court or otherwise) with respect to personal
jurisdiction or venue.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">This Release Agreement shall be interpreted and enforced under the laws of the Commonwealth of
Massachusetts, without regard to conflict of law principles. In the event of any dispute, this Release Agreement is intended by
the parties to be construed as a whole, to be interpreted in accordance with its fair meaning, and not to be construed strictly
for or against either you or the Company or the &ldquo;drafter&rdquo; of all or any portion of this Release Agreement.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">9.</TD><TD STYLE="text-align: justify"><U>Successors and Assigns</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">You may not assign this Release Agreement. The Company
may assign this Release Agreement. The benefits of this Release Agreement shall inure to the successors and assigns of the Company.
In the event of your death during the Severance Period, then, upon the Chief Executive Officer or the Chief Financial Officer of
the Company becoming aware of such event, the remaining severance payments pursuant to Section 1 hereof shall be paid to your surviving
spouse, or if no surviving spouse, to your estate.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">10.</TD><TD STYLE="text-align: justify"><U>Severability</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">If one or more of the provisions contained in this Release
Agreement shall for any reason be held to be excessively broad as to scope, activity, subject or otherwise so as to be unenforceable
at law, such provision or provisions shall be construed by the appropriate judicial body by limiting or reducing it or them, so
as to be enforceable to the maximum extent compatible with the applicable law as it shall then appear.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 7</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">11.</TD><TD STYLE="text-align: justify"><U>Entire Agreement</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">Except as otherwise expressly stated in this Release
Agreement or in the Consulting Agreement, (a)&nbsp;this Release Agreement and the Consulting Agreement contain all the terms and
conditions agreed upon by the parties hereto regarding the subject matter of this Release Agreement and (b)&nbsp;any prior agreements,
promises, negotiations, or representations, either oral or written, relating to the subject matter of this Release Agreement are
of no force and effect. This Release Agreement may not be changed, amended, modified, altered or rescinded except upon the express
written consent of both you and an authorized Company officer. Any waiver of any provision of this Release Agreement shall not
constitute a waiver of any other provision of this Release Agreement unless expressly so indicated otherwise.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">12.</TD><TD STYLE="text-align: justify"><U>Construction</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify">This Agreement may be executed in counterparts, each of which shall be deemed an original but both
of which together shall constitute one and the same instrument. Counterparts may be delivered via electronic mail (including pdf
or any electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission method
and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">For purposes of this Agreement:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD STYLE="text-align: justify">headings used in this Agreement are for convenience of reference only and shall not, for any purpose,
be deemed a part of this Agreement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD STYLE="text-align: justify">the words &ldquo;include,&rdquo; &ldquo;includes&rdquo; and &ldquo;including&rdquo; shall not be
construed so as to exclude any other thing not referred to or described; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD STYLE="text-align: justify">unless the context otherwise requires, (A) references to an agreement, instrument or other document
(including this Agreement) mean such agreement, instrument or other document as amended, supplemented and modified from time to
time to the extent permitted by the provisions thereof and (B) references to a statute mean such statute as amended from time to
time and include any successor legislation thereto and any rules and regulations promulgated thereunder.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">13.</TD><TD STYLE="text-align: justify"><U>Waiver of Rights and Claims Under the Age Discrimination in Employment Act of 1967</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">Since you are 40 years of age or older, you have been
informed that you have or might have specific rights and/or other Claims under the Age Discrimination in Employment Act of 1967
(&ldquo;ADEA&rdquo;) and you agree that:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(a)</TD><TD STYLE="text-align: justify">In consideration for the amount described in Section&nbsp;1 of this Release Agreement, you specifically
waive such rights and/or other Claims under the ADEA to the extent that such rights and/or Claims arose prior to or on the date
this Release Agreement was executed.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 8</P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt"></P>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(b)</TD><TD STYLE="text-align: justify">You understand that rights and/or other Claims under the ADEA that may arise after the date this
Release Agreement is executed are not waived by you.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(c)</TD><TD STYLE="text-align: justify">You acknowledge that you have been advised of your right to consult with your counsel of choice
prior to executing this Release Agreement and you have not been subject to any undue or improper influence interfering with the
exercise of your free will in deciding whether to consult with counsel.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(d)</TD><TD STYLE="text-align: justify">You have carefully read and fully understand all of the provisions of this Release Agreement, you
knowingly and voluntarily agree to all of the terms set forth in this Release Agreement, and you acknowledge that in entering into
this Release Agreement, you are not relying on any representation, promise or inducement made by the Company or its attorneys with
the exception of those promises contained in this document.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(e)</TD><TD STYLE="text-align: justify">When the Company presented you with this Release Agreement, you were informed that you have at
least 21 days to review this Release Agreement and consider its terms before signing it.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">(f)</TD><TD STYLE="text-align: justify">The 21-day review period will not be affected or extended by any revisions, whether material or
immaterial, that might be made to this Release Agreement.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">14.</TD><TD STYLE="text-align: justify"><U>Time for Consideration; Effective Date</U></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">As set forth above, you have the opportunity to consider
this Release Agreement for 21 days before signing it. To accept this Release Agreement, you must return a signed original or PDF
copy of this Release Agreement so that it is received by the Company&rsquo;s Vice President of Human Resources at or before the
expiration of this 21-day period. If you sign this Release Agreement within fewer than 21 days of the date of its delivery to you,
you must also sign the acknowledgement page to the Release Agreement that such decision was entirely voluntary and that you had
the opportunity to consider this Release Agreement for the entire 21-day period. For the period of seven days from the date when
this Release Agreement becomes fully executed, you have the right to revoke this Release Agreement by written notice to the Company&rsquo;s
Vice President of Human Resources. For such a revocation to be effective, it must be delivered so that it is received by the Company&rsquo;s
Vice President of Human Resources at or before the expiration of the seven-day revocation period. This Release Agreement shall
not become effective or enforceable during the revocation period, but rather shall become effective on the first business day following
the expiration of the revocation period.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0 0pt 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">*&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; * &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;*</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Please indicate your agreement to the terms of this Release Agreement
by signing and returning to the Company&rsquo;s Vice President of Human Resources your executed copy of this Release Agreement
within the time period set forth above.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Very truly yours,</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2"><FONT STYLE="font-variant: small-caps">Anika Therapeutics, Inc.</FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">/s/ Joseph G. Darling</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 27%">President</TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 16%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0; text-indent: 0.25in"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0; text-indent: 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dr. Charles H. Sherwood</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">March 8, 2018</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Page 9</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0; text-indent: 0.25in"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>I, CHARLES H. SHERWOOD, REPRESENT THAT I HAVE READ THE FOREGOING
RELEASE AGREEMENT, THAT I FULLY UNDERSTAND THE TERMS AND CONDITIONS OF SUCH RELEASE AGREEMENT AND THAT I AM VOLUNTARILY EXECUTING
THE SAME. IN ENTERING INTO THIS RELEASE AGREEMENT, I DO NOT RELY ON ANY REPRESENTATION, PROMISE OR INDUCEMENT MADE BY THE RELEASEES
WITH THE EXCEPTION OF THE CONSIDERATION DESCRIBED IN THE CONSULTING AGREEMENT AND THIS RELEASE AGREEMENT.</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><FONT STYLE="font-variant: small-caps">ACCEPTED:</FONT></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/
Charles H. Sherwood</TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;March 8, 2018</TD>
    <TD COLSPAN="2"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2" STYLE="padding-bottom: 1pt">Charles H. Sherwood, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 27%"></TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 16%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>IF YOU DO NOT WISH TO USE THE 21-DAY PERIOD,</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><U>PLEASE CAREFULLY REVIEW AND SIGN THIS DOCUMENT</U></B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.25in; margin: 0pt 0">I, Charles H. Sherwood, acknowledge that I
was informed and understand that I have 21&nbsp;days within which to consider the attached Release Agreement and, having been advised
of my right to consult with an attorney regarding such Release Agreement and have considered carefully every provision of the Release
Agreement, and that after having engaged in those actions, I prefer to and have requested that I enter into the Release Agreement
prior to the expiration of the 21-day period.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid">/s/
Charles H. Sherwood</TD>
    <TD>&nbsp;&nbsp;&nbsp;&nbsp;March 8, 2018</TD>
    <TD COLSPAN="2"></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD COLSPAN="2" STYLE="padding-bottom: 1pt">Charles H. Sherwood, Ph.D.</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 27%"></TD>
    <TD STYLE="width: 34%">&nbsp;</TD>
    <TD STYLE="width: 17%">&nbsp;</TD>
    <TD STYLE="width: 16%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>



<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0"></P>

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<DOCUMENT>
<TYPE>EX-10.4
<SEQUENCE>3
<FILENAME>exh_104.htm
<DESCRIPTION>EXHIBIT 10.4
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0; text-align: right"><B>Exhibit 10.4</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">AMENDMENT
No.&nbsp;1 TO<BR>
EMPLOYMENT AGREEMENT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-variant: small-caps">This
Amendment No.&nbsp;1 to Employment Agreement</FONT> dated as of March 8, 2018 (this &ldquo;<I>Amendment</I>&rdquo;) is entered
into by and between Anika Therapeutics, Inc., a Massachusetts corporation (the &ldquo;<I>Company</I>&rdquo;), and Joseph Darling
(the &ldquo;<I>Executive</I>&rdquo;), and relates to the Employment Agreement effective as of July&nbsp;27, 2017 (the &ldquo;<I>Original
Agreement</I>&rdquo;), between the Company and the Executive.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">The Board of Directors
of the Company has appointed the Executive as the Chief Executive Officer of the Company effective as of 5 p.m., Eastern standard
time, on March&nbsp;9, 2018. The Company and the Executive desire to amend the Original Agreement as set forth herein regarding
such appointment and certain related changes to the Executive&rsquo;s compensation. Section 17 of the Original Agreement provides
that the Original Agreement may be modified only by a written instrument duly executed by both parties to the Original Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-variant: small-caps">Now,
Therefore</FONT>, in consideration of the premises and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the Company and the Executive agree as follows with respect to the Original Agreement, all effective as
of the date hereof:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">1.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>Section 2 of the Original Agreement is amended in its entirety as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&ldquo;2.&#9;<U>Position
and Duties</U>. Effective as of 5 p.m., Eastern standard time, on March&nbsp;9, 2018 and during the remainder of the Term, the
Executive shall serve as the President and Chief Executive Officer of the Company and, as such: (a)&nbsp;shall have general supervision
and direction of the business and affairs of the Corporation; (b)&nbsp;shall be responsible for corporate policy and strategy;
(c)&nbsp;in the absence of a separately appointed Chief Operating Officer, shall exercise all the powers and perform the duties
of the office of the chief operating officer of the Corporation, with general responsibility for the management and control of
the operations of the Corporation; and (d)&nbsp;shall perform such other duties as the Board of Directors of the Company (the &ldquo;Board&rdquo;)
may from time to time determine, <I>provided</I> that such other duties are consistent with the other position or positions that
the Executive holds from time to time. The Executive shall devote his full working time and efforts to the business and affairs
of the Company. Notwithstanding the foregoing, the Executive may serve on other boards of directors, or engage in religious, charitable
or other community activities, <I>provided</I> that any services and activities proposed after the date of this Agreement are disclosed
to the Board and the Board determines that those services or activities will not materially interfere with the Executive&rsquo;s
performance of his duties to the Company as provided in this Agreement (as amended from time to time).&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">2.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>Section&nbsp;3(a) of the Original Agreement is amended in its entirety as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&ldquo;(a)&#9;<U>Base
Salary</U>. Effective as of March 10, 2018, the Executive&rsquo;s annual base salary shall be $550,000. The Executive&rsquo;s base
salary shall be redetermined annually by the Board or its Compensation Committee of the Board (the &ldquo;Compensation Committee&rdquo;).
The base salary in effect at any given time is referred to herein as &ldquo;Base Salary.&rdquo; The Base Salary shall be payable
in substantially equal bi-weekly installments.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">3.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>Section&nbsp;3(b) of the Original Agreement is amended in its entirety as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&ldquo;(b)&#9;<U>Incentive
Compensation</U>. The Executive shall be eligible to receive cash incentive compensation as approved by the Board or the Compensation
Committee from time to time in its sole discretion. Effective as of March 10, 2018, the Executive&rsquo;s target annual bonus shall
be 75% percent of his Base Salary, subject to adjustment in the sole discretion of the Board or its Compensation Committee with
respect to any fiscal year after 2018.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&nbsp;</P>

<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 4pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">4.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>The following is added to the end of Section&nbsp;3(c) of the Original Agreement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0in">&ldquo;As of 5 p.m.,
Eastern standard time, on March 9, 2018, the Executive shall be granted restricted stock awards with an accounting value of $400,000,
which restricted stock awards shall be (I)&nbsp;granted under the Anika Therapeutics, Inc. 2017 Omnibus Incentive Plan, (II)&nbsp;documented
on the Company&rsquo;s standard form of notice of restricted stock award, and (III)&nbsp;subject to vesting or restriction lapsing
as follows: 25% upon grant and an additional 25% on March 9 of each year from 2019 through 2021.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">5.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>Section&nbsp;3(d) of the Original Agreement is amended in its entirety as follows:</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&ldquo;(d)&#9;<U>Expenses</U>.
The Executive shall be entitled to receive prompt reimbursement for all reasonable expenses incurred by him in performing services
hereunder during the Term, in accordance with the policies and procedures then in effect and established by the Company for its
senior executive officers. Notwithstanding the foregoing, in connection with expenses associated with performing his responsibilities
at, or moving his personal residence closer to, the Company&rsquo;s Bedford, Massachusetts headquarters, the Company:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD STYLE="text-align: justify; padding-right: 0.5in">has previously provided the Executive with expense reimbursement, in accordance
with the Company&rsquo;s standard expense reimbursement practices, up to an amount of $15,000 for personal expenses; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD STYLE="text-align: justify; padding-right: 0.5in">will pay to the Executive $50,000 and, to the extent the payment of such
$50,000 results in taxable income to the Executive (without any offsetting deduction), will pay to the Executive an additional
amount such that the net after-tax proceeds to the Executive of such $50,000 and such additional amount (at the Executive&rsquo;s
then-current combined state and federal marginal income tax rates, taking into account the deductibility of state and local income
taxes for federal income tax purposes) is equal to $50,000.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify">Further, the Executive shall be entitled
to receive prompt reimbursement for up to an amount of $10,000 for reasonable legal fees and expenses incurred by the Executive
in connection with the negotiation and review of this Agreement.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">6.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>Section&nbsp;3(f) of the Original Agreement is amended in its entirety as follows:</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&ldquo;(f)&#9;<U>Vacations</U>.
The Executive shall be entitled to thirty paid vacation days in each calendar year, which shall be accrued ratably during the calendar
year. The Executive shall also be entitled to all paid holidays given by the Company to its executives.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-size: 10pt">7.<FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT></FONT>Section 6(a)(i)(A) of the Original Agreement is amended in its entirety as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&ldquo;(A)&#9;Subject
to the signing of the Release by the Executive within 45 days of the receipt of the Release and not revoking the Release during
the seven-day revocation period, the Company shall pay the Executive a lump sum in cash in an amount (the &ldquo;Change in Control
Severance Amount&rdquo;) equal to two times the sum of (I)&nbsp;the Executive&rsquo;s current Base Salary (or the Executive&rsquo;s
Base Salary in effect immediately prior to the Change in Control, if higher) plus (II)&nbsp;the Executive&rsquo;s target annual
bonus for the current fiscal year (or if higher, the target annual bonus for the fiscal year immediately prior to the Change in
Control). The Change in Control Severance Amount shall be paid to the Executive by the later of (x)&nbsp;the sixtieth day after
the date of the Change in Control and (y)&nbsp;the tenth day after the Date of Termination.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0.5in; text-align: justify; text-indent: 0.2in">&nbsp;</P>

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</FONT></FONT>Except as set forth herein, the terms of the Original Agreement are unchanged and remain in full force and effect.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="font-variant: small-caps">In
Witness Whereof</FONT>, the parties hereby execute this Amendment as of the date first written above.</P>

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<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-variant: small-caps">Anika Therapeutics, Inc.</FONT></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 45%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>By:</TD>
    <TD STYLE="border-bottom: Black 1pt solid">/s/ Joseph L. Bower</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Name:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Joseph
L. Bower</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Title:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Chairman
of the Board</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-variant: small-caps">Joseph Darling</FONT></TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">/s/ Joseph G. Darling</TD></TR>
</TABLE>

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<FILENAME>exh_991.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN"><html lang="en-US"><head><title>EdgarFiling</title><meta content="text/html; charset=windows-1252" /><meta name="GENERATOR" content="MSHTML 8.00.7601.18094" /></head><body bgcolor="#ffffff"><p style="text-align: right;"><strong>EXHIBIT 99.1</strong></p><p style="text-align: center;"><strong>Joseph Darling Named CEO and Director of Anika Therapeutics</strong></p><p style="text-align: center;">Dr. Charles Sherwood to retire after 20 years of innovation and leadership at the Company</p><p>
     <p>BEDFORD, Mass., March  05, 2018  (GLOBE NEWSWIRE) -- Anika Therapeutics, Inc. (NASDAQ:ANIK) today announced the appointment of Joseph Darling as Chief Executive Officer, succeeding Dr. Charles Sherwood, who will retire as Chief Executive Officer and a director of Anika on March 9, 2018, after almost 20 years of service. Mr. Darling, who succeeded Dr. Sherwood as Anika&#8217;s President in July 2017, will serve as Chief Executive Officer, President and a director of Anika.<br /></p>      <p>&#8220;First, I would like to thank Chuck Sherwood for his close to two decades of commitment to Anika and for establishing Anika as a global innovator in joint health and tissue repair,&#8221; said Joseph Bower, Chairman of Anika&#8217;s Board of Directors. &#8220;Chuck Sherwood built Anika as we know it. As CEO for 15 years, he has delivered outstanding product innovation and development and operational, commercial, and financial achievements. Chuck has worked tirelessly and successfully to position the Company well as it enters its next phase of growth. His contributions to Anika and its constituents are too numerous to recount, and he leaves a clear and positive legacy. We wish him all the best in his retirement.&#8221;</p>      <p>&#8220;Among the most important responsibilities of a CEO is preparing for succession. That process began almost two years ago with discussions between Chuck Sherwood and the Board followed by an extensive search. The handing of the CEO mantle to Joe Darling reflects Anika&#8217;s evolution to a new and exciting phase of direct commercial activity, driven by a series of novel technologies that can both disrupt and expand the growing need for non-opioid joint pain solutions and more effective orthopedic regenerative healing technologies,&#8221; continued Dr. Bower.</p>      <p>President and newly named CEO Joseph Darling said, &#8220;Anika is at the cusp of transformational growth. It is an honor and a great opportunity to lead such a talented group of people as we seek to invest in and deliver a series of novel and impactful new treatments to the global orthopedic community over the coming years. Our mandate going forward is clear - we plan to make Anika&#8217;s HA-based solutions a standard of care for a number of the most common conditions associated with aging and injury. By achieving that goal through the U.S. launch of CINGAL and other innovative therapies, along with driving financial value associated with a direct commercial effort, we believe we will position the Company to accelerate revenue and earnings growth over the next several years and beyond.&#8221;</p>      <p>Mr. Darling joined Anika as President in July 2017, bringing more than 20 years of extensive experience in executive management and leadership from publicly-traded, commercial-stage companies, including Abbott Laboratories, Baxter Healthcare, Smith &amp; Nephew, CONMED, and Wyeth-Ayerst. Most recently, Mr. Darling held executive leadership positions with two small privately held orthopedic companies. Prior to these roles, Mr. Darling held senior level executive positions at CONMED Corporation, a global, publicly-held, diversified medical device company, as Global President of its wholly-owned subsidiary, Linvatec Corporation, and as Executive Vice President of Global Corporate Commercial Operations. At CONMED, Mr. Darling led five global business units with approximately $760 million in annual revenues and re-energized the organizational efforts in sales, marketing, R&amp;D, and business development activities that allowed the company to expand its portfolio of product offerings to its customers. Mr. Darling oversaw the launch and commercialization of many key new products while at Linvatec including several new sports medicine technologies in the shoulder (Shoulder Restoration System, Y-Knot Shoulder Anchor line), along with new products in the knee and hip joints. Before joining CONMED, Mr. Darling was Senior Vice President and General Manager for the sports medicine and biologics business at Smith &amp; Nephew, where he played an important role in defining a global strategy that propelled the company to a leadership position in the sports medicine field. While at Smith &amp; Nephew, Mr. Darling and his team were pioneers in developing the Hip Arthroscopy space from a commercial perspective. Mr. Darling launched his career at Abbott Laboratories where he was involved in the commercialization efforts of many pharmaceutical products in the neuroscience, antimicrobial, cardiovascular, and HIV treatment space. While at Abbott Laboratories, he held management positions in sales and marketing before joining Wyeth-Ayerst Pharmaceuticals in roles of marketing for the pain and inflammation and women&#8217;s healthcare franchises. He later joined Baxter Healthcare as a Vice President of marketing and health systems. Mr. Darling holds a Bachelor of Arts in Political Science from Syracuse University.</p>      <p><strong>About&#160;Anika Therapeutics, Inc.</strong></p>      <p>Anika Therapeutics, Inc.&#160;(NASDAQ:ANIK) is a global, integrated orthopedic medicines company based in&#160;Bedford, Massachusetts. Anika is committed to improving the lives of patients with degenerative orthopedic diseases and traumatic conditions with clinically meaningful therapies along the continuum of care, from palliative pain management to regenerative tissue repair. The Company has over two decades of global expertise developing, manufacturing, and commercializing more than 20 products based on its proprietary hyaluronic acid (HA) technology. Anika's orthopedic medicine portfolio includes ORTHOVISC, MONOVISC, and&#160;CINGAL, which alleviate pain and restore joint function by replenishing depleted HA, and&#160;HYALOFAST, a solid HA-based scaffold to aid cartilage repair and regeneration. For more information about Anika, please visit www.anikatherapeutics.com.</p>      <p>ANIKA, ANIKA THERAPEUTICS, CINGAL, HYALOFAST, MONOVISC, and ORTHOVISC are our registered trademarks. This press release may contain registered marks, trademarks and trade names that are the property of other companies.</p>      <p><strong>Forward-Looking Statements</strong></p>      <p>The statements made in the third and fourth paragraphs of this press release, which are not statements of historical fact, are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. These statements include, but are not limited to, those relating to the Company's direct commercial activity, use of novel technologies, delivery of new orthopedic treatments, launch of CINGAL and other therapies, and revenue and earnings growth. These statements are based upon the current beliefs and expectations of the Company's management and are subject to significant risks, uncertainties and other factors. The Company's actual results could differ materially from any anticipated future results, performance, or achievements described in the forward-looking statements as a result of a number of factors including, but not limited to: (i) the Company's ability to successfully commence and/or complete clinical trials of its products on a timely basis or at all; (ii) the Company's ability to obtain pre-clinical or clinical data to support domestic and international pre-market approval applications, 510(k) applications, or new drug applications, or to timely file and receive FDA or other regulatory approvals or clearances of its products; (iii) that such approvals will not be obtained in a timely manner or without the need for additional clinical trials, other testing or regulatory submissions, as applicable; (iv) the Company's research and product development efforts and their relative success, including whether we have any meaningful sales of any new products resulting from such efforts; (v) the cost effectiveness and efficiency of the Company's clinical studies, manufacturing operations, and production planning; (vi) the strength of the economies in which the Company operates or will be operating, as well as the political stability of any of those geographic areas; (vii) future determinations by the Company to allocate resources to products and in directions not presently contemplated; (viii) the Company's ability to successfully commercialize its products, in the U.S. and abroad; (ix) the Company's ability to provide an adequate and timely supply of its products to its customers; and (x) the Company's ability to achieve its growth targets. Additional factors and risks are described in the Company's periodic reports filed with the Securities and Exchange Commission, and they are available on the SEC's website at www.sec.gov. Forward-looking statements are made based on information available to the Company on the date of this press release, and the Company assumes no obligation to update the information contained in this press release.</p>   <table style="width:100%; border-collapse:collapse !important;" style="border-collapse: collapse; "><tr><td style="border-top: solid black 1pt ; border-right: solid black 1pt ; border-bottom: solid black 1pt ; border-left: solid black 1pt ; vertical-align: bottom ; ">For Investor Inquiries:<br /> Anika Therapeutics, Inc.<br /> Sylvia Cheung, 781-457-9000<br /> Chief Financial Officer</td><td style="border-top: solid black 1pt ; border-right: solid black 1pt ; border-bottom: solid black 1pt ; vertical-align: bottom ; ">For Media Inquiries:<br /> Pure Communications<br /> Sonal Vasudev, 917-523-1418 <br />sonal@purecommunicationsinc.com</td></tr></table>   <p> </p> </p><p /></body></html>
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