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Note 3 - Revenue by Product Group, by Significant Customer and by Geographic Location; Geographic Information - Product Revenue by Product Group (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Revenue | $ 26,956 | $ 26,787 | $ 30,548 | $ 21,264 | $ 29,388 | $ 27,184 | $ 33,462 | $ 23,386 | $ 105,555 | $ 113,420 | $ 103,379
Orthobiologics [Member] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 93,556 | $ 93,816 | $ 89,695
Percentage of Product Revenue |  |  |  |  |  |  |  |  | 89.00% | 87.00% | 87.00%
Dermal [Member] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 396 | $ 2,755 | $ 2,759
Percentage of Product Revenue |  |  |  |  |  |  |  |  | 0.00% | 3.00% | 3.00%
Surgical [Member] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 5,514 | $ 5,262 | $ 5,427
Percentage of Product Revenue |  |  |  |  |  |  |  |  | 5.00% | 5.00% | 5.00%
Manufactured Product, Other [Member] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  |  |  |  | $ 6,065 | $ 5,950 | $ 5,051
Percentage of Product Revenue |  |  |  |  |  |  |  |  | 6.00% | 5.00% | 5.00%
Product [Member] |  |  |  |  |  |  |  |  |  |  |
Revenue | $ 26,950 | $ 26,781 | $ 30,542 | $ 21,258 | $ 28,884 | $ 27,178 | $ 28,340 | $ 23,381 | $ 105,531 | $ 107,783 | $ 102,932
Percentage of Product Revenue |  |  |  |  |  |  |  |  | 100.00% | 100.00% | 100.00%

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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 4 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130543-203045 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130539-203045 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045 + Details
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