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Note 12 - Equity Incentive Plan (Tables) | 6 Months Ended
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Jun. 30, 2022
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
Cost of product revenue |  | $ | 227 |  |  | $ | 214 |  |  | $ | 403 |  |  | $ | 343 |
Research & development |  |  | 503 |  |  |  | 402 |  |  |  | 870 |  |  |  | 643 |
Selling, general & administrative |  |  | 3,351 |  |  |  | 2,181 |  |  |  | 5,323 |  |  |  | 4,070 |
Total stock-based compensation expense |  | $ | 4,081 |  |  | $ | 2,797 |  |  | $ | 6,626 |  |  | $ | 5,056 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (in years) |  |  | Aggregate Intrinsic Value (in thousands) |
Outstanding as of December 31, 2021 |  |  | 1,175,993 |  |  | $ | 39.56 |  |  |  |  |  |  |  |  |
Granted |  |  | 464,775 |  |  | $ | 23.21 |  |  |  |  |  |  |  |  |
Exercised |  |  | (437 | ) |  | $ | 9.10 |  |  |  |  |  |  | $ | 10 |
Forfeited and canceled |  |  | (130,925 | ) |  | $ | 44.25 |  |  |  |  |  |  |  |  |
Outstanding as of June 30, 2022 |  |  | 1,509,406 |  |  | $ | 35.53 |  |  |  | 8.5 |  |  | $ | 21 |
Vested, June 30, 2022 |  |  | 459,732 |  |  | $ | 40.07 |  |  |  | 7.5 |  |  | $ | 7 |
Vested or expected to vest, June 30, 2022 |  |  | 1,509,406 |  |  | $ | 35.53 |  |  |  | 8.5 |  |  | $ | 21 |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Six Months Ended June 30, |
|  | 2022 |  |  | 2021 |
Risk free interest rate |  |  | 1.3% | - | 3.0% |  |  |  | 0.3% | - | 0.6% |
Expected volatility |  |  | 53.8% | - | 55.2% |  |  |  | 54.8% | - | 55.9% |
Expected life (years) |  |  |  | 4.5 |  |  |  |  |  | 4.0 |  |
Expected dividend yield |  |  |  | 0.0% |  |  |  |  |  | 0.0% |  |
Fair value per option |  |  |  | 11.28 |  |  |  |  |  | 14.19 |  |
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] |
|  | Number of Shares |  |  | Weighted Average Fair Value |
Outstanding as of December 31, 2021 |  |  | 412,658 |  |  | $ | 36.33 |
Granted |  |  | 498,189 |  |  | $ | 25.18 |
Vested |  |  | (149,365 | ) |  | $ | 36.26 |
Forfeited and cancelled |  |  | (41,095 | ) |  | $ | 33.75 |
Outstanding as of June 30, 2022 |  |  | 720,387 |  |  | $ | 28.78 |
Schedule of Nonvested Performance-Based Units Activity [Table Text Block] |
|  | Number of Shares |  |  | Weighted Average Fair Value |
Outstanding as of December 31, 2021 |  |  | 158,297 |  |  | $ | 37.44 |
Performance factor adjustment |  |  | 2,125 |  |  | $ | 32.53 |
Vested |  |  | (19,125 | ) |  | $ | 32.53 |
Forfeited and cancelled |  |  | (23,400 | ) |  | $ | 41.86 |
Outstanding as of June 30, 2022 |  |  | 117,897 |  |  | $ | 34.98 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested performance-based units. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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