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Consolidated Statements of Equity (USD $) | Total USD ($) | Preferred Stock [Member] | Common Stock [Member] USD ($) | Additional Paid-in Capital [Member] USD ($) | Accumulated Deficit [Member] USD ($) | Accumulated Other Comprehensive Income (Loss) [Member] USD ($) | Noncontrolling Interest [Member] USD ($) | Warrants For Cash [Member] USD ($) | Warrants For Cash [Member] Common Stock [Member] USD ($) | Warrants For Cash [Member] Additional Paid-in Capital [Member] USD ($) | Equity Financing [Member] USD ($) | Equity Financing [Member] Additional Paid-in Capital [Member] USD ($)
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at at Dec. 31, 2009 | $ 61,184,947 |  | $ 102,746 | $ 237,577,970 | $ (177,224,433) | $ 105,796 | $ 622,868 |  |  |  |  |
Balance shares, at at Dec. 31, 2009 |  | 26 | 102,746,058 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares |  |  | 1,994,672 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, value | 2,314,124 |  | 1,995 | 2,312,129 |  |  |  |  |  |  |  |
Exercise of stock options and warrants for cash, shares |  |  | 297,462 |  |  |  |  |  |  |  |  |
Exercise of stock options and warrants for cash | 168,665 |  | 297 | 168,368 |  |  |  |  |  |  |  |
Stock-based compensation | 1,174,867 |  |  | 1,174,867 |  |  |  |  |  |  |  |
Comprehensive loss: |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (17,638,746) |  |  |  | (17,613,796) |  | (24,950) |  |  |  |  |
Unrealized gain (loss) on short-term investments | 0 |  |  |  |  |  |  |  |  |  |  |
Foreign currency translation adjustments | (102,946) |  |  |  |  | (102,946) |  |  |  |  |  |
Comprehensive loss | (17,741,692) |  |  |  |  |  |  |  |  |  |  |
Balance at at Dec. 31, 2010 | 47,100,911 |  | 105,038 | 241,233,334 | (194,838,229) | 2,850 | 597,918 |  |  |  |  |
Balance shares, at at Dec. 31, 2010 |  | 26 | 105,038,192 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares |  |  | 1,028,905 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, value | 1,351,669 |  | 1,029 | 1,350,640 |  |  |  |  |  |  |  |
Issuance of common stock and warrants for cash, net of financing costs, shares |  |  | 21,130,400 |  |  |  |  |  | 7,699,712 |  |  |
Issuance of common stock and warrants for cash, net of financing costs, value | 22,957,803 |  | 21,130 | 22,936,673 |  |  |  | 3,685,129 | 7,700 | 3,677,429 |  |
Fair value of common stock warrants issued in connection with equity financing | (11,727,372) |  |  | (11,727,372) |  |  |  |  |  |  | (1,905,679) | (1,905,679)
Exercise of stock options and warrants for cash, shares |  |  | 71,185 |  |  |  |  |  |  |  |  |
Exercise of stock options and warrants for cash | 15,930 |  | 71 | 15,859 |  |  |  |  |  |  |  |
Stock-based compensation | 1,654,823 |  |  | 1,654,823 |  |  |  |  |  |  |  |
Comprehensive loss: |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (15,304,095) |  |  |  | (15,252,945) |  | (51,150) |  |  |  |  |
Unrealized gain (loss) on short-term investments | 35,806 |  |  |  |  | 35,806 |  |  |  |  |  |
Foreign currency translation adjustments | (3,263) |  |  |  |  | (3,263) |  |  |  |  |  |
Comprehensive loss | (15,271,552) |  |  |  |  |  |  |  |  |  |  |
Balance at at Dec. 31, 2011 | 47,861,662 |  | 134,968 | 257,235,707 | (210,091,174) | 35,393 | 546,768 |  |  |  |  |
Balance shares, at at Dec. 31, 2011 |  | 26 | 134,968,394 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares |  |  | 9,344,611 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, value | 5,325,141 |  | 9,345 | 5,315,796 |  |  |  |  |  |  |  |
Stock-based compensation | 1,345,613 |  |  | 1,345,613 |  |  |  |  |  |  |  |
Comprehensive loss: |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (19,712,980) |  |  |  | (19,668,955) |  | (44,025) |  |  |  |  |
Unrealized gain (loss) on short-term investments | 35,985 |  |  |  |  | 35,985 |  |  |  |  |  |
Foreign currency translation adjustments | 1,984 |  |  |  |  | 1,984 |  |  |  |  |  |
Comprehensive loss | (19,675,011) |  |  |  |  |  |  |  |  |  |  |
Balance at at Dec. 31, 2012 | $ 34,857,405 |  | $ 144,313 | $ 263,897,116 | $ (229,760,129) | $ 73,362 | $ 502,743 |  |  |  |  |
Balance shares, at at Dec. 31, 2012 |  | 26 | 144,313,005 |  |  |  |  |  |  |  |  |

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