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Stockholders' Equity (Details Textual) (USD $) | 12 Months Ended |  |  | 12 Months Ended | 0 Months Ended | 12 Months Ended |  | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |  | 12 Months Ended |
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Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Jan. 31, 2011 | Dec. 31, 2009 | Dec. 31, 2012 Employee [Member] | Dec. 31, 2011 Employee [Member] | Dec. 31, 2010 Employee [Member] | Dec. 31, 2012 Research and Development Expense [Member] | Dec. 31, 2011 Research and Development Expense [Member] | Dec. 31, 2010 Research and Development Expense [Member] | Dec. 31, 2012 General and Administrative Expense [Member] | Dec. 31, 2011 General and Administrative Expense [Member] | Dec. 31, 2010 General and Administrative Expense [Member] | Dec. 31, 2012 Non Employee [Member] | Dec. 31, 2011 Non Employee [Member] | Dec. 31, 2010 Non Employee [Member] | May 14, 2010 Stock and Cash Based Incentive Plan [Member] | Dec. 31, 2012 Stock and Cash Based Incentive Plan [Member] | Dec. 31, 2012 Amended 2000 Stock Option Plan [Member] | Aug. 31, 2012 Common Stock Warrants [Member] | Oct. 31, 2011 Common Stock Warrants [Member] | Dec. 31, 2010 Common Stock Warrants [Member] | Sep. 30, 2010 Common Stock Warrants [Member] | Jun. 30, 2012 Sales Agreement [Member] | Aug. 31, 2010 Sales Agreement [Member] | Dec. 31, 2012 Sales Agreement [Member] | Dec. 31, 2011 Sales Agreement [Member] | Dec. 31, 2010 Sales Agreement [Member] | Dec. 31, 2011 Underwritten public offering [Member] | Dec. 31, 2012 Underwritten public offering [Member] | Dec. 31, 2011 Underwritten public offering [Member] | Dec. 31, 2011 Overallotment option [Member] | Jan. 31, 2011 Investor purchase agreements [Member] | Dec. 31, 2012 Investor purchase agreements [Member] | Dec. 31, 2011 Investor purchase agreements [Member] | Dec. 31, 2012 VGX Equity Compensation Plan [Member] | Dec. 31, 2012 Minimum [Member] | Dec. 31, 2012 Series C Preferred Stock [Member] | Dec. 31, 2011 Series C Preferred Stock [Member]
Preferred Stock [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, redemption price per share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000 |
Preferred stock, par value (Dollars per share) | $ 0.001 | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.001 | $ 0.001
Notice period for mandatory conversion of preferred stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 30 days |
Average daily trading volume triggering mandatory conversion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000 |  |
Convertible preferred stock, shares issued upon conversion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 38,233 |
Convertible preferred stock, shares issued upon conversion, conversion price per share | $ 6.80 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Daily market price triggering mandatory conversion | $ 18.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential sales proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 25,000,000.0 | $ 25,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Rate of commission or discount rate to placement agent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% | 3.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock sold under sales agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,344,611 | 3,023,577 | 3,023,577 |  |  |  |  |  |  |  |  |  |  |
Weighted average price per share on sale of common stock | $ 0.59 | $ 1.25 | $ 1.25 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from the transaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,300,000 | 3,700,000 | 3,700,000 | 3,700,000 |  |  |  | 23,000,000 |  |  |  |  |  |
Common stock shares issued | 144,313,005 | 134,968,394 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,699,712 |  | 7,699,712 | 962,465 | 21,130,400 |  |  |  |  |  |
Warrants to purchase number of shares of common stock | 21,593,844 | 21,743,844 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,774,784 |  | 5,774,784 |  | 10,565,200 |  |  |  |  |  |
Purchase price per unit of common stock and warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.5195 |  |  |  | 1.15 |  |  |  |  |  |
Ratio to determine the number of warrants received per one share of common stock sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.75 |  |  |  | 0.50 |  |  |  |  |  |
Term of the warrants in years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |  | 5 years |  |  |  |  |  |
Exercise Price |  |  |  | 1.40 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.65 |  | 0.65 |  |  |  |  |  |  |  |
Closing bid price of warrants, minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.30 |  |  |  | $ 2.80 |  |  |  |  |  |
Trading date of warrants in days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20 days |  |  |  | 20 days |  |  |  |  |  |
Change in fair value of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 115,000 | 58,000 |  |  | 2,400,000 | 8,600,000 |  |  |  |
Aggregate purchase price under securities purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 24,300,000 |  |  |  |  |  |
First exercisable date from the date of issuance in days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 180 days |  |  |  |  |  |
Reimbursement of expenses to placement agent | 30,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reimbursement of expenses, ongoing maintenance due diligence and other, placement agent | 5,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expired to purchase number of shares of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 150,000 | 2,364,394 | 3,462,451 | 150,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increased number of securities available for future issuance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of potential shares authorized for issuance under a share-based compensation plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,055,331 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reserved number of shares under the Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,860,662 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increased aggregate number of shares available for grants under the Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,875,287 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of vested restricted stock outstanding under the plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 240,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of common stock outstanding under the Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,430,162 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period of Incentive Plan | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual year term of Incentive Plan | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of options outstanding to purchase common stock | 16,257,444 | 14,302,803 | 12,649,968 |  | 13,142,039 |  |  |  |  |  |  |  |  |  | 6,704,409 |  |  |  |  | 1,371,435 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,455,847 |  |  |
Share-based Compensation | 1,345,613 | 1,654,823 | 1,174,867 |  |  | 1,200,000 | 1,600,000 | 898,000 | 555,000 | 472,000 | 281,000 | 638,000 | 1,100,000 | 617,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Total Compensation Cost Not yet Recognized | 944,000 | 981,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Total Compensation Cost Not yet Recognized, Period for Recognition | 1 year 10 months 24 days | 1 year 8 months 12 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 153,000 | 33,000 | 277,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate intrinsic value of options outstanding | 1,100,000 | 294,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate intrinsic value for options exercisable | 901,000 | 294,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options exercisable, remaining contractual term | 4 years 8 months 12 days | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, expirations in period, weighted average exercise price | $ 1.83 | $ 2.08 | $ 15.28 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, expirations in period | 207,498 | 100,000 | 4,250 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, grants in period, weighted average grant date fair value | $ 0.47 | $ 0.90 | $ 0.93 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Stock Options Exercised | 0 | 15,930 | 168,665 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, exercises in period, aggregate intrinsic value | $ 0 | $ 65,000 | $ 193,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph i -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 19 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph c(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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