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Consolidated Statements of Equity (USD $)
Total
USD ($)
Preferred Stock [Member]
Common Stock [Member]
USD ($)
Additional Paid-in Capital [Member]
USD ($)
Accumulated Deficit [Member]
USD ($)
Accumulated Other Comprehensive Income (Loss) [Member]
USD ($)
Noncontrolling Interest [Member]
USD ($)
Warrants For Cash [Member]
USD ($)
Warrants For Cash [Member]
Common Stock [Member]
USD ($)
Warrants For Cash [Member]
Additional Paid-in Capital [Member]
USD ($)
Equity Financing [Member]
USD ($)
Equity Financing [Member]
Additional Paid-in Capital [Member]
USD ($)
Balance at at Dec. 31, 2009 $ 61,184,947   $ 102,746 $ 237,577,970 $ (177,224,433) $ 105,796 $ 622,868          
Balance shares, at at Dec. 31, 2009   26 102,746,058                  
Issuance of common stock for cash, net of financing costs, shares     1,994,672                  
Issuance of common stock for cash, net of financing costs, value 2,314,124   1,995 2,312,129                
Exercise of stock options and warrants for cash, shares     297,462                  
Exercise of stock options and warrants for cash 168,665   297 168,368                
Stock-based compensation 1,174,867     1,174,867                
Comprehensive loss:                        
Net loss (17,638,746)       (17,613,796)   (24,950)          
Unrealized gain (loss) on short-term investments 0                      
Foreign currency translation adjustments (102,946)         (102,946)            
Comprehensive loss (17,741,692)                      
Balance at at Dec. 31, 2010 47,100,911   105,038 241,233,334 (194,838,229) 2,850 597,918          
Balance shares, at at Dec. 31, 2010   26 105,038,192                  
Issuance of common stock for cash, net of financing costs, shares     1,028,905                  
Issuance of common stock for cash, net of financing costs, value 1,351,669   1,029 1,350,640                
Issuance of common stock and warrants for cash, net of financing costs, shares     21,130,400           7,699,712      
Issuance of common stock and warrants for cash, net of financing costs, value 22,957,803   21,130 22,936,673       3,685,129 7,700 3,677,429    
Fair value of common stock warrants issued in connection with equity financing (11,727,372)     (11,727,372)             (1,905,679) (1,905,679)
Exercise of stock options and warrants for cash, shares     71,185                  
Exercise of stock options and warrants for cash 15,930   71 15,859                
Stock-based compensation 1,654,823     1,654,823                
Comprehensive loss:                        
Net loss (15,304,095)       (15,252,945)   (51,150)          
Unrealized gain (loss) on short-term investments 35,806         35,806            
Foreign currency translation adjustments (3,263)         (3,263)            
Comprehensive loss (15,271,552)                      
Balance at at Dec. 31, 2011 47,861,662   134,968 257,235,707 (210,091,174) 35,393 546,768          
Balance shares, at at Dec. 31, 2011   26 134,968,394                  
Issuance of common stock for cash, net of financing costs, shares     9,344,611                  
Issuance of common stock for cash, net of financing costs, value 5,325,141   9,345 5,315,796                
Stock-based compensation 1,345,613     1,345,613                
Comprehensive loss:                        
Net loss (19,712,980)       (19,668,955)   (44,025)          
Unrealized gain (loss) on short-term investments 35,985         35,985            
Foreign currency translation adjustments 1,984         1,984            
Comprehensive loss (19,675,011)                      
Balance at at Dec. 31, 2012 $ 34,857,405   $ 144,313 $ 263,897,116 $ (229,760,129) $ 73,362 $ 502,743          
Balance shares, at at Dec. 31, 2012   26 144,313,005