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Consolidated Statements of Cash Flows (Unaudited) (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Cash flows from operating activities:      
Net loss $ (19,712,980) $ (15,304,095) $ (17,638,746)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 173,750 142,197 194,629
Amortization of intangible assets 1,821,170 1,869,517 1,913,912
Change in value of common stock warrants (1,982,620) (8,690,658) (2,403,924)
Change in value of short-term investments—auction rate securities 0 0 (3,152,470)
Change in value of auction rate security rights 0 0 3,145,156
Stock-based compensation 1,345,613 1,654,823 1,174,867
Interest expense accrued on line of credit 0 0 61,152
Interest income accrued on short-term investments (1,147) 6,271 (6,271)
Recognition of deferred tax liabilities 22,806 25,673 53,186
Deferred rent (15,799) 13,763 55,774
Impairment of long-term investments 0 0 25,000
Loss on disposal of fixed assets 0 0 21,182
(Gain) Loss on investment in affiliated entity (1,631,819) 2,390,498 969,914
Gain on sale of intangible assets (1,151,000) (587,000) 0
Changes in operating assets and liabilities:      
Accounts receivable (362,524) (435,022) 226,320
Accounts receivable from affiliated entity 2,172 33,743 (13,296)
Prepaid expenses and other current assets 363,584 (472,074) 35,890
Prepaid expenses and other current assets from affiliated entity (445,981) 212,250 (553,456)
Restricted cash (351) (100,059) 0
Other assets (14,794) 50,866 21,419
Accounts payable and accrued expenses (790,844) 1,789,376 (156,073)
Accounts payable and accrued expenses due to affiliated entity 166,931 (1,660,603) 1,235,856
Deferred revenue 282,048 (333,725) 140,757
Deferred revenue from affiliated entity (375,000) (361,458) 2,711,694
Net cash used in operating activities (22,306,785) (19,755,717) (11,937,528)
Cash flows from investing activities:      
Purchases of investments (9,142,220) (18,193,614) (8,000,000)
Maturities of investments 14,008,771 7,206,000 6,160,000
Sales of investments-auction rate securities 0 0 13,550,000
Purchases of capital assets (240,986) (161,187) (181,649)
Sale of capital assets 0 0 32,500
Additional investment in affiliated entity 0 (101,123) 0
Proceeds from sale of intangible assets 650,000 350,000 0
Acquired intangible assets and other assets 0 0 (124,980)
Net cash provided by (used in) investing activities 5,275,565 (10,899,924) 11,435,871
Cash flows from financing activities:      
Proceeds from issuance of common stock and warrants, net of issuance costs 5,325,141 27,994,601 2,314,124
Proceeds from stock option and warrant exercises 0 15,930 168,665
Repayment of line of credit 0 0 (12,175,912)
Net cash provided by (used in) financing activities 5,325,141 28,010,531 (9,693,123)
Effect of exchange rate changes on cash and cash equivalents 1,984 (3,263) (102,946)
Decrease in cash and cash equivalents (11,704,095) (2,648,373) (10,297,726)
Cash and cash equivalents, beginning of period 17,350,116 19,998,489 30,296,215
Cash and cash equivalents, end of period $ 5,646,021 $ 17,350,116 $ 19,998,489