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Stockholders' Equity (Details Textual) (USD $) | 12 Months Ended |  |  |  |  | 12 Months Ended | 0 Months Ended | 12 Months Ended |  | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |  | 12 Months Ended |  | 12 Months Ended |  | 12 Months Ended |  | 12 Months Ended |
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Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011 | May 31, 2013 | Apr. 30, 2013 | Jan. 31, 2011 | Dec. 31, 2009 | Dec. 31, 2013 Employee [Member] | Dec. 31, 2012 Employee [Member] | Dec. 31, 2011 Employee [Member] | Dec. 31, 2013 Research and Development Expense [Member] | Dec. 31, 2012 Research and Development Expense [Member] | Dec. 31, 2011 Research and Development Expense [Member] | Dec. 31, 2013 General and Administrative Expense [Member] | Dec. 31, 2012 General and Administrative Expense [Member] | Dec. 31, 2011 General and Administrative Expense [Member] | Dec. 31, 2013 Non Employee [Member] | Dec. 31, 2012 Non Employee [Member] | Dec. 31, 2011 Non Employee [Member] | May 14, 2010 Stock and Cash Based Incentive Plan [Member] | Dec. 31, 2013 Stock and Cash Based Incentive Plan [Member] | Dec. 31, 2013 Amended 2000 Stock Option Plan [Member] | Aug. 31, 2012 Common Stock Warrants [Member] | Dec. 31, 2013 Common Stock Warrants [Member] | Jun. 30, 2012 Sales Agreement [Member] | Dec. 31, 2013 Sales Agreement [Member] | Dec. 31, 2012 Sales Agreement [Member] | Mar. 31, 2013 Underwritten public offering [Member] | Dec. 31, 2011 Underwritten public offering [Member] | Dec. 31, 2013 Underwritten public offering [Member] | Dec. 31, 2012 Underwritten public offering [Member] | Dec. 31, 2012 Overallotment option [Member] | Jan. 31, 2011 Investor purchase agreements [Member] | Dec. 31, 2013 Investor purchase agreements [Member] | Dec. 31, 2012 Investor purchase agreements [Member] | Dec. 31, 2013 VGX Equity Compensation Plan [Member] | Dec. 31, 2013 Minimum [Member] | Dec. 31, 2013 Series C Preferred Stock [Member] | Dec. 31, 2012 Series C Preferred Stock [Member] | Dec. 31, 2013 March 2013 financing [Member] | Dec. 31, 2012 March 2013 financing [Member] | Dec. 31, 2013 December Two Thousand Eleven Financing [Member] | Dec. 31, 2012 December Two Thousand Eleven Financing [Member] | Dec. 31, 2013 January Two Thousand Eleven Financing [Member] | Dec. 31, 2012 January Two Thousand Eleven Financing [Member]
Preferred Stock [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, redemption price per share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000 |  |  |  |  |  |  |
Preferred stock, par value (Dollars per share) | $ 0.001 | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |  |
Notice period for mandatory conversion of preferred stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 30 days |  |  |  |  |  |  |
Average daily trading volume triggering mandatory conversion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000 |  |  |  |  |  |  |  |
Convertible preferred stock, shares issued upon conversion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 38,233 |  |  |  |  |  |  |
Convertible preferred stock, shares issued upon conversion, conversion price per share | $ 6.80 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Daily market price triggering mandatory conversion | $ 18.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized | 600,000,000 | 300,000,000 |  | 600,000,000 | 300,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, capital shares reserved for future issuance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 27,377,266 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, number of securities called by warrants or rights |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 13,688,633 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, number of securities called by each warrant or right |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.50 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, securities called by warrants or rights, price per share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.7936 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential proceeds from issue of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 14,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants, fair value disclosure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase (decrease) in fair value of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued during period, shares, warrants exercised |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,665,908 |  | 5,774,784 |  | 3,870,200 |
Transaction costs associated with issuance of warrants | 315,970 | 0 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential sales proceeds |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Rate of commission or discount rate to placement agent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares of common stock sold under sales agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,700,668 | 9,344,611 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Weighted average price per share on sale of common stock | $ 1.24 | $ 0.59 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from the transaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 18,900,000 | 5,300,000 |  | 3,700,000 |  |  |  | 23,000,000 |  |  |  |  |  |  | 8,500,000 |  | 3,800,000 |  | 5,400,000 |
Common stock shares issued | 210,304,821 | 144,313,005 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,699,712 | 962,465 | 21,130,400 |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase number of shares of common stock | 14,059,260 | 21,593,844 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,774,784 |  | 10,565,200 |  |  |  |  |  |  | 3,022,725 | 0 | 0 | 5,774,784 | 6,695,000 | 10,565,200
Purchase price per unit of common stock and warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.55 | 0.5195 |  |  |  | 1.15 |  |  |  |  |  |  |  |  |  |  |  |
Ratio to determine the number of warrants received per one share of common stock sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.75 |  |  |  | 0.50 |  |  |  |  |  |  |  |  |  |  |  |
Term of the warrants in years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years 6 months |  |  | 5 years |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |
Exercise Price |  |  |  |  |  | 1.40 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0.65 |  |  |  |  |  |  |  |  | 0.79 | 0.79 | 0.65 | 0.65 | 1.40 | 1.40
Closing bid price of warrants, minimum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.30 |  |  |  | $ 2.80 |  |  |  |  |  |  |  |  |  |  |  |
Trading date of warrants in days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20 days |  |  |  | 20 days |  |  |  |  |  |  |  |  |  |  |  |
Change in fair value of warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (4,900,000) | 115,000 |  |  | (15,800,000) | 2,400,000 |  |  |  |  |  |  |  |  |  |
Aggregate purchase price under securities purchase agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 24,300,000 |  |  |  |  |  |  |  |  |  |  |  |
First exercisable date from the date of issuance in days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 180 days |  |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, number of warrants exercised | 3,870,200 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expired to purchase number of shares of common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 150,000 | 58,220 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increased number of securities available for future issuance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of potential shares authorized for issuance under a share-based compensation plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,055,331 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reserved number of shares under the Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,915,993 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increased aggregate number of shares available for grants under the Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,197,306 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares of vested restricted stock outstanding under the plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 240,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of common stock outstanding under the Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,163,063 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vesting period of Incentive Plan | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual year term of Incentive Plan | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of options outstanding to purchase common stock | 16,538,118 | 16,257,444 | 14,302,803 |  |  |  | 12,649,968 |  |  |  |  |  |  |  |  |  | 4,794,496 |  |  |  |  | 1,091,750 |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,283,305 |  |  |  |  |  |  |  |  |
Share-based Compensation | 1,868,345 | 1,345,613 | 1,654,823 |  |  |  |  | 1,200,000 | 1,200,000 | 1,600,000 | 550,000 | 555,000 | 472,000 | 605,000 | 638,000 | 1,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | 956,000 | 944,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition | 1 year 10 months 0 days | 1 year 10 months 24 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 714,000 | 153,000 | 33,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate intrinsic value of options outstanding | 28,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate intrinsic value for options exercisable | 20,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options exercisable, remaining contractual term | 4 years 8 months 12 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of options expected to vest | 3,540,163 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, expirations in period, weighted average exercise price | $ 1.33 | $ 1.83 | $ 2.08 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, expirations in period | 496,012 | 207,498 | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, grants in period, weighted average grant date fair value | $ 0.44 | $ 0.47 | $ 0.90 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from stock options exercised | 1,600,000 | 0 | 16,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Options, exercises in period, aggregate intrinsic value | $ 2,500,000 | $ 0 | $ 65,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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