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Summary of Significant Accounting Policies - Net Loss per Share (Details) | 12 Months Ended
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Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect |  |  |
Total | 30,635,611 | 37,889,521 | 36,084,880
Options to purchase common stock [Member] |  |  |
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect |  |  |
Total | 16,538,118 | 16,257,444 | 14,302,803
Warrants to purchase common stock [Member] |  |  |
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect |  |  |
Total | 14,059,260 | 21,593,844 | 21,743,844
Convertible preferred stock [Member] |  |  |
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect |  |  |
Total | 38,233 | 38,233 | 38,233

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- Definition Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Antidilution -URI http://asc.fasb.org/extlink&oid=6505113 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Diluted Earnings Per Share -URI http://asc.fasb.org/extlink&oid=6510752 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Contingent Stock Agreement -URI http://asc.fasb.org/extlink&oid=6508534 + Details
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