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Consolidated Statements of Stockholders' Equity (USD $) | Total USD ($) | Preferred Stock [Member] | Common Stock [Member] USD ($) | Additional Paid-in Capital [Member] USD ($) | Accumulated Deficit [Member] USD ($) | Accumulated Other Comprehensive Income (Loss) [Member] USD ($) | Noncontrolling Interest [Member] USD ($) | Warrants For Cash [Member] USD ($) | Warrants For Cash [Member] Common Stock [Member] USD ($) | Warrants For Cash [Member] Additional Paid-in Capital [Member] USD ($) | Equity Financing [Member] USD ($) | Equity Financing [Member] Additional Paid-in Capital [Member] USD ($)
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance, value at Dec. 31, 2010 | $ 47,100,911 |  | $ 105,038 | $ 241,233,334 | $ (194,838,229) | $ 2,850 | $ 597,918 |  |  |  |  |
Beginning balance, shares at Dec. 31, 2010 |  | 26 | 105,038,192 |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares |  |  | 1,028,905 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, value | 1,351,669 |  | 1,029 | 1,350,640 |  |  |  |  |  |  |  |
Issuance of common stock and warrants for cash, net of financing costs, shares |  |  | 21,130,400 |  |  |  |  |  | 7,699,712 |  |  |
Issuance of common stock and warrants for cash, net of financing costs, value | 22,957,803 |  | 21,130 | 22,936,673 |  |  |  | 3,685,129 | 7,700 | 3,677,429 |  |
Fair value of common stock warrants issued in connection with equity financing | (11,727,372) |  |  | (11,727,372) |  |  |  |  |  |  | (1,905,679) | (1,905,679)
Exercise of stock options and warrants for cash, shares |  |  | 71,185 |  |  |  |  |  |  |  |  |
Exercise of stock options and warrants for cash, value | 15,930 |  | 71 | 15,859 |  |  |  |  |  |  |  |
Stock-based compensation | 1,654,823 |  |  | 1,654,823 |  |  |  |  |  |  |  |
Net loss attributable to common stockholders | (15,304,095) |  |  |  | (15,252,945) |  | (51,150) |  |  |  |  |
Unrealized gain (loss) on short-term investments | 35,806 |  |  |  |  | 35,806 |  |  |  |  |  |
Foreign currency translation adjustments | (3,263) |  |  |  |  | (3,263) |  |  |  |  |  |
Ending balance, value at Dec. 31, 2011 | 47,861,662 |  | 134,968 | 257,235,707 | (210,091,174) | 35,393 | 546,768 |  |  |  |  |
Ending balance, shares at Dec. 31, 2011 |  | 26 | 134,968,394 |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares |  |  | 9,344,611 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, value | 5,325,141 |  | 9,345 | 5,315,796 |  |  |  |  |  |  |  |
Stock-based compensation | 1,345,613 |  |  | 1,345,613 |  |  |  |  |  |  |  |
Net loss attributable to common stockholders | (19,712,980) |  |  |  | (19,668,955) |  | (44,025) |  |  |  |  |
Unrealized gain (loss) on short-term investments | 35,985 |  |  |  |  | 35,985 |  |  |  |  |  |
Foreign currency translation adjustments | 1,984 |  |  |  |  | 1,984 |  |  |  |  |  |
Ending balance, value at Dec. 31, 2012 | 34,857,405 |  | 144,313 | 263,897,116 | (229,760,129) | 73,362 | 502,743 |  |  |  |  |
Ending balance, shares at Dec. 31, 2012 |  | 26 | 144,313,005 |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares |  |  | 15,700,668 |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, value | 18,924,856 |  | 15,701 | 18,909,155 |  |  |  |  |  |  |  |
Issuance of common stock and warrants for cash, net of financing costs, shares |  |  | 27,377,266 |  |  |  |  |  |  |  |  |
Issuance of common stock and warrants for cash, net of financing costs, value | 14,274,819 |  | 27,377 | 14,247,442 |  |  |  |  |  |  |  |
Fair value of common stock warrants issued in connection with equity financing | (5,968,244) |  |  | (5,968,244) |  |  |  |  |  |  |  |
Exercise of stock options and warrants for cash, shares |  |  | 22,849,755 |  |  |  |  |  |  |  |  |
Exercise of stock options and warrants for cash, value | 19,808,232 |  | 22,850 | 19,785,382 |  |  |  |  |  |  |  |
Cashless exercise of warrants, shares |  |  | 64,127 |  |  |  |  |  |  |  |  |
Cashless exercise of warrants, value | 0 |  | 64 | (64) |  |  |  |  |  |  |  |
Change in classification of warrants from liability to equity due to exercise | 35,370,529 |  |  | 35,370,529 |  |  |  |  |  |  |  |
Stock-based compensation | 1,868,345 |  |  | 1,868,345 |  |  |  |  |  |  |  |
Net loss attributable to common stockholders | (66,083,532) |  |  |  | (66,028,448) |  | (55,084) |  |  |  |  |
Unrealized gain (loss) on short-term investments | (149,845) |  |  |  |  | (149,845) |  |  |  |  |  |
Foreign currency translation adjustments | 118 |  |  |  |  | 118 |  |  |  |  |  |
Ending balance, value at Dec. 31, 2013 | $ 52,902,683 |  | $ 210,305 | $ 348,109,661 | $ (295,788,577) | $ (76,365) | $ 447,659 |  |  |  |  |
Ending balance, shares at Dec. 31, 2013 |  | 26 | 210,304,821 |  |  |  |  |  |  |  |  |

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