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Consolidated Statements of Stockholders' Equity (USD $)
Total
USD ($)
Preferred Stock [Member]
Common Stock [Member]
USD ($)
Additional Paid-in Capital [Member]
USD ($)
Accumulated Deficit [Member]
USD ($)
Accumulated Other Comprehensive Income (Loss) [Member]
USD ($)
Noncontrolling Interest [Member]
USD ($)
Warrants For Cash [Member]
USD ($)
Warrants For Cash [Member]
Common Stock [Member]
USD ($)
Warrants For Cash [Member]
Additional Paid-in Capital [Member]
USD ($)
Equity Financing [Member]
USD ($)
Equity Financing [Member]
Additional Paid-in Capital [Member]
USD ($)
Beginning balance, value at Dec. 31, 2010 $ 47,100,911   $ 105,038 $ 241,233,334 $ (194,838,229) $ 2,850 $ 597,918          
Beginning balance, shares at Dec. 31, 2010   26 105,038,192                  
Increase (Decrease) in Stockholders' Equity [Roll Forward]                        
Issuance of common stock for cash, net of financing costs, shares     1,028,905                  
Issuance of common stock for cash, net of financing costs, value 1,351,669   1,029 1,350,640                
Issuance of common stock and warrants for cash, net of financing costs, shares     21,130,400           7,699,712      
Issuance of common stock and warrants for cash, net of financing costs, value 22,957,803   21,130 22,936,673       3,685,129 7,700 3,677,429    
Fair value of common stock warrants issued in connection with equity financing (11,727,372)     (11,727,372)             (1,905,679) (1,905,679)
Exercise of stock options and warrants for cash, shares     71,185                  
Exercise of stock options and warrants for cash, value 15,930   71 15,859                
Stock-based compensation 1,654,823     1,654,823                
Net loss attributable to common stockholders (15,304,095)       (15,252,945)   (51,150)          
Unrealized gain (loss) on short-term investments 35,806         35,806            
Foreign currency translation adjustments (3,263)         (3,263)            
Ending balance, value at Dec. 31, 2011 47,861,662   134,968 257,235,707 (210,091,174) 35,393 546,768          
Ending balance, shares at Dec. 31, 2011   26 134,968,394                  
Increase (Decrease) in Stockholders' Equity [Roll Forward]                        
Issuance of common stock for cash, net of financing costs, shares     9,344,611                  
Issuance of common stock for cash, net of financing costs, value 5,325,141   9,345 5,315,796                
Stock-based compensation 1,345,613     1,345,613                
Net loss attributable to common stockholders (19,712,980)       (19,668,955)   (44,025)          
Unrealized gain (loss) on short-term investments 35,985         35,985            
Foreign currency translation adjustments 1,984         1,984            
Ending balance, value at Dec. 31, 2012 34,857,405   144,313 263,897,116 (229,760,129) 73,362 502,743          
Ending balance, shares at Dec. 31, 2012   26 144,313,005                  
Increase (Decrease) in Stockholders' Equity [Roll Forward]                        
Issuance of common stock for cash, net of financing costs, shares     15,700,668                  
Issuance of common stock for cash, net of financing costs, value 18,924,856   15,701 18,909,155                
Issuance of common stock and warrants for cash, net of financing costs, shares     27,377,266                  
Issuance of common stock and warrants for cash, net of financing costs, value 14,274,819   27,377 14,247,442                
Fair value of common stock warrants issued in connection with equity financing (5,968,244)     (5,968,244)                
Exercise of stock options and warrants for cash, shares     22,849,755                  
Exercise of stock options and warrants for cash, value 19,808,232   22,850 19,785,382                
Cashless exercise of warrants, shares     64,127                  
Cashless exercise of warrants, value 0   64 (64)                
Change in classification of warrants from liability to equity due to exercise 35,370,529     35,370,529                
Stock-based compensation 1,868,345     1,868,345                
Net loss attributable to common stockholders (66,083,532)       (66,028,448)   (55,084)          
Unrealized gain (loss) on short-term investments (149,845)         (149,845)            
Foreign currency translation adjustments 118         118            
Ending balance, value at Dec. 31, 2013 $ 52,902,683   $ 210,305 $ 348,109,661 $ (295,788,577) $ (76,365) $ 447,659          
Ending balance, shares at Dec. 31, 2013   26 210,304,821