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Summary of Significant Accounting Policies - Antidilutive Securities Table (Details)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total 5,576,939us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount 7,658,904us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount 9,472,381us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
Options to purchase common stock      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total 4,840,514us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_EmployeeStockOptionMember
4,134,530us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_EmployeeStockOptionMember
4,064,361us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_EmployeeStockOptionMember
Warrants to purchase common stock      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total 727,969us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_WarrantMember
3,514,815us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_WarrantMember
5,398,461us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_WarrantMember
Convertible preferred stock      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total 8,456us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_ConvertiblePreferredStockMember
9,559us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_ConvertiblePreferredStockMember
9,559us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
/ us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis
= us-gaap_ConvertiblePreferredStockMember