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Income Taxes (Details 1) - USD ($) | 12 Months Ended
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Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Income Tax Disclosure [Abstract] |  |  |
Statutory tax rate | 35.00% | 35.00% | 35.00%
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract] |  |  |
Income (benefit) taxes at statutory rates | $ (10,920,000) | $ (12,639,000) | $ (23,118,000)
State income tax, net of federal benefit | (2,640,000) | (2,362,000) | (1,651,000)
Change in valuation allowance | 7,882,000 | 14,235,000 | 8,819,000
Research and development tax credits | (1,537,000) | (849,000) | (1,230,000)
Fair value warrant | (253,000) | (180,000) | 16,129,000
Stock compensation | 2,288,000 | 1,573,000 | 279,000
Uncertain tax positions | 1,968,000 | 340,000 | 495,000
Expired NOL's and credits | 339,000 | 728,000 | 338,000
Limited NOL's and credits | (297,000) | (749,000) | 605,000
Change in state tax rate | 676,000 | (60,000) | (623,000)
Other | 396,000 | (8,000) | (12,000)
Income Tax Expense (Benefit) | $ (2,098,000) | $ 29,000 | $ 31,000

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