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Income Taxes (Details Textual) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Income tax benefit | $ 308,520 | $ 1,789,246 | $ 0 | $ 0 | $ 2,097,766 | $ 0 | $ 0
Tax benefits expired | 27,200,000 |  |  |  | 27,200,000 |  |
Unrecognized tax benefits that would impact effective tax rate | 4,300,000 |  |  |  | 4,300,000 |  |
Federal |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards that will expire due to IRC Section 382 limitations | 177,400,000 |  |  |  | 177,400,000 |  |
Domestic Tax Authority |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Operating loss carryforwards | 177,400,000 |  |  |  | 177,400,000 |  |
Operating loss carryforwards related to excess share-based compensation | 1,900,000 |  |  |  | 1,900,000 |  |
State |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Operating loss carryforwards | 197,800,000 |  |  |  | 197,800,000 |  |
Operating loss carryforwards related to excess share-based compensation | 1,000,000 |  |  |  | 1,000,000 |  |
California |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards that will expire due to IRC Section 382 limitations | 56,500,000 |  |  |  | 56,500,000 |  |
Pennsylvania |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards that will expire due to IRC Section 382 limitations | 141,300,000 |  |  |  | 141,300,000 |  |
Research Tax Credit Carryforward | Federal |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Tax credit carryforward amount | 4,400,000 |  |  |  | 4,400,000 |  |
Research Tax Credit Carryforward | State |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Tax credit carryforward amount | $ 2,100,000 |  |  |  | $ 2,100,000 |  |

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