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Stockholders' Equity (Details Textual) |  |  |  |  | 1 Months Ended | 12 Months Ended
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May. 08, 2015 shares | Jun. 05, 2014 | May. 22, 2014 shares | May. 14, 2010 shares | May. 31, 2015 USD ($) $ / shares shares | Jul. 31, 2014 shares | Mar. 31, 2014 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2014 USD ($) $ / shares shares | Dec. 31, 2013 USD ($) $ / shares shares
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |
Stock split ratio |  | 0.25 |  |  |  |  |  |  |  |
Preferred Stock [Abstract] |  |  |  |  |  |  |  |  |  |
Preferred stock, par value (Dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |
Convertible preferred stock, shares issued upon conversion, conversion price ($ per share) | $ / shares |  |  |  |  |  |  |  | 27.20 |  |
Daily market price triggering mandatory conversion ($ per share) | $ / shares |  |  |  |  |  |  |  | $ 72.00 |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares (shares) |  |  |  |  | 10,925,000 |  |  |  |  |
Offering price ($ per share) | $ / shares |  |  |  |  | $ 8.00 |  |  |  |  |
Proceeds from offering | $ |  |  |  |  | $ 81,900,000 |  |  |  |  |
Proceeds from issuance of common stock | $ |  |  |  |  |  |  |  | $ 81,902,363 | $ 59,209,182 | $ 32,883,705
Number of securities called by warrants or rights expired |  |  |  |  |  | 83,334 |  |  |  |
Vesting period of Incentive Plan |  |  |  |  |  |  |  | 3 years |  |
Contractual year term of Incentive Plan |  |  |  |  |  |  |  | 10 years |  |
Number of options outstanding to purchase common stock |  |  |  |  |  |  |  | 5,862,364 | 4,840,514 |
Share-based compensation | $ |  |  |  |  |  |  |  | $ 6,186,848 | $ 5,428,946 | $ 1,868,345
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | $ |  |  |  |  |  |  |  | $ 5,400,000 | $ 5,300,000 |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition |  |  |  |  |  |  |  | 1 year 10 months 15 days | 2 years |
Aggregate intrinsic value of options outstanding | $ |  |  |  |  |  |  |  | $ 8,800,000 |  |
Aggregate intrinsic value for options exercisable | $ |  |  |  |  |  |  |  | $ 8,100,000 |  |
Options exercisable, remaining contractual term |  |  |  |  |  |  |  | 4 years 8 months 12 days |  |
Number of options expected to vest |  |  |  |  |  |  |  | 1,511,930 |  |
Options, expirations in period, weighted average exercise price ($ per share) | $ / shares |  |  |  |  |  |  |  | $ 10.89 | $ 15.95 | $ 5.32
Options, expirations in period |  |  |  |  |  |  |  | 83,696 | 70,517 | 124,003
Options, grants in period, weighted average grant date fair value ($ per share) | $ / shares |  |  |  |  |  |  |  | $ 4.60 | $ 9.19 | $ 1.76
Proceeds from stock options exercised | $ |  |  |  |  |  |  |  | $ 552,000 | $ 1,400,000 | $ 1,600,000
Options, exercises in period, aggregate intrinsic value | $ |  |  |  |  |  |  |  | 456,000 | 2,000,000 | 2,500,000
Employee |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Share-based compensation | $ |  |  |  |  |  |  |  | 5,800,000 | 4,800,000 | 1,200,000
Research and Development Expense |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Share-based compensation | $ |  |  |  |  |  |  |  | 3,200,000 | 2,800,000 | 555,000
General and Administrative Expense |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Share-based compensation | $ |  |  |  |  |  |  |  | $ 2,600,000 | 2,000,000 | 605,000
Non Employee |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Number of options outstanding to purchase common stock |  |  |  |  |  |  |  | 991,346 |  |
Allocated share-based compensation expense | $ |  |  |  |  |  |  |  | $ 385,000 | $ 585,000 | $ 714,000
Stock and Cash Based Incentive Plan |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Increased number of securities available for future issuance | 2,000,000 |  | 1,250,000 | 500,000 |  |  |  |  |  |
Number of potential shares authorized for issuance under a share-based compensation plan |  |  |  | 513,833 |  |  |  |  |  |
Reserved number of shares under the Incentive Plan |  |  |  |  |  |  |  | 7,256,664 |  |
Increased aggregate number of shares available for grants under the Incentive Plan |  |  |  |  |  |  |  | 2,020,627 |  |
Number of shares of vested restricted stock outstanding under the plan |  |  |  |  |  |  |  | 230,000 |  |
Number of common stock shares outstanding under the Incentive Plan |  |  |  |  |  |  |  | 4,478,425 |  |
Amended 2000 Stock Option Plan |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Number of options outstanding to purchase common stock |  |  |  |  |  |  |  | 148,878 |  |
Restricted Stock Units (RSUs) |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | $ |  |  |  |  |  |  |  | $ 1,200,000 |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition |  |  |  |  |  |  |  | 2 years 1 month 6 days |  |
Weighted average grant date fair value ($ per share) | $ / shares |  |  |  |  |  |  |  | $ 7.76 |  |
VGX Equity Compensation Plan |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Number of options outstanding to purchase common stock |  |  |  |  |  |  |  | 1,235,061 |  |
Over-Allotment Option |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares (shares) |  |  |  |  | 1,425,000 |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |
Preferred Stock [Abstract] |  |  |  |  |  |  |  |  |  |
Average daily trading volume triggering mandatory conversion (shares) |  |  |  |  |  |  |  | 6,250 |  |
Series C Preferred Stock |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |
Shares converted (shares) |  |  |  |  |  |  |  |  | 3 |
Preferred Stock [Abstract] |  |  |  |  |  |  |  |  |  |
Preferred stock, redemption price ($ per share) | $ / shares |  |  |  |  |  |  |  | $ 10,000 |  |
Preferred stock, par value (Dollars per share) | $ / shares |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |
Notice period for mandatory conversion of preferred stock |  |  |  |  |  |  |  | 30 days |  |
Convertible preferred stock, shares issued upon conversion (shares) |  |  |  |  |  |  |  | 8,456 |  |
Common stock |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |
Conversions of preferred stock to common stock, shares |  |  |  |  |  |  |  |  | 1,103 |
March 2013 financing |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Stock issued during period, shares, warrants exercised |  |  |  |  |  |  |  | 0 | 471,590 |
Net proceeds from the transaction | $ |  |  |  |  |  |  |  |  | $ 1,500,000 |
January Two Thousand Eleven Financing |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Stock issued during period, shares, warrants exercised |  |  |  |  |  |  |  |  | 1,673,750 |
Net proceeds from the transaction | $ |  |  |  |  |  |  |  |  | $ 9,400,000 |
Warrants Assumed in June Two Thousand Nine Merger |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Stock issued during period, shares, warrants exercised |  |  |  |  |  |  |  | 426,625 | 274,083 |
Net proceeds from the transaction | $ |  |  |  |  |  |  |  | $ 2,000,000 | $ 1,000,000 |
Common stock |  |  |  |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |
Conversions of preferred stock to common stock, shares |  |  |  |  |  |  |  |  | 1,103 |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares (shares) |  |  |  |  |  |  |  | 10,925,000 | 5,452,725 | 3,925,167
Common stock | Underwritten public offering |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs, shares (shares) |  |  |  |  |  |  | 5,452,725 |  |  |
Public offering price ($ per share) | $ / shares |  |  |  |  |  |  | $ 11.60 |  |  |
Proceeds from issuance of common stock | $ |  |  |  |  |  |  | $ 59,200,000 |  |  |
Common stock | Underwritten Public Offering Overallotment Option |  |  |  |  |  |  |  |  |  |
Stockholders' Equity (Textual) [Abstract] |  |  |  |  |  |  |  |  |  |
Common stock, capital shares reserved for future issuance (shares) |  |  |  |  |  |  | 711,225 |  |  |

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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2)(iii)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(4) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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