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Summary of Significant Accounting Policies - Antidilutive Securities Table (Details) - shares	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	6,377,633	5,576,939	7,658,904
Options to purchase common stock
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	5,862,364	4,840,514	4,134,530
Warrants to purchase common stock
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	276,813	727,969	3,514,815
Restricted stock units
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	230,000	0	0
Convertible preferred stock
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	8,456	8,456	9,559