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Summary of Significant Accounting Policies - Stock-Based Compensation (Details) - Stock Options	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Employees and Directors
Summary of assumptions used to estimate the fair value of stock options
Risk-free interest rate	0.99%	1.47%	0.41%
Expected volatility	74.00%	109.00%	111.00%
Expected life in years	5 years	5 years	4 years
Dividend yield	0.00%	0.00%	0.00%
Forfeiture rate	7.00%	8.00%	8.00%
Non Employee
Summary of assumptions used to estimate the fair value of stock options
Risk-free interest rate (minimum)	2.14%	1.52%	0.84%
Risk-free interest rate (maximum)	2.31%	2.73%	1.52%
Dividend yield	0.00%	0.00%	0.00%
Non Employee | Minimum
Summary of assumptions used to estimate the fair value of stock options
Expected volatility	105.00%	104.00%	102.00%
Expected life in years	7 years	7 years	7 years
Non Employee | Maximum
Summary of assumptions used to estimate the fair value of stock options
Expected volatility	108.00%	115.00%	113.00%
Expected life in years	10 years	10 years	10 years

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- Definition

Assumptions used in estimation of fair value of stock options.

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Forfeiture rate.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iii)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(ii)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iv)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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The maximum risk-free interest rate assumption that is used in valuing an option on its own shares.

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The minimum risk-free interest rate assumption that is used in valuing an option on its own shares.

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Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 14.D.2)
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-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
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-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 14
-Section D
-Subsection 2

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