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Consolidated Statements of Stockholders' Equity - USD ($)
Total
Preferred stock
Common stock
Additional paid-in capital
Accumulated deficit
Accumulated other comprehensive income (loss)
Non- controlling interest
Beginning balance, shares at Dec. 31, 2012   26 36,078,435        
Beginning balance, value at Dec. 31, 2012 $ 34,857,405   $ 36,079 $ 264,005,350 $ (229,760,129) $ 73,362 $ 502,743
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Issuance of common stock and warrants for cash, net of financing costs, shares     6,844,317        
Issuance of common stock and warrants for cash, net of financing costs, value 14,274,819   $ 6,844 14,267,975      
Fair value of common stock warrants issued in connection with equity financing (5,968,244)     (5,968,244)      
Issuance of common stock for cash, net of financing costs, shares (shares)     3,925,167        
Issuance of common stock for cash, net of financing costs, value 18,924,856   $ 3,925 18,920,931      
Exercise of stock options and warrants for cash, shares     5,712,439        
Exercise of stock options and warrants for cash, value 19,808,232   $ 5,713 19,802,519      
Cashless exercise of warrants, shares     16,032        
Cashless exercise of warrants, value 0   $ 16 (16)      
Change in classification of warrants from liability to equity due to exercise 35,370,529     35,370,529      
Stock-based compensation 1,868,345     1,868,345      
Net loss attributable to common stockholders (66,083,532)       (66,028,448)   (55,084)
Unrealized gain (loss) on short-term investments (149,845)         (149,845)  
Unrealized gain on investment in affiliated entity, net of tax 0            
Foreign currency translation adjustments 118         118  
Ending balance, shares at Dec. 31, 2013   26 52,576,390        
Ending balance, value at Dec. 31, 2013 52,902,683   $ 52,577 348,267,389 (295,788,577) (76,365) 447,659
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Issuance of shares related to reverse stock split (shares)     6,378        
Issuance of shares related to reverse stock split 57,187   $ 6 57,181      
Issuance of common stock for cash, net of financing costs, shares (shares)     5,452,725        
Issuance of common stock for cash, net of financing costs, value 59,209,182   $ 5,453 59,203,729      
Conversions of preferred stock to common stock, shares   (3) 1,103        
Conversions of preferred stock to common stock, value 0   $ 1 (1)      
Acquisition of non-controlling interest 0     118,621     (118,621)
Exercise of stock options and warrants for cash, shares     2,689,868        
Exercise of stock options and warrants for cash, value 13,252,543   $ 2,689 13,249,854      
Cashless exercise of warrants, shares     14,618        
Cashless exercise of warrants, value 0   $ 15 (15)      
Change in classification of warrants from liability to equity due to exercise 17,002,211     17,002,211      
Stock-based compensation 5,428,946     5,428,946      
Net loss attributable to common stockholders (36,140,133)       (36,121,713)   (18,420)
Unrealized gain (loss) on short-term investments (173,336)         (173,336)  
Unrealized gain on investment in affiliated entity, net of tax 0            
Foreign currency translation adjustments (1,689)         (1,689)  
Ending balance, shares at Dec. 31, 2014   23 60,741,082        
Ending balance, value at Dec. 31, 2014 111,537,594   $ 60,741 443,327,915 (331,910,290) (251,390) 310,618
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Issuance of common stock for cash, net of financing costs, shares (shares)     10,925,000        
Issuance of common stock for cash, net of financing costs, value 81,902,363   $ 10,925 81,891,438      
Payment to minority stockholders (149,559)           (149,559)
Exercise of stock options and warrants for cash, shares     551,883        
Exercise of stock options and warrants for cash, value 2,598,915   $ 552 2,598,363      
Stock-based compensation 6,186,848     6,186,848      
Net loss attributable to common stockholders (29,102,837)       (29,187,606)   84,769
Unrealized gain (loss) on short-term investments 7,528         7,528  
Unrealized gain on investment in affiliated entity, net of tax 2,952,201         2,952,201  
Foreign currency translation adjustments 0            
Ending balance, shares at Dec. 31, 2015   23 72,217,965        
Ending balance, value at Dec. 31, 2015 $ 175,933,053   $ 72,218 $ 534,004,564 $ (361,097,896) $ 2,708,339 $ 245,828