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Stockholders' Equity (Details Textual)
 1 Months Ended 12 Months Ended
May. 08, 2015
shares
Jun. 05, 2014
May. 22, 2014
shares
May. 14, 2010
shares
May. 31, 2015
USD ($)
$ / shares
shares
Jul. 31, 2014
shares
Mar. 31, 2014
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Dec. 31, 2014
USD ($)
$ / shares
shares
Dec. 31, 2013
USD ($)
$ / shares
shares
Class of Stock [Line Items]                    
Stock split ratio   0.25                
Preferred Stock [Abstract]                    
Preferred stock, par value (Dollars per share) | $ / shares               $ 0.001 $ 0.001  
Convertible preferred stock, shares issued upon conversion, conversion price ($ per share) | $ / shares               27.20    
Daily market price triggering mandatory conversion ($ per share) | $ / shares               $ 72.00    
Stockholders' Equity (Textual) [Abstract]                    
Issuance of common stock for cash, net of financing costs, shares (shares)         10,925,000          
Offering price ($ per share) | $ / shares         $ 8.00          
Proceeds from offering | $         $ 81,900,000          
Proceeds from issuance of common stock | $               $ 81,902,363 $ 59,209,182 $ 32,883,705
Number of securities called by warrants or rights expired           83,334        
Vesting period of Incentive Plan               3 years    
Contractual year term of Incentive Plan               10 years    
Number of options outstanding to purchase common stock               5,862,364 4,840,514  
Share-based compensation | $               $ 6,186,848 $ 5,428,946 $ 1,868,345
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | $               $ 5,400,000 $ 5,300,000  
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition               1 year 10 months 15 days 2 years  
Aggregate intrinsic value of options outstanding | $               $ 8,800,000    
Aggregate intrinsic value for options exercisable | $               $ 8,100,000    
Options exercisable, remaining contractual term               4 years 8 months 12 days    
Number of options expected to vest               1,511,930    
Options, expirations in period, weighted average exercise price ($ per share) | $ / shares               $ 10.89 $ 15.95 $ 5.32
Options, expirations in period               83,696 70,517 124,003
Options, grants in period, weighted average grant date fair value ($ per share) | $ / shares               $ 4.60 $ 9.19 $ 1.76
Proceeds from stock options exercised | $               $ 552,000 $ 1,400,000 $ 1,600,000
Options, exercises in period, aggregate intrinsic value | $               456,000 2,000,000 2,500,000
Employee                    
Stockholders' Equity (Textual) [Abstract]                    
Share-based compensation | $               5,800,000 4,800,000 1,200,000
Research and Development Expense                    
Stockholders' Equity (Textual) [Abstract]                    
Share-based compensation | $               3,200,000 2,800,000 555,000
General and Administrative Expense                    
Stockholders' Equity (Textual) [Abstract]                    
Share-based compensation | $               $ 2,600,000 2,000,000 605,000
Non Employee                    
Stockholders' Equity (Textual) [Abstract]                    
Number of options outstanding to purchase common stock               991,346    
Allocated share-based compensation expense | $               $ 385,000 $ 585,000 $ 714,000
Stock and Cash Based Incentive Plan                    
Stockholders' Equity (Textual) [Abstract]                    
Increased number of securities available for future issuance 2,000,000   1,250,000 500,000            
Number of potential shares authorized for issuance under a share-based compensation plan       513,833            
Reserved number of shares under the Incentive Plan               7,256,664    
Increased aggregate number of shares available for grants under the Incentive Plan               2,020,627    
Number of shares of vested restricted stock outstanding under the plan               230,000    
Number of common stock shares outstanding under the Incentive Plan               4,478,425    
Amended 2000 Stock Option Plan                    
Stockholders' Equity (Textual) [Abstract]                    
Number of options outstanding to purchase common stock               148,878    
Restricted Stock Units (RSUs)                    
Stockholders' Equity (Textual) [Abstract]                    
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | $               $ 1,200,000    
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition               2 years 1 month 6 days    
Weighted average grant date fair value ($ per share) | $ / shares               $ 7.76    
VGX Equity Compensation Plan                    
Stockholders' Equity (Textual) [Abstract]                    
Number of options outstanding to purchase common stock               1,235,061    
Over-Allotment Option                    
Stockholders' Equity (Textual) [Abstract]                    
Issuance of common stock for cash, net of financing costs, shares (shares)         1,425,000          
Minimum                    
Preferred Stock [Abstract]                    
Average daily trading volume triggering mandatory conversion (shares)               6,250    
Series C Preferred Stock                    
Class of Stock [Line Items]                    
Shares converted (shares)                 3  
Preferred Stock [Abstract]                    
Preferred stock, redemption price ($ per share) | $ / shares               $ 10,000    
Preferred stock, par value (Dollars per share) | $ / shares               $ 0.001 $ 0.001  
Notice period for mandatory conversion of preferred stock               30 days    
Convertible preferred stock, shares issued upon conversion (shares)               8,456    
Common stock                    
Class of Stock [Line Items]                    
Conversions of preferred stock to common stock, shares                 1,103  
March 2013 financing                    
Stockholders' Equity (Textual) [Abstract]                    
Stock issued during period, shares, warrants exercised               0 471,590  
Net proceeds from the transaction | $                 $ 1,500,000  
January Two Thousand Eleven Financing                    
Stockholders' Equity (Textual) [Abstract]                    
Stock issued during period, shares, warrants exercised                 1,673,750  
Net proceeds from the transaction | $                 $ 9,400,000  
Warrants Assumed in June Two Thousand Nine Merger                    
Stockholders' Equity (Textual) [Abstract]                    
Stock issued during period, shares, warrants exercised               426,625 274,083  
Net proceeds from the transaction | $               $ 2,000,000 $ 1,000,000  
Common stock                    
Class of Stock [Line Items]                    
Conversions of preferred stock to common stock, shares                 1,103  
Stockholders' Equity (Textual) [Abstract]                    
Issuance of common stock for cash, net of financing costs, shares (shares)               10,925,000 5,452,725 3,925,167
Common stock | Underwritten public offering                    
Stockholders' Equity (Textual) [Abstract]                    
Issuance of common stock for cash, net of financing costs, shares (shares)             5,452,725      
Public offering price ($ per share) | $ / shares             $ 11.60      
Proceeds from issuance of common stock | $             $ 59,200,000      
Common stock | Underwritten Public Offering Overallotment Option                    
Stockholders' Equity (Textual) [Abstract]                    
Common stock, capital shares reserved for future issuance (shares)             711,225