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Income Taxes (Details 1) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Income Tax Disclosure [Abstract]
Statutory tax rate	35.00%	35.00%	35.00%
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]
Income (benefit) taxes at statutory rates	$ (10,920,000)	$ (12,639,000)	$ (23,118,000)
State income tax, net of federal benefit	(2,640,000)	(2,362,000)	(1,651,000)
Change in valuation allowance	7,882,000	14,235,000	8,819,000
Research and development tax credits	(1,537,000)	(849,000)	(1,230,000)
Fair value warrant	(253,000)	(180,000)	16,129,000
Stock compensation	2,288,000	1,573,000	279,000
Uncertain tax positions	1,968,000	340,000	495,000
Expired NOL's and credits	339,000	728,000	338,000
Limited NOL's and credits	(297,000)	(749,000)	605,000
Change in state tax rate	676,000	(60,000)	(623,000)
Other	396,000	(8,000)	(12,000)
Income Tax Expense (Benefit)	$ (2,098,000)	$ 29,000	$ 31,000

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