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Income Taxes (Details Textual) - USD ($)	3 Months Ended				12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Operating Loss Carryforwards [Line Items]
Income tax benefit	$ 308,520	$ 1,789,246	$ 0	$ 0	$ 2,097,766	$ 0	$ 0
Tax benefits expired	27,200,000				27,200,000
Unrecognized tax benefits that would impact effective tax rate	4,300,000				4,300,000
Federal
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards that will expire due to IRC Section 382 limitations	177,400,000				177,400,000
Domestic Tax Authority
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards	177,400,000				177,400,000
Operating loss carryforwards related to excess share-based compensation	1,900,000				1,900,000
State
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards	197,800,000				197,800,000
Operating loss carryforwards related to excess share-based compensation	1,000,000				1,000,000
California
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards that will expire due to IRC Section 382 limitations	56,500,000				56,500,000
Pennsylvania
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards that will expire due to IRC Section 382 limitations	141,300,000				141,300,000
Research Tax Credit Carryforward | Federal
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	4,400,000				4,400,000
Research Tax Credit Carryforward | State
Operating Loss Carryforwards [Line Items]
Tax credit carryforward amount	$ 2,100,000				$ 2,100,000

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