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v3.5.0.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2016 | Sep. 30, 2015
Cash flows from operating activities: |  |
Net loss | $ (47,506,869) | $ (11,150,792)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 1,292,696 | 733,722
Amortization of intangible assets | 968,986 | 658,049
Change in value of common stock warrants | 517,334 | (467,877)
Stock-based compensation | 7,384,318 | 4,900,898
Amortization of premiums on investments | 200,000 | 242,384
Gain on short-term investments | (44,928) | 0
Deferred rent | (125,408) | 317,922
Gain on investment in affiliated entity | (5,817,309) | (5,849,782)
Gain on sale of intangible assets | (1,000,000) | (1,000,000)
Income tax benefit from other unrealized gains on securities | 0 | (1,789,246)
Changes in operating assets and liabilities: |  |
Accounts receivable | (10,122,049) | (8,161,066)
Prepaid expenses and other current assets | (473,995) | (550,917)
Prepaid expenses and other current assets from affiliated entity | (1,086,561) | 748,049
Other assets | (811,233) | (123,002)
Accounts payable and accrued expenses | 2,949,097 | 2,390,927
Accrued clinical trial expenses | 4,615,783 | 935,012
Accounts payable and accrued expenses due to affiliated entity | 328,373 | 2,784,612
Deferred revenue | 1,642,479 | 9,625,906
Deferred revenue from affiliated entity | (562,827) | 90,239
Net cash used in operating activities | (47,652,113) | (5,664,962)
Cash flows from investing activities: |  |
Purchases of investments | (42,495,236) | (37,391,913)
Maturities of investments | 51,721,024 | 4,745,000
Purchases of capital assets | (2,672,235) | (1,955,621)
Proceeds from sale of intangible assets | 1,000,000 | 1,000,000
Purchase of intangible assets and other assets | (1,200,000) | 0
Net cash provided by (used in) investing activities | 6,353,553 | (33,602,534)
Cash flows from financing activities: |  |
Proceeds from issuance of common stock, net of issuance costs | 5,458,284 | 81,902,363
Proceeds from stock option and warrant exercises, net of tax payments | 1,607,904 | 2,439,506
Other financing activities | (149,559) | (149,559)
Net cash provided by financing activities | 6,916,629 | 84,192,310
(Decrease) Increase in cash and cash equivalents | (34,381,931) | 44,924,814
Cash and cash equivalents, beginning of period | 57,632,693 | 40,543,982
Cash and cash equivalents, end of period | 23,250,762 | 85,468,796
Supplemental disclosure of non-cash activities |  |
Common stock issued for purchase of Bioject | 4,300,000 | 0
Change in amounts accrued for purchases of property and equipment | 169,980 | 475,123
Lease incentive recorded as fixed assets and deferred rent | $ 134,500 | $ 186,573

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- Definition Amount of cash outflow to a noncontrolling interest. Includes, but not limited to, reduction of noncontrolling interest ownership. Excludes dividends paid to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition The cash inflow from disposal of asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow from sales of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=65897068&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=68079674&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=64809438&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=65897068&loc=SL4591551-111686 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=64809438&loc=SL4573702-111684 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition Difference between actual rental income due and rental income recognized on a straight-line basis. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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