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v3.6.0.2

Consolidated Statements of Cash Flows | 12 Months Ended
--- | ---
Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($) | Dec. 31, 2014 USD ($)
Cash flows from operating activities: |  |  |
Net loss | $ (73,740,339) | $ (29,102,837) | $ (36,140,133)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 1,708,498 | 1,048,431 | 626,554
Amortization of intangible assets | 1,377,466 | 870,199 | 942,719
Change in value of common stock warrants | (127,554) | (177,561) | (348,143)
Stock-based compensation | 10,479,135 | 6,186,848 | 5,428,946
Issuance of shares in connection with reverse stock split | 0 | 0 | 57,187
Amortization of premiums on investments | 266,290 | 348,566 | 54,534
Deferred taxes | (849) | 14,166 | 27,537
Deferred rent | (16,728) | 383,584 | 762,616
Loss on short-term investments | 139,249 | 432,174 | 36,949
Gain on investment in affiliated entity | (1,110,787) | (2,600,467) | (2,676,224)
Gain on sale of intangible assets | (1,000,000) | (1,000,000) | 0
Income tax benefit from other unrealized gains on securities | 0 | (2,097,766) | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (8,521,899) | (4,497,225) | 499,176
Accounts receivable from affiliated entity | (714,908) | (31,627) | (1,820)
Prepaid expenses and other current assets | (831,802) | (119,284) | (160,540)
Prepaid expenses and other current assets from affiliated entity | (901,772) | 771,723 | 674,975
Restricted cash | 0 | 0 | 100,762
Other assets | (1,442,314) | (196,265) | (72,493)
Accounts payable and accrued expenses | 6,367,965 | 6,456,581 | 925,820
Accrued clinical trial expenses | 3,767,906 | 593,051 | 561,252
Accounts payable and accrued expenses due to affiliated entity | 907,532 | 136,640 | (493,848)
Deferred revenue | 1,527,686 | 10,191,840 | (260,719)
Deferred revenue from affiliated entity | (687,827) | (49,672) | (368,751)
Net cash used in operating activities | (62,555,052) | (12,438,901) | (29,823,644)
Cash flows from investing activities: |  |  |
Purchases of investments | (57,317,671) | (63,526,830) | (47,185,945)
Maturities of investments | 76,528,030 | 10,484,267 | 12,753,719
Purchases of capital assets | (2,738,470) | (2,781,544) | (1,379,980)
Proceeds from sale of intangible assets | 1,000,000 | 1,000,000 | 0
Purchase of intangible and other assets | (1,200,000) | 0 | 0
Net cash provided by (used in) investing activities | 16,271,889 | (54,824,107) | (35,812,206)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock and warrants, net of issuance costs | 6,295,761 | 81,902,363 | 59,209,182
Proceeds from stock option and warrant exercises, net of tax payments | 1,640,740 | 2,598,915 | 13,252,543
Other financing activities | (149,559) | (149,559) | 0
Net cash provided by financing activities | 7,786,942 | 84,351,719 | 72,461,725
Effect of exchange rate changes on cash and cash equivalents | 0 | 0 | (1,689)
Increase (Decrease) in cash and cash equivalents | (38,496,221) | 17,088,711 | 6,824,186
Cash and cash equivalents, beginning of period | 57,632,693 | 40,543,982 | 33,719,796
Cash and cash equivalents, end of period | 19,136,472 | 57,632,693 | 40,543,982
Supplemental disclosure of non-cash activities |  |  |
Common stock issued for purchase of Bioject | 4,300,000 | 0 | 0
Change in amounts accrued for purchases of property and equipment | 164,923 | 225,148 | 12,842
Lease incentive recorded as fixed assets and deferred rent | $ 523,856 | $ 773,000 | $ 933,000

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- Definition Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3521-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 25 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3536-108585 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 + Details
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- Definition The cash outflow for securities or other assets acquired, which qualify for treatment as an investing activity and are to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow (outflow) from financing activities classified as other. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3095-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3098-108585 + Details
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- Definition The cash inflow from disposal of asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow from sales of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=65897068&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=68079674&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=64809438&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=65897068&loc=SL4591551-111686 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=64809438&loc=SL4573702-111684 + Details
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- Definition Difference between actual rental income due and rental income recognized on a straight-line basis. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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