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Consolidated Statements of Stockholders' Equity - USD ($)
Total
Preferred stock
Common stock
Additional paid-in capital
Accumulated deficit
Accumulated other comprehensive income (loss)
Non- controlling interest
Beginning balance (shares) at Dec. 31, 2013   26 52,576,390        
Beginning balance at Dec. 31, 2013 $ 52,902,683   $ 52,577 $ 348,267,389 $ (295,788,577) $ (76,365) $ 447,659
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Issuance of shares related to reverse stock split (shares)     6,378        
Issuance of shares related to reverse stock split 57,187   $ 6 57,181      
Issuance of common stock for cash, net of financing costs (shares)     5,452,725        
Issuance of common stock for cash, net of financing costs 59,209,182   $ 5,453 59,203,729      
Conversions of preferred stock to common stock (shares)   (3) 1,103        
Conversions of preferred stock to common stock 0   $ 1 (1)      
Acquisition of non-controlling interest 0     118,621     (118,621)
Exercise of stock options and warrants for cash (shares)     2,689,868        
Exercise of stock options and warrants for cash 13,252,543   $ 2,689 13,249,854      
Cashless exercise of warrants (shares)     14,618        
Cashless exercise of warrants 0   $ 15 (15)      
Change in classification of warrants from liability to equity due to exercise 17,002,211     17,002,211      
Stock-based compensation 5,428,946     5,428,946      
Net loss attributable to common stockholders (36,140,133)       (36,121,713)   (18,420)
Unrealized gain (loss) on short-term investments (173,336)         (173,336)  
Unrealized gain (loss) on investment in affiliated entity, net of tax 0            
Foreign currency translation adjustments (1,689)         (1,689)  
Ending balance (shares) at Dec. 31, 2014   23 60,741,082        
Ending balance at Dec. 31, 2014 111,537,594   $ 60,741 443,327,915 (331,910,290) (251,390) 310,618
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Issuance of common stock for cash, net of financing costs (shares)     10,925,000        
Issuance of common stock for cash, net of financing costs 81,902,363   $ 10,925 81,891,438      
Payment to minority stockholders (149,559)           (149,559)
Exercise of stock options and warrants for cash (shares)     551,883        
Exercise of stock options and warrants for cash 2,598,915   $ 552 2,598,363      
Stock-based compensation 6,186,848     6,186,848      
Net loss attributable to common stockholders (29,102,837)       (29,187,606)   84,769
Unrealized gain (loss) on short-term investments 7,528         7,528  
Unrealized gain (loss) on investment in affiliated entity, net of tax 2,952,201         2,952,201  
Foreign currency translation adjustments 0            
Ending balance (shares) at Dec. 31, 2015   23 72,217,965        
Ending balance at Dec. 31, 2015 $ 175,933,053   $ 72,218 534,004,564 (361,097,896) 2,708,339 245,828
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Issuance of common stock for cash, net of financing costs (shares) 658,748   658,748        
Issuance of common stock for cash, net of financing costs $ 6,295,761   $ 659 6,295,102      
Issuance of common stock for Bioject acquisition (shares)     440,122        
Issuance of common stock for Bioject acquisition 4,300,000   $ 440 4,299,560      
Payment to minority stockholders (149,559)           (149,559)
Exercise of stock options and warrants for cash (shares)     450,045        
Exercise of stock options and warrants for cash 1,640,740   $ 449 1,640,291      
Cashless exercise of warrants (shares)     295,490        
Cashless exercise of warrants 0   $ 296 (296)      
Stock-based compensation (shares)     0        
Stock-based compensation 10,479,135   $ 0 10,479,135      
Net loss attributable to common stockholders (73,740,339)       (73,740,339)   0
Unrealized gain (loss) on short-term investments (111,967)         (111,967)  
Unrealized gain (loss) on investment in affiliated entity, net of tax (1,268,404)         (1,268,404)  
Foreign currency translation adjustments 0            
Ending balance (shares) at Dec. 31, 2016   23 74,062,370        
Ending balance at Dec. 31, 2016 $ 123,378,420   $ 74,062 $ 556,718,356 $ (434,838,235) $ 1,327,968 $ 96,269