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Income Taxes (Details Textual) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2017
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating Loss Carryforwards [Line Items]                
Income tax benefit   $ 308,520 $ 1,789,246 $ 0 $ 0 $ 0 $ 2,097,766 $ 0
Tax benefits expired           20,800,000    
Unrecognized tax benefits that would impact effective tax rate           5,700,000    
Federal                
Operating Loss Carryforwards [Line Items]                
Net operating loss carryforwards that will expire due to IRC Section 382 limitations           255,600,000    
California                
Operating Loss Carryforwards [Line Items]                
Net operating loss carryforwards that will expire due to IRC Section 382 limitations           73,600,000    
Pennsylvania                
Operating Loss Carryforwards [Line Items]                
Net operating loss carryforwards that will expire due to IRC Section 382 limitations           75,600,000    
Research Tax Credit Carryforward | Federal                
Operating Loss Carryforwards [Line Items]                
Tax credit carryforward amount           7,600,000    
Research Tax Credit Carryforward | State                
Operating Loss Carryforwards [Line Items]                
Tax credit carryforward amount           $ 2,100,000    
Accounting Standards Update 2016-09 | Scenario, Forecast                
Operating Loss Carryforwards [Line Items]                
Excess tax benefits $ 1,100,000