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Summary of Significant Accounting Policies - Antidilutive Securities Table (Details) - shares	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	7,897,564	6,377,633	5,576,939
Options to purchase common stock
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	6,806,183	5,862,364	4,840,514
Warrants to purchase common stock
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	284,091	276,813	727,969
Restricted stock units
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	798,834	230,000	0
Convertible preferred stock
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect
Total	8,456	8,456	8,456