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Income Taxes (Details 1) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
Statutory tax rate	35.00%	35.00%	35.00%
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]
Income (benefit) taxes at statutory rates	$ (25,809)	$ (10,920)	$ (12,639)
State income tax, net of federal benefit	(4)	(2,640)	(2,362)
Change in valuation allowance	29,678	7,882	14,235
Research and development tax credits	(3,117)	(1,537)	(849)
Fair value warrant	(47)	(253)	(180)
Stock compensation	113	2,288	1,573
Uncertain tax positions	1,367	1,968	340
Expired NOL's and credits	4,269	339	728
Limited NOL's and credits	(6,456)	(297)	(749)
Change in state tax rate	(495)	676	(60)
Other	501	396	(8)
Income Tax Expense (Benefit)	$ 0	$ (2,098)	$ 29

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