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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2017 | Mar. 31, 2016
Cash flows from operating activities: |  |
Net loss | $ (23,085,907) | $ (8,042,820)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 522,298 | 387,867
Amortization of intangible assets | 406,299 | 209,542
Change in value of common stock warrants | (116,477) | 409,369
Stock-based compensation | 5,372,797 | 3,057,312
Amortization of premiums on investments | 69,004 | 66,057
Loss on short-term investments | 51,706 | 4,532
Deferred rent | 1,208,085 | 9,769
Loss (Gain) on investment in affiliated entity | 1,608,817 | (7,480,977)
Changes in operating assets and liabilities: |  |
Accounts receivable | 5,956,611 | (3,819,700)
Accounts receivable from affiliated entity | 484,550 | 0
Prepaid expenses and other current assets | (2,457,068) | (205,450)
Prepaid expenses and other current assets from affiliated entity | (304,345) | (927,911)
Other assets | 587,993 | (361,070)
Accounts payable and accrued expenses | (5,643,054) | (1,621,449)
Accrued clinical trial expenses | (458,516) | 1,550,313
Accounts payable and accrued expenses due to affiliated entity | (543,410) | 42,186
Deferred revenue | 2,207,277 | 1,420,279
Deferred revenue from affiliated entity | (125,000) | (437,827)
Net cash used in operating activities | (15,227,440) | (15,739,978)
Cash flows from investing activities: |  |
Purchases of investments | (5,925,232) | (12,162,941)
Maturities of investments | 24,882,273 | 12,505,928
Purchases of capital assets | (789,257) | (681,141)
Net cash provided by (used in) investing activities | 18,167,784 | (338,154)
Cash flows from financing activities: |  |
Proceeds from stock option and warrant exercises, net of tax payments | 826,437 | 69,484
Net cash provided by financing activities | 826,437 | 69,484
Increase in cash and cash equivalents | 3,766,781 | (16,008,648)
Cash and cash equivalents, beginning of period | 19,136,472 | 57,632,693
Cash and cash equivalents, end of period | 22,903,253 | 41,624,045
Supplemental disclosure of non-cash activities |  |
Change in amounts accrued for purchases of property and equipment | 511,052 | 658,853
Lease incentive recorded as fixed assets and deferred rent | $ 0 | $ 134,500

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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=65897068&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=68079674&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=64809438&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=65897068&loc=SL4591551-111686 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=64809438&loc=SL4573702-111684 + Details
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