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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Cash flows from operating activities:    
Net loss $ (23,085,907) $ (8,042,820)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 522,298 387,867
Amortization of intangible assets 406,299 209,542
Change in value of common stock warrants (116,477) 409,369
Stock-based compensation 5,372,797 3,057,312
Amortization of premiums on investments 69,004 66,057
Loss on short-term investments 51,706 4,532
Deferred rent 1,208,085 9,769
Loss (Gain) on investment in affiliated entity 1,608,817 (7,480,977)
Changes in operating assets and liabilities:    
Accounts receivable 5,956,611 (3,819,700)
Accounts receivable from affiliated entity 484,550 0
Prepaid expenses and other current assets (2,457,068) (205,450)
Prepaid expenses and other current assets from affiliated entity (304,345) (927,911)
Other assets 587,993 (361,070)
Accounts payable and accrued expenses (5,643,054) (1,621,449)
Accrued clinical trial expenses (458,516) 1,550,313
Accounts payable and accrued expenses due to affiliated entity (543,410) 42,186
Deferred revenue 2,207,277 1,420,279
Deferred revenue from affiliated entity (125,000) (437,827)
Net cash used in operating activities (15,227,440) (15,739,978)
Cash flows from investing activities:    
Purchases of investments (5,925,232) (12,162,941)
Maturities of investments 24,882,273 12,505,928
Purchases of capital assets (789,257) (681,141)
Net cash provided by (used in) investing activities 18,167,784 (338,154)
Cash flows from financing activities:    
Proceeds from stock option and warrant exercises, net of tax payments 826,437 69,484
Net cash provided by financing activities 826,437 69,484
Increase in cash and cash equivalents 3,766,781 (16,008,648)
Cash and cash equivalents, beginning of period 19,136,472 57,632,693
Cash and cash equivalents, end of period 22,903,253 41,624,045
Supplemental disclosure of non-cash activities    
Change in amounts accrued for purchases of property and equipment 511,052 658,853
Lease incentive recorded as fixed assets and deferred rent $ 0 $ 134,500