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Income Taxes - Reconciliation of Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]
Income (benefit) taxes at statutory rates	$ (30,872)	$ (25,809)	$ (10,920)
State income tax, net of federal benefit	(4)	(4)	(2,640)
Change in valuation allowance	(20,965)	29,678	7,882
Research and development tax credits	(3,456)	(3,117)	(1,537)
Fair value warrant	(282)	(47)	(253)
Stock compensation	2,332	113	2,288
Uncertain tax positions	846	1,367	1,968
Expired NOLs and credits	454	4,269	339
Limited NOLs and credits	(165)	(6,456)	(297)
Change in state tax rate	50,019	(495)	676
Other	2,093	501	396
Income tax expense (benefit)	$ 0	$ 0	$ (2,098)

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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