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Impact of Recently Issued Accounting Standards (Tables) | 3 Months Ended
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Mar. 31, 2018
Accounting Policies [Abstract] |
Schedule of New Accounting Pronouncements and Changes in Accounting Principles | The following table illustrates the impact that adopting Topic 606 has had on our reported results in the condensed consolidated statement of operations.
| Balances Without Adoption of Topic 606 at March 31, 2018 |  | Impact of Adopting Topic 606 |  | As reported at March 31, 2018
Revenues: |  |  |  |  |
Revenue under collaborative research and development arrangements | $ | 1,289,046 |  |  | $ | — |  |  | $ | 1,289,046 |
Revenue under collaborative research and development arrangements with affiliated entities | 148,008 |  |  | — |  |  | 148,008 |
Grants and miscellaneous revenue | 1,850,341 |  |  | (1,757,751 | ) |  | 92,590 |
Grants and miscellaneous revenue from affiliated entity | 464,400 |  |  | (464,400 | ) |  | — |
Total revenues | 3,751,795 |  |  | (2,222,151 | ) |  | 1,529,644 |
Operating expenses: |  |  |  |  |
Research and development | 22,355,600 |  |  | (2,222,151 | ) |  | 24,577,751 |
General and administrative | 9,698,015 |  |  | — |  |  | 9,698,015 |
Total operating expenses | $ | 32,053,615 |  |  | $ | (2,222,151 | ) |  | $ | 34,275,766 |
The cumulative effect of the changes made to the Company's condensed consolidated balance sheet as of January 1, 2018 for the adoption of ASU No. 2016-01 are included in the table below:
Equity: | Balance at December 31, 2017 |  | Adjustments due to ASU No. 2016-01 |  | Balance at January 1, 2018
Accumulated deficit | $ | (523,356,317 | ) |  | $ | 231,366 |  |  | $ | (523,124,951 | )
Accumulated other comprehensive loss | $ | (117,005 | ) |  | $ | (231,366 | ) |  | $ | (348,371 | )

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- Definition Tabular disclosure of changes in accounting principles, including adoption of new accounting pronouncements, that describes the new methods, amount and effects on financial statement line items. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 250 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22580-107794 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=68064558&loc=d3e765-108305 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 250 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22499-107794 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.10-01.(b)(6)) -URI http://asc.fasb.org/extlink&oid=27015980&loc=d3e46468-122699 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 250 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=64853466&loc=d3e22583-107794 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=68064558&loc=d3e725-108305 + Details
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