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Impact of Recently Issued Accounting Standards - Narrative (Details) - USD ($) | 3 Months Ended |
--- | --- | ---
Mar. 31, 2018 | Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |
Contra-research and development expense | $ 2,200,000 |
Accounting Standards Update 2016-01 | Retained Earnings |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |
Cumulative effect |  | $ 231,366
Accounting Standards Update 2016-01 | AOCI Attributable to Parent |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |
Cumulative effect |  | $ (231,366)
Plumbline Life Sciences |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |
Gain on investment in affiliated entities | $ 982,000 |

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