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v3.8.0.1

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2018 | Mar. 31, 2017
Cash flows from operating activities: |  |
Net loss | $ (32,350,828) | $ (23,085,907)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 897,709 | 522,298
Amortization of intangible assets | 404,062 | 406,299
Change in value of common stock warrants | 127,841 | (116,477)
Stock-based compensation | 3,575,750 | 5,372,797
Amortization of premiums on investments | 55,522 | 69,004
Loss on short-term investments | 253,316 | 51,706
Deferred rent | (87,007) | 1,208,085
Loss (gain) on equity investment in affiliated entities | (2,380,423) | 1,608,817
Changes in operating assets and liabilities: |  |
Accounts receivable | 855,354 | 5,956,611
Accounts receivable from affiliated entity | (1,755,950) | (484,550)
Prepaid expenses and other current assets | 598,891 | (2,457,068)
Prepaid expenses and other current assets from affiliated entity | 171,026 | (304,345)
Other assets | 190,726 | 587,993
Accounts payable and accrued expenses | (6,363,762) | (5,643,054)
Accrued clinical trial expenses | (183,011) | (458,516)
Accounts payable and accrued expenses due to affiliated entity | 371,798 | (543,410)
Deferred revenue | 22,900,404 | 2,207,277
Deferred revenue from affiliated entity | (117,943) | (125,000)
Other liabilities | 261,325 | 0
Net cash used in operating activities | (12,575,200) | (15,227,440)
Cash flows from investing activities: |  |
Purchases of investments | (9,568,082) | (5,925,232)
Maturities of investments | 37,525,434 | 24,882,273
Purchases of capital assets | (1,153,465) | (789,257)
Net cash provided by investing activities | 26,803,887 | 18,167,784
Cash flows from financing activities: |  |
Proceeds (payments) for stock option and warrant exercises, net of tax payments | (506,403) | 826,437
Net cash (used in) provided by financing activities | (506,403) | 826,437
Increase in cash and cash equivalents | 13,722,284 | 3,766,781
Cash and cash equivalents, beginning of period | 23,786,579 | 19,136,472
Cash and cash equivalents, end of period | 37,508,863 | 22,903,253
Supplemental disclosure of non-cash activities |  |
Change in amounts accrued for purchases of property and equipment | $ 164,288 | $ 511,052

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