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Impact of Recently Issued Accounting Standards (Tables)
 3 Months Ended
Mar. 31, 2018
Accounting Policies [Abstract]  
Schedule of New Accounting Pronouncements and Changes in Accounting Principles
The following table illustrates the impact that adopting Topic 606 has had on our reported results in the condensed consolidated statement of operations.
 
Balances Without Adoption of Topic 606 at March 31, 2018
 
Impact of Adopting Topic 606
 
As reported at March 31, 2018
Revenues:
 
 
 
 
 
Revenue under collaborative research and development arrangements
$
1,289,046


$
—

 
$
1,289,046

Revenue under collaborative research and development arrangements with affiliated entities
148,008


—

 
148,008

Grants and miscellaneous revenue
1,850,341


(1,757,751
)
 
92,590

Grants and miscellaneous revenue from affiliated entity
464,400


(464,400
)
 
—

Total revenues
3,751,795

 
(2,222,151
)
 
1,529,644

Operating expenses:
 
 
 
 
 
Research and development
22,355,600

 
(2,222,151
)
 
24,577,751

General and administrative
9,698,015

 
—

 
9,698,015

Total operating expenses
$
32,053,615

 
$
(2,222,151
)
 
$
34,275,766

The cumulative effect of the changes made to the Company's condensed consolidated balance sheet as of January 1, 2018 for the adoption of ASU No. 2016-01 are included in the table below:
Equity:
Balance at December 31, 2017
 
Adjustments due to ASU No. 2016-01
 
Balance at January 1, 2018
Accumulated deficit
$
(523,356,317
)
 
$
231,366

 
$
(523,124,951
)
Accumulated other comprehensive loss
$
(117,005
)
 
$
(231,366
)
 
$
(348,371
)