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Condensed Consolidated Statements of Cash Flows - USD ($) | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
Cash flows from operating activities: |  |
Net loss | $ (38,989,953) | $ (32,565,023)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 1,841,084 | 1,020,679
Amortization of intangible assets | 716,458 | 810,539
Change in value of common stock warrants | (132,130) | 196,023
Stock-based compensation | 6,164,958 | 7,937,473
Amortization of premiums on investments | 71,559 | 140,599
Loss on short-term investments | 373,822 | 67,366
Deferred rent | (177,096) | 1,869,341
Loss (gain) on equity investment in affiliated entities | (287,815) | 1,439,721
Changes in operating assets and liabilities: |  |
Accounts receivable | 4,290,243 | 8,298,963
Accounts receivable from affiliated entities | (473,834) | (440,945)
Prepaid expenses and other current assets | 815,825 | (3,165,705)
Prepaid expenses and other current assets from affiliated entities | 58,710 | 260,694
Other assets | (85,022) | 438,896
Accounts payable and accrued expenses | (9,443,933) | (4,305,114)
Accrued clinical trial expenses | 1,747,980 | 820,362
Accounts payable and accrued expenses due to affiliated entities | (326,242) | (225,158)
Deferred revenue | (453,688) | (14,325,900)
Deferred revenue from affiliated entities | (118,985) | (219,792)
Deferred grant funding | 2,620,985 | 0
Deferred grant funding from affiliated entities | 188,800 | 0
Net cash used in operating activities | (31,598,274) | (31,946,981)
Cash flows from investing activities: |  |
Purchases of investments | (31,318,982) | (14,600,112)
Maturities of investments | 53,753,066 | 32,173,342
Purchases of capital assets | (1,614,767) | (5,828,137)
Net cash provided by investing activities | 20,819,317 | 11,745,093
Cash flows from financing activities: |  |
Proceeds from issuance of common stock, net of issuance costs | 1,973,401 | 24,060,196
Proceeds from stock option and warrant exercises, net of tax payments | 104,620 | 865,857
Net cash provided by financing activities | 2,078,021 | 24,926,053
(Decrease) Increase in cash and cash equivalents | (8,700,936) | 4,724,165
Cash and cash equivalents, beginning of period | 23,786,579 | 19,136,472
Cash and cash equivalents, end of period | 15,085,643 | 23,860,637
Supplemental disclosure of non-cash activities |  |
Change in amounts accrued for purchases of property and equipment | $ 1,224,906 | $ 1,185,087

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Difference between actual rental income due and rental income recognized on a straight-line basis. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
Name: | us-gaap_StraightLineRent
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration