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Impact of Recently Issued Accounting Standards - Narrative (Details) | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) lease | Dec. 31, 2017 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Contra-research and development expense | $ 1,900,000 | $ 4,100,000 |
Number of operating leases | lease |  | 3 |
Accounting Standards Update 2016-01 | Retained Earnings |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Cumulative effect |  |  | $ (231,366)
Accounting Standards Update 2016-01 | AOCI Attributable to Parent |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Cumulative effect |  |  | $ (231,366)
Plumbline Life Sciences |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Gain (loss) on investment in affiliated entities | $ (639,000) | $ 343,000 |

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