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Condensed Consolidated Statements of Cash Flows - USD ($)
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Cash flows from operating activities:    
Net loss $ (38,989,953) $ (32,565,023)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 1,841,084 1,020,679
Amortization of intangible assets 716,458 810,539
Change in value of common stock warrants (132,130) 196,023
Stock-based compensation 6,164,958 7,937,473
Amortization of premiums on investments 71,559 140,599
Loss on short-term investments 373,822 67,366
Deferred rent (177,096) 1,869,341
Loss (gain) on equity investment in affiliated entities (287,815) 1,439,721
Changes in operating assets and liabilities:    
Accounts receivable 4,290,243 8,298,963
Accounts receivable from affiliated entities (473,834) (440,945)
Prepaid expenses and other current assets 815,825 (3,165,705)
Prepaid expenses and other current assets from affiliated entities 58,710 260,694
Other assets (85,022) 438,896
Accounts payable and accrued expenses (9,443,933) (4,305,114)
Accrued clinical trial expenses 1,747,980 820,362
Accounts payable and accrued expenses due to affiliated entities (326,242) (225,158)
Deferred revenue (453,688) (14,325,900)
Deferred revenue from affiliated entities (118,985) (219,792)
Deferred grant funding 2,620,985 0
Deferred grant funding from affiliated entities 188,800 0
Net cash used in operating activities (31,598,274) (31,946,981)
Cash flows from investing activities:    
Purchases of investments (31,318,982) (14,600,112)
Maturities of investments 53,753,066 32,173,342
Purchases of capital assets (1,614,767) (5,828,137)
Net cash provided by investing activities 20,819,317 11,745,093
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs 1,973,401 24,060,196
Proceeds from stock option and warrant exercises, net of tax payments 104,620 865,857
Net cash provided by financing activities 2,078,021 24,926,053
(Decrease) Increase in cash and cash equivalents (8,700,936) 4,724,165
Cash and cash equivalents, beginning of period 23,786,579 19,136,472
Cash and cash equivalents, end of period 15,085,643 23,860,637
Supplemental disclosure of non-cash activities    
Change in amounts accrued for purchases of property and equipment $ 1,224,906 $ 1,185,087