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Impact of Recently Issued Accounting Standards - Narrative (Details) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2018 USD ($) | Sep. 30, 2018 USD ($) lease | Dec. 31, 2017 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Contra-research and development expense | $ 2,600 | $ 6,700 |
Number of operating leases | lease |  | 3 |
Accounting Standards Update 2016-01 | AOCI Attributable to Parent |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Cumulative effect |  |  | $ (231)
Accounting Standards Update 2016-01 | Retained Earnings |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Cumulative effect |  |  | $ (231)
Plumbline Life Sciences |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Gain (loss) on investment in affiliated entities | $ 531 | $ 873 |

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- Definition Amount of unrealized and realized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI). + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 321 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=84241550&loc=SL75117546-209714 + Details
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